Review
Biochemistry & Molecular Biology
Mi Eun Kim, Jun Sik Lee
Summary: Aging is associated with weakened immune function and increased susceptibility to diseases. Telomere shortening, tissue inflammation, and altered signaling pathways play key roles in immune dysfunction. Targeting tissue inflammation and immunomodulation is vital for treating immune disorders in older adults. Anti-inflammatory medications, immunotherapy, and novel approaches may enhance immune responses in this population.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Eric T. Klopack, Eileen M. Crimmins, Steve W. Cole, Teresa E. Seeman, Judith E. Carroll
Summary: Exposure to stress is associated with accelerated immune aging, characterized by a decrease in naive T cells and an increase in terminally differentiated T cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cardiac & Cardiovascular Systems
Virginia Smit, Jill de Mol, Frank H. Schaftenaar, Marie A. C. Depuydt, Rimke J. Postel, Diede Smeets, Fenne W. M. Verheijen, Laurens Bogers, Janine van Duijn, Robin A. F. Verwilligen, Hendrika W. Grievink, Mireia N. A. Bernabe Kleijn, Eva van Ingen, Maaike J. M. de Jong, Lauren Goncalves, Judith A. H. M. Peeters, Harm J. Smeets, Anouk Wezel, Julia K. Polansky, Menno P. J. de Winther, Christoph J. Binder, Dimitrios Tsiantoulas, Ilze Bot, Johan Kuiper, Amanda C. Foks
Summary: This study found that aging promotes advanced atherosclerosis in mice and induces immunological alterations. The expression of genes involved in atherogenic processes shifted with age, and age-associated T- and B-cells emerged in atherosclerotic plaques and blood. Further research on age-associated immunity may contribute to novel diagnostic and therapeutic tools for cardiovascular disease.
CARDIOVASCULAR RESEARCH
(2023)
Review
Cell Biology
Leah S. Hohman, Lisa C. Osborne
Summary: This review discusses emerging data on age-related loss of intestinal barrier integrity and suggests that IEC dysfunction may play a central role in age-associated alterations in microbiota composition and immune homeostasis.
Review
Immunology
Jasper Iske, Tomohisa Matsunaga, Hao Zhou, Stefan G. Tullius
Summary: The transplantation of aged organs may have negative effects on recipients due to the accumulation of senescent cells, which can promote aging in recipient cells through the secretion of pro-inflammatory molecules. Studies have shown that transplanting old organs may limit the physical reserve of recipients.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Yunan Wang, Chen Dong, Yudian Han, Zhifeng Gu, Chi Sun
Summary: Immunosenescence, the immune related changes caused by aging, plays crucial roles in various age-related diseases, including neurodegenerative diseases, tumors, cardiovascular diseases, autoimmune diseases, and COVID-19. However, the mechanisms, association with aging and successful aging, as well as the effects on diseases, are not clearly understood. This review highlights the involvement of aging-related phenotypic changes, deterioration of immune organ function, and alterations of immune cell subsets in the process of immunosenescence, which significantly impact the occurrence and development of age-related diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Jill de Mol, Johan Kuiper, Dimitrios Tsiantoulas, Amanda C. Foks
Summary: Aging is a significant risk factor for inflammatory diseases, where B cells play a crucial role. Different B cell subsets are involved in infections and autoimmune diseases. With age-related changes in B cell development and function, the impact on chronic inflammatory diseases can be substantial.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Gabor Papp, Krisztina Szabo, Ilona Jambor, Marianna Mile, Alexandra Reka Berki, Attila Csaba Arany, Gabriella Makra, Peter Szodoray, Zoltan Csiki, Laszlo Balogh
Summary: Regular exercise in healthy elderly individuals can lead to improvements in body composition and physical performance, as well as significant changes in the ratios of natural killer cells, T and B lymphocyte subtypes, and functional capability of Treg cells. This indicates a positive impact on age-related redistribution of naive and memory cell proportions and immune regulation in older ages.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Stefania Cuzzubbo, Sara Mangsbo, Divya Nagarajan, Kinana Habra, Alan Graham Pockley, Stephanie E. B. McArdle
Summary: The discovery of tumor antigens has led to the development of cancer vaccines, but many antigens lack immunogenicity. Adjuvants are added to vaccine formulations to trigger immune responses. Aging can lead to immunosenescence and chronic inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Nutrition & Dietetics
Monika Fekete, Zsofia Szarvas, Vince Fazekas-Pongor, Agnes Feher, Tamas Csipo, Judit Forrai, Norbert Dosa, Anna Peterfi, Andrea Lehoczki, Stefano Tarantini, Janos Tamas Varga
Summary: An increasing number of studies suggest that diet plays an important role in regulating aging processes and modulates the development of age-related diseases. Certain diets with anti-aging action can slow down or prevent the development of cardiovascular and cerebrovascular diseases, neurodegenerative diseases, cognitive impairment, and dementia. The Mediterranean diet, incorporating fasting elements, may play a significant role in healthy aging.
Article
Medicine, General & Internal
Leah Zuroff, Ayman Rezk, Koji Shinoda, Diego A. Espinoza, Yehezqel Elyahu, Bo Zhang, Andrew A. Chen, Russell T. Shinohara, Dina Jacobs, Roy N. Alcalay, Thomas F. Tropea, Alice Chen-Plotkin, Alon Monsonego, Rui Li, Amit Bar-Or
Summary: In the study comparing untreated MS patients with normal controls, it was found that MS patients exhibited early and persistent redistribution of naive and memory CD4 T-cell compartments. While most CD4 and CD8 T-cell aging trajectories were similar between groups, MS patients demonstrated abnormal age-associated increases, particularly in patients over 60.
Review
Geriatrics & Gerontology
Mingxuan Chi, Zijun Tian, Kuai Ma, Yunlong Li, Li Wang, Moussa Ide Nasser, Chi Liu
Summary: Immunosenescence is the deterioration of the immune system associated with aging, leading to impaired immune protection and chronic inflammation. It is more pronounced in patients with kidney diseases and increases the risk of permanent renal damage and cardiovascular events. Biological drugs can be used to target the aging immune system and protect the kidneys.
Article
Clinical Neurology
Erin Diane Lewis, Dayong Wu, Simin Nikbin Meydani
Summary: Immunosenescence refers to age-related changes in the immune system, characterized by complex alterations in immune function and dysregulation of inflammatory processes. These changes include alterations in innate immune responses and a decline in the number and function of T cells, which can contribute to increased susceptibility to infection and cancer in older adults. Additionally, older adults have higher levels of inflammatory mediators circulating in their bodies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Review
Genetics & Heredity
Antero Salminen
Summary: Tissue-resident fibroblasts are mesenchymal cells that play a crucial role in maintaining the structural integrity of the extracellular matrix. Under various stresses, including those associated with aging, these fibroblasts can differentiate into myofibroblasts which not only contribute to tissue fibrosis but also interact with immune cells to regulate immune responses. The differentiation of myofibroblasts is induced by factors such as TGF-β cytokine and reactive oxygen species (ROS), which also play important roles in mediating signaling between immunosuppressive cells.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Geriatrics & Gerontology
Juliana Ruiz Fernandes, Thalyta Nery Carvalho Pinto, Lia Barbara Arruda, Cibele Cristine Berto Marques da Silva, Celso Ricardo Fernandes de Carvalho, Regina Maria Carvalho Pinto, Alberto Jose da Silva Duarte, Gil Benard
Summary: COPD patients exhibit abnormal immune response, while smoking has dual effects on immune response. Our study compared the phenotypes of T-cell subsets in COPD patients, smokers, and healthy individuals, and found significant alterations in COPD patients, while smokers were closer to healthy aged individuals.
Review
Pharmacology & Pharmacy
Amandda Evelin Silva-Carvalho, Marlon Henrique Cardoso, Thuany Alencar-Silva, Gabriela Muller Reche Bogea, Juliana Lott Carvalho, Octavio Luiz Franco, Felipe Saldanha-Araujo
Summary: Mesenchymal stem cells (MSCs) have the ability to control the immune response and fight pathogen infection through the production of antimicrobial peptides (AMPs). These AMPs exhibit activity against a wide range of microorganisms and also interact with MSCs to modulate their functions. Therefore, utilizing the antimicrobial properties of MSCs in clinical therapy holds great potential.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Microbiology
Manoel Neres Santos-Junior, Wanderson Souza Neves, Ronaldo Silva Santos, Palloma Porto Almeida, Janaina Marinho Fernandes, Bruna Carolina de Brito Guimaraes, Maysa Santos Barbosa, Lucas Santana Coelho da Silva, Camila Pacheco Gomes, Beatriz Almeida Sampaio, Izadora de Souza Rezende, Thiago Macedo Lopes Correia, Nayara Silva de Macedo Neres, Guilherme Barreto Campos, Bruno Lopes Bastos, Jorge Timenetsky, Lucas Miranda Marques
Summary: Ureaplasma diversum is a bacterial pathogen that infects cattle and can cause severe inflammation of the genital and reproductive systems. In this study, the researchers successfully expressed and purified recombinant GUDIV-103 (rGUDIV-103) and demonstrated its immunoreactivity and immunomodulatory effects in bovine peripheral blood mononuclear cells (PBMCs). They also showed that rGUDIV-103 induced lymphocyte proliferation and increased the expression of immune-related genes. These findings suggest that rGUDIV-103 has potential applications in immunobiology.
Article
Biology
Jianhua Zhang, Zachery R. Gregorich, Ran Tao, Gina C. Kim, Pratik A. Lalit, Juliana L. Carvalho, Yogananda Markandeya, Deane F. Mosher, Sean P. Palecek, Timothy J. Kamp, Gordana Vunjak-Novakovic
Summary: This study reveals the importance of extracellular matrix (ECM) proteins, specifically fibronectin (FN), in promoting cardiac differentiation of human pluripotent stem cells (hPSCs). The presence of FN in the ECM is essential for effective cardiac differentiation, while other ECM proteins like laminin-111 and laminin-521 inhibit this process. Inhibition of certain integrin receptors and integrin-linked kinase can also impair cardiac differentiation.
Article
Oncology
Thalita Basso Scandolara, Sara Ferreira Valle, Cristiane Esteves Teixeira, Nicole de Miranda Scherer, Elvismary Molina de Armas, Carolina Furtado, Mariana Boroni, Hellen dos Santos Jaques, Fernanda Mara Alves, Daniel Rech, Carolina Panis, Cibele Rodrigues Bonvicino
Summary: This study found that breast cancer patients exposed to pesticides had more pathogenic and likely pathogenic variants in their tumors compared to unexposed patients. Additionally, pesticide-exposed patients had a higher mutational burden when diagnosed before the age of 50 and/or when carrying BRCA1, BRCA2, and PALB2 variants.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Gabriela Alves Moreira, Monica Maria Magalhaes Caetano, Juliana Alves do Vale, Janine Cerqueira de Paiva, Victor Hugo Sousa Goncalves, Alisson Andrade Almeida, Lucas Viana Gomes Silva, Fernanda Rebellato Giordano Martim, Marcus Vinicius de Andrade Barros, Gabriela Rapozo Guimaraes, Leandro de Oliveira Santos, Ana Paula Martins de Souza, Mariana Machado-Neves, Robson Ricardo Teixeira, Abelardo Silva-Junior, Juliana Lopes Rangel Fietto, Mariana Boroni, Leandro Licursi de Oliveira, Gustavo Costa Bressan
Summary: Cancers have a strong relationship with immune cells in their microenvironment, and pharmacological strategies that stimulate the immune system to combat tumor cells show promise for better therapeutic efficacy. This study found that overexpression of SRPK1/2 in melanoma is associated with alterations in the immune system pathway. Treatment with the SRPK1/2 inhibitor SRPIN340 in mice bearing metastatic melanoma increased the presence of immune cells and enhanced immunological susceptibility. These findings suggest that SRPKs may play a role in tumor biology by modulating the immune response.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Tatiana Dandolini Saccon, Felippe Mousovich-Neto, Raissa Guimaraes Ludwig, Victor Corasolla Carregari, Ana Beatriz dos Anjos Souza, Amanda Stephane Cruz dos Passos, Matheus Cavalheiro Martini, Priscilla Paschoal Barbosa, Gabriela Fabiano de Souza, Stefanie Primon Muraro, Julia Forato, Mariene Ribeiro Amorim, Rafael Elias Marques, Flavio Protasio Veras, Ester Barreto, Tiago Tomazini Goncalves, Isadora Marques Paiva, Narayana P. B. Fazolini, Carolina Mie Kawagosi Onodera, Ronaldo Braganca Martins Junior, Paulo Henrique Cavalcanti de Araujo, Sabrina Setembre Batah, Rosa Maria Mendes Viana, Danilo Machado de Melo, Alexandre Todorovic Fabro, Eurico Arruda, Fernando Queiroz Cunha, Thiago Mattar Cunha, Marco Antonio M. Pretti, Bradley Joseph Smith, Henrique Marques-Souza, Thiago L. Knittel, Gabriel Palermo Ruiz, Gerson S. Profeta, Tereza Cristina Minto Fontes-Cal, Mariana Boroni, Marco Aurelio Ramirez Vinolo, Alessandro S. Farias, Pedro Manoel M. Moraes-Vieira, Joyce Maria Annichino Bizzacchi, Tambet Teesalu, Felipe David Mendonca Chaim, Everton Cazzo, Elinton Adami Chaim, Jose Luiz Proenca-Modena, Daniel Martins-de-Souza, Mariana Kiomy Osako, Luiz Osorio Leiria, Marcelo A. Mori
Summary: Visceral adiposity is a risk factor for severe COVID-19, and the degree of adipose tissue infection and cellular response to SARS-CoV-2 depend on the adipose tissue depot and viral lineage. Visceral fat cells are more susceptible to SARS-CoV-2 infection and show higher expression of pro-inflammatory cytokines. Cell death occurs to a similar degree regardless of cell origin or viral lineage.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Bruna Palma Matta, Renan Gomes, Daniel Mattos, Renata Olicio, Caroline Macedo Nascimento, Gerson Moura Ferreira, Ayslan Castro Brant, Mariana Boroni, Carolina Furtado, Valdirene Lima, Miguel Angelo Martins Moreira, Anna Claudia Evangelista dos Santos
Summary: This study estimated the prevalence of pathogenic germline variants in BRCA1, BRCA2, and TP53 genes in Brazilian patients suspected of hereditary breast/ovarian cancer syndrome (HBOC). The study found that 15.9% of the tested patients carried pathogenic variants, with TP53 c.1010G > A (p.Arg337His) being the most common mutation. The use of familial history of cancer was found to improve patient selection for genetic testing in settings with limited resources.
SCIENTIFIC REPORTS
(2022)
Article
Genetics & Heredity
Monica Maria Magalhaes Caetano, Gabriela Alves Moreira, Maria Romeria da Silva, Gabriela Rapozo Guimaraes, Leandro de Oliveira Santos, Amanda de Ambrosio Pacheco, Raoni Pais Siqueira, Flavia Carneiro Mendes, Eduardo De Almeida Marques Da Silva, Abelardo Silva Junior, Juliana Lopes Rangel Fietto, Angela Saito, Mariana Boroni, Gustavo Costa Bressan
Summary: This study found that the expression of SRPK2 is associated with poor prognosis in melanoma patients. Genetic targeting of SRPK2 reduced the proliferative and invasive capacity of melanoma cells, leading to slower tumor progression. These findings suggest different functional roles for SRPK1/2 in metastatic melanoma.
FRONTIERS IN GENETICS
(2022)
Article
Pharmacology & Pharmacy
Jessika L. Rocha, Felipe Q. Pires, Idejan P. Gross, Thuany Alencar-Silva, Tais Gratieri, Guilherme M. Gelfuso, Livia Sa-Barreto, Juliana Lott Carvalho, Marcilio Cunha-Filho
Summary: This study investigated the feasibility of using PPL-loaded nanostructured lipid carriers (NLC) for safer topical treatment of infantile hemangioma. The NLC exhibited good stability, controlled drug release, low drug accumulation in deeper skin layers, and superior therapeutic effects over non-formulated PPL in human brain microvascular endothelial cells. Topical PPL-loaded NLC shows promise as a drug delivery system for infantile hemangioma treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Oscar Moreno Loaiza, Narendra Vera Nunez, Ainhoa Rodriguez de Yurre Guirao, Leonardo Maciel, Humberto Muzzi, Dahienne Ferreira de Oliveira, Luan Pereira Diniz, Mario Costa Cruz, Leonardo Ribeiro Batista-Silva, Archimedes Barbosa Castro-Junior, Marco Antonio Prettie, Pedro Nic, Mariana Boroni, Martin Bonamino, Isalira Peroba Ramos, Joao Paulo do Vale Madeiro, Roberto Coury Pedrosa, Marcela Sorelli Carneiro-Ramos, Herculano da Silva Martinho, Ariel L. Escobar, Emiliano Medei
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Multidisciplinary Sciences
Ariane F. Busso-Lopes, Leandro X. Neves, Guilherme A. Camara, Daniela C. Granato, Marco Antonio M. Pretti, Henry Heberle, Fabio M. S. Patroni, Jamile Sa, Sami Yokoo, Cesar Rivera, Romenia R. Domingues, Ana Gabriela C. Normando, Tatiane De Rossi, Barbara P. Mello, Nayane A. L. Galdino, Bianca A. Pauletti, Pammela A. Lacerda, Andre Afonso N. Rodrigues, Andre Luis M. Casarim, Reydson A. De Lima-Souza, Ingrid I. Damas, Fernanda Mariano, Kenneth J. Gollob, Tiago S. Medina, Nilva K. Cervigne, Ana Carolina Prado-Ribeiro, Thais Bianca Brandao, Luisa L. Villa, Miyuki Uno, Mariana Boroni, Luiz Paulo Kowalski, Wilfredo Alejandro Gonzalez-Arriagada, Adriana F. Paes Leme
Summary: This study provides insights into the biology and potential biomarkers associated with metastasis in head and neck cancer through proteomic characterization and machine learning analysis.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Cristhiane Favero Aguiar, Felipe Correa-da-Silva, Michelangelo Bauwelz Gonzatti, Monara Kaelle Angelim, Marco Antonio Pretti, Gustavo Gastao Davanzo, Bianca Gazieri Castelucci, Lauar Brito Monteiro, Gisele Castro, Joao Victor Virgilio-da-Silva, Guilherme Ribeiro, Vitor Jaccomo, Mirella C. Pereira Andrade, Webster Leonardo Costa, Victor Gambarini, Fernanda Fernandes Terra, Jose Carlos Alves-Filho, Niels Olsen Saraiva Camara, Mariana Boroni, Alexandre Castro Keller, Pedro M. Moraes-Vieira
Summary: This study reveals that splenic and hepatic iNKT cells rely on glycolytic metabolism, while adipose tissue iNKT cells have a distinctive immunometabolic profile involving AMPK. Deletion of the Pkm2 gene impairs the response and injury mitigation ability of splenic and hepatic iNKT cells, while AMPK deficiency affects the physiology and inflammation regulation ability of adipose tissue iNKT cells during obesity.
Review
Parasitology
Emanuella Melgaco Garcez, Nelio Gomes, Aline Silva Moraes, Robert Pogue, Rosa Harumi Uenishi, Mariana Hecht, Juliana Lott Carvalho
Summary: Extracellular vesicle (EVs) traffic is an important cellular communication process between cells, which can occur within a single organism or between different organisms. The relevance of EV-mediated cellular communication is being increasingly studied, particularly in pathological conditions like parasitic disorders. In the context of Chagas Disease (CD), EVs have been explored, but a systematic review is lacking. This review identified 25 studies investigating EVs in CD, revealing their critical roles in the interaction between T. cruzi and mammalian hosts, immune system evasion, and chronic inflammation.
Review
Cell & Tissue Engineering
Aurelio Matos Andrade, Vitoria Rodrigutes Teixera, Robert Pogue, Ana Claudia Morais Godoy Figueiredo, Juliana Lott Carvalho
Summary: This study evaluated the cost-effectiveness of tisagenlecleucel compared with conventional salvage therapies for pediatric and young adult patients with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL). The results showed that tisagenlecleucel is more expensive than traditional therapies, but its ICER value is still good, and it is more effective than conventional drugs in terms of life years and QALY gained.
Article
Surgery
Gleide Gatti Fontes, Rodrigo de Barros Freitas, Palloma Porto Almeida, Luciana Moreira Lima, Silvia Almeida Cardoso, Virginia Ramos Pizziolo, Ricardo Tabach, Almir Goncalves Wanderley, Ricardo Mario Arida, Afonso Caricati-Neto, Murched Omar Taha, Camilo Amaro de Carvalho, Fernando Sabia Tallo, Francisco Sandro Menezes-Rodrigues
Summary: The study found that Calendula officinalis extract can reduce lipid infiltration in the liver, modulate oxidative stress and lipid metabolism markers, and therefore has a modulatory effect on dyslipidemia.
ACTA CIRURGICA BRASILEIRA
(2023)
