Review
Biochemistry & Molecular Biology
Carl Randall Harrell, Valentin Djonov, Vladislav Volarevic
Summary: This review article summarizes the therapeutic effects and mechanisms of mesenchymal stem cells (MSC) and their exosomes (MSC-Exos) in the treatment of inflammatory eye diseases and ocular graft-versus-host disease (oGVHD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Mahmoud Al-Azab, Elina Idiiatullina, Mohammed Safi, Kamal Hezam
Summary: Mesenchymal stem cells (MSCs) have the ability to differentiate into multiple cell types, and enhanced MSCs-dependent therapies have been explored for the treatment of inflammatory and degenerative diseases. Various strategies, including the use of pharmaceutical compounds, cytokines, growth factors, hormones, and vitamins, have been used to improve the therapeutic potency of MSCs. This study reviewed the current advances in enhancing techniques that aim to promote MSCs' therapeutic effectiveness and stemness in vivo with potential mechanisms and applications.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Rosario Hervas-Salcedo, Maria Fernandez-Garcia, Miriam Hernando-Rodriguez, Cristian Suarez-Cabrera, Juan A. Bueren, Rosa M. Yanez
Summary: Previous clinical trials have shown that mesenchymal stromal cells (MSCs) can modulate graft versus host disease (GvHD) after allogeneic hematopoietic transplantation. Adipose tissue derived-human MSCs (Ad-MSCs) were engineered to express CXCR4 and IL-10, resulting in CXCR4-IL10-MSCs with enhanced migration and immunomodulatory properties. In vitro and in vivo studies demonstrated the improved therapeutic effects of CXCR4-IL10-MSCs, suggesting their potential as a new generation of MSCs for GvHD treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell & Tissue Engineering
Donald G. Phinney, Ryang Hwa Lee, Siddaraju Boregowda
Summary: This article discusses the role of TWIST1 in MSCs and how it can be used to develop MSC therapeutics tailored to specific diseases. Based on evidence from pre-clinical models, MSCs exert therapeutic effects by suppressing inflammation and immune-mediated responses and by changing the polarization state of tissue resident macrophages. The article also highlights the mechanistic link between the stem/progenitor and paracrine functions of MSCs and proposes the development of metrics to predict MSC potency.
Review
Cell & Tissue Engineering
Ying Li, Jie Hao, Zheng Hu, Yong-Guang Yang, Qi Zhou, Liguang Sun, Jun Wu
Summary: This study summarized 79 clinical trials involving the use of MSCs to prevent or treat GVHD, analyzing their characteristics and results. The researchers aimed to gain a comprehensive understanding of the progress, challenges, limitations, and future trends in the field, and provide new perspectives for the design of future trials.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Immunology
Kilian Kelly, John E. J. Rasko
Summary: GvHD is a life-threatening complication of hematopoietic stem cell transplantation, often requiring high-dose corticosteroid treatment. MSCs show promise as a potential therapy due to their immunosuppressive and immunoregulatory effects, but their efficacy may be influenced by donor variability and manufacturing processes.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Makoto Murata, Takanori Teshima
Summary: This article discusses the potential of MSC therapy in the treatment of acute GVHD, along with a comparison of studies on the two products, Remestemcel-L and Temcell. While Temcell's real-world efficacy was found to be equivalent to that observed in a prospective study, the precise position of Remestemcel-L/Temcell therapy in the treatment of acute GVHD remains to be determined.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Orthopedics
Litao Yan, Gejun Liu, Xing Wu
Summary: Mechanical stimulation can enhance the production and biological function of exosomes derived from umbilical cord mesenchymal stem cells, promoting chondrocyte proliferation, matrix synthesis, and apoptosis inhibition, which is beneficial for cartilage repair.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Article
Immunology
Raghavan Chinnadurai, Paul D. Bates, Keith A. Kunugi, Kwangok P. Nickel, Larry A. DeWerd, Christian M. Capitini, Jacques Galipeau, Randall J. Kimple
Summary: MSCs are being tested as a cell therapy in clinical trials for inflammatory disorders, but suitable preclinical animal models are rare. In this study, two robust animal models of immune pathology were introduced to study the effect of IFN gamma primed bone marrow derived MSCs in acute radiation syndrome and graft versus host disease. The results showed that infused IFN gamma primed allogeneic MSCs protect against lethality from ARS, but not GvHD.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Yoshiyuki Tago, Chiho Kobayashi, Mineko Ogura, Jutaro Wada, Sho Yamaguchi, Takashi Yamaguchi, Masahiro Hayashi, Tomoyuki Nakaishi, Hiroshi Kubo, Yasuyoshi Ueda
Summary: The study found that human amnion-derived mesenchymal stem cells (AMSC) exhibit significant immunosuppressive effects and can delay the progression of acute graft-versus-host disease (GVHD) mainly by preventing T cell activation and proliferation through the PD-1 pathway.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Ying Wang
Summary: In this study, the therapeutic effect of MSC on GVHD was investigated using a mouse model. The results showed that MSC significantly reduced the incidence of GVHD and improved the survival rate of mice.
Article
Cell & Tissue Engineering
Weijiang Liu, Na Zhou, Yuanlin Liu, Wei Zhang, Xue Li, Yang Wang, Rongxiu Zheng, Yi Zhang
Summary: High expression of miR-223 in MSCs-Exo was found, and it could inhibit the adhesion and migration of T cells by targeting ICAM-1. Infusion of miR-223 Agomir alleviated clinical symptoms of aGvHD, reduced donor T cell infiltration, and lowered levels of inflammatory cytokines IFN-gamma, TNF-alpha, and IL-17.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Yingjun Xie, Fei Chen, Lei Jia, Rui Chen, Victor Wei Zhang, Xinqi Zhong, Ding Wang
Summary: The study evaluated the therapeutic effects of MSCs from different sources in treating a BPD animal model, showing that antenatal AF-MSCs had better therapeutic results, while UC-MSCs exhibited superior immunosuppressive effects with safe and effective treatments.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Immunology
Simone I. I. Richardson, Frances Ayres, Nelia P. P. Manamela, Brent Oosthuysen, Zanele Makhado, Bronwen E. E. Lambson, Lynn Morris, Penny L. L. Moore
Summary: The study revealed that IgG3 bNAbs demonstrate stronger protective ability and phagocytosis against HIV infection, especially against certain specific HIV strains, indicating that altering the constant region of antibodies may enhance their neutralizing and Fc effector activity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuchen Zhang, Naijun Dong, Huanle Hong, Jingxuan Qi, Shibo Zhang, Jiao Wang
Summary: Due to the aging population, stroke has become more prevalent, leading to increased socioeconomic burden. Stem cell transplantation, particularly using mesenchymal stem cells (MSCs), has shown promise in treating stroke by attenuating inflammation, promoting therapeutic effects, inducing blood vessel formation, promoting neurogenesis, reducing infarct volume, and replacing damaged cells. This review discusses the mechanisms of MSCs and their secreted extracellular vehicles (EVs) in stroke treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
