Suppression of the fibrotic encapsulation of silicone implants by inhibiting the mechanical activation of pro-fibrotic TGF-β

2020 special issue: Twenty years of breast reconstruction: Past, present, and future

(2020) Aldona J. Spiegel et al.   Breast Journal

Comparison of round smooth and shaped micro-textured implants in terms of quality of life and aesthetic outcomes in women undergoing breast reconstruction: a single-centre prospective study

(2020) Oreste Claudio Buonomo et al.   Updates in Surgery

Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis

(2020) Tatsuya Tsukui et al.   Nature Communications

Response to “Intra- and Inter-Shell Roughness Variability of Breast Implant Surfaces”

(2020) Roger N Wixtrom et al.   Aesthetic Surgery Journal

The myofibroblast at a glance

(2020) Pardis Pakshir et al.   JOURNAL OF CELL SCIENCE

New injectable self-assembled hydrogels that promote angiogenesis through a bioactive degradation product

(2020) K.R. Sindhu et al.   Acta Biomaterialia

Substrate stiffness directs the phenotype and polarization state of cord blood derived macrophages

(2020) Rebecca A. Scott et al.   Acta Biomaterialia

TRPV4 Plays a Role in Matrix Stiffness-Induced Macrophage Polarization

(2020) Bidisha Dutta et al.   Frontiers in Immunology

Cadherin-11–mediated adhesion of macrophages to myofibroblasts establishes a profibrotic niche of active TGF-β

(2019) Monika Lodyga et al.   Science Signaling

Mechanical regulation of myofibroblast phenoconversion and collagen contraction

(2019) Boris Hinz et al.   EXPERIMENTAL CELL RESEARCH

Immunoregulation of macrophages by dynamic ligand presentation via ligand–cation coordination

(2019) Heemin Kang et al.   Nature Communications

Patch repair of deep wounds by mobilized fascia

(2019) Donovan Correa-Gallegos et al.   NATURE

Stiffness Sensing in Cells and Tissues

(2019) Paul A. Janmey et al.   PHYSIOLOGICAL REVIEWS

MRTF-A controls myofibroblastic differentiation of human multipotent stromal cells and their tumour-supporting function in xenograft models

(2019) Sara Werner et al.   Scientific Reports

TGF-β1 – A truly transforming growth factor in fibrosis and immunity

(2019) Monika Lodyga et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The fibronectin ED-A domain enhances recruitment of latent TGF-β-binding protein-1 to the fibroblast matrix

(2018) Franco Klingberg et al.   JOURNAL OF CELL SCIENCE

The big five in fibrosis: Macrophages, myofibroblasts, matrix, mechanics, and miscommunication

(2018) Pardis Pakshir et al.   MATRIX BIOLOGY

Cryo-EM structure of the αvβ8 integrin reveals a mechanism for stabilizing integrin extension

(2018) Anthony Cormier et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair

(2018) Brett A. Shook et al.   SCIENCE

Mutual dependence of the MRTF–SRF and YAP–TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics

(2017) Charles T. Foster et al.   GENES & DEVELOPMENT

Functional biocompatibility testing of silicone breast implants and a novel classification system based on surface roughness

(2017) S. Barr et al.   Journal of the Mechanical Behavior of Biomedical Materials

Fibronectin, the extracellular glue

(2017) Alicia J. Zollinger et al.   MATRIX BIOLOGY

Sensing the mechano-chemical properties of the extracellular matrix

(2017) Pia Ringer et al.   MATRIX BIOLOGY

Force interacts with macromolecular structure in activation of TGF-β

(2017) Xianchi Dong et al.   NATURE

Atypical interactions of integrin αVβ8with pro-TGF-β1

(2017) Jianchuan Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Breast Augmentation and Reconstruction from a Regenerative Medicine Point of View: State of the Art and Future Perspectives

(2017) Luke E. Visscher et al.   TISSUE ENGINEERING PART B-REVIEWS

TGF-β1 Signaling and Tissue Fibrosis

(2017) Kevin K. Kim et al.   Cold Spring Harbor Perspectives in Biology

αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis

(2017) I. R. Murray et al.   Nature Communications

Fibroblasts: Diverse Cells Critical to Biomaterials Integration

(2017) Riley T. Hannan et al.   ACS Biomaterials-Science & Engineering

Fibroblasts: Diverse Cells Critical to Biomaterials Integration

(2017) Riley T. Hannan et al.   ACS Biomaterials Science & Engineering

Myofibroblasts

(2016) Boris Hinz   EXPERIMENTAL EYE RESEARCH

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

The pathology of the foreign body reaction against biomaterials

(2016) R. Klopfleisch et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Integrin-mediated mechanotransduction

(2016) Zhiqi Sun et al.   JOURNAL OF CELL BIOLOGY

MicroRNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells

(2016) Chen Xi Li et al.   NATURE MATERIALS

Examination of the foreign body response to biomaterials by nonlinear intravital microscopy

(2016) Eleonora Dondossola et al.   Nature Biomedical Engineering

Facial Contouring Surgery with Custom Silicone Implants Based on a 3D Prototype Model and CT-Scan: A Preliminary Study

(2015) Hyung Woo Yim et al.   AESTHETIC PLASTIC SURGERY

Novel micropatterns mechanically control fibrotic reactions at the surface of silicone implants

(2015) Hicham Majd et al.   BIOMATERIALS

Acute suppression of TGF-ß with local, sustained release of tranilast against the formation of fibrous capsules around silicone implants

(2015) Subin Park et al.   JOURNAL OF CONTROLLED RELEASE

The extracellular matrix and transforming growth factor-β1: Tale of a strained relationship

(2015) Boris Hinz   MATRIX BIOLOGY

Electronic dura mater for long-term multimodal neural interfaces

(2015) I. R. Minev et al.   SCIENCE

The α v β 1 integrin plays a critical in vivo role in tissue fibrosis

(2015) Nilgun I. Reed et al.   Science Translational Medicine

Comparison of the Postoperative Incidence Rate of Capsular Contracture among Different Breast Implants: A Cumulative Meta-Analysis

(2015) Xing Liu et al.   PLoS One

Quantitative Characterization of Collagen in the Fibrotic Capsule Surrounding Implanted Polymeric Microparticles through Second Harmonic Generation Imaging

(2015) Dana Akilbekova et al.   PLoS One

Foreign body response to subcutaneous biomaterial implants in a mast cell-deficient Kitw-Sh murine model

(2014) M.N. Avula et al.   Acta Biomaterialia

Biomedical Implant Capsule Formation

(2014) Paul DiEgidio et al.   ANNALS OF PLASTIC SURGERY

The relationship between glial cell mechanosensitivity and foreign body reactions in the central nervous system

(2014) Pouria Moshayedi et al.   BIOMATERIALS

Integrin-directed modulation of macrophage responses to biomaterials

(2014) Toral D. Zaveri et al.   BIOMATERIALS

Integrins αvβ5 and αvβ3 promote latent TGF-β1 activation by human cardiac fibroblast contraction

(2014) Vincent Sarrazy et al.   CARDIOVASCULAR RESEARCH

Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation

(2014) Franco Klingberg et al.   JOURNAL OF CELL BIOLOGY

The Nano-Scale Mechanical Properties of the Extracellular Matrix Regulate Dermal Fibroblast Function

(2014) Volker F. Achterberg et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Matricellular proteins and biomaterials

(2014) Aaron H. Morris et al.   MATRIX BIOLOGY

Selective Targeting of TGF-  Activation to Treat Fibroinflammatory Airway Disease

(2014) S. Minagawa et al.   Science Translational Medicine

TGF-β Activation and Function in Immunity

(2013) Mark A. Travis et al.   Annual Review of Immunology

Designing implant surface topography for improved biocompatibility

(2013) Alison G Harvey et al.   Expert Review of Medical Devices

It has to be the αv: myofibroblast integrins activate latent TGF-β1

(2013) Boris Hinz   NATURE MEDICINE

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

(2013) Neil C Henderson et al.   NATURE MEDICINE

Risk Factor Analysis for Capsular Contracture

(2013) W. Grant Stevens et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

The Mechanical Environment Modulates Intracellular Calcium Oscillation Activities of Myofibroblasts

(2013) Charles Godbout et al.   PLoS One

Host Responses in Tissue Repair and Fibrosis

(2012) Jeremy S. Duffield et al.   Annual Review of Pathology-Mechanisms of Disease

Integrin-mediated regulation of TGFβ in fibrosis

(2012) Neil C. Henderson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin αvβ6-dependent physical force

(2012) Marilyn M. Giacomini et al.   EXPERIMENTAL CELL RESEARCH

The mechanical memory of lung myofibroblasts

(2012) Jenna L. Balestrini et al.   Integrative Biology

Rupture of Poly Implant Prothèse Silicone Breast Implants

(2012) Eric Swarts et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Immune responses to implants – A review of the implications for the design of immunomodulatory biomaterials

(2011) Sandra Franz et al.   BIOMATERIALS

The Single-Molecule Mechanics of the Latent TGF-β1 Complex

(2011) Lara Buscemi et al.   CURRENT BIOLOGY

Endotoxin contamination delays the foreign body reaction

(2011) Sander M. van Putten et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Integrin  v 5-Mediated TGF-  Activation by Airway Smooth Muscle Cells in Asthma

(2011) A. L. Tatler et al.   JOURNAL OF IMMUNOLOGY

Latent TGF-β structure and activation

(2011) Minlong Shi et al.   NATURE

Matrix elasticity, cytoskeletal forces and physics of the nucleus: how deeply do cells 'feel' outside and in?

(2010) A. Buxboim et al.   JOURNAL OF CELL SCIENCE

Localized Immunosuppressive Environment in the Foreign Body Response to Implanted Biomaterials

(2009) David M. Higgins et al.   AMERICAN JOURNAL OF PATHOLOGY

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

Mechanically Activated Integrin Switch Controls  5 1 Function

(2009) J. C. Friedland et al.   SCIENCE

The covalent attachment of adhesion molecules to silicone membranes for cell stretching applications

(2008) Pierre-Jean Wipff et al.   BIOMATERIALS

Integrins and the activation of latent transforming growth factor β1 – An intimate relationship

(2008) P WIPFF et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces

(2008) Jianghai Zhu et al.   MOLECULAR CELL