Article
Biochemistry & Molecular Biology
Ji-Hyeon Jeon, Jin-Hyang Park, So Yeon Jeon, Minyeong Pang, Min-Koo Choi, Im-Sook Song
Summary: This study investigates the interactions between red ginseng extract (RGE) and lactic acid bacteria (LAB) in terms of in vitro and in vivo deglycosylation metabolism and the pharmacokinetics of ginsenosides. The results show that the co-administration of RGE and LAB significantly increases the plasma concentrations of deglycosylated ginsenosides and facilitates the deglycosylation metabolism of ginsenosides.
Article
Plant Sciences
Soon-Kyung Hwang, Yun-Jeong Jeong, Hyun-Ji Cho, Yoon-Yub Park, Kwon-Ho Song, Young-Chae Chang
Summary: Rg3-RGE exhibits anti-proliferative and pro-apoptotic effects in lung cancer cells, accompanied by increased expression of mitophagy-related proteins. Combination treatment of Rg3-RGE with mitophagy inhibitors leads to cell death.
JOURNAL OF GINSENG RESEARCH
(2022)
Article
Plant Sciences
Rui Ma, Baoyu Fu, Shikuan Song, Chunyang Zhang, Xiajun Yuan, Tingshi Zhang, Daqing Zhao, Liwei Sun
Summary: Red-skin disease (RSD) in ginseng is closely related to soil properties such as acidification and metal stress, leading to a reduction in ginsenoside content. Factors like planting slope, soil moisture, pH, and metal content influence the occurrence of RSD. Metal absorption and nitrogen metabolism are associated with RSD induction.
JOURNAL OF SOIL SCIENCE AND PLANT NUTRITION
(2021)
Article
Pharmacology & Pharmacy
Haijing Zhang, Chunhui Zhao, Jinli Hou, Ping Su, Yifei Yang, Bing Xia, Xiaoang Zhao, Rong He, Lifang Wang, Chunyu Cao, Ting Liu, Jixiang Tian
Summary: The therapeutic effects of red ginseng extract on mice with chronic fatigue syndrome are mainly achieved by improving mitochondrial function, including reducing mitochondrial swelling and membrane permeability, enhancing mitochondrial biogenesis, and thus ameliorating mitochondrial dysfunction.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Chi Hwan Jeong, Jisu Kim, Bo Kyeong Kim, Kang Bin Dan, Hyeyoung Min
Summary: This study investigated the antiviral activity of Korean Red Ginseng (KRG) and ten ginsenosides against Human coronavirus OC43 (HCoVOC43) in vitro. It found that KRG extract can reduce the expression of viral proteins and mRNA while increasing the expression of interferon genes, indicating its potential as a treatment for HCoV-OC43 infections.
JOURNAL OF GINSENG RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Hui Wang, Shuai Zhang, Lu Zhai, Liwei Sun, Daqing Zhao, Zeyu Wang, Xiangyan Li
Summary: The study showed that total ginsenosides (TGS) can extend the lifespan of worms, improve mobility, have antioxidant and health benefits, and achieve these effects by activating signaling pathways related to antioxidant regulation and longevity.
Article
Pharmacology & Pharmacy
Saebyul Yoo, Bom- Park, Do-hyun Kim, Sooyoung Lee, Seung-hoon Lee, Wang-Seob Shim, Yong Ki Seo, Kimoon Kang, Kyung-Tae Lee, Sung-Vin Yim, Do Yu Soung, Bo-Hyung Kim
Summary: Black ginseng extract, with mainly low molecular weight ginsenosides, showed faster absorption and higher exposure compared to red ginseng extract which predominantly contains high molecular weight ginsenosides. The safety and tolerability profiles were similar for both extracts.
Article
Chemistry, Multidisciplinary
Ho Myeong Kim, Seul-Gi Jeong, In Min Hwang, Hae Woong Park
Summary: This study investigated the shelf-life extension effects of a highly efficient and eco-friendly cryoprotective agent and a cold adaptation method on Lactobacillus sakei WiKim31. Results showed that citrus byproduct exhibited high antioxidant activity and could be used as a novel cryoprotective agent either alone or in combination with soy powder to improve the storage conditions of L. sakei WiKim31.
Article
Pharmacology & Pharmacy
Jong Chan Ahn, Ramya Mathiyalagan, Jinnatun Nahar, Zelika Mega Ramadhania, Byoung Man Kong, Dong-Wook Lee, Sung Keun Choi, Chang Soon Lee, Vinothini Boopathi, Dong Uk Yang, Bo Yeon Kim, Hyon Park, Deok Chun Yang, Se Chan Kang
Summary: In this study, a CK-enriched fermented red ginseng extract was prepared and its pharmacokinetics were studied. The extract showed better pharmacokinetic properties and exhibited higher antioxidant capacity and toxicity against lung cancer cells in vitro.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Plant Sciences
Eui-Man Jung, Geun-Shik Lee
Summary: Severe cases of COVID-19 are characterized by dysregulation of cytokine secretion, pneumonia, and acute lung injury, leading to multiple organ failure and death. SARS-CoV-2 directly or indirectly affects the activation of NLRP3 inflammasome, resulting in inflammatory disruption in severe COVID-19. Korean Red Ginseng (KRG) has been found to inhibit the NLRP3 inflammasome signaling and shows potential as a treatment for COVID-19.
JOURNAL OF GINSENG RESEARCH
(2022)
Article
Multidisciplinary Sciences
Amira M. G. Darwish, Marwa G. Allam, Enaam S. Shokery, Eman H. E. Ayad
Summary: The present study aimed to isolate and characterize new Lactic Acid Bacteria (LAB) strains from Egyptian Laban Rayeb, Zabady, and mothers' breast milk as potential probiotics. These strains showed health-promoting traits and were able to reduce atherogenic indices and modulate gut microbiota. They also enhanced the organoleptic properties of fermented dairy products.
Article
Plant Sciences
Young Kyun Kim, Keun-Sang Yum
Summary: This study explores the effects of red ginseng extract on the gut microbiome. The results indicate that ingestion of red ginseng extract can increase gut microbiome richness and significantly impact the abundance of certain strains in the gut microbiome.
JOURNAL OF GINSENG RESEARCH
(2022)
Article
Veterinary Sciences
Young Beom Kwak, Eunkyu Lee, Hyunjoo Choi, Taemook Park, Ahram Kim, Jungon Kim, Jungho Yoon, Hye Hyun Yoo
Summary: This study examines the pharmacokinetic interaction between red ginseng and furosemide in horse plasma. The results show that the consumption of red ginseng leads to increased concentration of furosemide and decreased clearance and distribution volume. These findings indicate the potential pharmacokinetic interactions between red ginseng and furosemide.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Food Science & Technology
Vincenzo Castellone, Elena Bancalari, Josep Rubert, Monica Gatti, Erasmo Neviani, Benedetta Bottari
Summary: Lactic acid bacteria (LAB) are involved in producing various fermented products that are consumed globally, and many of these LAB-fermented foods are recognized for their health benefits, containing probiotic LAB or their metabolites. This review focuses on the health-related effects of LAB-fermented foods, particularly popular options like yoghurt, kefir, cheese, sauerkrauts, and kimchi.
Article
Food Science & Technology
Blandine M. L. Genet, Hang Xiao, Lise Friis Christensen, Ida Nynne Laforce, Mohammad Amin Mohammadifar, Claus Heiner Bang-Berthelsen, Egon Bech Hansen
Summary: This study investigated strains isolated from different environments in Denmark for their ability to produce curd from fermentation of Soy Based Milk Alternative (SBMA). Acidification dynamics and metabolite production were analyzed in commercial SBMA, and proteomics were used to determine the hydrolysis profile of soy proteins. Certain strains showed proteolytic activity and were considered potential candidates for producing a soy-based yogurt-like product.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yun Ju Kang, Chul Haeng Lee, Soo-Jin Park, Hye Suk Lee, Min-Koo Choi, Im-Sook Song
Summary: The study found that OAT1 and OAT3 are important transporters that may regulate the pharmacokinetic properties of rosmarinic acid and potentially cause herb-drug interactions with the compound.
Article
Pharmacology & Pharmacy
Ria Park, Eun Jeong Park, Yong-Yeon Cho, Joo Young Lee, Han Chang Kang, Im-Sook Song, Hye Suk Lee
Summary: Tetrahydrofurofuranoid lignans, such as eudesmin and magnolin, were found to inhibit UGT1A1 and UGT1A3 activities in human liver microsomes. This suggests a potential for drug-drug interactions involving these lignans with UGT1A1 and UGT1A3 substrates in vivo.
Article
Pharmacology & Pharmacy
Im-Sook Song, So-Jeong Nam, Ji-Hyeon Jeon, Soo-Jin Park, Min-Koo Choi
Summary: The study found that silymarin-SD formulation showed improved bioavailability and liver distribution in rats with acetaminophen-induced hepatotoxicity, leading to higher concentrations of silybin in the liver and decreased liver enzyme levels. The use of TPGS as a solubilizing agent and permeation enhancer contributed to the enhanced therapeutic effects of silymarin-SD compared to silymarin alone.
Editorial Material
Pharmacology & Pharmacy
Min-Koo Choi, Im-Sook Song
Article
Pharmacology & Pharmacy
Jaehyeok Lee, Chul Haeng Lee, Jong-Geon Lee, So Yeon Jeon, Min-Koo Choi, Im-Sook Song
Summary: A pH-modified extended-release formulation of Ursodeoxycholate (UDCA) was developed, which improved the solubility and dissolution profile of UDCA. This formulation increased the oral bioavailability of UDCA in rats by 251%.
Article
Pharmacology & Pharmacy
Young Yoon Bang, Im-Sook Song, Min Seo Lee, Chang Ho Lim, Yong-Yeon Cho, Joo Young Lee, Han Chang Kang, Hye Suk Lee
Summary: The toxicokinetics of beta-amanitin, a toxic compound found in Amanitaceae mushrooms, were studied in mice. The compound was rapidly eliminated from plasma and mainly excreted through feces after oral administration. It distributed predominantly in the intestines and stomach.
Article
Pharmacology & Pharmacy
Minyeong Pang, So Yeon Jeon, Min-Koo Choi, Ji-Hyeon Jeon, Hye-Young Ji, Ji-Soo Choi, Im-Sook Song
Summary: This study investigated the pharmacokinetics and tissue distribution of enavogliflozin in mice and rats. The results showed that enavogliflozin exhibited dose-proportional pharmacokinetics and high distribution to the kidneys. It also showed favorable biliary excretion and was not accumulated in the plasma and major tissues following repeated oral administration.
Article
Pharmacology & Pharmacy
Hyeon-Cheol Jeong, Min-Gul Kim, Zhuodu Wei, Kyeong-Ryoon Lee, Jaehyeok Lee, Im-Sook Song, Kwang-Hee Shin
Summary: A physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model was developed to predict the pharmacokinetic and pharmacodynamic properties of tegoprazan and its metabolite M1. The model was validated using clinical study data and showed good agreement with observed concentration-time profiles. It can be used to predict the pharmacokinetic properties after repeated administrations of tegoprazan and changes in gastrointestinal factors.
Article
Chemistry, Medicinal
Dong Yu Lim, Minyeong Pang, Jaehyeok Lee, Jihoon Lee, Ji-Hyeon Jeon, Jin-Hyang Park, Min-Koo Choi, Im-Sook Song
Summary: This study developed a solid dispersion formulation of silymarin using freeze-drying method to enhance its oral bioavailability. The formulation significantly increased silymarin permeability in the intestines and showed higher cumulative dissolution compared to silymarin alone. It also exhibited superior hepatoprotective effect compared to silymarin.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Bhupendra Raj Giri, Hyun Seok Yang, Im-Sook Song, Han-Gon Choi, Jung Hyun Cho, Dong Wuk Kim
Summary: This study developed spray-dried amorphous inclusion complexes of methotrexate (MTX) with beta-cyclodextrin derivatives to enhance the drug's solubility, stability, and oral bioavailability in rats. The findings showed significant improvements in pharmacokinetic profiles with DM-beta-CD as the host, indicating a successful oral formulation technique for preventing drug degradation and enhancing pharmacological properties.
Article
Environmental Sciences
So-Yeon Jeon, Ji-Hyeon Jeon, Jin-Hyang Park, Jihoon Lee, Minyeong Pang, Min-Koo Choi, Im-Sook Song
Summary: This study developed and validated an analytical method for multiple antihypertensive drugs in rat plasma. The results showed no significant differences in the pharmacokinetic parameters between triple combination administration and single administration. Additionally, the use of red ginseng extract was found to affect the intestinal permeability of one of the drugs.
Article
Chemistry, Multidisciplinary
Jae Woon Son, Jong Mun Son, Ki Ho Hur, Wonhwa Lee, Im-Sook Song, Dong Hee Na
Summary: The purpose of this study was to develop fibrinogen formulation using isothermal chemical denaturation (ICD) technique. 10 formulations of fibrinogen were initially prepared and screened via automated, high-throughput ICD measurements. The optimal formulation of fibrinogen was determined through osmolality measurements and accelerated stability study.
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Ji-Hyeon Jeon, Jin-Hyang Park, So Yeon Jeon, Minyeong Pang, Min-Koo Choi, Im-Sook Song
Summary: This study investigates the interactions between red ginseng extract (RGE) and lactic acid bacteria (LAB) in terms of in vitro and in vivo deglycosylation metabolism and the pharmacokinetics of ginsenosides. The results show that the co-administration of RGE and LAB significantly increases the plasma concentrations of deglycosylated ginsenosides and facilitates the deglycosylation metabolism of ginsenosides.
Review
Pharmacology & Pharmacy
Min-Koo Choi, Jihoon Lee, Im-Sook Song
Summary: Pharmaceutical excipients affect drug solubility, manufacturability, and drug release in vivo and in vitro. They also influence intestinal permeability and metabolism. The selection of proper excipients can enhance oral bioavailability.
JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2023)
Review
Chemistry, Medicinal
Jihoon Lee, Min-Koo Choi, Im-Sook Song
Summary: Doxorubicin (DOX), a commonly used cancer chemotherapy drug, induces cell death through multiple intracellular interactions. However, it often leads to drug resistance and cardiotoxicity. Various formulations of DOX, such as liposomes and polymeric nanoparticles, have been developed to improve its therapeutic efficacy. pH- or redox-sensitive and receptor-targeted systems have been proposed to overcome DOX resistance and increase therapeutic efficacy without causing toxicity. Oral formulations of DOX with mucoadhesiveness and increased intestinal permeability are also being developed.