Advances in Biological Functions and Clinical Studies of FGF21

Fibroblast growth factor 21 (FGF21) regulates many crucial biological processes in human and mammals, particularly metabolic modulation and protective effect after injury. Therefore, determining complex regulatory mechanisms and elucidating the signaling pathway may greatly promote the prevention, diagnosis, and treatment of related injury and metabolic diseases. This review focused on the metabolic modulation and protective effect of FGF21 and summarized the molecular mechanisms and clinical research developments.

Automated summary

FGF21, a crucial factor regulating biological processes in humans and mammals, plays an important role in metabolic modulation and protective effects after injury. Understanding the complex regulatory mechanisms and signaling pathways can greatly benefit the prevention, diagnosis, and treatment of related injuries and metabolic diseases.