期刊
MICROORGANISMS
卷 9, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/microorganisms9071353
关键词
Acinetobacter baumannii; biofilm; multidrug-resistant; prevention; treatment
类别
资金
- Italian Ministry of Health [SG2018-12365432]
- Dani Di Gio Foundation-Onlus, Rome, Italy
- Progetto NAOCON (Nuovi Antimicrobici Ottenuti da Composti di Origine Naturale) from MIUR [ARS01_00597, CUP B56G18000200005]
- Progetto di ricerca PNRM Analisi Genomica Resistoma Infezioni Nosocomiali dei Teatri Operativi (AGRINTO) from Ministero della Difesa
Bacterial biofilms pose a serious global public health problem, especially with the rise of antibiotic-resistant Gram-negative bacteria. Acinetobacter baumannii is a significant opportunistic pathogen in healthcare settings, forming biofilms that serve as a main source of patient infections. The limited therapeutic options available for multidrug-resistant A. baumannii biofilm-forming isolates highlight the urgent need for effective antibiofilm approaches.
Bacterial biofilms are a serious public-health problem worldwide. In recent years, the rates of antibiotic-resistant Gram-negative bacteria associated with biofilm-forming activity have increased worrisomely, particularly among healthcare-associated pathogens. Acinetobacter baumannii is a critically opportunistic pathogen, due to the high rates of antibiotic resistant strains causing healthcare-acquired infections (HAIs). The clinical isolates of A. baumannii can form biofilms on both biotic and abiotic surfaces; hospital settings and medical devices are the ideal environments for A. baumannii biofilms, thereby representing the main source of patient infections. However, the paucity of therapeutic options poses major concerns for human health infections caused by A. baumannii strains. The increasing number of multidrug-resistant A. baumannii biofilm-forming isolates in association with the limited number of biofilm-eradicating treatments intensify the need for effective antibiofilm approaches. This review discusses the mechanisms used by this opportunistic pathogen to form biofilms, describes their clinical impact, and summarizes the current and emerging treatment options available, both to prevent their formation and to disrupt preformed A. baumannii biofilms.
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