期刊
ISCIENCE
卷 24, 期 8, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.isci.2021.102835
关键词
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资金
- Australian Research Council [APP160100627]
- Australian Government Research Training Program Scholarship
A large-scale mouse study using mixture modeling identified carbohydrate as a major driver of B cell development and function. Increasing dietary carbohydrate was shown to promote B cell development in various immune organs and enhance antibody production after immunization. This study highlights the importance of macronutrients in modulating B cell development and function.
While dietmodulates immunity, its impact on B cell ontogeny remains unclear. Using mixture modeling, a large-scale isocaloric dietary cohort mouse study identified carbohydrate as a major driver of B cell development and function. Increasing dietary carbohydrate increased B cell proportions in spleen, mesenteric lymph node and Peyer's patches, and increased antigen-specific immunoglobulin G production after immunization. This was linked to increased B lymphopoiesis in the bone marrow. Glucose promoted early B lymphopoiesis and higher total B lymphocyte numbers than fructose. It drove B cell development through glycolysis and oxidative phosphorylation, independently of fatty acid oxidation in vitro and reduced B cell apoptosis in early development via mTOR activation, independently of interleukin-7. Ours is the first comprehensive study showing the impact of macronutrients on B cell development and function. It shows the quantitative and qualitative interplay between dietary carbohydrate and B cells and argues for dietary modulation in B cell-targeting strategies.
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