Article
Parasitology
Yihan Wu, Zhu Ying, Jing Liu, Zhepeng Sun, Shuang Li, Qun Liu
Summary: This study identified and characterized the ANT protein in T. gondii. Depletion of TgANT inhibited parasite growth, impaired mitochondrial and apicoplast biogenesis, and resulted in abnormal cell division.
PARASITES & VECTORS
(2022)
Article
Biochemistry & Molecular Biology
Justin Sui, Jennifer C. Boatz, Jian Shi, Qianjiang Hu, Xiaoyun Li, Yingze Zhang, Melanie Koenigshoff, Corrine R. Kliment
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease characterized by lung scarring and remodeling. This study investigates the role of adenine nucleotide translocases (ANTs) in IPF pathogenesis and finds that the loss of ANT1 leads to mitochondrial dysfunction, increased cellular senescence, and enhanced lung fibrosis. The findings suggest that modulation of ANTs could be a potential therapeutic avenue for limiting pulmonary fibrosis.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Biochemical Research Methods
Jean Finlayson, Neusha Barakati, Paul R. Langlais, Janet Funk, Rocio Zapata Bustos, Dawn K. Coletta, Moulun Luo, Wayne T. Willis, Lawrence J. Mandarino
Summary: This study characterized ANT1 abundance and acetylation in human skeletal muscle using a novel method with small amounts of tissue samples. The findings indicate that acetylation of Lys23 reduces ADP binding to ANT1, providing insights into the potential effects of acetylation on ANT1 function in human muscle.
ANALYTICAL BIOCHEMISTRY
(2021)
Article
Entomology
Zhen He, Yang Fang, Fengchao Zhang, Yang Liu, Xinkai Cheng, Jiajia Wang, Dechen Li, Dengsong Chen, Fan Wu
Summary: In Drosophila, Ant2 plays a crucial role in spermatid individualization and maturation. Knockdown of Ant2 leads to abnormalities in spermatid individualization and sperm maturation, resulting in male infertility. Ant2 knockdown also causes a decrease in tubulin polyglycylation, disruption of mitochondrial function, and an increase in apoptotic cells. Transcriptome and proteome analyses reveal significant changes in gene and protein expression, including reproductive-related glutathione transferases.
Article
Biochemistry & Molecular Biology
Meng Zhang, Yuanzhan Yang, Zhu Zhu, Zixuan Chen, Dongyang Huang
Summary: Mitochondrial dysfunction plays a critical role in acute myocardial infarction (AMI). Inhibiting adenine nucleotide translocase 2 (ANT2) could alleviate myocardial cell injury. ANT2 is involved in myocardial apoptosis by activating the mTOR-dependent PGC-1 alpha pathway. RNA interference technology may hold therapeutic potential for AMI.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Pavla Pruchova, Klara Gotvaldova, Katarina Smolkova, Lukas Alan, Blanka Holendova, Jan Tauber, Alexander Galkin, Petr Jezek, Martin Jaburek
Summary: This study reveals the antioxidant and anti-inflammatory roles of iPLA(2)gamma in the brain. It demonstrates that iPLA(2)gamma is activated by tert-butylhydroperoxide and releases free fatty acids, which leads to an increase in respiratory rate and a decrease in mitochondrial superoxide production. It also shows that iPLA(2)gamma plays a key role in the remodeling of cardiolipins in the brain.
Article
Cell Biology
Corrine R. Kliment, Jennifer M. K. Nguyen, Mary Jane Kaltreider, YaWen Lu, Steven M. Claypool, Josiah E. Radder, Frank C. Sciurba, Yingze Zhang, Alyssa D. Gregory, Pablo A. Iglesias, Venkataramana K. Sidhaye, Douglas N. Robinson
Summary: Airway hydration and ciliary function are critical to airway homeostasis and dysregulated in chronic obstructive pulmonary disease (COPD), and members of the mitochondrial ADP/ATP transporter family adenine nucleotide translocase (ANT) play a protective role against cigarette smoke, highlighting a potential for upregulation of ANT proteins in COPD protection.
JOURNAL OF CELL SCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Zilong Xiao, Xiang Wei, Minghui Li, Kun Yang, Ruizhen Chen, Yangang Su, Ziqing Yu, Yixiu Liang, Junbo Ge
Summary: This study demonstrated that depletion of Capns1 in macrophages can mitigate myocardial infarction (MI) injury by maintaining mitochondrial homeostasis and inhibiting the NLRP3 inflammasome signaling pathway.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Review
Cell Biology
Elena Frigo, Ludovica Tommasin, Giovanna Lippe, Michela Carraro, Paolo Bernardi
Summary: This article introduces the formation of Ca2+-activated, high-conductance channels by F1FO (F)-ATP synthase and adenine nucleotide translocase (ANT) in the inner membrane of mitochondria from various eukaryotes. The permeability transition (PT), a Ca2+-dependent increase in permeability in the inner mitochondrial membrane, and its molecular mechanisms have been challenging for scientists for the past 70 years. The features of the PT (or lack thereof) in mammals, yeast, fruit flies, brine shrimp, and nematodes, as well as the intrinsic pathway of apoptosis and other forms of cell death, are discussed in this review.
Review
Cardiac & Cardiovascular Systems
Yanguo Xin, Xiaodong Zhang, Jingye Li, Hui Gao, Jiayu Li, Junli Li, Wenyu Hu, Hongwei Li
Summary: Ischemic heart disease is a significant global cause of mortality and morbidity, with mitochondrial dysfunction playing a crucial role in its pathogenesis. Targeting mitochondria, including mitophagy, mtROS, and mitochondria-related inflammation, may offer potential therapeutic approaches for this condition.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Physiology
Tomas A. Schiffer, Liza Loef, Radiosa Gallini, Masood Kamali-Moghaddam, Mattias Carlstroem, Fredrik Palm
Summary: The study reveals a dynamic interaction between ANT2 and UCP2 that is regulated by mitochondrial respiratory activity, potentially impacting mitochondrial efficiency and cellular substrate utilization.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Immunology
Zhiyang Li, Yan Ding, Yudong Peng, Jian Yu, Chengliang Pan, Yifan Cai, Qian Dong, Yucheng Zhong, Ruirui Zhu, Kunwu Yu, Qiutang Zeng
Summary: Macrophages play a crucial role in inflammation, heart protection, and tissue repair after myocardial ischemia and myocardial infarction. IL-38 can regulate macrophage inflammatory response, promote differentiation of M1 macrophages into M2 macrophages, and improve myocardial ischemia and ventricular remodeling.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Xavier R. Chapa-Dubocq, Jorge F. Garcia-Baez, Jason N. Bazil, Sabzali Javadov
Summary: This study investigates the modulation of mitochondrial metabolism and function by changes in matrix Ca2+. It identifies the main mechanism responsible for mitochondrial Ca2+ overload and proposes a potential role of adenine nucleotide translocator (ANT) in the gating of mitochondrial permeability transition pores (PTP).
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Andrea Doerner, Oleg Lynetskiy, Gerhild Euler, Ulf Landmesser, Klaus-Dieter Schlueter, Jacqueline Heger
Summary: Transgenic overexpression of ANT1 showed stronger protective effects on mitochondrial function than wild-type rats, coping with I/R injury more efficiently by maintaining mitochondrial energy balance, improving diastolic function, and enhancing calcium dynamics after reperfusion.
Article
Cardiac & Cardiovascular Systems
Ling Gao, Yichao Zhao, Haiyan Wu, Xianhua Lin, Fei Guo, Jie Li, Yuhang Long, Bokang Zhou, Junsen She, Chen Zhang, Jianzhong Sheng, Li Jin, Yanting Wu, Hefeng Huang
Summary: PCOS may promote myocardial macrophage accumulation and post-MI cardiac remodeling through enhanced splenic myelopoiesis.
Review
Cardiac & Cardiovascular Systems
Isabel Witvrouwen, Emeline M. Van Craenenbroeck, Ana Abreu, Trine Moholdt, Nicolle Kraenkel
Summary: Exercise-based cardiac rehabilitation is highly recommended for coronary artery disease and heart failure, but the response to exercise training varies among individuals, especially between men and women. Women rely more on fat oxidation, have lower aerobic capacities and smaller increases in cardiac function during exercise. More studies focusing on female patients are needed to tailor exercise prescription and improve outcomes.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Nicolle Kraenkel, Elisabeth Straessler, Madlen Uhlemann, Maja Mueller, Sylvie Briand-Schumacher, Roland Klingenberg, P. Christian Schulze, Volker Adams, Gerhard Schuler, Thomas F. Luescher, Sven Moebius-Winkler, Ulf Landmesser
Summary: This study examined the effects of medium-size and small extracellular vesicles on endothelial cells, finding that in patients with chronic coronary syndrome, the repair function mediated by medium-size extracellular vesicles is impaired. However, high-intensity interval training can partially restore this repair function.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Medicine, Research & Experimental
Pia von Korn, Shelley Keating, Stephan Mueller, Bernhard Haller, Nicolle Kraenkel, Sophia Dinges, Andre Duvinage, Johannes Scherr, Ulrik Wisloff, Arnt Erik Tjonna, Martin Halle, Katharina Lechner
Summary: In patients with metabolic syndrome, there was no significant difference between low- or high-intensity interval training and moderate intensity continuous training in improving exercise capacity or metabolic health.
METABOLIC SYNDROME AND RELATED DISORDERS
(2021)
Letter
Cardiac & Cardiovascular Systems
Martin Halle, Constantinos H. Davos, Paul Dendale, Michael Papadakis, Camille Pfaff, Nicolle Kraenkel
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Henner Hanssen, Henry Boardman, Arne Deiseroth, Trine Moholdt, Maria Simonenko, Nicolle Kraenkel, Josef Niebauer, Monica Tiberi, Ana Abreu, Erik Ekker Solberg, Linda Pescatello, Jana Brguljan, Antonio Coca, Paul Leeson
Summary: The treatment of hypertension and its complications is a major health care challenge, with personalized exercise prescription being proposed for better blood pressure control based on individual's initial BP level. More research is needed to further optimize lifestyle interventions for hypertension prevention and treatment.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Dominique Hansen, Ana Abreu, Marco Ambrosetti, Veronique Cornelissen, Andreas Gevaert, Hareld Kemps, Jari A. Laukkanen, Roberto Pedretti, Maria Simonenko, Matthias Wilhelm, Constantinos H. Davos, Wolfram Doehner, Marie-Christine Iliou, Nicolle Krankel, Heinz Voller, Massimo Piepoli
Summary: The proper determination of exercise intensity is crucial for the rehabilitation of patients with cardiovascular disease, as it affects the effectiveness and safety of exercise training. Various organizations have published position statements on aerobic exercise intensity assessment and prescription in cardiovascular rehabilitation. Subsequent research has highlighted controversies and refinements in commonly applied concepts related to exercise intensity determination in cardiovascular rehabilitation.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Arash Haghikia, Friederike Zimmermann, Paul Schumann, Andrzej Jasina, Johann Roessler, David Schmidt, Philipp Heinze, Johannes Kaisler, Vanasa Nageswaran, Annette Aigner, Uta Ceglarek, Roodline Cineus, Ahmed N. Hegazy, Emiel P. C. van der Vorst, Yvonne Doring, Christopher M. Strauch, Ina Nemet, Valentina Tremaroli, Chinmay Dwibedi, Nicolle Krankel, David M. Leistner, Markus M. Heimesaat, Stefan Bereswill, Geraldine Rauch, Ute Seeland, Oliver Soehnlein, Dominik N. Mueller, Ralf Gold, Fredrik Baeckhed, Stanley L. Hazen, Aiden Haghikia, Ulf Landmesser
Summary: This study examined the effects of the gut microbiota-derived metabolite propionic acid (PA) on intestinal cholesterol metabolism and found that it can reduce blood levels of total and LDL cholesterol. PA increased the number of regulatory T cells and IL-10 levels in the intestinal microenvironment, which in turn suppressed the expression of the intestinal cholesterol transporter Npc1l1. The findings suggest that targeting the gut immune system could be a potential therapeutic strategy for controlling dyslipidemia and preventing atherosclerotic cardiovascular diseases.
EUROPEAN HEART JOURNAL
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Nicolle Kraenkel
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Nicolle Kraenkel
EUROPEAN HEART JOURNAL
(2022)
Article
Immunology
Kai Jakobs, Leander Reinshagen, Marianna Puccini, Julian Friebel, Anne-Christin Beatrice Wilde, Ayman Alsheik, Andi Rroku, Ulf Landmesser, Arash Haghikia, Nicolle Kraenkel, Ursula Rauch-Kroehnert
Summary: The study found that in patients with moderate-to-severe COVID-19, disease severity was associated with platelet hyperreactivity and a typical inflammatory signature, emphasizing the importance of antithrombotic therapy for reducing disease severity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Hector Giral, Vedran Franke, Minoo Moobed, Maja F. Mueller, Laura Luebking, Divya Maria James, Johannes Hartung, Kira Kuschnerus, Denitsa Meteva, Claudio Seppelt, Philipp Jakob, Roland Klingenberg, Nicolle Kraenkel, David Leistner, Tanja Zeller, Stefan Blankenberg, Friederike Zimmermann, Arash Haghikia, Thomas F. Luescher, Altuna Akalin, Ulf Landmesser, Adelheid Kratzer
Summary: This study found that in AMI patients, monocyte subpopulations exhibit attenuated rapid inflammasome activation, accompanied by a significant increase in TNFAIP3 and IRAKM expression. This unexpected response may be a protective phenotype occurring after an acute inflammatory wave in the ischemic area.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Arne Thies, Vikram Sunkara, Sourav Ray, Hanna Wulkow, M. Oezguer Celik, Fatih Yergoez, Christof Schuette, Christoph Stein, Marcus Weber, Stefanie Winkelmann
Summary: We have successfully designed, synthesized, and tested the prototype opioid painkiller NFEPP, which does not have adverse side effects. The design process was based on mathematical modeling of interactions between G-protein coupled receptors (GPCRs) and ligands, considering the different functions of GPCRs under pathological and healthy conditions. Additionally, we have proposed a novel stochastic model of GPCR function that takes into account intracellular dissociation of G-protein subunits and modulation of plasma membrane calcium channels, which depend on the parameters of inflamed and healthy tissue (pH, radicals). The model has been validated using in vitro experimental data for NFEPP and fentanyl at different pH values and radical concentrations.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Melih Oezguer Celik, Viola Seitz, Fatih Yergoez, Sandeep Dembla, Nina Kathleen Blum, Stefan Schulz, Christoph Stein
Summary: N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide is a newly-designed pain killer that selectively activates G-protein-coupled mu-opioid receptors (MOR) in acidic injured tissues, devoid of central side effects. The inhibitory effects of NFEPP on calcium currents in rat DRG neurons and its pH-dependent MOR signaling were investigated.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Marco Ambrosetti, Ana Abreu, Veronique Cornelissen, Dominique Hansen, Marie Christine Iliou, Hareld Kemps, Roberto Franco Enrico Pedretti, Heinz Voller, Mathias Wilhelm, Massimo Francesco Piepoli, Chiara Giuseppina Beccaluva, Paul Beckers, Thomas Berger, Costantinos H. Davos, Paul Dendale, Wolfram Doehner, Ines Frederix, Dan Gaita, Andreas Gevaert, Evangelia Kouidi, Nicolle Kraenkel, Jari Laukkanen, Francesco Maranta, Antonio Mazza, Miguel Mendes, Daniel Neunhaeuserer, Josef Niebauer, Bruno Pavy, Carlos Pena Gil, Bernhard Rauch, Simona Sarzi Braga, Maria Simonenko, Alain Cohen-Solal, Marinella Sommaruga, Elio Venturini, Carlo Vigorito
Summary: This Delphi consensus by 28 experts from the European Association of Preventive Cardiology provides initial recommendations on how cardiovascular rehabilitation facilities should modulate their activities during the ongoing COVID-19 pandemic. Consensus was reached on 58 statements, mainly focusing on referral, core components, and structure of CR activities suitable for managing cardiac COVID-19 patients. Experts suggested maintaining usual activities for traditional patient groups referred to CR during the pandemic, with minimal downgrading of intervention for COVID-19 patients as comorbidities.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
