Deficient adaptation to centrosome duplication defects in neural progenitors causes microcephaly and subcortical heterotopias

CDK5RAP2 primary microcephaly is associated with hypothalamic, retinal and cochlear developmental defects

(2020) Hala Nasser et al.   JOURNAL OF MEDICAL GENETICS

Cep55 promotes cytokinesis of neural progenitors but is dispensable for most mammalian cell divisions

(2020) Antonio Tedeschi et al.   Nature Communications

Mutation in CEP135 causing primary microcephaly and subcortical heterotopia

(2020) Daniel Bamborschke et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis

(2019) Hendrik A. Messal et al.   NATURE

Subcortical heterotopic gray matter brain malformations

(2019) Renske Oegema et al.   NEUROLOGY

The Genetics of Primary Microcephaly

(2018) Divya Jayaraman et al.   Annual Review of Genomics and Human Genetics

A centrosomal view of CNS growth

(2018) Murielle Saade et al.   DEVELOPMENT

p53 deletion rescues lethal microcephaly in a mouse model with neural stem cell abscission defects

(2018) Jessica Neville Little et al.   HUMAN MOLECULAR GENETICS

CDK5RAP2 Is Required to Maintain the Germ Cell Pool during Embryonic Development

(2017) Sami Zaqout et al.   Stem Cell Reports

Nextpresso: Next Generation Sequencing Expression Analysis Pipeline

(2017) O. Graña et al.   Current Bioinformatics

ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules

(2016) Marta Gai et al.   EMBO REPORTS

SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture

(2016) Manuel Hilbert et al.   NATURE CELL BIOLOGY

Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate

(2016) Divya Jayaraman et al.   NEURON

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

A novel splice site mutation in CEP135 is associated with primary microcephaly in a Pakistani family

(2015) Muhammad Farooq et al.   JOURNAL OF HUMAN GENETICS

CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination

(2015) Marko Marjanović et al.   Nature Communications

Cortical neurogenesis in the absence of centrioles

(2014) Ryan Insolera et al.   NATURE NEUROSCIENCE

Patches of Disorganization in the Neocortex of Children with Autism

(2014) Rich Stoner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo

(2014) H. Bazzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology

(2014) Lori A. Orosco et al.   Nature Communications

Molecular and Cellular Basis of Autosomal Recessive Primary Microcephaly

(2014) Marine Barbelanne et al.   Biomed Research International

Human microcephaly protein CEP135 binds to hSAS-6 and CPAP, and is required for centriole assembly

(2013) Yu-Chih Lin et al.   EMBO JOURNAL

Abnormal centrosomal structure and duplication in Cep135-deficient vertebrate cells

(2013) Burcu Inanç et al.   MOLECULAR BIOLOGY OF THE CELL

A Truncating Mutation of CEP135 Causes Primary Microcephaly and Disturbed Centrosomal Function

(2012) Muhammad Sajid Hussain et al.   AMERICAN JOURNAL OF HUMAN GENETICS

BLD10/CEP135 Is a Microtubule-Associated Protein that Controls the Formation of the Flagellum Central Microtubule Pair

(2012) Zita Carvalho-Santos et al.   DEVELOPMENTAL CELL

Towards a molecular architecture of centriole assembly

(2012) Pierre Gönczy   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cdk5rap2 exposes the centrosomal root of microcephaly syndromes

(2011) Timothy L. Megraw et al.   TRENDS IN CELL BIOLOGY

Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors

(2010) S. B. Lizarraga et al.   DEVELOPMENT

Stepwise evolution of the centriole-assembly pathway

(2010) Z. Carvalho-Santos et al.   JOURNAL OF CELL SCIENCE

Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture

(2010) Timothy W Yu et al.   NATURE GENETICS

Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline

(2010) J. N. Pulvers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila Bld10 Is a Centriolar Protein That Regulates Centriole, Basal Body, and Motile Cilium Assembly

(2009) Violaine Mottier-Pavie et al.   MOLECULAR BIOLOGY OF THE CELL

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Primary microcephaly: do all roads lead to Rome?

(2009) Gemma K. Thornton et al.   TRENDS IN GENETICS

A Genome-Wide RNAi Screen to Dissect Centriole Duplication and Centrosome Maturation in Drosophila

(2008) Jeroen Dobbelaere et al.   PLOS BIOLOGY