PFKFB3 Inhibition Impairs Erlotinib-Induced Autophagy in NSCLCs

Inhibition of PFKFB3 induces cell death and synergistically enhances chemosensitivity in endometrial cancer

(2021) Yinan Xiao et al.   ONCOGENE

Oxidative stress-mediated AMPK inactivation determines the high susceptibility of LKB1-mutant NSCLC cells to glucose starvation

(2021) Yi Ren et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System

(2020) Jingyue Jia et al.   MOLECULAR CELL

Acquired resistance to osimertinib in patients with non-small-cell lung cancer: mechanisms and clinical outcomes

(2020) Yuxin Mu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Role of PARP1-mediated autophagy in EGFR-TKI resistance in non-small cell lung cancer

(2020) Zhimin Zhang et al.   Scientific Reports

Protective autophagy decreases osimertinib cytotoxicity through regulation of stem cell-like properties in lung cancer

(2019) Li Li et al.   CANCER LETTERS

Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis

(2019) Lorena Fernandez-Mosquera et al.   Autophagy

Increased 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 activity in response to EGFR signaling contributes to non-small cell lung cancer cell survival

(2019) Nadiia Lypova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of tumor and host autophagy in cancer metabolism

(2019) Laura Poillet-Perez et al.   GENES & DEVELOPMENT

Intrinsic resistance to EGFR-Tyrosine Kinase Inhibitors in EGFR-Mutant Non-Small Cell Lung Cancer: Differences and Similarities with Acquired Resistance

(2019) Santoni-Rugiu et al.   Cancers

The Lysosome Signaling Platform: Adapting With the Times

(2019) Subothan Inpanathan et al.   Frontiers in Cell and Developmental Biology

PAQR3 suppresses the growth of non-small cell lung cancer cells via modulation of EGFR-mediated autophagy

(2019) Qianqian Cao et al.   Autophagy

PFKFB3 inhibition reprograms malignant pleural mesothelioma to nutrient stress-induced macropinocytosis and ER stress as independent binary adaptive responses

(2019) Sayantani Sarkar Bhattacharya et al.   Cell Death & Disease

Targeting Autophagy in Cancer: Recent Advances and Future Directions

(2019) Ravi K. Amaravadi et al.   Cancer Discovery

Targeting Autophagy for Overcoming Resistance to Anti-EGFR Treatments

(2019) Yoojung Kwon et al.   Cancers

PFKFB3 Inhibition Attenuates Oxaliplatin-Induced Autophagy and Enhances Its Cytotoxicity in Colon Cancer Cells

(2019) Siyuan Yan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing Pfkfb3 expression

(2019) Alyssa La Belle Flynn et al.   Nature Communications

Measuring autophagosome flux

(2018) Andre du Toit et al.   Autophagy

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

(2018) Mario Mauthe et al.   Autophagy

Enhanced glycolysis supports cell survival in EGFR-mutant lung adenocarcinoma by inhibiting autophagy-mediated EGFR degradation

(2018) Ji Hye Kim et al.   CANCER RESEARCH

Autophagy Modulation in Cancer: Current Knowledge on Action and Therapy

(2018) Mija Marinković et al.   Oxidative Medicine and Cellular Longevity

Therapeutic targeting of PFKFB3 with a novel glycolytic inhibitor PFK158 promotes lipophagy and chemosensitivity in gynecologic cancers

(2018) Susmita Mondal et al.   INTERNATIONAL JOURNAL OF CANCER

AZD9291 promotes autophagy and inhibits PI3K/Akt pathway in NSCLC cancer cells

(2018) Zhirui Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The clinical significance of autophagy in patients with non small cell lung cancer.

(2018) Nariyasu Nakashima et al.   JOURNAL OF CLINICAL ONCOLOGY

AMPK contributes to autophagosome maturation and lysosomal fusion

(2018) Minsu Jang et al.   Scientific Reports

Alternative drug sensitivity metrics improve preclinical cancer pharmacogenomics

(2017) Marc Hafner et al.   NATURE BIOTECHNOLOGY

Influence of autophagy on the efficacy of radiotherapy

(2017) Shing Yau Tam et al.   Radiation Oncology

Oncogenic driver mutations, treatment, and EGFR-TKI resistance in a Caucasian population with non-small cell lung cancer: survival in clinical practice

(2017) Martin Faehling et al.   Oncotarget

6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 spatially mediates autophagy through the AMPK signaling pathway

(2017) Siyuan Yan et al.   Oncotarget

EGFR Family Members’ Regulation of Autophagy Is at a Crossroads of Cell Survival and Death in Cancer

(2017) Elizabeth Henson et al.   Cancers

Inhibition of 6-phosphofructo-2-kinase (PFKFB3) suppresses glucose metabolism and the growth of HER2+ breast cancer

(2016) Julie O’Neal et al.   BREAST CANCER RESEARCH AND TREATMENT

A Kinase-Independent Role for EGF Receptor in Autophagy Initiation

(2015) Xiaojun Tan et al.   CELL

Dysregulated metabolism contributes to oncogenesis

(2015) Matthew D. Hirschey et al.   SEMINARS IN CANCER BIOLOGY

Targeting molecular addictions in cancer

(2014) I Vivanco   BRITISH JOURNAL OF CANCER

Evaluation of acridine orange, LysoTracker Red, and quinacrine as fluorescent probes for long-term tracking of acidic vesicles

(2014) Agnieszka Pierzyńska-Mach et al.   CYTOMETRY PART A

Activation of AMP-activated protein kinase sensitizes lung cancer cells and H1299 xenografts to erlotinib

(2014) Helen J. Hülsmann et al.   LUNG CANCER

Control of Glycolytic Flux by AMP-Activated Protein Kinase in Tumor Cells Adapted to Low pH

(2014) Erin E. Mendoza et al.   Translational Oncology

EGFR inhibitors and autophagy in cancer treatment

(2014) Jie Cui et al.   TUMOR BIOLOGY

Glucose-starved Cells Do Not Engage in Prosurvival Autophagy

(2013) Silvia Ramírez-Peinado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Concentrations of Fructose 2,6-Bisphosphate Contribute to the Warburg Effect in Phosphatase and Tensin Homolog (PTEN)-deficient Cells

(2013) Lucía Cordero-Espinoza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Autophagy Inhibitor Chloroquine Overcomes the Innate Resistance of Wild-Type EGFR Non-Small-Cell Lung Cancer Cells to Erlotinib

(2013) Yiyu Zou et al.   Journal of Thoracic Oncology

Enhanced autophagy is required for survival in EGFR-independent EGFR-mutant lung adenocarcinoma cells

(2013) Yuji Sakuma et al.   LABORATORY INVESTIGATION

Erlotinib-induced autophagy in epidermal growth factor receptor mutated non-small cell lung cancer

(2013) Yuan-yuan Li et al.   LUNG CANCER

Glycolysis Inhibition Sensitizes Non-Small Cell Lung Cancer with T790M Mutation to Irreversible EGFR Inhibitors via Translational Suppression of Mcl-1 by AMPK Activation

(2013) S. M. Kim et al.   MOLECULAR CANCER THERAPEUTICS

Suppression of basal autophagy reduces lung cancer cell proliferation and enhances caspase-dependent and -independent apoptosis by stimulating ROS formation

(2012) Vitaliy O. Kaminskyy et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

EGFR tyrosine kinase inhibition induces autophagy in cancer cells

(2012) Christopher Fung et al.   CANCER BIOLOGY & THERAPY

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Roles of autophagy in cetuximab-mediated cancer therapy against EGFR

(2010) Xinqun Li et al.   Autophagy

Survival of Cancer Cells Is Maintained by EGFR Independent of Its Kinase Activity

(2008) Zhang Weihua et al.   CANCER CELL

Autophagy and multivesicular bodies: two closely related partners

(2008) C M Fader et al.   CELL DEATH AND DIFFERENTIATION