Shear-stress sensing by PIEZO1 regulates tendon stiffness in rodents and influences jumping performance in humans

Tendon response to matrix unloading is determined by the patho-physiological niche

(2020) Stefania L. Wunderli et al.   MATRIX BIOLOGY

Reporting Genetic Markers and the Social Determinants of Health in Clinical Cardiovascular Research—It Is Time to Recalibrate the Use of Race

(2020) Clyde W. Yancy et al.   JAMA Cardiology

The world-wide burden of musculoskeletal diseases: a systematic analysis of the World Health Organization Burden of Diseases Database

(2019) Eden Sebbag et al.   ANNALS OF THE RHEUMATIC DISEASES

Tendon tissue microdamage and the limits of intrinsic repair

(2019) Tino Stauber et al.   MATRIX BIOLOGY

The mechanosensitive Piezo1 channel is required for bone formation

(2019) Weijia Sun et al.   eLife

Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection

(2018) Shang Ma et al.   CELL

GPR68 Senses Flow and Is Essential for Vascular Physiology

(2018) Jie Xu et al.   CELL

Structure of the mechanosensitive OSCA channels

(2018) Mingfeng Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells

(2018) Bifeng Pan et al.   NEURON

OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels

(2018) Swetha E Murthy et al.   eLife

Minimal mechanical load and tissue culture conditions preserve native cell phenotype and morphology in tendon-a novel ex vivo mouse explant model

(2017) Stefania L. Wunderli et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Advanced glycation end-products: Mechanics of aged collagen from molecule to tissue

(2017) Alfonso Gautieri et al.   MATRIX BIOLOGY

TrackMate: An open and extensible platform for single-particle tracking

(2017) Jean-Yves Tinevez et al.   METHODS

Piezos thrive under pressure: mechanically activated ion channels in health and disease

(2017) Swetha E. Murthy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CHIPS: an Extensible Toolbox for Cellular and Hemodynamic Two-Photon Image Analysis

(2017) Matthew J. P. Barrett et al.   NEUROINFORMATICS

Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens

(2017) David W. Morgens et al.   Nature Communications

Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes

(2017) M Rocio Servin-Vences et al.   eLife

Novel Model of Tendon Regeneration Reveals Distinct Cell Mechanisms Underlying Regenerative and Fibrotic Tendon Healing

(2017) Kristen Howell et al.   Scientific Reports

Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release

(2016) ShengPeng Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Piezo2 senses airway stretch and mediates lung inflation-induced apnoea

(2016) Keiko Nonomura et al.   NATURE

Surface-Driven Collagen Self-Assembly Affects Early Osteogenic Stem Cell Signaling

(2016) Tojo Razafiarison et al.   Advanced Healthcare Materials

Heavy Slow Resistance Versus Eccentric Training as Treatment for Achilles Tendinopathy

(2015) Rikke Beyer et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Tendon mechanobiology:Current knowledge and future research opportunities

(2015) Michael Lavagnino et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Piezo2 is the principal mechanotransduction channel for proprioception

(2015) Seung-Hyun Woo et al.   NATURE NEUROSCIENCE

Tendon injury: from biology to tendon repair

(2015) Geoffroy Nourissat et al.   Nature Reviews Rheumatology

Time-Resolved Imaging Reveals Heterogeneous Landscapes of Nanomolar Ca2+ in Neurons and Astroglia

(2015) Kaiyu Zheng et al.   NEURON

Transcriptome analysis of ageing in uninjured human Achilles tendon

(2015) Mandy Peffers et al.   ARTHRITIS RESEARCH & THERAPY

Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia

(2015) Viktor Lukacs et al.   Nature Communications

Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis

(2015) Elisavet Fotiou et al.   Nature Communications

Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling

(2015) Kevin Retailleau et al.   Cell Reports

Chemical activation of the mechanotransduction channel Piezo1

(2015) Ruhma Syeda et al.   eLife

Piezo1 links mechanical forces to red blood cell volume

(2015) Stuart M Cahalan et al.   eLife

Life-long endurance running is associated with reduced glycation and mechanical stress in connective tissue

(2014) Christian Couppé et al.   AGE

CRISPRdirect: software for designing CRISPR/Cas guide RNA with reduced off-target sites

(2014) Yuki Naito et al.   BIOINFORMATICS

Piezo2 is the major transducer of mechanical forces for touch sensation in mice

(2014) Sanjeev S. Ranade et al.   NATURE

Piezo1 integration of vascular architecture with physiological force

(2014) Jing Li et al.   NATURE

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Piezo1, a mechanically activated ion channel, is required for vascular development in mice

(2014) S. S. Ranade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysyl oxidase-mediated collagen crosslinks may be assessed as markers of functional properties of tendon tissue formation

(2013) Joseph E. Marturano et al.   Acta Biomaterialia

A new experimental system for simultaneous application of cyclic tensile strain and fluid shear stress to tenocytes in vitro

(2013) Eijiro Maeda et al.   BIOMEDICAL MICRODEVICES

Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells

(2013) Rémi Peyronnet et al.   EMBO REPORTS

Lack of tissue renewal in human adult Achilles tendon is revealed by nuclear bomb 14C

(2013) Katja Maria Heinemeier et al.   FASEB JOURNAL

Advanced glycation end-products diminish tendon collagen fiber sliding

(2013) Yufei Li et al.   MATRIX BIOLOGY

Uphill running improves rat Achilles tendon tissue mechanical properties and alters gene expression without inducing pathological changes

(2012) K. M. Heinemeier et al.   JOURNAL OF APPLIED PHYSIOLOGY

Mapping the Mechanome of Live Stem Cells Using a Novel Method to Measure Local Strain Fields In Situ at the Fluid-Cell Interface

(2012) Min Jae Song et al.   PLoS One

Influence of Muscle–Tendon Unit Structure on Rate of Force Development During the Squat, Countermovement, and Drop Jumps

(2011) Jacob E Earp et al.   JOURNAL OF STRENGTH AND CONDITIONING RESEARCH

Mechanical properties of the equine superficial digital flexor tendon relate to specific collagen cross-link levels

(2010) C. T. THORPE et al.   EQUINE VETERINARY JOURNAL

The pathogenesis of tendinopathy: balancing the response to loading

(2010) S. Peter Magnusson et al.   Nature Reviews Rheumatology

C. elegans TRP Family Protein TRP-4 Is a Pore-Forming Subunit of a Native Mechanotransduction Channel

(2010) Lijun Kang et al.   NEURON

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Corticosteroid injections, eccentric decline squat training and heavy slow resistance training in patellar tendinopathy

(2009) M. Kongsgaard et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Functional Fibered Confocal Microscopy: A Promising Tool for Assessing Tendon Regeneration

(2009) Jess G. Snedeker et al.   TISSUE ENGINEERING PART C-METHODS

Tendinopathy—from basic science to treatment

(2008) Graham Riley   Nature clinical practice. Rheumatology