Article
Biotechnology & Applied Microbiology
Mariano Volonte, Lucila Traverso, Jose Manuel Latorre Estivalis, Francisca Cunha Almeida, Sheila Ons
Summary: This study performed a comparative analysis on the complement of xenobiotic detoxification gene superfamilies across five hemipteran species. The results showed that heteropterans have an expansion of detoxification enzymes compared to other species. Interestingly, the most polyphagous species analyzed here (H. halys) also has the largest repertoire of detoxification enzymes, which may be due to gene duplication events. These detoxification-related gene families play important roles in the detoxification of diet products and conferring tolerance or resistance to synthetic insecticides.
Article
Biochemistry & Molecular Biology
Dries Amezian, Ralf Nauen, Gaelle Le Goff
Summary: The genus Spodoptera is known for being polyphagous and destructive agricultural pests, with detoxification genes playing a crucial role in overcoming plant defense mechanisms. Despite a significant amount of expression data produced in the past decade for Spodoptera larvae in response to xenobiotics, the scattered information makes it difficult to clearly identify candidate genes involved in host plant adaptation and insecticide resistance. This review highlights the importance of detoxification genes in the genus and reveals a lack of genetic and biochemical information in some species, suggesting a need for further research in this area.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Genki Ichihara, Yoshinori Katsumata, Yuki Sugiura, Yuta Matsuoka, Rae Maeda, Jin Endo, Atsushi Anzai, Kohsuke Shirakawa, Hidenori Moriyama, Hiroki Kitakata, Takahiro Hiraide, Shinichi Goto, Seien Ko, Yuji Iwasawa, Kazuhisa Sugai, Kyohei Daigo, Shinya Goto, Kazuki Sato, Ken-ichi Yamada, Makoto Suematsu, Masaki Ieda, Motoaki Sano
Summary: This study found that glutathione release during ischemia-reperfusion (IR) is primarily dependent on the transporter MRP1, and its release induces ferroptosis. Suppression of glutathione release attenuates ferroptosis and reduces myocardial infarct size following IR.
CIRCULATION RESEARCH
(2023)
Article
Agronomy
Zhenzhen Zhao, Lan Zhang, Yanning Zhang, Liangang Mao, Lizhen Zhu, Xingang Liu, Hongyun Jiang
Summary: The study investigated the enzymatic response of cytochrome P450 monooxygenase (CYP) and glutathione S-transferase (GST) genes after CPT treatment in the fat body cells of Spodoptera exigua. The effects of CPT on the growth and development of S. exigua larvae were also examined. The relative expression levels of selected CYP and GST genes changed significantly during the CPT treatment period, suggesting their involvement in CPT metabolism.
Article
Environmental Sciences
Diana Dimunova, Petra Matouskova, Martina Navratilova, Linh Thuy Nguyen, Martin Ambroz, Ivan Vokral, Barbora Szotakova, Lenka Skalova
Summary: This study found that the environmental circulation of veterinary anthelmintics may contribute to drug resistance in parasitic nematodes, as it improves their ability to deactivate the drugs.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Biochemistry & Molecular Biology
Dries Amezian, Ralf Nauen, Gaelle Le Goff
Summary: Arthropods have evolved various strategies, including the induction of detoxification enzymes, to defend themselves against a wide array of chemicals in their environment. Studies using advanced genetic tools in insects have substantially contributed to our understanding of the genomic basis of their xenobiotic response. Signaling pathways such as nuclear receptors and transcription factors play crucial roles in the upregulation of detoxification enzymes and can impact insects' adaptive processes.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Victoria Yurchenko, Alexey Morozov
Summary: The study found that humic substances can affect enzyme activities and antioxidant defense in fish, with different isozymes showing varied responses to humic acid, ensuring a balanced interaction of proteins in the metabolism of humic acid in fish liver.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Viatcheslav Mordvinov, Maria Pakharukova
Summary: This article discusses the structure and functional significance of the xenobiotic-metabolizing system in trematodes, emphasizing the importance of understanding this system for finding new targets for antiparasitic therapy, understanding the adaptation mechanisms and drug resistance development in parasites, and discovering new anthelmintics.
Article
Biochemistry & Molecular Biology
Su Mon Shwe, Sivaprasath Prabu, Dapeng Jing, Kanglai He, Zhenying Wang
Summary: The Cry1Ah and Vip3Aa19 proteins have a synergistic interaction in controlling the Yellow peach moth. Cry1Ah has a higher binding affinity for midgut receptors compared to Vip3Aa19, and there is no competition between them.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biotechnology & Applied Microbiology
Guichun Liu, Wei Liu, Ruoping Zhao, Jinwu He, Zhiwei Dong, Lei Chen, Wenting Wan, Zhou Chang, Wen Wang, Xueyan Li
Summary: The study identified multiple ABC transporter and Rab protein family members in the genome of the swallowtail butterfly, revealing their significant role in body coloration. This provides new insights into the morphological development of butterflies.
Article
Biochemistry & Molecular Biology
Rossana Visigalli, Bianca Maria Rotoli, Francesca Ferrari, Maria Di Lascia, Benedetta Riccardi, Paola Puccini, Valeria Dall'Asta, Amelia Barilli
Summary: In this study, the expression and activity of ABC transporters in human alveoli were analyzed. The results showed that MRP1 was the only transporter expressed and functional at the basolateral side, while the other studied transporters were not expressed on the apical membrane. This suggests the presence of unidentified transporters involved in drug efflux from alveolar epithelium.
Review
Agronomy
Agnieszka Murawska, Pawel Migdal, Adam Roman
Summary: The research focuses primarily on the biochemical effects of plant protection products (PPPs) in honey bees, especially insecticides such as neonicotinoids. Sublethal doses of PPPs can have harmful effects on bee colonies, affecting their physiology, health, and performance. Additionally, PPPs may alter the antioxidant defense, detoxification process, gene expression, and immune response in bees.
Review
Pharmacology & Pharmacy
Patrick T. Ronaldson, Thomas P. Davis
Summary: Ischemic stroke is a major cause of morbidity and mortality globally. Despite positive results in preclinical studies, only one compound has advanced to Phase III clinical trial evaluation. This may be due to the neglect of transport mechanisms at the blood-brain barrier and neurovascular unit. This review highlights the role of BBB transporters in drug delivery and their expression in different brain cell types.
Article
Pharmacology & Pharmacy
Lukas Cerveny, Sara Karbanova, Rona Karahoda, Hana Horackova, Lucie Jiraskova, Mohammed Naji Husaen Ali, Frantisek Staud
Summary: The nucleoside analog entecavir (ETV) is a first-line pharmacotherapy for chronic hepatitis B in adult and pediatric patients. However, insufficient data on placental transfer and pregnancy effects limit its recommended use in women after conception. This study investigated the contribution of various transporters to the placental kinetics of ETV and found that ENTs, but not CNTs, ABCB1, ABCG2, and ABCC2, significantly affect ETV transport across the placenta.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Cell Biology
Zhuo-Xun Wu, Yuqi Yang, Jing-Quan Wang, Silpa Narayanan, Zi-Ning Lei, Qiu-Xu Teng, Leli Zeng, Zhe-Sheng Chen
Summary: The study confirmed that MLN7243 is a substrate of ABCG2, and overexpression of ABCG2 leads to resistance in cancer cells against MLN7243. Combining MLN7243 with ABCG2 inhibitors may enhance the therapeutic efficacy for tumors with high ABCG2 levels.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Daniel Gonzalez, Karen Rihani, Fabrice Neiers, Nicolas Poirier, Stephane Fraichard, Guillaume Gotthard, Thomas Chertemps, Martine Maibeche, Jean-Francois Ferveur, Loic Briand
CELLULAR AND MOLECULAR LIFE SCIENCES
(2020)
Article
Biology
Claude Rispe, Fabrice Legeai, Paul D. Nabity, Rosa Fernandez, Arinder K. Arora, Patrice Baa-Puyoulet, Celeste R. Banfill, Leticia Bao, Miquel Barbera, Maryem Bouallegue, Anthony Bretaudeau, Jennifer A. Brisson, Federica Calevro, Pierre Capy, Olivier Catrice, Thomas Chertemps, Carole Couture, Laurent Deliere, Angela E. Douglas, Keith Dufault-Thompson, Paula Escuer, Honglin Feng, Astrid Forneck, Toni Gabaldon, Roderic Guigo, Frederique Hilliou, Silvia Hinojosa-Alvarez, Yi-Min Hsiao, Sylvie Hudaverdian, Emmanuelle Jacquin-Joly, Edward B. James, Spencer Johnston, Benjamin Joubard, Gaelle Le Goff, Gael Le Trionnaire, Pablo Librado, Shanlin Liu, Eric Lombaert, Hsiao-Ling Lu, Martine Maibeche, Mohamed Makni, Marina Marcet-Houben, David Martinez-Torres, Camille Meslin, Nicolas Montagne, Nancy A. Moran, Daciana Papura, Nicolas Parisot, Yvan Rahbe, Melanie Ribeiro Lopes, Aida Ripoll-Cladellas, Stephanie Robin, Celine Roques, Pascale Roux, Julio Rozas, Alejandro Sanchez-Gracia, Jose F. Sanchez-Herrero, Didac Santesmasses, Iris Scatoni, Remy-Felix Serre, Ming Tang, Wenhua Tian, Paul A. Umina, Manuella van Munster, Carole Vincent-Monegat, Joshua Wemmer, Alex C. C. Wilson, Ying Zhang, Chaoyang Zhao, Jing Zhao, Serena Zhao, Xin Zhou, Francois Delmotte, Denis Tagu
Correction
Biology
Claude Rispe, Fabrice Legeai, Paul D. Nabity, Rosa Fernandez, Arinder K. Arora, Patrice Baa-Puyoulet, Celeste R. Banfill, Leticia Bao, Miquel Barbera, Maryem Bouallegue, Anthony Bretaudeau, Jennifer A. Brisson, Federica Calevro, Pierre Capy, Olivier Catrice, Thomas Chertemps, Carole Couture, Laurent Deliere, Angela E. Douglas, Keith Dufault-Thompson, Paula Escuer, Honglin Feng, Astrid Forneck, Toni Gabaldon, Roderic Guigo, Frederique Hilliou, Silvia Hinojosa-Alvarez, Yi-min Hsiao, Sylvie Hudaverdian, Emmanuelle Jacquin-Joly, Edward B. James, Spencer Johnston, Benjamin Joubard, Gaelle Le Goff, Gael Le Trionnaire, Pablo Librado, Shanlin Liu, Eric Lombaert, Hsiao-ling Lu, Martine Maibeche, Mohamed Makni, Marina Marcet-Houben, David Martinez-Torres, Camille Meslin, Nicolas Montagne, Nancy A. Moran, Daciana Papura, Nicolas Parisot, Yvan Rahbe, Melanie Ribeiro Lopes, Aida Ripoll-Cladellas, Stephanie Robin, Celine Roques, Pascale Roux, Julio Rozas, Alejandro Sanchez-Gracia, Jose F. Sanchez-Herrero, Didac Santesmasses, Iris Scatoni, Remy-Felix Serre, Ming Tang, Wenhua Tian, Paul A. Umina, Manuella van Munster, Carole Vincent-Monegat, Joshua Wemmer, Alex C. C. Wilson, Ying Zhang, Chaoyang Zhao, Jing Zhao, Serena Zhao, Xin Zhou, Francois Delmotte, Denis Tagu
Article
Agronomy
Benoit Barres, Marie-France Corio-Costet, Daniele Debieu, Christophe Delye, Sabine Fillinger, Bertrand Gauffre, Gaelle Le Goff, Jacques Grosman, Mourad Hannachi, Pauline de Jerphanion, Lise Nistrup-Jorgensen, Christophe Plantamp, Myriam Siegwart, Anne-Sophie Walker
Summary: A large-scale survey involving 162 experts from 48 countries identified and analyzed 250 resistance monitoring systems. The main factor differentiating monitoring systems was the capabilities of the actors involved. Governmental and private systems have more data generation capacities, while academic systems are more specialized. It is suggested that more focus be placed on detecting emerging resistances and increasing collaborative efforts and transparency for enhanced resistance monitoring.
PEST MANAGEMENT SCIENCE
(2021)
Article
Biology
Jeremy Gauthier, Helene Boulain, Joke J. F. A. van Vugt, Lyam Baudry, Emma Persyn, Jean-Marc Aury, Benjamin Noel, Anthony Bretaudeau, Fabrice Legeai, Sven Warris, Mohamed A. Chebbi, Geraldine Dubreuil, Bernard Duvic, Natacha Kremer, Philippe Gayral, Karine Musset, Thibaut Josse, Diane Bigot, Christophe Bressac, Sebastien Moreau, Georges Periquet, Myriam Harry, Nicolas Montagne, Isabelle Boulogne, Mahnaz Sabeti-Azad, Martine Maibeche, Thomas Chertemps, Frederique Hilliou, David Siaussat, Joelle Amselem, Isabelle Luyten, Claire Capdevielle-Dulac, Karine Labadie, Bruna Lais Merlin, Valerie Barbe, Jetske G. de Boer, Martial Marbouty, Fernando Luis Consoli, Stephane Dupas, Aurelie Hua-Van, Gaelle Le Goff, Annie Bezier, Emmanuelle Jacquin-Joly, James B. Whitfield, Louise E. M. Vet, Hans M. Smid, Laure Kaiser, Romain Koszul, Elisabeth Huguet, Elisabeth A. Herniou, Jean-Michel Drezen
Summary: Endogenous viruses make up a significant portion of eukaryote genomes and provide new functions, although the evolution of large DNA viruses integrated into genomes that benefit their host remains unknown. A study on parasitoid wasps reveals that bracovirus genes have colonized all ten chromosomes, with these gene clusters being established over 53 million years ago and showing remarkable stability in genomic structures constrained by evolution. Transcriptional analysis shows temporal synchronization of viral gene expression without immune gene induction, suggesting a lack of conflict between ancient symbiotic partners.
COMMUNICATIONS BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Dries Amezian, Ralf Nauen, Gaelle Le Goff
Summary: Arthropods have evolved various strategies, including the induction of detoxification enzymes, to defend themselves against a wide array of chemicals in their environment. Studies using advanced genetic tools in insects have substantially contributed to our understanding of the genomic basis of their xenobiotic response. Signaling pathways such as nuclear receptors and transcription factors play crucial roles in the upregulation of detoxification enzymes and can impact insects' adaptive processes.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Entomology
Camille Meslin, Francoise Bozzolan, Virginie Braman, Solenne Chardonnet, Cedric Pionneau, Marie-Christine Francois, Dany Severac, Christophe Gadenne, Sylvia Anton, Martine Maibeche, Emmanuelle Jacquin-Joly, David Siaussat
Summary: Insect pest management heavily relies on neurotoxic insecticides, with low doses of neonicotinoids like clothianidin potentially enhancing various life traits in target pests. Residual accumulation of these insecticides may modify chemical communication through neuronal and behavioral responses. High-throughput RNAseq and proteomic analyses revealed that exposure to clothianidin induced significant changes in gene and protein expression in moth brains, potentially leading to enhanced responses to environmental stressors.
Editorial Material
Entomology
Gaelle Le Goff, Ralf Nauen
Article
Biochemistry & Molecular Biology
Thomas Chertemps, Gaelle Le Goff, Martine Maibeche, Frederique Hilliou
Summary: This study manually annotated 198 detoxification genes potentially involved in plant host manipulation by Phylloxera. The findings highlight the roles of the phylloxera detoxification gene repertoire in insect physiology and adaptation to plant secondary metabolites.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
(2021)
Article
Environmental Sciences
Manuel Massot, Thibaut Bagni, Annick Maria, Philippe Couzi, Thomas Drozdz, Aude Malbert-Colas, Martine Maibeche, David Siaussat
Summary: Climate warming is expected to impact the response of species to insecticides. Studies have shown that transgenerational effects play a role in the interaction between insecticides and temperature, influencing factors such as survival, development, and body mass. These results suggest that the effects of insecticides and temperature on species can be additive and influenced by transgenerational effects.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemistry & Molecular Biology
Dries Amezian, Ralf Nauen, Gaelle Le Goff
Summary: The genus Spodoptera is known for being polyphagous and destructive agricultural pests, with detoxification genes playing a crucial role in overcoming plant defense mechanisms. Despite a significant amount of expression data produced in the past decade for Spodoptera larvae in response to xenobiotics, the scattered information makes it difficult to clearly identify candidate genes involved in host plant adaptation and insecticide resistance. This review highlights the importance of detoxification genes in the genus and reveals a lack of genetic and biochemical information in some species, suggesting a need for further research in this area.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Biology
Sylvie Gimenez, Heba Abdelgaffar, Gaelle Le Goff, Frederique Hilliou, Carlos A. Blanco, Sabine Haenniger, Anthony Bretaudeau, Fabrice Legeai, Nicolas Negre, Juan Luis Jurat-Fuentes, Emmanuelle d'Alencon, Kiwoong Nam
COMMUNICATIONS BIOLOGY
(2020)