Article
Neurosciences
Sahil Shah, Lilly M. Wong, Kendra Ellis, Brittany Bodnar, Sami Saribas, Julia Ting, Zhengyu Wei, Yuyang Tang, Xianwei Wang, Hong Wang, Binhua Ling, David M. Margolis, J. Victor Garcia, Wenhui Hu, Guochun Jiang
Summary: The minimal/native promoter of the HEXB gene, specifically active in microglia, has been characterized and identified as a potential candidate for microglia-targeting AAV gene therapy in the CNS.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Rezvan Abtahi, Parvaneh Karimzadeh, Alireza Rezayi, Shadab Salehpour, Diba Akbarzadeh, Seyed Hassan Tonekaboni, Reza Zolfaghari Emameh, Massoud Houshmand
Summary: The study provided additional insights into the genotype of sphingolipidoses diseases among Iranian patients, identifying novel mutations and expanding the genotypic spectrum for MLD, SD, TSD, and NPD disorders. This research can potentially lead to the development of more effective methods for genetic carrier detection, diagnosis, and counseling of affected Iranian patients.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Jun Ma, Clark C. Chen, Ming Li
Summary: The interaction between glioblastoma and its microenvironment, particularly involving tumor-associated macrophages and microglia, plays a crucial role in tumor development and treatment outcomes. Understanding the changes and functions of these cells may lead to new therapeutic approaches and improved prognosis for patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Alisa A. Shaimardanova, Daria S. Chulpanova, Valeriya V. Solovyeva, Aleksandr M. Aimaletdinov, Albert A. Rizvanov
Summary: By utilizing a bicistronic lentiviral vector encoding cDNA of HEXA and HEXB genes, we successfully increased the activity of HexA enzyme in HEK293T cells and human umbilical cord blood mononuclear cells, demonstrating the potential of this gene therapy strategy.
NEURAL REGENERATION RESEARCH
(2022)
Review
Neurosciences
Eduard Yakubov, Thomas Eibl, Alexander Hammer, Markus Holtmannspotter, Nicolai Savaskan, Hans-Herbert Steiner
Summary: Little progress has been made in the long-term management of malignant brain tumors, especially in the case of glioblastoma. Selenium may have positive effects in glioblastoma treatment, offering promising chances to overcome the current limitations in surgical treatment and radiochemotherapy outcomes.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Medicine, Research & Experimental
Chunzhi Zhang, Yuan Zhou, Ya Gao, Ze Zhu, Xianliang Zeng, Weizi Liang, Songwei Sun, Xiuli Chen, Hu Wang
Summary: Radiation therapy increases the release of exosomes that promote the growth of irradiated glioblastoma cells by inducing M2 polarization of microglia. A circRNA called circ_0012381, which enters microglia via exosomes, induces M2 polarization by sponging with miR-340-5p. The inhibition of exosome secretion can significantly inhibit the growth of irradiated glioblastoma cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Immunology
Guoqing Wang, Kunhong Zhong, Zeng Wang, Zongliang Zhang, Xin Tang, Aiping Tong, Liangxue Zhou
Summary: This review discusses the characteristics and functions of TAMs in GBM, and evaluates the current state of TAMs-targeting strategies. TAMs are logical therapeutic targets for GBM, and understanding how TAMs promote GBM progression is of great significance for new immune therapeutic approaches for GBM patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Neurosciences
Alice Buonfiglioli, Dolores Hambardzumyan
Summary: GBM is a highly aggressive and lethal primary brain tumor, characterized by malignant growth, invasion into brain parenchyma, and resistance to therapy. The GBM microenvironment consists of neoplastic and non-neoplastic cells, with tumor-associated macrophages (TAMs) being the most abundant non-neoplastic cells. TAMs play essential roles in promoting tumor progression by interacting with tumor cells and other non-neoplastic cells in the tumor microenvironment.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Review
Oncology
Noelia Geribaldi-Doldan, Cecilia Fernandez-Ponce, Roberto Navarro Quiroz, Ismael Sanchez-Gomar, Lorena Gomez Escorcia, Erika Puentes Velasquez, Elkin Navarro Quiroz
Summary: This article summarizes the altered signaling pathways in microglia in the context of GB, as well as the interactions with glioblastoma cells and the epigenetic mechanisms involved. Glioblastoma stem cells (GSC) are similar to neural stem cells (NSC) in some aspects, which may be the origin of GB.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Evelien Schaafsma, Chongming Jiang, Thinh Nguyen, Kenneth Zhu, Chao Cheng
Summary: This study investigated the relationship between immune-related genes (IRGs) and patient prognosis in glioma. By analyzing gene expression datasets and using single-cell RNAseq data, the researchers found that microglia abundance is negatively associated with survival in glioma patients. They also developed a 23-gene risk score that can effectively stratify patients into low- and high-risk categories.
Article
Immunology
Peiwen Chen
Summary: TFPI2 has been identified as a crucial molecule in the symbiotic interaction between glioblastoma stem cells and microglia. Blocking this symbiosis not only inhibits tumor growth but also synergizes with an immune checkpoint inhibitor in mouse models of glioblastoma.
Article
Oncology
Lucia Longhitano, Nunzio Vicario, Stefano Forte, Cesarina Giallongo, Giuseppe Broggi, Rosario Caltabiano, Giuseppe Maria Vincenzo Barbagallo, Roberto Altieri, Giuseppina Raciti, Michelino Di Rosa, Massimo Caruso, Rosalba Parenti, Arcangelo Liso, Federica Busi, Marco Lolicato, Maria Caterina Mione, Giovanni Li Volti, Daniele Tibullo
Summary: This study investigates the crosstalk between lactate metabolism and IGFBP6 in the tumor microenvironment and progression of glioblastoma. The results demonstrate that lactate and IGFBP6 can increase the expression of related genes in microglia, contributing to immune escape activation. Additionally, glioblastoma cells can also influence the expression of lactate and IGFBP6. Animal experiments and analysis of human datasets support the hypothesis that there is a lactate/IGFBP6 interaction in microglial cells, with IGFBP6 expression regulated by lactate production.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Engineering, Biomedical
Yen N. Diep, Hee Jung Park, Joon-Ho Kwon, Minh Tran, Hae Young Ko, Hanhee Jo, Jisu Kim, Jee-In Chung, Tai Young Kim, Dongwoo Kim, Jong Hee Chang, You Jung Kang, C. Justin Lee, Mijin Yun, Hansang Cho
Summary: Background: Glial scar formation is a reactive glial response confining injured regions in a central nervous system. However, it remains challenging to identify key factors formulating glial scar in response to glioblastoma (GBM) due to complex glia-GBM crosstalk. Methods: Here, we constructed an astrocytic scar enclosing GBM in a human assembloid and a mouse xenograft model. GBM spheroids were preformed and then co-cultured with microglia and astrocytes in 3D Matrigel. For the xenograft model, U87-MG cells were subcutaneously injected to the Balb/C nude female mice. Results: Additional glutamate was released from GBM-microglia assembloid by 3.2-folds compared to GBM alone. The glutamate upregulated astrocytic monoamine oxidase-B (MAO-B) activity and chondroitin sulfate proteoglycans (CSPGs) deposition, forming the astrocytic scar and restricting GBM growth. Attenuating scar formation by the glutamate-MAO-B inhibition increased drug penetration into GBM assembloid, while reducing GBM confinement. Conclusions: Taken together, our study suggests that astrocytic scar could be a critical modulator in GBM therapeutics.
BIOMATERIALS RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Thomas Kuntzel, Dominique Bagnard
Summary: Macrophages and microglia play different roles in various diseases due to their ability to adopt different polarization states. Modulating their polarization states could be a potential treatment strategy. This review focuses on compounds targeting the polarization of macrophages and microglia in multiple sclerosis and glioblastoma, illustrating the promising approach and broad applications of this treatment strategy.
Article
Multidisciplinary Sciences
Hyun-Jin Kim, Jang Hyun Park, Hyeon Cheol Kim, Chae Won Kim, In Kang, Heung Kyu Lee
Summary: This study identifies a subset of macrophages in the immune microenvironment of glioblastoma that have anti-tumoral properties. These CD169(+) macrophages produce pro-inflammatory chemokines, leading to the accumulation of T cells and NK cells and facilitating the phagocytosis of apoptotic glioma cells. The depletion of CD169(+) macrophages impairs antitumor lymphocytes and reduces survival in mice with glioma.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Yunqi Zhu, Xiangmin Tong, Ying Wang, Xiaoya Lu
Summary: WTIP, a potential tumor suppressor, is significantly reduced in AML, and low levels of WTIP are associated with decreased overall survival in AML patients. Overexpression of WTIP inhibits cell proliferation and induces apoptosis through the transcriptional activation of FOXO3a.
CELL DEATH & DISEASE
(2022)
Article
Cell & Tissue Engineering
Qian Wu, Xingxing Xu, Xuemeng Miao, Xiaomei Bao, Xiuchun Li, Ludan Xiang, Wei Wang, Siyu Du, Yi Lu, Xiwu Wang, Danlu Yang, Jingjing Zhang, Xiya Shen, Fayi Li, Sheng Lu, Yiren Fan, Shujie Xu, Zihao Chen, Ying Wang, Honglin Teng, Zhihui Huang
Summary: This study reveals the involvement of the S1P/S1PR2/YAP pathway in the regeneration of the olfactory epithelium after injury. Activation of YAP by S1P/S1PR2 signaling promotes the proliferation of horizontal basal cells (HBCs) and regeneration of the epithelium. Deletion of YAP impairs the regeneration of the olfactory epithelium and functional recovery of olfaction, while activation of YAP signaling enhances these processes.
Review
Oncology
Wu Yi, Tianxin Yang, Sisi Lin, Rui Hao, Jin Yu, Ying Wang, Xiangming Tong
Summary: Extranodal NK/T cell lymphoma is a rare subtype of lymphoma with poor prognosis. It commonly occurs in the nasal cavity, nasopharynx, paranasal sinuses, tonsils, and larynx. The resistance of ENKL cells to anthracycline-based chemotherapy is due to P-glycoprotein expression. New treatments such as immune checkpoint inhibitors, histone deacetylase inhibitors, and monoclonal antibodies are being investigated.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Jing Yang, Yi Zhou, Yanchun Li, Wanye Hu, Chen Yuan, Shida Chen, Gaoqi Ye, Yuzhou Chen, Yunyi Wu, Jing Liu, Ying Wang, Jing Du, Xiangmin Tong
Summary: This study analyzed the expression of succinate dehydrogenase (SDH) genes in clear cell renal cell carcinoma (ccRCC) and found that SDHs were significantly downregulated in ccRCC tissues and correlated with ccRCC progression. Increased methylation and high SDH promoter mutation rates may be the cause of reduced SDH expression in ccRCC. The study also demonstrated that SDH inhibition dampened oxidative phosphorylation, reduced ferroptotic events, and restored ferroptotic cell death.
Article
Biotechnology & Applied Microbiology
Chaoting Zhou, Luyang Wang, Wanye Hu, Lusheng Tang, Ping Zhang, Yan Gao, Jing Du, Yanchun Li, Ying Wang
Summary: The study identified CDC25C as being overexpressed in pancreatic adenocarcinoma (PAAD) and its enhanced expression being strongly correlated with poor prognosis, highlighting its potential as a biological marker and therapeutic target for early diagnosis and treatment of PAAD. Additionally, CDC25C was found to be involved in energy metabolism by maintaining mitochondrial homeostasis.
Article
Genetics & Heredity
Luyang Wang, Hairui Wang, Chen Yang, Yunyi Wu, Guojie Lei, Yanhua Yu, Yan Gao, Jing Du, Xiangmin Tong, Feifei Zhou, Yanchun Li, Ying Wang
Summary: CENPW expression is up-regulated in breast carcinoma and is associated with a worse prognosis. The mutation of CENPW contributes to the poor prognosis. CENPW interacts with genes mainly involved in the cell cycle pathway, and is co-expressed with CDCA7, which is also highly expressed in breast carcinoma and leads to a worse prognosis. Knockdown of CENPW inhibits the proliferation and migration of breast carcinoma cells and promotes apoptosis. Inhibition of CENPW sensitizes breast cancer cells to chemotherapeutic drugs.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Haoran Li, Bing Xu, Jing Du, Yunyi Wu, Fangchun Shao, Yan Gao, Ping Zhang, Junyu Zhou, Xiangmin Tong, Ying Wang, Yanchun Li
Summary: This study found that autophagy exhibited significant heterogeneity in gastric cancer patients. Three autophagy patterns were closely associated with overall survival and the immunophenotype of the tumor microenvironment. Autophagy score could serve as an independent prognostic biomarker and predict the effectiveness of immunotherapy and ferroptosis-based therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yanchun Li, Bing Xu, Xueying Ren, Luyang Wang, Yaqing Xu, Yefeng Zhao, Chen Yang, Chen Yuan, Huanjuan Li, Xiangmin Tong, Ying Wang, Jing Du
Summary: The study revealed that knockdown of CISD2 accelerated ferroptotic cell death induced by Erastin, characterized by increased lipid peroxidation, GSH exhaustion, and iron accumulation. CISD2 depletion enhanced lysosomal activity and activated ferritinophagy under Erastin exposure. Additionally, CISD2 knockdown inhibited the p62-Keap1-NRF2 pathway, leading to oxidative stress and ferroptosis.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Cell Biology
Lingting Jin, Jingjing Zhang, Xin Hua, Xingxing Xu, Jia Li, Jiaojiao Wang, Mianxian Wang, Huitao Liu, Haoyu Qiu, Man Chen, Xu Zhang, Ying Wang, Zhihui Huang
Summary: Astrocytic SARM1 promotes neuroinflammation and axonal demyelination in EAE by inhibiting the expression of GDNF.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Haifeng Xu, Bing Xu, Jiayu Hu, Jun Xia, Le Tong, Ping Zhang, Lei Yang, Lusheng Tang, Sufeng Chen, Jing Du, Ying Wang, Yanchun Li
Summary: This study developed a prognostic model based on the specific role of autophagy-related genes (ATGs) in gastric cancer (GC), which improved the prediction of GC outcomes and could help with individualized treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Neurosciences
Xingxing Xu, Jiaojiao Wang, Siyu Du, Xiya Shen, Jiashu Lian, Jian Zhou, Mianxian Wang, Wenjin Feng, Zhaoting Lv, Junzhe Zhu, Lingting Jin, Huankun Sun, Lihao Wu, Xiaoning Wang, Haoyu Qiu, Wei Wang, Honglin Teng, Ying Wang, Zhihui Huang
Summary: Our study reveals that YAP signaling plays an important role in the regulation of glutamate homeostasis through the beta-catenin/EAAT2 pathway in astrocytes. This finding provides new insights into the pathogenesis of brain diseases related to EAAT2 dysfunction or dysregulation and may contribute to the development of clinical strategies.
Article
Physiology
Jingjing Zhang, Lingting Jin, Xin Hua, Mianxian Wang, Jiaojiao Wang, Xingxing Xu, Huitao Liu, Haoyu Qiu, Huankun Sun, Tianyingying Dong, Danlu Yang, Xu Zhang, Ying Wang, Zhihui Huang
Summary: This study aimed to investigate the roles of SARM1 in multiple sclerosis (MS) and its underlying mechanisms. The results showed that SARM1 was upregulated in the spinal cords of MS model mice, and its knockout ameliorated the neuroinflammation, demyelination, and neuronal death. Mechanistically, SARM1 knockout led to the downregulation of insulin-like growth factor-binding protein 2 (IGFBP2) in neurons, which inhibited neuroinflammation through NF-kappa B signaling. Additionally, activation of NF-kappa B partially aggravated the neuroinflammation and demyelination deficits in SARM1 knockout mice. These findings suggest a novel drug target pathway (SARM1/IGFBP2/NF-kappa B) for MS.
Article
Medicine, Research & Experimental
Mengmeng Wang, Shuqiao Xing, Jiamei Jia, Weiquan Zeng, Jia Lei, Yiming Qian, Zhenrong Xiong, Xin Wang, Liying Cao, Yongjie Wang, Ying Wang, Yuanyuan Jiang, Zhihui Huang
Summary: In this study, it was found that angelicin has anti-tumor effects on glioblastoma (GBM) by inhibiting proliferation and migration of GBM cells through modulation of the YAP signaling pathway. This natural compound has potential as a promising treatment for GBM.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Neurosciences
Wenbin Zhang, Mengxian Jia, Jiashu Lian, Sheng Lu, Jian Zhou, Ziwei Fan, Zhoule Zhu, Yaozhi He, Changgang Huang, Mingyu Zhu, Jian Wang, Ying Wang, Zhihui Huang, Honglin Teng
Summary: TBK1 plays an important role in the pathogenesis of spinal cord injury (SCI) by mediating innate immune pathways in astrocytes through YAP signaling. Inhibition of TBK1 activity alleviates neuroinflammation, reduces motor neuron loss, and improves functional recovery.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Chemistry, Medicinal
Chunqi Huang, Zhou Yin, Yeqing Yang, Nan Mo, Hui Yang, Ying Wang
Summary: The purpose of this study was to explore the pharmacokinetics, bioequivalence, food effect, and safety of oral ibuprofen sustained-release capsules from two different sponsors. The findings showed that ibuprofen had a favorable safety profile and achieved bioequivalence under both fasting and fed conditions.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
