Probing tissue transglutaminase mediated vascular smooth muscle cell aging using a novel transamidation-deficient Tgm2-C277S mouse model

Commonly used mouse strains have distinct vascular properties

(2020) Jochen Steppan et al.   HYPERTENSION RESEARCH

Lysyl oxidase-like 2 (LOXL2) depletion is protective in age-associated vascular stiffening

(2019) Jochen Steppan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Small Molecules Target the Interaction between Tissue Transglutaminase and Fibronectin

(2019) Livia Elena Sima et al.   MOLECULAR CANCER THERAPEUTICS

Smooth muscle cell and arterial aging: basic and clinical aspects

(2018) Patrick Lacolley et al.   CARDIOVASCULAR RESEARCH

Non-alcoholic fatty liver disease severity is modulated by transglutaminase type 2

(2018) Mauro Piacentini et al.   Cell Death & Disease

Tissue Transglutaminase in Alzheimer's Disease: Involvement in Pathogenesis and its Potential as a Therapeutic Target

(2018) Micha M.M. Wilhelmus et al.   JOURNAL OF ALZHEIMERS DISEASE

Knockdown of transglutaminase-2 prevents early age-induced vascular changes in mice

(2018) Dinani Matoso Filho Armstrong et al.   Acta Cirurgica Brasileira

Structure–Activity Relationships of Potent, Targeted Covalent Inhibitors That Abolish Both the Transamidation and GTP Binding Activities of Human Tissue Transglutaminase

(2017) Abdullah Akbar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Vascular Smooth Muscle Cells and Arterial Stiffening: Relevance in Development, Aging, and Disease

(2017) Patrick Lacolley et al.   PHYSIOLOGICAL REVIEWS

Tissue Transglutaminase Modulates Vascular Stiffness and Function Through Crosslinking‐Dependent and Crosslinking‐Independent Functions

(2017) Jochen Steppan et al.   Journal of the American Heart Association

Involvement of transglutaminase 2 and voltage-gated potassium channels in cystamine vasodilatation in rat mesenteric small arteries

(2016) Morten Engholm et al.   BRITISH JOURNAL OF PHARMACOLOGY

Transamidase site-targeted agents alter the conformation of the transglutaminase cancer stem cell survival protein to reduce GTP binding activity and cancer stem cell survival

(2016) C Kerr et al.   ONCOGENE

Matrix Metalloproteinases Promote Arterial Remodeling in Aging, Hypertension, and Atherosclerosis

(2015) M. Wang et al.   HYPERTENSION

Inhibitors of tissue transglutaminase

(2015) Jeffrey W. Keillor et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Tissue Transglutaminase, Not Lysyl Oxidase, Dominates Early Calcium-Dependent Remodeling of Fibroblast-Populated Collagen Lattices

(2015) D.D. Simon et al.   CELLS TISSUES ORGANS

Discovery of Potent and Specific Dihydroisoxazole Inhibitors of Human Transglutaminase 2

(2014) Cornelius Klöck et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small Molecule Inhibitors Target the Tissue Transglutaminase and Fibronectin Interaction

(2014) Bakhtiyor Yakubov et al.   PLoS One

Exercise, Vascular Stiffness, and Tissue Transglutaminase

(2014) Jochen Steppan et al.   Journal of the American Heart Association

Increased tissue transglutaminase activity contributes to central vascular stiffness in eNOS knockout mice

(2013) Sung Mee Jung et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Vena cava and aortic smooth muscle cells express transglutaminases 1 and 4 in addition to transglutaminase 2

(2012) Kyle B. Johnson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Transglutaminase 2 and Its Role in Pulmonary Fibrosis

(2011) Keith C. Olsen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Nitric oxide regulates tissue transglutaminase localization and function in the vasculature

(2011) Simran K. Jandu et al.   AMINO ACIDS

Recent advances in the development of tissue transglutaminase (TG2) inhibitors

(2011) E. Badarau et al.   AMINO ACIDS

Tissue-specific responses to loss of transglutaminase 2

(2011) Stephanie Deasey et al.   AMINO ACIDS

TG2, a novel extracellular protein with multiple functions

(2011) Zhuo Wang et al.   AMINO ACIDS

Targeting Ovarian Tumor Cell Adhesion Mediated by Tissue Transglutaminase

(2011) M. Khanna et al.   MOLECULAR CANCER THERAPEUTICS

The Redox State of Transglutaminase 2 Controls Arterial Remodeling

(2011) Jeroen van den Akker et al.   PLoS One

Decreased S -Nitrosylation of Tissue Transglutaminase Contributes to Age-Related Increases in Vascular Stiffness

(2010) Lakshmi Santhanam et al.   CIRCULATION RESEARCH

Importance of syndecan-4 and syndecan -2 in osteoblast cell adhesion and survival mediated by a tissue transglutaminase−fibronectin complex

(2010) Z. Wang et al.   EXPERIMENTAL CELL RESEARCH

RGD-independent Cell Adhesion via a Tissue Transglutaminase-Fibronectin Matrix Promotes Fibronectin Fibril Deposition and Requires Syndecan-4/2 and α5β1 Integrin Co-signaling

(2010) Zhuo Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The treatment of collagen fibrils by tissue transglutaminase to promote vascular smooth muscle cell contractile signaling

(2009) Tighe A. Spurlin et al.   BIOMATERIALS

Transglutaminases and neurodegeneration

(2009) Thomas M. Jeitner et al.   JOURNAL OF NEUROCHEMISTRY

Serotonylation of Vascular Proteins Important to Contraction

(2009) Stephanie W. Watts et al.   PLoS One

Intracellular Localization and Conformational State of Transglutaminase 2: Implications for Cell Death

(2009) Soner Gundemir et al.   PLoS One

Clinical and Biological Significance of Tissue Transglutaminase in Ovarian Carcinoma

(2008) J. Y. Hwang et al.   CANCER RESEARCH

Xeno-Cannibalism as an Exacerbation of Self-Cannibalism: A Possible Fruitful Survival Strategy for Cancer Cells

(2008) W. Malorni et al.   CURRENT PHARMACEUTICAL DESIGN

Fibronectin-Tissue Transglutaminase Matrix Rescues RGD-impaired Cell Adhesion through Syndecan-4 and β1Integrin Co-signaling

(2008) Dilek Telci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY