期刊
PATHOGENS
卷 10, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/pathogens10070818
关键词
cumin-essential-oil; cuminaldehyde; Campylobacter jejuni; enteropathogenic infection; immune-modulatory effects; secondary abiotic IL-10(-/-) mice; experimental campylobacteriosis model; host-pathogen interaction; preclinical intervention study; natural antibiotics-independent compounds
类别
资金
- German Federal Ministries of Education and Research (BMBF) [IP7/01KI2007D]
- Federal Ministry for Economic Affairs and Energy [ZF4117908]
Cumin essential oil shows potential anti-pathogenic and immune-modulatory effects in acute experimental campylobacteriosis, reducing pathogen numbers, improving clinical outcomes, and alleviating apoptotic cell responses in colonic epithelia. Furthermore, cumin essential oil can dampen the secretion of pro-inflammatory mediators and elevate systemic MCP-1 concentrations, providing promising evidence for the combat of human campylobacteriosis.
Human campylobacteriosis, commonly caused by Campylobacter jejuni, is a food-borne infection with rising prevalence causing significant health and socioeconomic burdens worldwide. Given the threat from emerging antimicrobial resistances, the treatment of infectious diseases with antibiotics-independent natural compounds is utmost appreciated. Since the health-beneficial effects of cumin-essential-oil (EO) have been known for centuries, its potential anti-pathogenic and immune-modulatory effects during acute experimental campylobacteriosis were addressed in the present study. Therefore, C. jejuni-challenged secondary abiotic IL-10(-/-) mice were treated perorally with either cumin-EO or placebo starting on day 2 post-infection. On day 6 post-infection, cumin-EO treated mice harbored lower ileal pathogen numbers and exhibited a better clinical outcome when compared to placebo controls. Furthermore, cumin-EO treatment alleviated enteropathogen-induced apoptotic cell responses in colonic epithelia. Whereas, on day 6 post-infection, a dampened secretion of pro-inflammatory mediators, including nitric oxide and IFN-gamma to basal levels, could be assessed in mesenteric lymph nodes of cumin-EO treated mice, systemic MCP-1 concentrations were elevated in placebo counterparts only. In conclusion, our preclinical intervention study provides first evidence for promising immune-modulatory effects of cumin-EO in the combat of human campylobacteriosis. Future studies should address antimicrobial and immune-modulatory effects of natural compounds as adjunct antibiotics-independent treatment option for infectious diseases.
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