From Immunogenic Cell Death to Immunogenic Modulation: Select Chemotherapy Regimens Induce a Spectrum of Immune-Enhancing Activities in the Tumor Microenvironment

Unfolded protein response in colorectal cancer

(2021) Jingjing Huang et al.   Cell and Bioscience

Differential combination immunotherapy requirements for inflamed (warm) tumors versus T cell excluded (cool) tumors: engage, expand, enable, and evolve

(2021) Kellsye P Fabian et al.   Journal for ImmunoTherapy of Cancer

Radiation dose and fraction in immunotherapy: one-size regimen does not fit all settings, so how does one choose?

(2021) Sandra Demaria et al.   Journal for ImmunoTherapy of Cancer

Neoadjuvant chemotherapy is associated with a transient increase of intratumoral T-cell density in microsatellite stable colorectal liver metastases

(2020) Vegar Johansen Dagenborg et al.   CANCER BIOLOGY & THERAPY

TRAIL Receptors Serve as Stress-Associated Molecular Patterns to Promote ER-Stress-Induced Inflammation

(2020) Graeme P. Sullivan et al.   DEVELOPMENTAL CELL

Clinicopathological significance of endoplasmic reticulum stress proteins in ovarian carcinoma

(2020) Soma Samanta et al.   Scientific Reports

Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology

(2020) Isaure Vanmeerbeek et al.   OncoImmunology

Molecular Mechanisms of Radiation-Induced Cancer Cell Death: A Primer

(2020) Joseph Sia et al.   Frontiers in Cell and Developmental Biology

Inhibition of transcription by dactinomycin reveals a new characteristic of immunogenic cell stress

(2020) Juliette Humeau et al.   EMBO Molecular Medicine

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

(2020) Lorenzo Galluzzi et al.   Journal for ImmunoTherapy of Cancer

Safety and efficacy of single cycle induction treatment with cisplatin/docetaxel/ durvalumab/tremelimumab in locally advanced HNSCC: first results of CheckRad-CD8

(2020) Markus Hecht et al.   Journal for ImmunoTherapy of Cancer

Metronomic Chemotherapy: A Systematic Review of the Literature and Clinical Experience

(2019) Cem Simsek et al.   Journal of Oncology

Targeting intrinsic RIG-I signaling turns melanoma cells into type I interferon-releasing cellular antitumor vaccines

(2019) Sarah Bek et al.   OncoImmunology

Realizing the Clinical Potential of Immunogenic Cell Death in Cancer Chemotherapy and Radiotherapy

(2019) Bernardo Rapoport et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies

(2019) Ivan Perrot et al.   Cell Reports

Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death

(2019) Wei Li et al.   Nature Communications

Immunogenic cell death in a combined synergic gene- and immune-therapy against cancer

(2019) Benjamin Nayagom et al.   OncoImmunology

Calreticulin exposure on malignant blasts correlates with improved natural killer cell-mediated cytotoxicity in acute myeloid leukemia patients

(2019) Iva Truxova et al.   HAEMATOLOGICA

The Diversification of Cell Death and Immunity: Memento Mori

(2019) Arnaud J. Legrand et al.   MOLECULAR CELL

Calreticulin exposure correlates with robust adaptive antitumor immunity and favorable prognosis in ovarian carcinoma patients

(2019) Lenka Kasikova et al.   Journal for ImmunoTherapy of Cancer

Medium dose intermittent cyclophosphamide induces immunogenic cell death and cancer cell autonomous type I interferon production in glioma models

(2019) Bin Du et al.   CANCER LETTERS

Immunogenic chemotherapy: Dose and schedule dependence and combination with immunotherapy

(2018) Junjie Wu et al.   CANCER LETTERS

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications

(2018) Aitor Almanza et al.   FEBS Journal

TFAM is a novel mediator of immunogenic cancer cell death

(2018) Minghua Yang et al.   OncoImmunology

Immunotherapy utilizing the combination of natural killer– and antibody dependent cellular cytotoxicity (ADCC)–mediating agents with poly (ADP-ribose) polymerase (PARP) inhibition

(2018) Kathleen E. Fenerty et al.   Journal for ImmunoTherapy of Cancer

Targeting the unfolded protein response in cancer

(2017) Rani Ojha et al.   PHARMACOLOGICAL RESEARCH

Molecular signatures reflecting microenvironmental metabolism and chemotherapy-induced immunogenic cell death in colorectal liver metastases

(2017) Olga Østrup et al.   Oncotarget

Natural Killer Cell Response to Chemotherapy-Stressed Cancer Cells: Role in Tumor Immunosurveillance

(2017) Alessandra Zingoni et al.   Frontiers in Immunology

Trial watch: Immunogenic cell death induction by anticancer chemotherapeutics

(2017) Abhishek D. Garg et al.   OncoImmunology

Calreticulin exposure by malignant blasts correlates with robust anticancer immunity and improved clinical outcome in AML patients

(2016) J. Fucikova et al.   BLOOD

Calreticulin Expression in Human Non–Small Cell Lung Cancers Correlates with Increased Accumulation of Antitumor Immune Cells and Favorable Prognosis

(2016) Jitka Fucikova et al.   CANCER RESEARCH

TRAIL receptor gene editing unveils TRAIL-R1 as a master player of apoptosis induced by TRAIL and ER stress

(2016) Florent Dufour et al.   Oncotarget

Androgen deprivation therapy sensitizes triple negative breast cancer cells to immune-mediated lysis through androgen receptor independent modulation of osteoprotegerin

(2016) Anna R. Kwilas et al.   Oncotarget

Sublethal exposure to alpha radiation (223Ra dichloride) enhances various carcinomas’ sensitivity to lysis by antigen-specific cytotoxic T lymphocytes through calreticulin-mediated immunogenic modulation

(2016) Anthony S. Malamas et al.   Oncotarget

A phase I trial combining carboplatin/doxorubicin with tocilizumab, an anti-IL-6R monoclonal antibody, and interferon-α2b in patients with recurrent epithelial ovarian cancer

(2015) E. M. Dijkgraaf et al.   ANNALS OF ONCOLOGY

Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1

(2015) E. Vacchelli et al.   SCIENCE

The Interplay of Immunotherapy and Chemotherapy: Harnessing Potential Synergies

(2015) Leisha A. Emens et al.   Cancer Immunology Research

Immunogenic cell death-related biomarkers: Impact on the survival of breast cancer patients after adjuvant chemotherapy

(2015) Sylvain Ladoire et al.   OncoImmunology

Role of Local Radiation Therapy in Cancer Immunotherapy

(2015) Sandra Demaria et al.   JAMA Oncology

Inhibition of the angiopoietin/Tie2 axis induces immunogenic modulation, which sensitizes human tumor cells to immune attack

(2015) Italia Grenga et al.   Journal for ImmunoTherapy of Cancer

Androgen deprivation therapy sensitizes prostate cancer cells to T-cell killing through androgen receptor dependent modulation of the apoptotic pathway

(2015) Andressa Ardiani et al.   Oncotarget

Radiation-induced immunogenic modulation of tumor enhances antigen processing and calreticulin exposure, resulting in enhanced T-cell killing

(2015) Sofia R. Gameiro et al.   Oncotarget

ERP57 Membrane Translocation Dictates the Immunogenicity of Tumor Cell Death by Controlling the Membrane Translocation of Calreticulin

(2014) M. Obeid   JOURNAL OF IMMUNOLOGY

Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

(2014) Antonella Sistigu et al.   NATURE MEDICINE

A pan inhibitor of DASH family enzymes induces immunogenic modulation and sensitizes murine and human carcinoma cells to antigen-specific cytotoxic T lymphocyte killing: implications for combination therapy with cancer vaccines

(2014) Renee N. Donahue et al.   VACCINE

Attacking malignant cells that survive therapy

(2014) James W Hodge et al.   OncoImmunology

Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell death

(2014) Encouse B Golden et al.   OncoImmunology

Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer

(2013) L Bracci et al.   CELL DEATH AND DIFFERENTIATION

Molecular mechanisms of ATP secretion during immunogenic cell death

(2013) I Martins et al.   CELL DEATH AND DIFFERENTIATION

Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells

(2013) Yuting Ma et al.   IMMUNITY

Chemotherapy-induced immunogenic modulation of tumor cells enhances killing by cytotoxic T lymphocytes and is distinct from immunogenic cell death

(2013) James W. Hodge et al.   INTERNATIONAL JOURNAL OF CANCER

Chemotherapy broadens the range of tumor antigens seen by cytotoxic CD8+ T cells in vivo

(2012) Connie Jackaman et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

ChemoImmunoModulation: Immune Regulation by the Antineoplastic Chemotherapeutic Agents

(2012) M. R. Shurin et al.   CURRENT MEDICINAL CHEMISTRY

Cardiac Glycosides Exert Anticancer Effects by Inducing Immunogenic Cell Death

(2012) L. Menger et al.   Science Translational Medicine

The Tipping Point for Combination Therapy: Cancer Vaccines With Radiation, Chemotherapy, or Targeted Small Molecule Inhibitors

(2012) James W. Hodge et al.   SEMINARS IN ONCOLOGY

Circulating immunogenic cell death biomarkers HMGB1 and RAGE in breast cancer patients during neoadjuvant chemotherapy

(2012) Oliver J. Stoetzer et al.   TUMOR BIOLOGY

Subversion of the chemotherapy-induced anticancer immune response by the ecto-ATPase CD39

(2012) Mickaël Michaud et al.   OncoImmunology

In the field: exploiting the untapped potential of immunogenic modulation by radiation in combination with immunotherapy for the treatment of cancer

(2012) Anna R. Kwilas   Frontiers in Oncology

Exploitation of differential homeostatic proliferation of T-cell subsets following chemotherapy to enhance the efficacy of vaccine-mediated antitumor responses

(2011) Sofia R. Gameiro et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Calreticulin as a potential diagnostic biomarker for lung cancer

(2011) Rongrong Liu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Human Tumor Cells Killed by Anthracyclines Induce a Tumor-Specific Immune Response

(2011) J. Fucikova et al.   CANCER RESEARCH

Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice

(2011) W. Joost Lesterhuis et al.   JOURNAL OF CLINICAL INVESTIGATION

Toll-like receptor 4 single-nucleotide polymorphisms Asp299Gly and Thr399Ile in head and neck squamous cell carcinomas

(2011) Christoph Bergmann et al.   Journal of Translational Medicine

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

(2011) Dmitri V. Krysko et al.   TRENDS IN IMMUNOLOGY

CD91-dependent programming of T-helper cell responses following heat shock protein immunization

(2011) Sudesh Pawaria et al.   Nature Communications

Chemotherapeutic agents in low noncytotoxic concentrations increase immunogenicity of human colon cancer cells

(2011) Ramon Kaneno et al.   CELLULAR ONCOLOGY

Modulation of death receptors by cancer therapeutic agents

(2010) Heath A. Elrod et al.   CANCER BIOLOGY & THERAPY

Chemotherapy induces ATP release from tumor cells

(2010) Isabelle Martins et al.   CELL CYCLE

Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice

(2010) Rupal Ramakrishnan et al.   JOURNAL OF CLINICAL INVESTIGATION

Metronomic Chemotherapy Enhances Antitumor Effects of Cancer Vaccine by Depleting Regulatory T Lymphocytes and Inhibiting Tumor Angiogenesis

(2010) Chi-An Chen et al.   MOLECULAR THERAPY

Restoration of the immunogenicity of cisplatin-induced cancer cell death by endoplasmic reticulum stress

(2010) I Martins et al.   ONCOGENE

Role of the Unfolded Protein Response Regulator GRP78/BiP in Development, Cancer, and Neurological Disorders

(2009) Miao Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Pre-treatment with chemotherapy can enhance the antigenicity and immunogenicity of tumours by promoting adaptive immune responses

(2009) W M Liu et al.   BRITISH JOURNAL OF CANCER

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death

(2009) Theocharis Panaretakis et al.   EMBO JOURNAL

Timed Sequential Treatment With Cyclophosphamide, Doxorubicin, and an Allogeneic Granulocyte-Macrophage Colony-Stimulating Factor–Secreting Breast Tumor Vaccine: A Chemotherapy Dose-Ranging Factorial Study of Safety and Immune Activation

(2009) Leisha A. Emens et al.   JOURNAL OF CLINICAL ONCOLOGY

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

Immunogenic death of colon cancer cells treated with oxaliplatin

(2009) A Tesniere et al.   ONCOGENE

Chemotherapy induced transient B-cell depletion boosts antibody-forming cells expansion driven by an epidermal growth factor-based cancer vaccine

(2009) Enrique Montero et al.   VACCINE

Treatment of ovarian cancer cell lines with 5-aza-2′-deoxycytidine upregulates the expression of cancer-testis antigens and class I major histocompatibility complex-encoded molecules

(2008) Sara J. Adair et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

A History of Cancer Chemotherapy

(2008) Vincent T. DeVita et al.   CANCER RESEARCH

The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death

(2008) T Panaretakis et al.   CELL DEATH AND DIFFERENTIATION

Unknown

(2008) John Klune et al.   MOLECULAR MEDICINE