Article
Multidisciplinary Sciences
Wenpeng Song, Yiming Yuan, Xiaohui Tan, Yangyang Gu, Jianyu Zeng, Weidong Song, Zhongcheng Xin, Dong Fang, Ruili Guan
Summary: This study investigated the effect and mechanism of Icariside II on the rapid phosphorylation of eNOS. The results demonstrated that Icariside II can promote cell proliferation and nitric oxide release, and regulate the phosphorylation of eNOS through multiple signaling pathways.
Review
Biochemistry & Molecular Biology
Ali Mohammad Pourbagher-Shahri, Tahereh Farkhondeh, Marjan Talebi, Dalia M. Kopustinskiene, Saeed Samarghandian, Jurga Bernatoniene
Summary: This review highlights the crucial role of nitric oxide (NO) in cellular aging processes, discussing its mechanisms and effects in various systems and organs, as well as the decline in NO levels and bioavailability associated with aging. Additionally, potential therapeutic agents affecting NO signaling mechanisms in aging are also discussed.
Article
Multidisciplinary Sciences
Takashi Shimizu, Akashi Taguchi, Yoshiki Higashijima, Yasuharu Kanki, Ryo Nakaki, Yoshihiro Urade, Youichiro Wada
Summary: Recent research has shown that the interaction between 23 K PRL and PERK signaling is cardioprotective during the peripartum period. The upregulation of 23 K PRL, compared to 16 K PRL, leads to activation of PERK signaling in neonatal rat cardiomyocytes. Additionally, CM-KO mice lacking PERK homogenous in cardiomyocytes exhibited PPCM phenotypes after consecutive deliveries, suggesting the importance of PERK signaling in protecting the heart during the perinatal period.
SCIENTIFIC REPORTS
(2021)
Review
Plant Sciences
Lingyan Jiang, Shizi Zhang, Jianbin Su, Scott C. Peck, Lijuan Luo
Summary: This review summarizes the current knowledge of protein kinase signaling pathways in plant-Colletotrichum interaction and their relation to plant immunity and pathogen virulence. It highlights the potential of combining genomic resources and phosphoproteomics research to understand the key molecular components of plant-Colletotrichum interactions. Understanding these molecular interactions is important for breeding disease-resistant cultivars and developing effective strategies to control anthracnose.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Chemistry, Medicinal
Zhikun Liu, Qingqing Liu, Bin Zhang, Qiao Liu, Lei Fang, Shaohua Gou
Summary: In this study, multifunctional nanoparticles (Reg-NPs) were developed to enhance the permeability of donepezil through the blood-brain barrier by regulating tight junction-associated proteins. Additionally, the nanoparticles activated the NO/cGMP/CREB signaling pathway, reducing cytotoxicity induced by aggregated A beta and promoting synaptic plasticity and memory formation in neurons.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Cell Biology
Ling Liu, Yihao Xing, Mengyao Cao, Jinglei Xu, Jingjing Chen
Summary: JS-K induces apoptosis in hepatocellular carcinoma cells by activating JNK and p38 MAPK and inhibiting the Raf/MEK/ERK signaling pathway.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemical Research Methods
Aydanur Senturk, Ayse T. Sahin, Ayse Armutlu, Murat Can Kiremit, Omer Acar, Selcuk Erdem, Sidar Bagbudar, Tarik Esen, Nurhan Ozlu
Summary: In this study, quantitative phosphoproteomics characterization of ccRCC tumor and normal adjacent tissues revealed significant differential regulation of phosphoproteins between tumor and normal tissues. These differentially regulated phosphoproteins are associated with proliferative and migratory behavior of renal tumors. Furthermore, master kinases responsible for phosphorylation of substrates associated with cell proliferation, inflammation, and migration were identified.
MOLECULAR & CELLULAR PROTEOMICS
(2022)
Article
Multidisciplinary Sciences
Maximilian W. Schenk, Sam Humphrey, A. S. Md Mukarram Hossain, Mitchell Revill, Sarah Pearsall, Alice Lallo, Stewart Brown, Samuel Bratt, Melanie Galvin, Tine Descamps, Cong Zhou, Simon P. Pearce, Lynsey Priest, Michelle Greenhalgh, Anshuman Chaturvedi, Alastair Kerr, Fiona Blackhall, Caroline Dive, Kristopher K. Frese
Summary: In small cell lung cancer, acquired resistance to standard platinum-etoposide chemotherapy often occurs, with Notch and nitric oxide pathways playing a role in mediating this resistance. Upregulation of soluble guanylate cyclase in residual tumor cells is associated with chemoresistance, highlighting this pathway as a potential target for treating relapsed SCLC.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Tenderano T. Muzorewa, Donald G. Buerk, Dov Jaron, Kenneth A. Barbee
Summary: This study demonstrates the differential regulation of NO production by classical and novel PKCs in response to shear stress and ATP stimulation. PKC eta plays a crucial role in modulating eNOS activation, while PKC beta has a more modest influence. The findings shed light on the intricate PKC signaling architecture and provide insights for the development of drugs targeting PKC-sensitive cardiovascular pathologies.
CELLULAR SIGNALLING
(2021)
Review
Pharmacology & Pharmacy
Kha Wai Hon, Syafiq Asnawi Zainal Abidin, Iekhsan Othman, Rakesh Naidu
Summary: Colorectal cancer is characterized by metabolic reprogramming, which plays a crucial role in promoting tumor progression by modulating core metabolic pathways. Activation of oncogenes and loss of tumor suppressor genes regulate metabolic reprogramming, with protein kinases serving as integral components in facilitating interactions between signaling pathways and metabolic pathways in CRC.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Laura Boccuni, Elke Podgorschek, Moritz Schmiedeberg, Ekaterini Platanitis, Peter Traxler, Philipp Fischer, Alessia Schirripa, Philipp Novoszel, Angel R. Nebreda, J. Simon C. Arthur, Nikolaus Fortelny, Matthias Farlik, Veronika Sexl, Christoph Bock, Maria Sibilia, Pavel Kovarik, Mathias Mueller, Thomas Decker
Summary: This study reveals the synergistic effect of cell stress-induced p38 MAPK signaling and IFN-stimulated signal transduction, and the impact of this synergy on ISG expression and macrophage infection ability.
Review
Cell Biology
A. T. Duarte-Silva, L. G. R. Ximenes, M. Guimaraes-Souza, I. Domith, R. Paes-de-Carvalho
Summary: The communication and interaction between developing neurons and neurotransmitters play crucial roles in the regulation of signaling pathways during central nervous system development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Plant Sciences
Xiao Wei Ji, Hang Ji Lyu, Guang Hai Zhou, Bo Wu, Yuan Yuan Zhu, Tian Hua Wu, Feng Zhang, Song Nan Jin, Kyung Woo Cho, Jin Fu Wen
Summary: The study demonstrates that physcion prevents Hcy-induced endothelial dysfunction by activating Ca2+- and Akt-eNOS-NO signaling pathways, suggesting its potential as a candidate agent for preventing cardiovascular disease.
Review
Biochemistry & Molecular Biology
Huihua Chen, Chen Chen, Michail Spanos, Guoping Li, Rong Lu, Yihua Bei, Junjie Xiao
Summary: Exercise training is recognized as a healthy lifestyle and an effective therapy for cardiovascular diseases. Studies have shown the beneficial impact of exercise on cardiovascular health and have identified the signaling pathways involved.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Ali Barandov, Souparno Ghosh, Alan Jasanoff
Summary: This review discusses the development and potential applications of MRI-detectable probes for studying nitrergic signaling in animals and potentially in human subjects. These probes offer a powerful tool for understanding and diagnosing the physiological processes in which nitric oxide (NO) plays a key role. By capturing and reporting NO levels, these probes provide valuable information and establish a foundation for improving the sensitivity, specificity, and clinical applicability of NO-related molecular MRI technology.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Han-Yan Zhu, Fen-Fang Hong, Shu-Long Yang
Summary: Vascular dementia is the second most common form of dementia worldwide, caused by cerebrovascular disease. Nitric oxide and nitric oxide synthase play vital roles in the pathogenesis of this disease, with different NOS subtypes having partitioned activities in the brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Sen Zhang, Sijing Rao, Meiwen Yang, Chen Ma, Fengfang Hong, Shulong Yang
Summary: Hepatic ischemia-reperfusion injury is a major cause of post-operative hepatic dysfunction and liver failure after transplantation. Mitochondrial pathways play a crucial role in hepatic cell apoptosis, depending on multiple factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
