Article
Engineering, Biomedical
Fernanda Furuse Ventura dos Santos, Stefan Habelitz, Fabio Dupart Nascimento, Victor Elias Arana-Chavez, Roberto Ruggiero Braga
Summary: This study aimed to verify the effectiveness of poly(aspartic acid), pAsp, in dentin regeneration using an animal model. The results showed that pAsp promoted dentin regeneration in rat molars and may be an alternative to MTA as a pulp-capping agent.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ali Vafaei, Mahsa Nikookhesal, Leila Erfanparast, Henrik Lovschall, Bahram Ranjkesh
Summary: The study demonstrated that vital pulp therapy using fast-setting calcium silicate cement had a significantly higher success rate compared to slow-setting MTA, with treatment under general anesthesia and restoration with stainless steel crowns influencing the outcome.
JOURNAL OF DENTISTRY
(2022)
Review
Biochemistry & Molecular Biology
Mihai Andrei, Raluca Paula Vacaru, Anca Coricovac, Radu Ilinca, Andreea Cristiana Didilescu, Ioana Demetrescu
Summary: The vitality of dental pulp is essential for maintaining the health and functionality of the tooth. Hydraulic calcium-silicate cements can stimulate reparative dentinogenesis in direct pulp capping procedures, leading to the formation of new dentin bridges. Different degrees of pulp inflammatory response and dentin bridge formation were observed during pulp healing, showing positive effects on tertiary dentin formation and pulp vitality preservation.
Review
Chemistry, Physical
Ermin Nie, Jiali Yu, Rui Jiang, Xiangzhen Liu, Xiang Li, Rafiqul Islam, Mohammad Khursheed Alam
Summary: This systematic review evaluated the dentin regeneration efficacy of direct pulp capping biomaterials, concluding that MTA and Biodentine can induce dentin regeneration. The results suggest that MTA and its variants have better efficacy in the DPC procedure for dentin regeneration.
Article
Chemistry, Physical
Joanna Metlerska, Irini Fagogeni, Marcin Metlerski, Alicja Nowicka
Summary: Calcium silicate-based cements have a significant impact on tooth coloration, with Ortho MTA, ProRoot MTA, MTA Plus, and Biodentine causing the most color change after 6 months, with Biodentine darkening the shade of the base color.
Article
Physiology
Yam Prasad Aryal, Chang-Yeol Yeon, Tae-Young Kim, Eui-Seon Lee, Shijin Sung, Elina Pokharel, Ji-Youn Kim, So-Young Choi, Hitoshi Yamamoto, Wern-Joo Sohn, Youngkyun Lee, Seo-Young An, Chang-Hyeon An, Jae-Kwang Jung, Jung-Hong Ha, Jae-Young Kim
Summary: The study demonstrates that apigenin can promote dentin regeneration by modulating inflammation and activating signaling regulations.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Wei-Ting Kuo, Xin Li, Fang-Yuan Chen, Yan-Jie Wang, Zhi Chen, Shinn-Jyh Ding, Lu Zhang
Summary: The study revealed that RDSC is more prone to discoloration compared to other pulp-capping agents, while showing significant potential in promoting dentin bridge formation, suggesting its recommendation as a pulp-capping agent in non-aesthetic areas.
FRONTIERS IN MATERIALS
(2021)
Article
Polymer Science
Shu-Fen Chuang, Yu-Hsuan Chen, Peter X. Ma, Helena H. Ritchie
Summary: In this study, the effectiveness of phosphophoryn (PP) and dentin sialoprotein (DSP) as bio-inductive pulp capping materials was examined through in vitro and in vivo experiments. Intermediate-dose PP was found to enhance cell migration and differentiation, while recDSP/PP proteins stimulated DSP-PP transcript expression. In vivo experiments showed that intermediate-dose PP and recDSP/PP proteins induced less pulp inflammation and promoted reparative dentin formation.
Article
Engineering, Multidisciplinary
Wenjuan Liu, Zhiguang Huan, Chengtie Wu, Zhihua Zhou, Jiang Chang
Summary: This study developed a composite bone cement with high compressive strength and desirable bioactivity by incorporating calcium silicate bioceramic into magnesium phosphate bone cement. The composite bone cement showed significantly higher compressive strength compared to traditional bone cements and demonstrated apatite mineralization ability and moderate degradation behavior.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Chemistry, Physical
Maria Teresa Xavier, Ana Luisa Costa, Francisco Jose Caramelo, Paulo Jorge Palma, Joao Carlos Ramos
Summary: This study revealed that the clinical variables of adhesive system, application of an additional HBL, and restoration time significantly affected the bond performance and ultra-morphological interface between composite adhesive restoration and CSC, as demonstrated by SBS tests and SEM analysis.
Article
Chemistry, Physical
Mohamed Mahmoud Abdalla, Christie Y. K. Lung, Mohammed Nadeem Bijle, Cynthia Kar Yung Yiu
Summary: In this study, calcium strontium silicate (CSR) ceramic was successfully synthesized and its physicochemical properties, bioactivity, cytocompatibility, and stimulatory effect on stem cell differentiation were evaluated. The results showed that CSR had shorter setting time, higher apatite formation, cell viability, and enhanced differentiation of stem cells compared to calcium silicate (CS).
Article
Dentistry, Oral Surgery & Medicine
Jose Luis Sanz, Anna Soler-Doria, Sergio Lopez-Garcia, David Garcia-Bernal, Francisco J. Rodriguez-Lozano, Adrian Lozano, Carmen Llena, Leopoldo Forner, Julia Guerrero-Girones, Maria Melo
Summary: The new Theracal PT shows improved in vitro cytocompatibility and mineralization potential on hDPSCs compared with its predecessor, Theracal LC, and has comparable biological properties to Biodentine.
JOURNAL OF ENDODONTICS
(2021)
Review
Materials Science, Ceramics
Sotoudeh Davaie, Tabassom Hooshmand, Sajjad Ansarifard
Summary: This study systematically reviewed the use of different types of bioceramics as direct dental pulp capping materials for dentin regeneration in permanent teeth. It found that calcium silicate-based materials, MTA, and Biodentine are currently the most effective bioceramics for this purpose, with calcium phosphates showing potential as future alternatives. Further well-designed in vitro and clinical studies are needed to confirm the most appropriate bioceramics for direct dental pulp capping procedures.
CERAMICS INTERNATIONAL
(2021)
Article
Cell Biology
Keita Ipposhi, Atsushi Tomokiyo, Taiga Ono, Kozue Yamashita, Muhammad Anas Alhasan, Daigaku Hasegawa, Sayuri Hamano, Shinichiro Yoshida, Hideki Sugii, Tomohiro Itoyama, Marina Ogawa, Hidefumi Maeda
Summary: SFRP1 plays a crucial role in dentinogenesis and promoting reparative dentin formation, as demonstrated by its effects on odontoblastic differentiation and mineralized nodule formation. The strong expression of SFRP1 in mature odontoblasts indicates its importance in dental pulp preservation and response to injury. Additionally, SFRP1 regulates odontoblast-related gene expression, particularly BMP-2, affecting the formation and structure of reparative dentin.
Review
Biochemistry & Molecular Biology
Foteini Machla, Ioannis Angelopoulos, Matthias Epple, Maria Chatzinikolaidou, Athina Bakopoulou
Summary: This systematic review evaluates the application of potential therapeutic signaling molecules on dentin-pulp complex and pulp tissue regeneration in animal studies. The results highlight the important role of signaling molecules in dentin/pulp regeneration and the need for further research to determine more efficient combinations.
Article
Multidisciplinary Sciences
Nicolas Obtel, Adeline Le Cabec, The Nghia Nguyen, Eloise Giabicani, Stijn J. M. Van Malderen, Jan Garrevoet, Aline Percot, Celine Paris, Christopher Dean, Smail Hadj-Rabia, Pascal Houillier, Tilman Breiderhoff, Claire Bardet, Thibaud Coradin, Fernando Ramirez Rozzi, Catherine Chaussain
Summary: Claudin proteins are crucial for determining the permeability and ion specificity of tight junctions in epithelia. Deficiency in claudin-10 is associated with severe enamel wear in HELIX syndrome patients. Analysis of a HELIX patient's molar revealed accentuated strontium variations in the enamel and dentin, possibly indicating episodes of worsening renal dysfunction.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Environmental Sciences
Ai Thu Bui, Sophia Houari, Sophia Loiodice, Dominique Bazin, Jeremy Sadoine, Nicolas Roubier, Elsa Vennat, Thu Thuy Tran, Ariane Berdal, Jean-Marc Ricort, Sakina Mhaouty-Kodja, Sylvie Babajko
Summary: This study analyzed the effects of exposure to low doses of DEHP on mouse teeth. The results showed that DEHP can directly affect dental cells, leading to impaired enamel development. Additionally, the study found delayed effects of DEHP on enamel hardness and mineralization. These findings are important for understanding the impact of environmental toxicant exposure and providing early markers.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2022)
Article
Cell Biology
Loic Louvet, Gaelle Lenglet, A. Michaela Krautzberger, Romuald Mentaverri, Frederic Hague, Clara Kowalewski, Nassim Mahtal, Julie Lesieur, Anne-Laure Bonnet, Caroline Andrique, Celine Gaucher, Cathy Gomila, Heinrich Schrewe, Pierre-Louis Tharaux, Said Kamel, Catherine Chaussain, Isabelle Six
Summary: In this study, we investigated the role of Vasn expression in vascular function. Vasn knockout mice showed decreases in blood pressure, angiotensin II levels, and vessel contractibility. In vitro experiments revealed that Vasn deficiency resulted in SMC contractile phenotype switching, changes in intracellular calcium levels, and impaired NO signaling. These findings highlight the importance of Vasn SMC expression in maintaining vascular functions.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sandra Minic, Sibylle Vital, Catherine Chaussain, Tchilalo Boukpessi, Francesca Mangione
Summary: The regenerative endodontic procedure (REP) is a treatment option for immature necrotic teeth with a periapical lesion. Studies have shown that REP can result in asymptomatic teeth, healing of apical lesions, and increased root thickness and length. However, further research is needed to successfully reproduce the physiological structure and function of the dentin-pulp complex.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Marion Florimond, Sandra Minic, Paul Sharpe, Catherine Chaussain, Emmanuelle Renard, Tchilalo Boukpessi
Summary: The main goal of vital pulp therapy is to preserve the vitality of the pulp tissue, but it does not regenerate the dentin pulp complex integrity. The Wnt protein-based strategy has been studied as a potential therapy for dentin pulp complex and bone regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Julia Andre, Volha V. Zhukouskaya, Anne-Sophie Lambert, Jean-Pierre Salles, Brigitte Mignot, Claire Bardet, Catherine Chaussain, Anya Rothenbuhler, Agnes Linglart
Summary: This study found that despite optimal conventional treatment, about 40-50% of children with well-controlled X-linked hypophosphatemia (XLH) experience linear growth failure. However, rhGH treatment significantly improved their final height.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Review
Microbiology
Virginie Gazil, Octave Nadile Bandiaky, Emmanuelle Renard, Katia Idiri, Xavier Struillou, Assem Soueidan
Summary: The success rates of dental implants at 5 and 10 years are nearly 90%. The prevalence of peri-implant diseases, such as peri-implantitis and peri-implant mucositis, is significant. Recent studies using new generation sequencing methods have compared the microbiota of healthy and diseased periodontal and peri-implant sites, revealing distinct differences in diversity and composition. Understanding the characteristics of the peri-implant microbiota can optimize therapeutic strategies for peri-implant diseases.
Article
Biochemistry & Molecular Biology
Virginie Bourdin, Philippe Charlier, Stephane Crevat, Lotfi Slimani, Catherine Chaussain, Melodie Kielbasa, Olivier Pible, Jean Armengaud
Summary: In 2022, a scientific examination was conducted on the heart of Blessed Pauline Jaricot, a French missionary figure. By combining metaproteomics and high-resolution microtomography imaging, researchers obtained a dataset of 6731 high-resolution MS/MS spectra, of which 968 could be assigned to specific peptidic biomolecules. The identified peptide sequences revealed the presence of 5 phyla among eukaryota (comprising 94% of the biomass), including Ascomycota (55%) and Chordata (42%). Bacteria represented only 6% of the biomass and no traces of embalming substance or pathogens were found.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Sophia Schonherr-Hellec, Eirini Chatzopoulou, Jean-Philippe Barnier, Yoann Atlas, Sebastien Dupichaud, Thomas Guilbert, Yves Dupraz, Julie Meyer, Catherine Chaussain, Carolin Gurin, Xavie Nassif, Stephane Germain, Laurent Muller, Mathieu Coureuil
Summary: This article describes the implantation of engineered human microvasculature in mice, which allows the study of human pathogens. Using Neisseria meningitidis as an example, the authors demonstrate the strength and opportunities associated with this approach.
Review
Biotechnology & Applied Microbiology
Melanie Maillard, Octave Nadile Bandiaky, Suzanne Maunoury, Charles Alliot, Brigitte Alliot-Licht, Samuel Serisier, Emmanuelle Renard
Summary: This systematic review evaluates the ability of different formulations of calcium phosphate to reduce dentin hypersensitivity pain level in clinical studies. The results show that calcium phosphates have properties that reduce dentin hypersensitivity pain. The biomimetic and non-toxic characteristics of these materials make them a major asset in treating dentin hypersensitivity.
BIOENGINEERING-BASEL
(2023)
Review
Engineering, Biomedical
Katia Idiri, Octave Bandiaky, Assem Soueidan, Christian Verner, Emmanuelle Renard, Xavier Struillou
Summary: Dental implants sometimes require bone augmentation, and the most commonly used procedure is xenografts with deproteinized bovine bone mineral (DBBM). Adding platelet-rich fibrin (PRF) to DBBM has shown better performance, but its role in preimplantation bone grafts is still unclear.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Meeting Abstract
Endocrinology & Metabolism
Elis Lira dos Santos, Kenta Nakajima, Julien Po, Agnes Linglart, Takashi Shimada, Catherine Chaussain, Claire Bardet
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Meeting Abstract
Endocrinology & Metabolism
Elis Lira dos Santos, Kenta Nakajima, Julien Po, Agnes Linglart, Takashi Shimada, Catherine Chaussain, Claire Bardet
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Margaux Gadion, Agathe Herve, Julia Herrou, Anya Rothenbuhler, Violaine Smail-Faugeron, Frederic Courson, Agnes Linglart, Catherine Chaussain, Martin Biosse Duplan
Summary: This study compared the incidence of dental abscesses in X-linked hypophosphatemia (XLH) children treated with either conventional treatment (CT) or burosumab. The results showed that burosumab treatment appears to be associated with a significant reduction in dental abscesses compared to CT.