Targeted Glucose or Glutamine Metabolic Therapy Combined With PD-1/PD-L1 Checkpoint Blockade Immunotherapy for the Treatment of Tumors - Mechanisms and Strategies
出版年份 2021 全文链接
标题
Targeted Glucose or Glutamine Metabolic Therapy Combined With PD-1/PD-L1 Checkpoint Blockade Immunotherapy for the Treatment of Tumors - Mechanisms and Strategies
作者
关键词
-
出版物
Frontiers in Oncology
Volume 11, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2021-07-13
DOI
10.3389/fonc.2021.697894
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Glucose metabolism involved in PD-L1-mediated immune escape in the malignant kidney tumour microenvironment
- (2021) Yongbo Yu et al. Cell Death Discovery
- EGFR activates GDH1 transcription to promote glutamine metabolism through MEK/ERK/ELK1 pathway in glioblastoma
- (2020) Rui Yang et al. ONCOGENE
- The immunological Warburg effect: Can a metabolic‐tumor‐stroma score (MeTS) guide cancer immunotherapy?
- (2020) Peter J. Siska et al. IMMUNOLOGICAL REVIEWS
- Metabolic reprogramming and cancer progression
- (2020) Brandon Faubert et al. SCIENCE
- Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells
- (2020) Min-Hee Oh et al. JOURNAL OF CLINICAL INVESTIGATION
- Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy
- (2020) Jackie E. Bader et al. MOLECULAR CELL
- PD-L1 in Lung Adenocarcinoma: Insights into the Role of 18F-FDG PET/CT
- (2020) Yan Cui et al. Cancer Management and Research
- Metabolic glycan labelling for cancer-targeted therapy
- (2020) Hua Wang et al. Nature Chemistry
- Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer
- (2020) Deanna N. Edwards et al. JOURNAL OF CLINICAL INVESTIGATION
- Increased glycolysis correlates with elevated immune activity in tumor immune microenvironment
- (2019) Zehang Jiang et al. EBioMedicine
- Navigating metabolic pathways to enhance antitumour immunity and immunotherapy
- (2019) Xiaoyun Li et al. Nature Reviews Clinical Oncology
- Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability
- (2019) Mark R Sullivan et al. eLife
- The Warburg Effect Is Associated With Tumor Aggressiveness in Testicular Germ Cell Tumors
- (2019) Murilo Bonatelli et al. Frontiers in Endocrinology
- Immunosuppressive Immature Myeloid Cell Generation Is Controlled by Glutamine Metabolism in Human Cancer
- (2019) Wen-Chao Wu et al. Cancer Immunology Research
- Glutamine Deprivation Induces PD-L1 Expression via Activation of EGFR/ERK/c-Jun Signaling in Renal Cancer
- (2019) Guofeng Ma et al. MOLECULAR CANCER RESEARCH
- VISTA is an acidic pH-selective ligand for PSGL-1
- (2019) Robert J. Johnston et al. NATURE
- The great escape: tumour cell plasticity in resistance to targeted therapy
- (2019) Soufiane Boumahdi et al. NATURE REVIEWS DRUG DISCOVERY
- Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion
- (2019) Robert D. Leone et al. SCIENCE
- A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells
- (2019) Hee Chan Yoo et al. Cell Metabolism
- Mechanisms of resistance to immune checkpoint inhibitors
- (2018) Russell W Jenkins et al. BRITISH JOURNAL OF CANCER
- Cancer-Cell-Intrinsic Mechanisms Shaping the Tumor Immune Landscape
- (2018) Max D. Wellenstein et al. IMMUNITY
- Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models
- (2018) Michael L Schulte et al. NATURE MEDICINE
- Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin
- (2018) Dannielle DeWaal et al. Nature Communications
- Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis
- (2018) Fu-Long Li et al. Nature Communications
- Targeting Tumor Metabolism: A New Challenge to Improve Immunotherapy
- (2018) Soumaya Kouidhi et al. Frontiers in Immunology
- Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo
- (2018) Kevin D. Courtney et al. Cell Metabolism
- Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism
- (2018) Marc O. Johnson et al. CELL
- Tumor-associated Macrophage-derived Interleukin-23 Interlinks Kidney Cancer Glutamine Addiction with Immune Evasion
- (2018) Qiang Fu et al. EUROPEAN UROLOGY
- Lactate: A Metabolic Driver in the Tumour Landscape
- (2018) Luigi Ippolito et al. TRENDS IN BIOCHEMICAL SCIENCES
- Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma
- (2017) Hui-Min Li et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Glucose feeds the TCA cycle via circulating lactate
- (2017) Sheng Hui et al. NATURE
- Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism
- (2017) Douglas E. Biancur et al. Nature Communications
- Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors
- (2017) Eva M. Palsson-McDermott et al. Frontiers in Immunology
- Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1α
- (2016) Sangbin Lim et al. CANCER RESEARCH
- Metabolic Heterogeneity in Human Lung Tumors
- (2016) Christopher T. Hensley et al. CELL
- LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells
- (2016) Almut Brand et al. Cell Metabolism
- Alternate Metabolic Programs Define Regional Variation of Relevant Biological Features in Renal Cell Carcinoma Progression
- (2016) S. A. Brooks et al. CLINICAL CANCER RESEARCH
- Baseline Biomarkers for Outcome of Melanoma Patients Treated with Pembrolizumab
- (2016) Benjamin Weide et al. CLINICAL CANCER RESEARCH
- Localized signals that regulate transendothelial migration
- (2016) William A Muller CURRENT OPINION IN IMMUNOLOGY
- Targeted Therapy and Checkpoint Immunotherapy Combinations for the Treatment of Cancer
- (2016) Paul E. Hughes et al. TRENDS IN IMMUNOLOGY
- Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia
- (2016) Nicole E. Scharping et al. Cancer Immunology Research
- Glutamate Dehydrogenase 1 Signals through Antioxidant Glutathione Peroxidase 1 to Regulate Redox Homeostasis and Tumor Growth
- (2015) Lingtao Jin et al. CANCER CELL
- Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy
- (2015) Suzanne L. Topalian et al. CANCER CELL
- Grade-Dependent Metabolic Reprogramming in Kidney Cancer Revealed by Combined Proteomics and Metabolomics Analysis
- (2015) H. I. Wettersten et al. CANCER RESEARCH
- Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses
- (2015) Ping-Chih Ho et al. CELL
- Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
- (2015) Chih-Hao Chang et al. CELL
- The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo
- (2015) Julianna Blagih et al. IMMUNITY
- Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction
- (2015) Ende Zhao et al. NATURE IMMUNOLOGY
- Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors
- (2015) Anneleen Daemen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Overcoming T cell exhaustion in infection and cancer
- (2015) Kristen E. Pauken et al. TRENDS IN IMMUNOLOGY
- Kinase-independent role for CRAF-driving tumour radioresistance via CHK2
- (2015) Sunil J. Advani et al. Nature Communications
- Pembrolizumab
- (2015) Leila Khoja et al. Journal for ImmunoTherapy of Cancer
- Targeting the Warburg Effect in cancer; relationships for 2-arylpyridazinones as inhibitors of the key glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3)
- (2014) Darby G. Brooke et al. BIOORGANIC & MEDICINAL CHEMISTRY
- 2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy
- (2014) Dongsheng Zhang et al. CANCER LETTERS
- Trafficking of T Cells into Tumors
- (2014) C. Y. Slaney et al. CANCER RESEARCH
- Nivolumab for the treatment of cancer
- (2014) Anasuya Gunturi et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Metabolic Reprogramming of Macrophages
- (2014) Alex J. Freemerman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
- (2014) Roy S. Herbst et al. NATURE
- PD-1 blockade induces responses by inhibiting adaptive immune resistance
- (2014) Paul C. Tumeh et al. NATURE
- Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
- (2013) Chih-Hao Chang et al. CELL
- Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
- (2013) Madhusudhanan Sukumar et al. JOURNAL OF CLINICAL INVESTIGATION
- Targeting lactate metabolism for cancer therapeutics
- (2013) Joanne R. Doherty et al. JOURNAL OF CLINICAL INVESTIGATION
- Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
- (2013) Jaekyoung Son et al. NATURE
- Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?
- (2013) L. M. Coussens et al. SCIENCE
- Altered metabolism in cancer
- (2012) Jason W Locasale et al. BMC BIOLOGY
- Metabolic reprogramming in cancer: Unraveling the role of glutamine in tumorigenesis
- (2012) Dania Daye et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
- (2011) Eric V. Dang et al. CELL
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation
- (2011) Ruoning Wang et al. IMMUNITY
- Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation
- (2011) Anna N. Mendler et al. INTERNATIONAL JOURNAL OF CANCER
- HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells
- (2011) Lewis Z. Shi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Erratum
- (2010) ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- The reverse Warburg Effect: Glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts
- (2010) Gloria Bonuccelli et al. CELL CYCLE
- Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation
- (2010) E. L. Carr et al. JOURNAL OF IMMUNOLOGY
- HIF-dependent induction of adenosine receptor A2b skews human dendritic cells to a Th2-stimulating phenotype under hypoxia
- (2009) Meixiang Yang et al. IMMUNOLOGY AND CELL BIOLOGY
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- Cancer Cell Metabolism: Warburg and Beyond
- (2008) Peggy P. Hsu et al. CELL
- Brick by brick: metabolism and tumor cell growth
- (2008) Ralph J DeBerardinis et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells
- (2008) Candace M. Cham et al. EUROPEAN JOURNAL OF IMMUNOLOGY
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