Article
Medicine, Research & Experimental
Randa A. A. Zaghloul, Ahmed M. M. Zaghloul, Dalia H. H. El-Kashef
Summary: This study found that baicalin has the potential to reduce liver fibrosis by inhibiting oxidative stress and inflammation, providing anti-oxidant and anti-inflammatory effects.
Article
Immunology
Ahmed M. Awad, Sally L. Elshaer, Rajashekhar Gangaraju, Rania R. Abdelaziz, Manar A. Nader
Summary: This study explored the renoprotective effect of montelukast (Mon) in streptozotocin (STZ)-induced diabetic nephropathy (DN) in rats compared to a standard insulin treatment. Mon administration for 8 weeks significantly improved renal function, reduced inflammation and fibrosis, restored redox hemostasis, and ameliorated dysregulation in autophagy. The renoprotective effect of Mon is potentially associated with its modulation of inflammatory cytokines, antioxidant properties, and autophagy.
INFLAMMOPHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Juan Tang, Tao Li, Xiaojing Xiong, Qiaoyun Yang, Zedazhong Su, Minming Zheng, Qingwei Chen
Summary: Atherosclerosis, a chronic inflammatory disease, is one of the leading causes of cardiovascular diseases. Current treatments are ineffective in reducing chronic inflammation-mediated plaque accumulation and disease progression. This study developed a novel delivery nanosystem that encapsulated colchicine and targeted inflammatory endothelial cells, resulting in reduced plaque area and enhanced plaque stability in a mouse model. The nanosystem showed improved biosafety and sustained drug release. It has the potential to overcome the limitations of colchicine and open new avenues for anti-atherosclerotic therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xueming Xu, Jing Li, Xiuyan Long, Sifan Tao, Xiaoyu Yu, Xixian Ruan, Kai Zhao, Li Tian
Summary: The inhibitor C646 targeting histone acetyltransferase p300 was found to exhibit anti-inflammatory effects in DSS-induced colitis mice by suppressing the NLRP3 inflammasome activity. Mechanistically, C646 not only reduced the expression of pro-inflammatory cytokines, but also disrupted the assembly of the NLRP3 inflammasome.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Keenan T. Hartert, Kerstin Wenzl, Jordan E. Krull, Michelle Manske, Vivekananda Sarangi, Yan Asmann, Melissa C. Larson, Matthew J. Maurer, Susan Slager, William R. Macon, Rebecca L. King, Andrew L. Feldman, Anita K. Gandhi, Brian K. Link, Thomas M. Habermann, Zhi-Zhang Yang, Stephen M. Ansell, James R. Cerhan, Thomas E. Witzig, Grzegorz S. Nowakowski, Anne J. Novak
Summary: A study identified a high-risk subset of non-GCB DLBCL patients with genomic alterations and expression signatures affecting treatment outcomes, showing unfavorable prognoses with RCHOP therapy. However, these high-risk patients had better outcomes when lenalidomide was added to RCHOP treatment.
Article
Immunology
Kai Tang, Wanhan Su, Chunhui Huang, Yiqi Wu, Xiuming Wu, Haichuan Lu
Summary: Notoginsenoside R1 (NR1) can suppress the development of intervertebral disc degeneration (IVDD), restore disc function, and improve mechanical and thermal hypersensitivity. Additionally, NR1 promotes extracellular matrix release, reduces proinflammatory cytokine expression, and enhances nucleus pulposus cell function. NR1 may protect against IVDD by inactivating the NF-κB/NLRP3 pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Juan Ouyang, Lihe Sun, Jiayue Pan, Zhuo Zeng, Cheng Zeng, Fang Zeng, Mei Tian, Shuizhu Wu
Summary: By developing a multifunctional nanosystem, active targeting, activatable imaging, and on-demand therapy against inflammatory diseases can be achieved through precise modulation of inflammatory signaling pathways.
Article
Cell Biology
Qiudong Yang, Wenhua Zhao, Yuyi Chen, Yue Chen, Jiali Shi, Ran Qin, Hua Wang, Ruixia Wang, Hua Yuan, Wen Sun
Summary: The study reveals that the RelA/miR-30a/NLRP3 signaling axis is involved in rheumatoid arthritis by regulating the NLRP3 inflammasome in macrophages.
CELL DEATH & DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Maja Jazvinscak Jembrek, Nada Orsolic, Lucija Mandic, Anja Sadzak, Suzana Segota
Summary: Neurodegenerative diseases are a major cause of disability and death worldwide, with pathways involving transcription factors playing a critical role in the pathological changes associated with oxidative stress and neuroinflammation. This review focuses on the role of transcription factor p53 in coordinating cellular response and potential therapeutic interventions using natural polyphenolic compounds with anti-oxidative, anti-inflammatory and anti-apoptotic effects. Further research is needed to fully understand the cellular and molecular mechanisms of these compounds for potential new treatments for neurodegenerative diseases.
Article
Medicine, Research & Experimental
Dalia H. El-Kashef, Randa A. Zaghloul
Summary: This study demonstrated that montelukast exerts hepatoprotective effects against CCl4-induced hepatotoxicity through antioxidant, anti-inflammatory, anti-fibrotic, and anti-apoptotic mechanisms.
Article
Plant Sciences
Jeong-Oog Lee, Yanyan Yang, Yu Tao, Young-Su Yi, Jae Youl Cho
Summary: This study investigates the anti-inflammatory role of ginsenosides from Korea red ginseng (KRG) in macrophages and their potential mechanism. The results suggest that ginsenosides inhibit the NF-kappa B and AP-1 signaling pathways, reducing the generation of inflammatory molecules and exhibiting anti-inflammatory effects.
JOURNAL OF GINSENG RESEARCH
(2022)
Article
Oncology
Weijun Wu, Jinghuan Wang, Chenxi Xiao, Zhenghua Su, Haibi Su, Wen Zhong, Jianchun Mao, Xinhua Liu, Yi Zhun Zhu
Summary: This study confirmed that cytoplasmic protein TRAF2 can be methylated by SMYD2 and contribute to the continuous activation of NF-kappa B signaling pathway. Knocking down SMYD2 showed varying degrees of mitigation in acute and chronic inflammation mouse models. Moreover, lysine-specific demethylase LSD1 was found to resist the methylation of TRAF2 induced by SMYD2.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Food Science & Technology
Qi Wang, Juqing Huang, Yafeng Zheng, Xuefang Guan, Chenchun Lai, Huiying Gao, Chi-Tang Ho, Bin Lin
Summary: The study investigated the anti-inflammatory effects of selenium-enriched oolong tea extract (Se-TE) on lipopolysaccharide-induced macrophages. The results showed that Se-TE significantly suppressed the overproduction of nitric oxide and prostaglandin E2, as well as inhibited the production of inflammatory cytokines. The underlying mechanism involved the blocking of mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Plant Sciences
Dong Zhen, Tian-qi Xuan, Boqin Hu, Xue Bai, Dan-ni Fu, Yu Wang, Yun Wu, Jingfeng Yang, Qianqian Ma
Summary: Pteryxin has anti-inflammatory properties by inhibiting NF-kappa B/MAPK signaling pathway and blocking NLRP3 activation, suggesting it as a potential treatment option for inflammatory-related diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Kun Yan, Jianqiang Hu, Tianhua Hou, Xinxin Ci, Liping Peng
Summary: This study demonstrates that Leonurine (Leo) can effectively protect against carrageenan-induced pleurisy by inhibiting the TXNIP/NLRP3 and NF-kappa B pathways through activating the Nrf2 pathway, which may serve as a promising agent for attenuating pleurisy.
PHYTOTHERAPY RESEARCH
(2022)
Article
Chemistry, Analytical
Lingfeng Xu, Lihe Sun, Fang Zeng, Shuizhu Wu
ANALYTICA CHIMICA ACTA
(2020)
Article
Chemistry, Multidisciplinary
Lingfeng Xu, Lihe Sun, Fang Zeng, Shuizhu Wu
CHINESE JOURNAL OF CHEMISTRY
(2020)
Article
Chemistry, Analytical
Zhuo Zeng, Juan Ouyang, Lihe Sun, Cheng Zeng, Fang Zeng, Shuizhu Wu
ANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Juan Ouyang, Lihe Sun, Jiayue Pan, Zhuo Zeng, Cheng Zeng, Fang Zeng, Mei Tian, Shuizhu Wu
Summary: By developing a multifunctional nanosystem, active targeting, activatable imaging, and on-demand therapy against inflammatory diseases can be achieved through precise modulation of inflammatory signaling pathways.
Article
Engineering, Biomedical
Lihe Sun, Juan Ouyang, Yunqing Ma, Zhuo Zeng, Cheng Zeng, Fang Zeng, Shuizhu Wu
Summary: This study demonstrates an activatable probe QY-N for diagnosing herbal-medicine-induced liver injury by detecting hepatic NO with NIR-II fluorescence and multispectral optoacoustic tomography (MSOT) imaging. Experimental results show that the probe can be successfully used to detect herbal-medicine-induced liver injury and monitor the rehabilitation of liver injury during treatment.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Analytical
Juan Ouyang, Lihe Sun, Fang Zeng, Shuizhu Wu
Summary: Development of high-quality dyes with enhanced NIR-II fluorescence for analyte sensing is crucial for improved imaging depths and resolution. By modifying heptamethine cyanines with pyridinium and tert-butyl groups, steric crowding is increased, water solubility is enhanced, and a site for analyte-responsive elements is provided, resulting in NP-N dyes that outperform benchmark heptamethine cyanines.
Article
Chemistry, Analytical
Cheng Zeng, Juan Ouyang, Lihe Sun, Zhuo Zeng, Yunyan Tan, Fang Zeng, Shuizhu Wu
Summary: Food additives play an important role in ensuring the safety of processed foods, but nitrites can generate toxic nitrosamines, causing liver damage. This study presents an activatable probe for detecting nitrosamine-induced acute liver injury and releasing drugs for therapy.
ANALYTICA CHIMICA ACTA
(2022)
Article
Engineering, Biomedical
Lihe Sun, Juan Ouyang, Fang Zeng, Shuizhu Wu
Summary: In this study, an oral-administration nanosystem (QM@EP) for the detection, targeted delivery, and therapy of ulcerative colitis was developed. The nanosystem successfully delivered the probe and drug to the colon and released them upon the stimulation of colonic pH. The released probe exhibited strong fluorescence for imaging and the released drug showed high therapeutic efficacy against ulcerative colitis.
Review
Chemistry, Inorganic & Nuclear
Juan Ouyang, Lihe Sun, Fang Zeng, Shuizhu Wu
Summary: Fluorophores with aggregation-induced emission (AIE) have many advantageous features for biomedical applications, especially for early diagnosis of diseases. Probes play a crucial role in fluorescent and optoacoustic imaging, and biomarker-activatable probes based on smart AIEgens have been widely researched and applied in this field.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Engineering, Biomedical
Zhuo Zeng, Juan Ouyang, Lihe Sun, Fang Zeng, Shuizhu Wu
Summary: A novel nanosystem (BM@EP) has been developed for detection and therapy of ulcerative colitis (UC). The system can be activated in the colon, releasing the drug and enabling diagnosis and recovery evaluation.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Zhuo Zeng, Junjie Chen, Lihe Sun, Fang Zeng, Shuizhu Wu
Summary: A nanoprobe has been created to detect hepatic ischemia-reperfusion injury. The nanoprobe emits noticeable optoacoustic and NIR-II fluorescent signals in response to the in situ biomarker H2O2 in the liver during ischemia-reperfusion injury.
CHEMICAL COMMUNICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Fang Zeng, Shuizhu Wu, Cheng Zeng, Yunyan Tan, Lihe Sun, Yi Long
Summary: Acute kidney injuries (AKI) have serious health threats and developing high-performance NIR-II probes for noninvasive detection of AKI is of great significance. In this study, a renal clearable, water soluble, and biomarker activatable probe PEG3-HC-PB was developed for real-time imaging of contrast-agent-induced and ischemia/reperfusion-induced AKI in mice using 3D-MSOT and NIR-II fluorescent dual-mode imaging. This probe can be utilized as a practical tool for detecting AKI and offers insights into the design of other large-conjugation NIR-II probes.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Multidisciplinary Sciences
Yinglong Wu, Lihe Sun, Xiaokai Chen, Jiawei Liu, Juan Ouyang, Xiaodong Zhang, Yi Guo, Yun Chen, Wei Yuan, Dongdong Wang, Ting He, Fang Zeng, Hongzhong Chen, Shuizhu Wu, Yanli Zhao
Summary: The authors address the challenges in using organic small-molecule contrast agents for multispectral optoacoustic imaging by constructing water-dispersible supramolecular optoacoustic assemblies based on cucurbit[8]uril. The constructed assemblies show enhanced optoacoustic performance due to increased absorption and decreased fluorescence. The formulated assemblies can effectively detect and diagnose various tumors and kidney injury in mouse models using multispectral optoacoustic imaging.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Zunpan She, Junjie Chen, Lihe Sun, Fang Zeng, Shuizhu Wu
Summary: An NO-responsive probe has been developed for imaging acute inflammation, which exhibits turn-on NIR-II fluorescence and optoacoustic signals in situ NO at acute inflammation sites such as LPS-induced acute dermatitis and MIA-induced acute joint inflammation.
CHEMICAL COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Jianqiu Yang, Zhenzhen Huang, Jiang Tan, Jingye Pan, Shixuan Chen, Wenbing Wan
Summary: By functionalizing a decellularized pomelo peel with an adhesive hydrogel and antibacterial materials, the hybrid wound dressing can effectively inhibit bacterial infection, promote granulation tissue formation and angiogenesis, and reduce scar formation during wound healing.
BIOACTIVE MATERIALS
(2024)
Article
Engineering, Biomedical
Yong Mei, Xiaohua Qin, Zhenyu Yang, Shiyao Song, Xiaoting Liu, Chong Wu, Jieying Qian, Xiaowan Huang, Yunjiao Zhang, Weiling He
Summary: This article presents a novel nanoparticle for treating KRAS-TP53 co-mutation in gastrointestinal cancers. The nanoparticle can degrade mutant p53 proteins (mutp53) and deliver the drug AMG510 to inhibit mutant KRAS and mutp53 signaling pathways. The results show that the nanoparticle can effectively reduce cell proliferation and migration, and demonstrate remarkable therapeutic efficacy in a tumor-bearing mouse model.
BIOACTIVE MATERIALS
(2024)