Article
Medicine, Research & Experimental
Chen-An Liu, Tong Liu, Yi-Zhong Ge, Meng-Meng Song, Guo-Tian Ruan, Shi-Qi Lin, Hai-Lun Xie, Jin-Yu Shi, Xin Zheng, Yue Chen, Liuyi Shen, Li Deng, Han-Ping Shi
Summary: According to the COX regression analysis, the distribution of muscle mass across different body parts, such as upper limbs, lower limbs, trunk, gynoid, and total lean mass, is positively associated with the survival rate of participants. Changes in the lean mass ratio and android-gynoid ratio attenuate the protective effect of lean mass. Age and sex act as potential modifiers, and the relationship between lean mass and prognosis is more significant in men and middle-aged participants. The impact of lean mass on prognosis is more substantial in the near-term rather than the long-term.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Jesus del Pozo-Cruz, Francisco Alvarez-Barbosa, Daniel Gallardo-Gomez, Borja del Pozo Cruz
Summary: This study found that there is a non-linear association between the number of steps per day and all-cause mortality among adults with prediabetes and diabetes. Accumulating more steps up to approximately 10,000 steps per day can lower the risk of all-cause mortality.
Article
Clinical Neurology
Jordan Weiss, May A. A. Beydoun, Hind A. A. Beydoun, Marie T. T. Fanelli-Kuczmarski, Sri Banerjee, Armin Hamrah, Michele K. K. Evans, Alan B. B. Zonderman
Summary: There are racial disparities in dementia incidence among middle-aged adults, which are influenced by socioeconomic status (SES), lifestyle, and health-related characteristics. Non-White adults have a higher risk of AD-specific (HR=2.05) and all-cause dementia (HR=2.01) compared to Non-Hispanic White adults. Diet, smoking, and physical activity mediate the relationship between race/ethnicity, SES, and dementia, with smoking and physical activity having health-mediating effects on dementia risk.
ALZHEIMERS & DEMENTIA
(2023)
Article
Nutrition & Dietetics
Yu-Jin Kwon, Hye Sun Lee, Goeun Park, Juyeon Yang, Hyung-Mi Kim, Ji-Won Lee
Summary: This study investigated the association between dietary zinc intake and total deaths, cancer, and cardiovascular disease death. The results showed that dietary zinc intake was inversely associated with all-cause mortality and cardiovascular disease mortality, but not with cancer mortality. These findings suggest that recommending optimal dietary zinc intake is beneficial for human health.
Article
Public, Environmental & Occupational Health
Kaihong Xie, Xiao Han, Xuanhan Hu
Summary: This study aimed to investigate the relationship between balance ability and all-cause death in middle-aged and elderly people, and to provide a basis for designing a balanced training plan for this population in China. The results showed that there was an association between balance ability and death, with a decrease in balance ability being associated with an increased risk of all-cause death. Additionally, there was no interaction between balance ability and chronic disease, overweight, and obesity.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Kulapong Jayanama, Olga Theou, Judith Godin, Andrea Mayo, Leah Cahill, Kenneth Rockwood
Summary: This study found that BMI is associated with frailty, and being overweight or obese is related to higher levels of frailty. Higher body fat percentage is associated with higher frailty, partially mediating the relationship between BMI and frailty.
Article
Multidisciplinary Sciences
Yayun Fan, Dingliu He
Summary: The study found that worse self-rated health is associated with higher all-cause mortality, especially among individuals living in rural areas, those who are literate, those with above-average household income, and those working in agriculture or related occupations.
SCIENTIFIC REPORTS
(2022)
Article
Transplantation
Yejin Kim, Jeonggyu Kang, Yoosoo Chang, Young Youl Hyun, Kyu-Beck Lee, Hocheol Shin, Sarah H. Wild, Christopher D. Byrne, Seungho Ryu
Summary: This study evaluated the association between coronary artery calcium scores (CACSs) and the development of chronic kidney disease (CKD). The results showed that higher CACS was progressively associated with an increased risk of CKD, indicating that individuals with higher CACS have a higher risk of developing CKD.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Katrina L. Kezios, Peiyi Lu, Sebastian Calonico, Adina Zeki Al Hazzouri
Summary: Preliminary research suggests that sustained low-wage earning during midlife may have long-term health consequences. This study found an association between sustained low-wage earning and mortality, particularly when accompanied by employment instability. If causal, these findings suggest that improving the financial standing of low-wage workers, such as through minimum wage laws, could improve mortality outcomes.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Environmental Sciences
Haiqing Zhang, Qin Fang, Meng Li, Liangle Yang, Xuefeng Lai, Hao Wang, Meian He, Zhichao Wang, Weijia Kong, Xiaomin Zhang
Summary: This study aimed to investigate the association between hearing loss and all-cause and cardiovascular disease mortality, as well as the potential modification by chronic conditions in middle-aged and older Chinese adults. The results showed that hearing loss was independently associated with an increased risk of all-cause and CVD mortality, and the risk increased with the severity of hearing loss. Additionally, individuals with both hearing loss and diabetes or hypertension had a higher risk of mortality.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Geriatrics & Gerontology
Ludmila L. P. Cabral, Yuri A. Freire, Rodrigo A. Browne, Geovani A. D. Macedo, Marcyo Camara, Daniel Schwade, Luiz Fernando Farias-Junior, Ronildo Paulo-Pereira, Raissa M. Silva, Telma M. A. M. Lemos, Tiago Barreira, Eduardo C. Costa
Summary: The study demonstrates an inverse association between steps/day and peak cadence with arterial stiffness in older adults, showing that increasing either steps/day or peak cadence leads to a decrease in arterial stiffness, indicating a dose-response relationship.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Cynthia Y. Yoon, Susan M. Mason, Katie Loth, David R. Jacobs
Summary: Adverse childhood experiences, including abuse, neglect, and substance abuse in the household, are linked to disordered eating in middle-aged adults. Emotional abuse, physical neglect, and emotional neglect are particularly associated with disordered eating in women, while emotional abuse is consistently related to most disordered eating behaviors in men.
PREVENTIVE MEDICINE
(2022)
Article
Physics, Multidisciplinary
Charles Dane Napoli, Karen S. Helfer, Richard E. A. van Emmerik
Summary: The traditional linear assessments of postural behavior neglect the nonlinear nature of the postural system and can lead to the conflation of variability with pathology. Assessing postural complexity during ecologically valid tasks provides unique insight into the natural dynamics of the postural system. In this study, postural complexity was assessed using Multiscale Sample Entropy in young and middle-aged adults during a listening task, with results showing that middle-aged adults exhibited higher postural complexity and that this difference increased with task difficulty.
Article
Public, Environmental & Occupational Health
Kaihong Xie, Xiao Han, Jia Lu, Xiao Xu, Xuanhan Hu
Summary: This study examines the balance ability as a predictor of death risk in middle-aged and older Chinese adults with overweight and obesity. The study develops a prediction model incorporating nine variables, including gender, age, marriage, hypertension, diabetes, stroke, ADL, IADL, and balance ability.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Andrew D. Nguyen, Theodore K. Malmstrom, Geetika Aggarwal, Douglas K. Miller, Bruno Vellas, John E. Morley
Summary: This study found a positive association between serum NfL levels and mortality in late middle-aged and older individuals, with higher serum NfL levels associated with reduced survival. The results suggest that serum NfL levels may be a useful biomarker for all-cause mortality, but further studies are needed to understand the biological mechanisms underlying this association.
Article
Psychology, Clinical
Che-Yuan Wu, Hugo Cogo-Moreira, Bradley J. MacIntosh, Jodi D. Edwards, Saffire H. Krance, Michael Eid, Pamela J. Schreiner, Lenore J. Launer, Walter Swardfager
Summary: This study found a weak correlation between depressive symptoms and insulin resistance, which was observed in specific occasions but not in cross-lagged associations. The study also found differences in these relationships among different population groups, suggesting a potential association between insulin resistance and subsequent depressive symptoms among White participants later in adulthood.
PSYCHOLOGICAL MEDICINE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Melissa A. Jones, Nathaniel D. Jenkins, Kelley P. Gabriel, Catarina I. Kiefe, David R. Jacobs, Kiarri N. Kershaw, Kara M. Whitaker
Meeting Abstract
Cardiac & Cardiovascular Systems
Abbi Lane, Kara M. Whitaker, Muna Tahir, Bethany Barone Gibbs, Janet M. Catov, Mercedes R. Carnethon, Erica P. Gunderson
Article
Cardiac & Cardiovascular Systems
Yinan Zheng, Brian Joyce, Shih-Jen Hwang, Jiantao Ma, Lei Liu, Norrina Allen, Amy Krefman, Jun Wang, Tao Gao, Drew Nannini, Haixiang Zhang, David R. Jacobs, Myron Gross, Myriam Fornage, Cora E. Lewis, Pamela J. Schreiner, Stephen Sidney, Dongquan Chen, Philip Greenland, Daniel Levy, Lifang Hou, Donald Lloyd-Jones
Summary: This study found that cardiovascular health from young adulthood is associated with midlife epigenetic programming. The findings demonstrate the role of epigenetic markers in response to cardiovascular health changes and highlight the potential of epigenomic markers for precision cardiovascular disease prevention and earlier detection of subclinical cardiovascular disease.
Article
Public, Environmental & Occupational Health
Amir S. Heravi, Erin D. Michos, Di Zhao, Bharath Ambale-Venkatesh, Henrique Doria De Vasconcellos, Donald Lloyd-Jones, Pamela J. Schreiner, Jared P. Reis, Colin Wu, Cora E. Lewis, James M. Shikany, Stephen Sidney, Eliseo Guallar, Chiadi E. Ndumele, Pamela Ouyang, Ron C. Hoogeveen, Joao A. C. Lima, Dhananjay Vaidya, Wendy S. Post
Summary: Postmenopausal women have higher oxidative stress levels, which may contribute to greater cardiovascular disease risk.
JOURNAL OF WOMENS HEALTH
(2022)
Article
Obstetrics & Gynecology
Duke Appiah, Pamela J. Schreiner, James S. Pankow, Guy Brock, Weihong Tang, Faye L. Norby, Erin D. Michos, Christie M. Ballantyne, Aaron R. Folsom
Summary: The study examined the differences and changes in plasma proteins between premenopausal and postmenopausal women, finding significant variations in 38 proteins at baseline and over 18-year follow-up. The identified proteins are associated with various biological processes and may provide insights into disease development during the postmenopausal period.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2022)
Article
Education & Educational Research
Jaclyn Dziewior, Lucas J. Carr, Gary L. Pierce, Kara Whitaker
Summary: This study investigated the impact of the COVID-19 pandemic on college students' movement behaviors, revealing a significant decrease in physical activity and increase in sedentary behavior. The top barrier was schoolwork, while social support was identified as the top facilitator.
JOURNAL OF AMERICAN COLLEGE HEALTH
(2022)
Article
Nursing
McKenzie K. Wallace, Melissa A. Jones, Kara Whitaker, Bethany Barone Gibbs
Summary: This study aimed to assess changes in physical activity and sedentary behavior from pre-pregnancy to pregnancy and examine their relationships with gestational weight gain, blood pressure, and blood glucose. The results showed that physical activity decreased in each trimester, while sedentary behavior increased. Increasing physical activity from pre-pregnancy levels was associated with lower blood pressure in the first trimester, while higher pre-pregnancy physical activity was associated with higher blood pressure and weight gain in the third trimester.
Article
Peripheral Vascular Disease
Melissa A. Jones, Kara M. Whitaker, Joshua L. Paley, Alexis Thrower, Lee Stoner, Bethany Barone Gibbs
Summary: This study aimed to determine the feasibility of measuring bfPWV in children ages 2-4 years and assess its comparability to cfPWV normative data for cardiovascular disease (CVD) risk assessment. The results showed that at least one acceptable bfPWV scan was obtained in all participants, and bfPWV was slightly higher than age-predicted cfPWV.
BLOOD PRESSURE MONITORING
(2023)
Article
Clinical Neurology
Christina S. Dintica, Mohamad Habes, Guray Erus, Tamar Simone, Pamela Schreiner, Kristine Yaffe
Summary: Long-term depressive symptoms in early adulthood are associated with accelerated brain aging and may have implications for brain health in midlife.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Medicine, General & Internal
Kelley Pettee Gabriel, Byron C. Jaeger, Cora E. Lewis, Stephen Sidney, Erin E. Dooley, Mercedes R. Carnethon, David R. Jacobs, Bjoern Hornikel, Jared P. Reis, Pamela J. Schreiner, JamesM. Shikany, Kara M. Whitaker, Alexander Arynchyn, Barbara Sternfeld
Summary: This study found that higher early-adulthood cardiorespiratory fitness and greater retention of early-adulthood cardiorespiratory fitness throughout midlife were associated with a lower risk of premature death and CVD events.
Article
Endocrinology & Metabolism
Pamela J. Schreiner, Sejong Bae, Norrina Allen, Kiang Liu, Jared P. Reis, Colin Wu, Katherine H. Ingram, Donald Lloyd-Jones, Cora E. Lewis, Jamal S. Rana
Summary: This study found an association between cumulative BMI and incident prediabetes. Over the 30-year follow-up, approximately 46.2% of the sample developed prediabetes. After multivariable adjustment, the highest cBMI quartile had a hazard rate ratio of 2.064 compared to the lowest quartile. This suggests that prevention strategies for prediabetes in middle age may include avoiding overweight during young adulthood to limit disease duration.
Article
Medicine, General & Internal
Daniel J. Mcdonough, Mahesh Mathew, Zachary C. Pope, Pamela J. Schreiner, David R. Jacobs Jr, Lisa B. Vanwagner, John Jeffrey Carr, James G. Terry, Kelley Pettee Gabriel, Jared P. Reis, Mark A. Pereira
Summary: This study examined the association between lifestyle factors and NAFLD and found that regular moderate-vigorous aerobic and muscle-strengthening activities, along with reduced television viewing time, significantly reduce the risk of NAFLD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Junia N. de Brito, Daniel J. McDonough, Mahesh Mathew, Lisa B. VanWagner, Pamela J. Schreiner, Kelley Pettee Gabriel, David R. Jacobs Jr, James G. Terry, John Jeffrey Carr, Mark A. Pereira
Summary: This study found that higher levels of vigorous-intensity physical activity (VPA) throughout young to middle adulthood were associated with a reduced risk of nonalcoholic fatty liver disease (NAFLD) in middle age.
Article
Education & Educational Research
H. G. Thompson, K. M. Whitaker, R. Young, L. J. Carr
Summary: This study found that university stakeholders had low awareness and support for pouring rights contracts. Males, undergraduate students, and those who believed individuals are responsible for their own consumption of sugar-sweetened beverages were more likely to support such contracts. Universities are encouraged to consider the health impacts and opinions of university stakeholders when deciding whether to enter into pouring rights contracts.
JOURNAL OF AMERICAN COLLEGE HEALTH
(2023)