Article
Pharmacology & Pharmacy
Gabriele Griffanti, Marc D. McKee, Showan N. Nazhat
Summary: Designing hydrogels with both biochemical cues and mineralization for bone tissue engineering is challenging. In this study, collagen-fibrin hybrid gel scaffolds were generated using an automated gel aspiration-ejection method, with micro-architectures and mechanical properties similar to native bone ECM. Functionalizing these hybrid scaffolds with negatively charged silk sericin promoted mineralization and modulated cell behavior. The design of dense collagen-fibrin hybrid gels through an automated GAE process provides a versatile platform for tailoring specific biochemical and mechanical properties in bone tissue engineering.
Article
Polymer Science
Soodeh Iranpour, Farnoosh Attari, Ehsan Seyedjafari, Jhamak Nourmohammadi
Summary: In this study, the bioactivity of Poly (epsilon-caprolactone) (PCL) scaffold was enhanced through surface modification with sericin. The sericin-coated scaffold exhibited improved hydrophilicity and well-defined interconnected pores, leading to enhanced cell adhesion and penetration. The results of various assays demonstrated the potential of sericin-coated scaffold for orthopedic applications.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Biochemistry & Molecular Biology
Ji-Xin Li, Shu-Xiang Zhao, Yu-Qing Zhang
Summary: This paper describes the use of silk protein for the clean degumming of silk and the preparation of silk protein bioinks for 3D printing of various composite scaffolds. The techniques described here allow for the recycling and utilization of sericin, a waste product of silk processing. The resulting composite scaffolds exhibit improved properties such as enhanced compressive strength and resistance to protease hydrolysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Hui Zhao, Liyi He
Summary: Ischemic stroke leads to severe cellular loss and impairment of brain function. This study introduces a hydrogel-based tissue engineering technique using sericin, a silk protein, to promote neuronal repair. The genipin conjugated sericin hydrogels (Gen-SH) show high porous morphology and aid in neuronal attachment and development in vitro. In vivo transplantation of Gen-SH demonstrates high cell survival and proliferation. This biomaterial can serve as an effective carrier for ischemic stroke treatment and care by delivering neuronal cells and protecting them from oxidative damage.
JOURNAL OF EXPERIMENTAL NANOSCIENCE
(2022)
Article
Chemistry, Applied
Zehao Li, Zhiyuan Meng, Zheng Zhao
Summary: The miR-222/CS NPs effectively enhance neuronal differentiation of NSCs, suggesting a promising approach for neural tissue regeneration.
CARBOHYDRATE POLYMERS
(2022)
Article
Materials Science, Ceramics
Nazan Goksen Tosun, Ali Ozer, Tugba Bektas, Kerim Emre Oksuz, Secil Erden Tayhan, Tugba Ozdemir
Summary: Building a successful bone-implant interface is a challenging task. Silkworm sericin and hydroxyapatite have shown promising results in promoting osteogenic differentiation and mineralization density. Combining these two materials in a scaffold can enhance cell proliferation and improve the success of bone biomaterial interfaces.
JOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY
(2023)
Article
Engineering, Biomedical
Chiara Barberio, Janire Saez, Aimee Withers, Malavika Nair, Francesco Tamagnini, Roisin M. Owens
Summary: 3D cell culture formats closely resemble tissue architecture complexity and offer better cell-cell and cell-microenvironment interactions compared to 2D systems. Scaffold-based systems with natural biomaterials can improve cell survival and growth by mimicking the chemical and physical cues of the natural extracellular matrix (ECM).
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Polymer Science
Nantaprapa Tuancharoensri, Sukhonthamat Sonjan, Sudarat Promkrainit, Jinjutha Daengmankhong, Preeyawass Phimnuan, Sararat Mahasaranon, Jirapas Jongjitwimol, Pensri Charoensit, Gareth M. Ross, Celine Viennet, Jarupa Viyoch, Sukunya Ross
Summary: Tailored porous hydrogel scaffolds with tailored porous structures were created using different crosslinking systems. The crosslinking methods significantly impacted the properties of the scaffolds, including pore size, morphology, degradation, and cytotoxicity. The incorporation of DMU in the crosslinking system resulted in smaller pore sizes and delayed gelation time. The hydrogel scaffolds showed no cytotoxicity to human skin dermal fibroblast cells.
Review
Biochemistry & Molecular Biology
Niranjana Jaya Prakash, Supriya Sanatkumar Sarkar, Balasubramanian Kandasubramanian
Summary: The development of implantable devices using biocompatible shape memory polymers offers a less invasive alternative to the insertion of large, impliable devices. Silk materials exhibit heterogeneity in their genetic structure and physical properties due to folding and unfolding processes, and possess stimuli-responsive properties. This article explores the stimuli-responsive nature of silk and its potential applications in biomedical devices.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Materials Science, Biomaterials
Konstantina Chachlioutaki, Christina Karavasili, Elisavet Adamoudi, Nikolaos Bouropoulos, Dimitrios Tzetzis, Athina Bakopoulou, Dimitrios G. Fatouros
Summary: Silk sericin-PLGA composite scaffolds with sustained anti-inflammatory action and favorable compatibility were investigated. The composite scaffolds showed improved hydrophilicity and mechanical properties compared to plain PLGA scaffolds, and promoted attachment and proliferation of human gingival fibroblasts. The study suggests that silk sericin-PLGA composite scaffolds have potential application in the treatment of periodontal diseases.
BIOMATERIALS ADVANCES
(2022)
Article
Cell & Tissue Engineering
Kenji Yamatoya, Yuya Nagai, Naozumi Teramoto, Woojin Kang, Kenji Miyado, Kazuya Nakata, Tohru Yagi, Yoshitaka Miyamoto
Summary: The effective cryopreservation of difficult-to-freeze cells, such as differentiated neuronal cells, is crucial for cell therapy. We developed a serum-free freezing solution that showed promising results in preserving differentiated neuronal cells. Evaluation of the freezing solutions was based on cell viability, recovery rate, and morphology. Cryoprotectants like fetal bovine serum, antifreeze proteins, and sugars were found to be essential for protecting against freeze damage.
REGENERATIVE THERAPY
(2022)
Article
Materials Science, Biomaterials
Rafael Lemos, F. Raquel Maia, Viviana P. Ribeiro, Joao B. Costa, Paulo J. G. Coutinho, Rui L. Reis, Joaquim M. Oliveira
Summary: The study developed advanced hierarchical scaffolds composed of silk fibroin, cell-derived extracellular matrix, and carbon nanotubes to improve the performance of standard silk fibroin scaffolds. The scaffolds were fabricated using various methods and showed satisfactory pore structure and mechanical properties for bone regeneration applications. In vitro studies demonstrated the bioactivity of the scaffolds and their support for cell proliferation, indicating their potential for bone tissue engineering.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Engineering, Manufacturing
Li Wang, Xianhong Zeng, Xiaohu Chen, Xiyang Zeng, Kun Luo
Summary: In this study, a porous composite biocompatible bone scaffold based on shape memory polymer materials was developed. The scaffold showed good mechanical and biological properties, and had the ability to fill bone defects and recover its initial shape. Hydroxyapatite played a role in promoting mineralization and accelerating tissue repair. These programmable scaffolds have potential applications in minimal invasive bone repair.
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
(2022)
Article
Materials Science, Multidisciplinary
Yu Wang, Xia Zhou, Shunyao Zhu, Xinlin Wei, Nazi Zhou, Xueyuan Liao, Yanhua Peng, Yaping Tang, Lin Zhang, Xi Yang, Yang Li, Xiang Xu, Jie Tao, Rui Liu
Summary: This work developed a cryoprinting platform that combined 3D printing and cryogelation technologies to fabricate nanoparticle-enhanced injectable and shape-memory cryogels. The cryogels showed rapid volumetric recovery after injection and promoted the participation of seeded stem cells in bone regeneration.
MATERIALS & DESIGN
(2022)
Article
Materials Science, Multidisciplinary
Berkant Yetiskin, Oguz Okay
Summary: In contrast to synthetic gels, biological hydrogels containing both hydrophilic and lyophilic phases, known as organohydrogels (OHGs), have the potential to mimic biological systems and find various applications. This study presents a simple strategy to obtain adaptive OHGs with tunable mechanics and viscoelasticity. By utilizing a hydrophilic cryogel scaffold and reaction loci within the scaffold, mechanically robust OHGs consisting of a silk fibroin (SF) scaffold and organogel microinclusions were successfully prepared. The OHGs exhibited switchable mechanics and viscoelasticity as well as shape-memory function.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hongzhen Wu, Yingying Liang, Zihua Wang, Caihong Tan, Ruimeng Yang, Xinhua Wei, Xinqing Jiang
Summary: This study evaluated the feasibility and diagnostic performance of the LI-RADS M targetoid criteria on CT and EOB-MRI in differentiating IMCC from HCC, and constructed a multivariate logistic regression model to distinguish the two types of liver cancer. The results showed that the model based on EOB-MRI had higher sensitivity, specificity, and accuracy compared to other LI-RADS targetoid appearance criteria on CT and EOB-MRI.
Review
Materials Science, Multidisciplinary
Qingqing Xin, Junqiu Zhang, Zhiwu Han, Houqi Zhao, Tao Hou, Yahua Liu, Shichao Niu, Qigang Han, Zhengzhi Mu, Bo Li, Ze Wang, Luquan Ren
Summary: The high-performance optimized design of industrial sensors has been a challenging point in high-end equipment manufacturing technology. Bio-sensors have served as a great inspiration for high-sensitivity and high-performance sensors. This study discusses the mechanisms of bio-sensors in mechanical detection and the latest research results in bio-mimetic devices. The development of bio-sensors relies on the design and development of mechanical structures and functional materials with various couplings.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Economics
Muhammad Nadeem, Siqi Lou, Zilong Wang, Ullah Sami, Syed Ahtsham Ali, Qaiser Abbas, Seyfettin Artan
Summary: Well-functioning domestic institutions play a crucial role in determining the impact of global value chains on the environment. This article empirically assesses the relationship between domestic institutional arrangements and environmental performance index for Asian countries participating in global value chains from 2001 to 2018. The findings suggest that participation in global value chains negatively affects environmental performance index, but this relationship can be reversed when accompanied by governance facilitation.
ECONOMIC RESEARCH-EKONOMSKA ISTRAZIVANJA
(2023)
Article
Substance Abuse
Zi-Liang Wang, Marc N. Potenza, Kun-Ru Song, Guang-Heng Dong, Xiao-Yi Fang, Jin-Tao Zhang
Summary: This study aims to identify subgroups of people with internet gaming disorder based on addiction-related functional connectivity and investigate the clinical correlates and treatment responses of these subgroups. Two subgroups with distinct connectivity patterns and clinical profiles were identified, suggesting the existence of different phenotypes within internet gaming disorder.
Article
Computer Science, Theory & Methods
Fei Guo, Zilong Wang, Guang Gong
Summary: In this paper, three secondary methods for constructing bent-negabent functions under different frameworks are presented. The necessary and sufficient conditions for generating these functions are analyzed. Several constructions are proposed based on these frameworks.
DESIGNS CODES AND CRYPTOGRAPHY
(2023)
Article
Computer Science, Information Systems
Peixin Ren, Xiaozhuo Gu, Ziliang Wang
Summary: This paper presents a quantum-safe password-authenticated key exchange protocol and demonstrates its practicality through rigorous security proofs and performance analysis.
IET INFORMATION SECURITY
(2023)
Article
Computer Science, Artificial Intelligence
Guijun Ma, Zidong Wang, Weibo Liu, Jingzhong Fang, Yong Zhang, Han Ding, Ye Yuan
Summary: This article proposes a two-stage integrated method for predicting the remaining useful life (RUL) of lithium-ion batteries. In the first stage, a convolutional neural network (CNN) is used to estimate the cycle life of each battery, and a similar degradation mode is chosen for capacity identification. In the second stage, a personalized prediction is made using the identified parameters. Experimental results demonstrate the superiority of this method over standard CNN-based and GPR-based prediction methods.
KNOWLEDGE-BASED SYSTEMS
(2023)
Article
Engineering, Mechanical
Chao He, Sanyang Liu, Junmin Li, Jiaxian Wang
Summary: This paper addresses the adaptive control for a kind of nonlinear system over the event-driven sensors-controller communication network. Two kinds of adaptive control strategies are proposed to overcome the limitations of the existing strategy. The decoupling structure of event-triggered mechanism and adaptive estimators saves communication cost and ensures the asymptotical stability of the system.
NONLINEAR DYNAMICS
(2023)
Article
Energy & Fuels
Wenjing Qu, Yuan Fang, Zixin Wang, Meijia Song, Qiukai Wang, Bin Tang, Liyan Feng
Summary: The present work conducted experiments to measure the ignition delay times of hydrogen/n-heptane mixture at high temperature and low pressure using a shock tube. The results showed that mixtures with higher hydrogen proportion and lower equivalence ratio had shorter ignition delay times. As the hydrogen proportion decreased, the inhibition effect of n-heptane on the mixture's ignition weakened. The NUI mechanism was selected for the kinetic study as it was consistent with the experimental values. A skeletal hydrogen/PRF mechanism was updated from a skeletal PRF mechanism based on the shock tube experimental data, and it was validated against various fuel mixtures.
Article
Automation & Control Systems
Chunyu Li, Zidong Wang, Weihao Song, Shixin Zhao, Jianan Wang, Jiayuan Shan
Summary: This article investigates the resilient unscented Kalman filtering fusion issue for a class of nonlinear systems under the dynamic event-triggered mechanism. The dynamic event-triggered scheme is capable of scheduling data transmission frequency more efficiently, reducing communication burden and energy consumption. Furthermore, the sequential covariance intersection fusion strategy is introduced to solve the problem of computing cross covariance between local filters.
IEEE TRANSACTIONS ON CONTROL SYSTEMS TECHNOLOGY
(2023)
Article
Thermodynamics
Chao Ding, Guangzhao Han, Manhou Li, Jinfu Guan, Ziyuan Wang
Summary: This study investigates the flame radiation of a rectangular pool fire in longitudinal wind. The results show that the incident heat flux initially increases and then decreases as the air speed increases, with a threshold value at approximately 0.96 m/s. The heat flux is primarily determined by the burning rate at lower air speeds, but is determined by the combination of flame morphology and burning rate at higher air speeds.
INTERNATIONAL JOURNAL OF THERMAL SCIENCES
(2023)
Article
Engineering, Civil
Fengying Wu, Zilong Wang, Lin Zhao, Tao Pan, Haizhu Xiao, Yaojun Ge
Summary: The influence of additional structural elements on the aerodynamic characteristics of a double-slotted box girder for hybrid bridges was investigated. It was found that wind barriers and balustrades have a considerable impact on Vortex-induced vibrations (VIVs), while maintenance rails have limited influence. The distribution of wind pressures on specific parts of the bridge deck further contributed to the generation of torsional VIVs.
JOURNAL OF BRIDGE ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Jie Sun, Zilong Wang, Huanming Lu, Wenrui Zhang
Summary: This study investigates the effect of selective site doping on the phase transition behavior of BiVO4 using in-situ high-temperature X-ray diffraction. It is found that doping agents assist in structure distortion and lower the transition temperature.
Article
Engineering, Industrial
Wei Zhang, Ziwei Wang, Xiang Li
Summary: In this paper, a blockchain-based decentralized federated transfer learning method is proposed for collaborative machinery fault diagnosis. The experimental results indicate that the proposed method is effective in data privacy-preserving collaborative fault diagnosis of multiple users, offering a promising tool for applications in the real industrial scenarios.
RELIABILITY ENGINEERING & SYSTEM SAFETY
(2023)
Article
Automation & Control Systems
Chuang Wang, Zidong Wang, Qing-Long Han, Fei Han, Hongli Dong
Summary: In this article, a novel leader-follower-based particle swarm optimization (LFPSO) algorithm is proposed, which maintains the diversity of the particle population while improving the possibility of escaping from the locally optimal solution. Experimental results demonstrate that the proposed algorithm significantly improves the accuracy and convergence rate of conventional particle swarm optimization algorithms, and its superiority is verified in denoising real-time signals in an oilfield pipeline network.
IEEE TRANSACTIONS ON SYSTEMS MAN CYBERNETICS-SYSTEMS
(2023)
Article
Engineering, Biomedical
Jianqiu Yang, Zhenzhen Huang, Jiang Tan, Jingye Pan, Shixuan Chen, Wenbing Wan
Summary: By functionalizing a decellularized pomelo peel with an adhesive hydrogel and antibacterial materials, the hybrid wound dressing can effectively inhibit bacterial infection, promote granulation tissue formation and angiogenesis, and reduce scar formation during wound healing.
BIOACTIVE MATERIALS
(2024)
Article
Engineering, Biomedical
Yong Mei, Xiaohua Qin, Zhenyu Yang, Shiyao Song, Xiaoting Liu, Chong Wu, Jieying Qian, Xiaowan Huang, Yunjiao Zhang, Weiling He
Summary: This article presents a novel nanoparticle for treating KRAS-TP53 co-mutation in gastrointestinal cancers. The nanoparticle can degrade mutant p53 proteins (mutp53) and deliver the drug AMG510 to inhibit mutant KRAS and mutp53 signaling pathways. The results show that the nanoparticle can effectively reduce cell proliferation and migration, and demonstrate remarkable therapeutic efficacy in a tumor-bearing mouse model.
BIOACTIVE MATERIALS
(2024)
