REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway

Reg3β is associated with cardiac inflammation and provides prognostic information in patients with acute coronary syndrome

(2018) Holger Lörchner et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Glycogen synthase kinase-3β ablation limits pancreatitis-induced acinar-to-ductal metaplasia

(2017) Li Ding et al.   JOURNAL OF PATHOLOGY

Acinar cell plasticity and development of pancreatic ductal adenocarcinoma

(2017) Peter Storz   Nature Reviews Gastroenterology & Hepatology

KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer

(2017) Andrew M. Waters et al.   Cold Spring Harbor Perspectives in Medicine

YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK–STAT3 Signaling

(2016) Ralph Gruber et al.   GASTROENTEROLOGY

Microarray-based gene expression profiling reveals genes and pathways involved in the oncogenic function of REG3A on pancreatic cancer cells

(2016) Qianqian Xu et al.   GENE

Dynamic landscape of pancreatic carcinogenesis reveals early molecular networks of malignancy

(2016) Bo Kong et al.   GUT

Therapeutic potential of targeting acinar cell reprogramming in pancreatic cancer

(2016) Chi-Hin Wong et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes

(2016) Yelin Wu et al.   Nature Communications

Reg proteins promote acinar-to-ductal metaplasia and act as novel diagnostic and prognostic markers in pancreatic ductal adenocarcinoma

(2016) Qing Li et al.   Oncotarget

Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions

(2016) Geou-Yarh Liou et al.   Cell Reports

REG3A accelerates pancreatic cancer cell growth under IL-6-associated inflammatory condition: Involvement of a REG3A–JAK2/STAT3 positive feedback loop

(2015) Xiulan Liu et al.   CANCER LETTERS

IL17 Functions through the Novel REG3 -JAK2-STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer

(2015) C. Loncle et al.   CANCER RESEARCH

The MAPK pathway across different malignancies: A new perspective

(2014) Mauricio Burotto et al.   CANCER

Activated Macrophages Create Lineage-Specific Microenvironments for Pancreatic Acinar- and β-Cell Regeneration in Mice

(2014) Angela Criscimanna et al.   GASTROENTEROLOGY

SOCS3 methylation in synergy with Reg3A overexpression promotes cell growth in pancreatic cancer

(2014) Jun Wang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Precursor Lesions for Sporadic Pancreatic Cancer: PanIN, IPMN, and MCN

(2014) M. Distler et al.   Biomed Research International

Reg3  Deficiency Impairs Pancreatic Tumor Growth by Skewing Macrophage Polarization

(2013) M. Gironella et al.   CANCER RESEARCH

Models of Acute and Chronic Pancreatitis

(2013) Markus M. Lerch et al.   GASTROENTEROLOGY

MAPK Signaling Is Required for Dedifferentiation of Acinar Cells and Development of Pancreatic Intraepithelial Neoplasia in Mice

(2013) Meredith A. Collins et al.   GASTROENTEROLOGY

Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation

(2013) Guido von Figura et al.   GUT

Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs

(2013) Geou-Yarh Liou et al.   JOURNAL OF CELL BIOLOGY

REG3β contributes to the immunosuppressive microenvironment of pancreatic cancer

(2013) Emma Folch-Puy   OncoImmunology

REG4contributes to the invasiveness of pancreatic cancer by upregulatingMMP-7andMMP-9

(2012) Xu-Jun He et al.   CANCER SCIENCE

Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia

(2012) Pierre-Paul Prévot et al.   GUT

The Antimicrobial Protein REG3A Regulates Keratinocyte Proliferation and Differentiation after Skin Injury

(2012) Yuping Lai et al.   IMMUNITY

Maintenance of acinar cell organization is critical to preventing Kras-induced acinar-ductal metaplasia

(2012) G Shi et al.   ONCOGENE

Pancreatic islet-specific overexpression of Reg3β protein induced the expression of pro-islet genes and protected the mice against streptozotocin-induced diabetes mellitus

(2011) Xiaoquan Xiong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

STAT3 Plays a Critical Role in KRAS-Induced Pancreatic Tumorigenesis

(2011) R. B. Corcoran et al.   CANCER RESEARCH

Acinar-to-ductal metaplasia accompanies c-myc-induced exocrine pancreatic cancer progression in transgenic rodents

(2011) Paul J. Grippo et al.   INTERNATIONAL JOURNAL OF CANCER

Regenerating Islet-derived 1α (Reg-1α) Protein Is New Neuronal Secreted Factor That Stimulates Neurite Outgrowth via Exostosin Tumor-like 3 (EXTL3) Receptor

(2011) Isabelle Acquatella-Tran Van Ba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Upregulation of REG Iα accelerates tumor progression in pancreatic cancer with diabetes

(2010) Lin Zhou et al.   INTERNATIONAL JOURNAL OF CANCER

β-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice

(2010) John P. Morris et al.   JOURNAL OF CLINICAL INVESTIGATION

Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras

(2009) Catherine Carrière et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ras Activity in Acinar Cells Links Chronic Pancreatitis and Pancreatic Cancer

(2009) Craig D. Logsdon et al.   Clinical Gastroenterology and Hepatology

Serum tumor antigen REG4 as a diagnostic biomarker in pancreatic ductal adenocarcinoma

(2009) Reiko Takayama et al.   JOURNAL OF GASTROENTEROLOGY