Review
Infectious Diseases
Victor Hugo Ahumada Topete, Kevin Jesus de Dios Sanchez, Gustavo Alejandro Casas Aparicio, Graciela Hernandez Silva, Cesar Emmanuel Lopez Vejar, Luz Maria Torres Espindola, Arnoldo Aquino-Galvez, Odalis Rodriguez Ganen, Manuel de Jesus Castillejos Lopez
Summary: The adverse events associated with sodium colistimethate vary in terms of the prevalence of nephrotoxicity, neurotoxicity, and less frequent respiratory depression. The increasing use of sodium colistimethate is due to multidrug-resistant bacteria, but its main adverse event, nephrotoxicity, has caused discrepancies among authors. The indiscriminate use of antibiotic therapy has led to multiple mechanisms of resistance, particularly colistin resistance. There is a lack of randomized clinical trials demonstrating the safety and efficacy of colistin, so dosing is based on expert opinion and observational studies.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Infectious Diseases
Vicente Merino-Bohorquez, Fernando Docobo-Perez, Adoracion Valiente-Mendez, Mercedes Delgado-Valverde, Manuel Camean, William W. Hope, Alvaro Pascual, Jesus Rodriguez-Bano
Summary: This study found that extended infusions of piperacillin were effective in treating Enterobacteriaceae bloodstream infections in non-critically ill patients. Long infusions reduced the expected toxicity risk in patients with renal impairment.
Article
Medicine, General & Internal
Vincenzo Russotto, Sheila Nainan Myatra, John G. Laffey, Elena Tassistro, Laura Antolini, Philippe Bauer, Jean Baptiste Lascarrou, Konstanty Szuldrzynski, Luigi Camporota, Paolo Pelosi, Massimiliano Sorbello, Andy Higgs, Robert Greif, Christian Putensen, Christina Agvald-Ohman, Athanasios Chalkias, Kristaps Bokums, David Brewster, Emanuela Rossi, Roberto Fumagalli, Antonio Pesenti, Giuseppe Foti, Giacomo Bellani
Summary: This observational study on intubation practices in critically ill patients from an international sample of 197 sites across 29 countries found that major adverse peri-intubation events, particularly cardiovascular instability, occurred frequently.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Critical Care Medicine
Dingxin Zhou, Jun Jiang, Jing Zhang, Fengsheng Cao, Zhiyong Peng
Summary: This study aimed to investigate the association between hyperchloremia and/or the increase of blood chloride levels at ICU admission and the incidence of major adverse kidney events within 30 days (MAKE30) in critically ill adults. The results showed that an increase in chloride levels ≥5 mmol/L within 48 hours of ICU admission was associated with an increased incidence of MAKE30, while hyperchloremia at ICU admission was not associated with the incidence of MAKE30.
Article
Critical Care Medicine
Alexander H. Flannery, Victor Ortiz-Soriano, Xilong Li, Fabiola G. Gianella, Robert D. Toto, Orson W. Moe, Prasad Devarajan, Stuart L. Goldstein, Javier A. Neyra
Summary: This study found that serum renin measured early in the ICU admission is associated with MAKE at discharge, particularly mortality, in critically ill patients. Patients in the highest renin tertile were more severely ill overall, with a higher incidence of MAKE.
Article
Medicine, General & Internal
Mohamad-Hani Temsah, Fahad Al-Sohime, Ali Alhaboob, Ayman Al-Eyadhy, Fadi Aljamaan, Gamal Hasan, Salma Ali, Ahmed Ashri, Assalh Ali Nahass, Rana Al-Barrak, Omar Temsah, Khalid Alhasan, Amr A. Jamal
Summary: This study examined healthcare workers' practices in patient transfers to and from the ICU, revealing significant risks of deterioration in respiratory and hemodynamic status. Lack of familiarity with common patient handover methods and compliance with hospital transfer policies among HCWs were identified as areas needing attention for patient safety improvement initiatives.
Article
Pharmacology & Pharmacy
Xu-ben Yu, Xiao-Shan Zhang, Ye-Xuan Wang, Yu-Zhen Wang, Hong-Min Zhou, Fang-Min Xu, Jun-Hui Yu, Li-Wen Zhang, Ying Dai, Zi-Ye Zhou, Chun-Hong Zhang, Guan-Yang Lin, Jing-Ye Pan
Summary: Colistin sulfate was effective in treating carbapenem-resistant organism infections, with clinical treatment success achieved in 59.52% of patients and successful bacteria elimination in 69.06% of patients. Pharmacokinetic modeling showed that renal function significantly affects colistin sulfate clearance, with a recommended dose regimen calculated for various MIC values. Monte Carlo simulations indicated the need to adjust dosage for patients based on renal function to avoid subtherapeutic exposure.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Critical Care Medicine
Michael L. Behal, Jonny L. Nguyen, Xilong Li, David J. Feola, Javier A. Neyra, Alexander H. Flannery
Summary: Early exposure to azithromycin in SA-AKI is independently associated with a reduction in major adverse kidney events (MAKE) at hospital discharge.
Article
Anesthesiology
Vincenzo Russotto, Jean Baptiste Lascarrou, Elena Tassistro, Matteo Parotto, Laura Antolini, Philippe Bauer, Konstanty Szuldrzynski, Luigi Camporota, Christian Putensen, Paolo Pelosi, Massimiliano Sorbello, Andy Higgs, Robert Greif, Giacomo Grasselli, Maria G. Valsecchi, Roberto Fumagalli, Giuseppe Foti, Pietro Caironi, Giacomo Bellani, John G. Laffey, NTUBE Study Investigators
Summary: Videolaryngoscopy is associated with higher first-pass intubation success rates in critically ill patients and does not increase the risk of major adverse events.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Review
Emergency Medicine
Maki Murata, Natsuki Nakagawa, Takeshi Kawasaki, Shunsuke Yasuo, Takuo Yoshida, Koichi Ando, Satoshi Okamori, Yohei Okada
Summary: This study investigated and described the safety and adverse events during intrahospital transport of critically ill patients. The findings suggest that adverse events can occur during intrahospital transport, but the frequency of critical adverse events is relatively low.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Urology & Nephrology
Javier A. Neyra, Victor Ortiz-Soriano, Lucas J. Liu, Taylor D. Smith, Xilong Li, Donglu Xie, Beverley Adams-Huet, Orson W. Moe, Robert D. Toto, Jin Chen
Summary: This study developed risk stratification models for mortality and major adverse kidney events (MAKE) in critically ill patients with acute kidney injury (AKI), which outperformed standard scoring tools commonly used in the ICU.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Infectious Diseases
Zaheer Udin Babar, Sunil Kumar Dodani, Asma Nasim
Summary: This study aimed to evaluate the efficacy and toxicity of colistin in patients with carbapenem-resistant gram-negative bacteremia in Pakistan. The study found that colistin had a good bacteriological clearance rate in patients, but some patients experienced reversible neurological adverse effects.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Urology & Nephrology
Shruti Gupta, Prakash Gudsoorkar, Kenar D. Jhaveri
Summary: Critically ill cancer patients have a higher incidence of acute kidney injury treated with renal replacement therapy. Acute kidney injury can be a direct or indirect result of cancer itself, its treatment, or complications. Recent studies show that having an underlying cancer is no longer a contraindication for initiating renal replacement therapy or advanced life-supportive measures. However, these results should not be used to justify unrealistic perseverance or deny palliative care in desperate cancer patients. The decision to initiate advanced therapy should consider the patient's long-term prognosis and quality of life.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Microbiology
Muhammad Bilal, Michael Zoller, Uwe Fuhr, Ulrich Jaehde, Sami Ullah, Uwe Liebchen, Soeren Buesker, Johannes Zander, Baharak Babouee Flury, Max Taubert
Summary: Cefepime has concentration-related neurotoxicity, especially in critically ill patients with renal failure. Through population pharmacokinetic modeling and Monte Carlo simulations, a dosing regimen for Cefepime was identified with the highest probability of target attainment and the lowest risk of neurotoxicity in critically ill patients.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Review
Emergency Medicine
Jessica Downing, Isha Yardi, Christine Ren, Stephanie Cardona, Manahel Zahid, Kaitlyn Tang, Vera Bzhilyanskaya, Priya Patel, Ali Pourmand, Quincy K. Tran
Summary: Peri-intubation major adverse events (MAEs) are common in critically ill patients intubated outside the OR and PACU, with a prevalence of approximately 30%. The risk is higher in the ICU compared to the ED. Factors such as hemodynamic instability and airway protection influence the occurrence of MAEs.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Infectious Diseases
Claire Roger, Bastian Nucci, Benjamin Louart, Arnaud Friggeri, Haroun Knani, Alexandre Evrard, Jean-Philippe Lavigne, Bernard Allaouchiche, Jean-Yves Lefrant, Jason A. Roberts, Laurent Muller
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2016)
Article
Nutrition & Dietetics
Pablo Lucas Massanet, Laurent Petit, Benjamin Louart, Philippe Corne, Celine Richard, Jean Charles Preiser
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2015)
Article
Anesthesiology
Claire Roger, Ludovic Palmier, Benjamin Louart, Nicolas Molinari, Pierre-Geraud Claret, Jean-Emmanuel de la Coussaye, Jean-Yves Lefrant, Laurent Muller
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2015)
Article
Emergency Medicine
Claire Roger, Benjamin Louart, Guillaume Louart, Xavier Bobbia, Pierre-Geraud Claret, Antonia Perez-Martin, Laurent Muller, Jean-Yves Lefrant
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2016)
Article
Infectious Diseases
Claire Roger, Steven C. Wallis, Benjamin Louart, Jean-Yves Lefrant, Jeffrey Lipman, Laurent Muller, Jason A. Roberts
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2016)
Article
Health Care Sciences & Services
Yann Gricourt, Camille Prin Derre, Christophe Demattei, Sebastien Bertran, Benjamin Louart, Laurent Muller, Natacha Simon, Jean-Yves Lefrant, Philippe Cuvillon, Samir Jaber, Claire Roger
Summary: This study aimed to validate the effectiveness of fluid challenges proposed by the closed-loop system in patients scheduled for elective major abdominal surgery, and the results showed an 80% agreement between the closed-loop system and anesthesiologists.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Infectious Diseases
Paul Laffont-Lozes, Didier Laureillard, Paul Loubet, Robin Stephan, Myriam Chiaruzzi, Edouard Clemmer, Aurelie Martin, Claire Roger, Laurent Muller, Pierre-Geraud Claret, Radjiv Goulabchand, Clarisse Roux, Jean-Philippe Lavigne, Albert Sotto, Romaric Larcher
Summary: We conducted a prospective cohort study to assess the factors associated with mortality in patients with SARS-CoV-2 pneumonia treated with tocilizumab. Our results showed that age, Charlson index, WHO-CPS, and early administration of tocilizumab were independently associated with mortality. There was no significant difference in mortality between patients treated with tocilizumab and standard of care alone, but better survival was observed in patients who received tocilizumab within 48 hours of hospital admission.
Article
Infectious Diseases
Anne Coste, Ronan Bellouard, Guillaume Deslandes, Laurence Jalin, Claire Roger, Severine Ansart, Eric Dailly, Cedric Bretonniere, Matthieu Gregoire
Summary: This study aimed to develop a nomogram guiding clinicians in selecting the appropriate initial amikacin dose for ICU patients in septic shock. The dose nomogram recommended ranges from 1700 mg to 4200 mg and from 28 mg/kg to 49 mg/kg depending on the patient's TBW and renal clearance. However, the probabilities of achieving a C-through <= 2.5 mg/L at 24 h and 48 h after an optimal dose of amikacin were 0.20 and 0.81, respectively.
Article
Infectious Diseases
Tayma Naciri, Boris Monnin, Alix Pantel, Claire Roger, Jean-Marie Kinowski, Paul Loubet, Jean-Philippe Lavigne, Albert Sotto, Romaric Larcher
Summary: This study compared the outcomes of beta-lactam allergic (BLA) patients and non-beta-lactam allergic (NBLA) patients with intra-abdominal infections (IAI). The results showed that BLA patients treated without beta-lactam had the same treatment outcomes as NBLA patients treated with beta-lactam.
Review
Infectious Diseases
Emmanuel Novy, Hugo Martiniere, Claire Roger
Summary: Beta-lactams (BL) are commonly used antibiotics for critically ill patients with sepsis or septic shock, but their concentrations can be unpredictable in the context of critical illness. Therapeutic drug monitoring (TDM) of BL in the ICU has gained attention, but there are barriers to its implementation and interpretation. Recent clinical studies have not shown improved mortality with TDM in ICU patients. This review discusses the value and complexity of TDM in critically ill patients and the need for further studies on clinical outcomes and future aspects of TDM.
Review
Microbiology
Gamze Kalin, Emine Alp, Arthur Chouaikhi, Claire Roger
Summary: The increasing antimicrobial resistance (AMR) worldwide poses a serious threat to sepsis management. Multidrug-resistant (MDR) pathogens, due to resistance to common antimicrobials, are associated with delays in adequate antimicrobial therapy and increased mortality rates. In response to MDR infections and delayed microbiological results, broad-spectrum antibiotics are frequently used in empirical antimicrobial therapy, which can further promote the development of resistance. Multiple measures have been suggested to combat AMR, focusing on the epidemiology and trends of MDR pathogens, as well as identifying patients susceptible to MDR infections and optimizing antimicrobial drug dosing.