Article
Medicine, General & Internal
Laura Alberto, Andrea P. Marshall, Rachel M. Walker, Fernando Palizas, Leanne M. Aitken
Summary: The study demonstrated that a qSOFA-based sepsis screening tool has moderate sensitivity and good specificity for predicting sepsis diagnosed at discharge. The qSOFA score could reasonably discriminate patients at risk of developing sepsis.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Medicine, General & Internal
Zuhaib Ahmed Wani, Khushboo Gulzar, Hilal Yatoo, Tamorish Kole
Summary: Sepsis and septic shock are significant healthcare problems with the potential to affect millions of people each year. The study aimed to validate the use of the qSOFA score as a clinical assessment tool for early identification of sepsis patients in the emergency department. The findings indicate that while the qSOFA score has acceptable specificity, its sensitivity is low, making it a poor screening tool for early detection of sepsis patients in the emergency department.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Bin Liu, Huimin Du, Jing Zhang, Jie Jiang, Xin Zhang, Faming He, Bailin Niu
Summary: This study developed a new simple screening tool for sepsis (LIP scoring system) and demonstrated its satisfactory sensitivity and specificity in sepsis screening.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Changya Liu, Xinxin Wu, Rou Deng, Xiangru Xu, Caiyu Chen, Linguangjin Wu, Wen Zhang, Hongqiang Yang, Yuerong Fei, Yuting Sun, Shuang Zhou, Bangjiang Fang
Summary: This study evaluated the prognostic ability of systemic immune-inflammation index (SII) combined with quick Sequential Organ Failure Assessment (qSOFA) criteria in predicting the 28-day mortality of sepsis. The results showed that the combination of SII and qSOFA provided an effective tool for predicting mortality in sepsis.
Article
Cardiac & Cardiovascular Systems
Bruna Gigante, Jerrold H. Levy, Eric van Gorp, Alessandro Bartoloni, Marie-Luce Bochaton-Piallat, Magnus Back, Hugo ten Cate, Christina Christersson, Jose Luis Ferreiro, Tobias Geisler, Esther Lutgens, Sam Schulman, Robert F. Storey, Jecko Thachil, Gemma Vilahur, Patricia C. Liaw, Bianca Rocca
Summary: Patients with severe infections and a pre-existing indication for antithrombotic therapy require integrated clinical counselling among coagulation, infectious disease, and cardiology specialists, due to sepsis-induced coagulopathy that frequently occurs. The association between bacterial and viral pathogens and patients with ongoing antithrombotic treatment is a growing threat to public health. This clinical consensus statement provides expert opinion and statements on the management of patients hospitalized for severe bacterial or viral infections with a pre-existing indication for antithrombotic therapy, in whom sepsis-induced coagulopathy is often observed.
EUROPEAN HEART JOURNAL
(2023)
Article
Hematology
Long Xiang, Hong Ren, Ying Wang, Jian Zhang, Juan Qian, Biru Li, Kang An, Lijun Fu
Summary: The study proposed a pediatric SIC scoring method and evaluated its effectiveness in diagnosing SIC and predicting 28-day outcomes in children. The pSIC score showed good predictive value for 28-day mortality in pediatric sepsis, as well as for nonovert DIC. It can be used to assess the severity of sepsis and organ dysfunction in children.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Public, Environmental & Occupational Health
Shelton W. Wright, Viriya Hantrakun, Kristina E. Rudd, Chuen-Yen Lau, Khie Chen Lie, Nguyen Van Vinh Chau, Prapit Teparrukkul, T. Eoin West, Direk Limmathurotsakul
Summary: In low-resource settings, combining point-of-care venous lactate with the quick Sequential Organ Failure Assessment (qSOFA) score can accurately identify patients at risk of sepsis-related mortality in Southeast Asia, with similar accuracy to a modified Sequential Organ Failure Assessment (SOFA) score.
LANCET GLOBAL HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Francesco Gavelli, Luca Molinari, Marco Baldrighi, Livia Salmi, Filippo Mearelli, Nicola Fiotti, Filippo Patrucco, Chiara Airoldi, Mattia Bellan, Pier Paolo Sainaghi, Salvatore Di Somma, Enrico Lupia, Efrem Colonetti, Maria Lorenza Muiesan, Gianni Biolo, Gian Carlo Avanzi, Luigi Mario Castello
Summary: This study found that measuring the concentration of sMer and Gas6 at the emergency department did not predict mortality, but these biomarkers were associated with acute kidney injury, thrombocytopenia, deranged prothrombin time-international normalized ratio, and sepsis-induced coagulopathy, suggesting a role in predicting sepsis-related organ damage.
Letter
Critical Care Medicine
Toshiaki Iba, Osamu Nishida, Jerrold H. Levy, Marcel Levi
Summary: Coagulation/fibrinolysis disorder is believed to be involved in the development of sepsis, and the association between disseminated intravascular coagulation (DIC) and poor outcomes has been reported. The recently released Japanese guidelines recommend the diagnosis and treatment of DIC in sepsis, while the updated international guidelines do not mention coagulation abnormalities or DIC. With evolving management strategies, the role of adjunctive anticoagulant treatment should be included in future international guidelines.
JOURNAL OF INTENSIVE CARE
(2022)
Article
Geriatrics & Gerontology
German Devia Jaramillo, Milciades Ibanez Pinilla
Summary: This study found that PCT had a higher diagnostic yield for sepsis in elderly patients aged 65 and above compared to qSOFA and SOFA, with similar results in the cohort of patients aged 75 and above. Additionally, PCT and lactate levels were significantly associated with in-hospital mortality.
Article
Medicine, General & Internal
Anjana Silva, Fiona E. Scorgie, Lisa F. Lincz, Kalana Maduwage, Sisira Siribaddana, Geoffrey K. Isbister
Summary: This study compared the recovery of VICC in patients who received and did not receive antivenom following Russell's viper envenoming, showing that antivenom significantly accelerated the recovery of VICC.
FRONTIERS IN MEDICINE
(2022)
Article
Emergency Medicine
Alex Williams, Thomas Griffies, Sophie Damianopoulos, Daniel Fatovich, Stephen Macdonald
Summary: The combination of CCI and qSOFA score was found to be superior to qSOFA alone in predicting outcomes for ED patients with suspected infection. Age and comorbid disease status were shown to enhance the predictive value of qSOFA for adverse outcomes. The limitations of qSOFA in detecting adverse outcome risk may be influenced by unmeasured patient factors according to the results.
EMERGENCY MEDICINE AUSTRALASIA
(2021)
Article
Urology & Nephrology
Jillian H. Gerrity, Jonathan S. Berger, Ryan F. Hsi, David L. Friedlander, Karen H. Stern, Ben Chew, Naren L. Nimmagadda, Nicholas T. Kavoussi, Tony E. Chen, Amy Krambeck, Tim K. Large, Seth Bechis, Manoj L. Monga, Nicole Miller, Dirk Lange, Bodo W. Knudsen, Michael R. Sourial, Mitchell Humphreys, Ojas E. Shah, Joel Abbott, Garen L. Abedi, Roger Sur, Edge Res Consortium
Summary: Recent literature suggests that qSOFA may be a more superior tool than SIRS criteria for predicting septic shock after PCNL surgery. In this study, we evaluated the use of qSOFA and SIRS in predicting septic shock based on prospectively collected data from PCNL patients.
JOURNAL OF ENDOUROLOGY
(2023)
Article
Pharmacology & Pharmacy
Jing Li, Ruijing Xuan, Weidong Wu, Hailong Zhang, Jie Zhao, Shan Zhang
Summary: This study found that Geldanamycin (GA) has a protective effect on sepsis caused by infections. It significantly improves liver, kidney, and lung injury, and inhibits microthrombosis and coagulopathy. Further molecular mechanism analysis suggests that GA may act through upregulation of heat shock factor 1 and tissue-type plasminogen activator. In conclusion, this study reveals the potential of GA as a promising agent for sepsis.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Atsushi Shiraishi, Satoshi Gando, Toshikazu Abe, Shigeki Kushimoto, Toshihiko Mayumi, Seitaro Fujishima, Akiyoshi Hagiwara, Yasukazu Shiino, Shin-ichiro Shiraishi, Toru Hifumi, Yasuhiro Otomo, Kohji Okamoto, Junichi Sasaki, Kiyotsugu Takuma, Kazuma Yamakawa, Yoshihiro Hanaki, Masahiro Harada, Kazuma Morino
Summary: The study validated the accuracy of qSOFA and SIRS criteria for predicting in-hospital mortality in emergency department patients with suspected infection. qSOFA was shown to be more accurate than SIRS criteria for predicting in-hospital mortality, but with insufficient sensitivity.
SCIENTIFIC REPORTS
(2021)
