期刊
WORLD JOURNAL OF STEM CELLS
卷 13, 期 7, 页码 737-752出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4252/wjsc.v13.i7.737
关键词
Mitochondrial unfolded protein response; Mammals; Stem cells; Cancer
资金
- Key Projects of Natural Science Foundation of Ningxia [2020AAC02020]
- Funds of Ningxia Medical University [XY201808]
The UPRmt is a crucial mechanism for maintaining cellular homeostasis and proteostasis, with stem cells playing important roles in this process. However, the roles and functions of the UPRmt in different types of stem cells may vary.
The mitochondrial unfolded protein response (UPRmt) is an evolutionarily conserved adaptive mechanism for improving cell survival under mitochondrial stress. Under physiological and pathological conditions, the UPRmt is the key to maintaining intracellular homeostasis and proteostasis. Important roles of the UPRmt have been demonstrated in a variety of cell types and in cell development, metabolism, and immune processes. UPRmt dysfunction leads to a variety of pathologies, including cancer, inflammation, neurodegenerative disease, metabolic disease, and immune disease. Stem cells have a special ability to self-renew and differentiate into a variety of somatic cells and have been shown to exist in a variety of tissues. These cells are involved in development, tissue renewal, and some disease processes. Although the roles and regulatory mechanisms of the UPRmt in somatic cells have been widely reported, the roles of the UPRmt in stem cells are not fully understood. The roles and functions of the UPRmt depend on stem cell type. Therefore, this paper summarizes the potential significance of the UPRmt in embryonic stem cells, tissue stem cells, tumor stem cells, and induced pluripotent stem cells. The purpose of this review is to provide new insights into stem cell differentiation and tumor pathogenesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据