Article
Biochemistry & Molecular Biology
Mohsen Ahmadi, Debora Singer, Felix Potlitz, Zahra Nasri, Thomas von Woedtke, Andreas Link, Sander Bekeschus, Kristian Wende
Summary: Cold physical plasma is a partially ionized gas that operates at body temperature and has applications in heat-sensitive technical and medical fields. It can be used to introduce oxidative modifications to biomolecules, including the activation of anticancer prodrugs. In a proof-of-concept study, a boronic pinacol ester fenretinide prodrug was activated using an atmospheric pressure argon plasma jet. The study demonstrated that the activation of the prodrug led to enhanced cytotoxic effects in vitro, making cold physical plasma-mediated prodrug activation a promising approach for combination cancer treatment studies.
Article
Biochemistry & Molecular Biology
Jie Zhuang, Qian Yuan, Congcong Chen, Gengliang Liu, Zhengyi Zhong, Kai Zhu, Jinsong Guo
Summary: This study investigates the potential molecular mechanism of ns-CAPJ in inhibiting the invasive migration of human GBM cells. The findings show that ns-CAPJ significantly reduces GBM cell invasion and migration, and induces apoptosis in GBM cells. Further mechanistic studies demonstrate that the suppression of the epithelial-mesenchymal transition (EMT) signaling pathway is correlated with ns-CAPJ's inhibitory effect on GBM cell invasion and migration.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Review
Cell Biology
Supat Chupradit, Gunawan Widjaja, Basman Radhi Majeed, Maria Kuznetsova, Mohammad Javed Ansari, Wanich Suksatan, Abduladheem Turki Jalil, Bahar Ghazi Esfahani
Summary: The development of cold atmospheric plasma (CAP) devices, rich in reactive species, has shown potential as a revolutionary platform for breast cancer therapy. However, current CAP-based therapeutic systems face limitations and challenges. This review discusses the latest developments in CAP-based therapeutic systems for breast cancer treatment and explores the integration with other treatment methods.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Benedikt Eggers, Anna-Maria Wagenheim, Susanne Jung, Johannes Kleinheinz, Marjan Nokhbehsaim, Franz-Josef Kramer, Sonja Sielker
Summary: Cold atmospheric plasma (CAP) has been found to have a stimulating effect on human calvaria osteoblasts (HCO) and may represent a potential therapeutic approach in the regeneration of hard tissue defects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Juan Tornin, Borja Gallego, Veronica Rey, Dzohara Murillo, Carmen Huergo, Aida Rodriguez, Cristina Canal, Rene Rodriguez
Summary: This study reveals the potential of Cold Plasma Treated Medium (PTM) in preventing doxorubicin (DX) resistance in osteosarcoma (OS). PTM treatment increases oxidative stress levels in DX-resistant cells and sensitizes them to DX.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Yuanbao Zhang, Yiqun Mo, Jiali Yuan, Yue Zhang, Luke Mo, Qunwei Zhang
Summary: Nano-CuO exposure led to increased ROS generation, MAPKs activation, and MMP-3 upregulation in BEAS-2B cells, resulting in EMT. The effects were mediated through the Nano-CuO-induced dysregulation of the ROS/MAPKs/MMP-3 pathway.
Article
Chemistry, Medicinal
Zhonglei He, Clara Charleton, Robert W. Devine, Mark Kelada, John M. D. Walsh, Gillian E. Conway, Sebnem Gunes, Julie Rose Mae Mondala, Furong Tian, Brijesh Tiwari, Gemma K. Kinsella, Renee Malone, Denis O'Shea, Michael Devereux, Wenxin Wang, Patrick J. Cullen, John C. Stephens, James F. Curtin
Summary: Pyrazolopyrimidinones are core scaffold in many pharmaceutically relevant compounds and have been demonstrated to be efficient in treating several diseases. This study tested the cytotoxic effects of 15 pyrazolopyrimidinones in combination with cold atmospheric plasma (CAP) on glioblastoma U-251MG cell line, and identified two drugs with enhanced cytotoxicity when combined with CAP. These findings suggest the potential of using CAP combined with pyrazolopyrimidinones as a programmable cytotoxic therapy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Food Science & Technology
Roberta Foligni, Cinzia Mannozzi, Lama Ismaiel, Filippo Capelli, Romolo Laurita, Silvia Tappi, Marco Dalla Rosa, Massimo Mozzon
Summary: Cold atmospheric plasma (CAP) is a non-thermal technology that can be used for food decontamination by producing reactive species (RS), but it may also promote food lipid oxidation. This study evaluated the oxidation degree of pistachio kernels after CAP treatment and found that the plasma treatment did not significantly affect the fatty acid composition, but led to an unexpected increase in γ-tocopherol content.
Article
Medicine, Research & Experimental
Peiyu Wang, Renwu Zhou, Rusen Zhou, Wenshao Li, Janith Weerasinghe, Shuxiong Chen, Bernd H. A. Rehm, Liqian Zhao, Francesca D. Frentiu, Zhifa Zhang, Kexin Yan, Mary Lor, Andreas Suhrbier, Derek J. Richard, Erik W. Thompson, Kostya Ken Ostrikov, Xiaofeng Dai
Summary: Cold atmospheric plasma (CAP) can effectively inhibit the entry of SARS-CoV-2 into cells and induce nuclear translocation of the virus receptor ACE2. This study provides support for the development of products utilizing CAP to prevent viruses like SARS-CoV-2.
Review
Biochemistry & Molecular Biology
Ahmed Yaseen Alqutaibi, Abdulbari Aljohani, Abdullah Alduri, Abdulmajid Masoudi, Anas M. Alsaedi, Hesham Mohammed Al-Sharani, Ahmed E. Farghal, Ahmad Abdulkareem Alnazzawi, Afaf Noman Aboalrejal, Abdel-Aleam H. Mohamed, Muhammad Sohail Zafar
Summary: This systematic review examines the bactericidal properties of cold atmospheric plasma (CAP) when used on various dental implant surfaces. The review found that CAP effectively reduces bacterial loads and combats biofilm and plaque formation on implant surfaces, leading to improved outcomes for implant patients.
Review
Pharmacology & Pharmacy
Sara Lovisa
Summary: EMT, a process crucial in wound healing, fibrosis, and cancer, has gained significant attention from researchers since its discovery in the seventies. Despite advances in understanding its functional role, targeting EMT in fibrotic diseases remains a challenge at an early stage of development.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Tianhao Min, Xin Xie, Kaijie Ren, Tuanhe Sun, Haonan Wang, Chengxue Dang, Hao Zhang
Summary: This article presents a narrative review on the therapeutic effects and killing mechanism of cold atmospheric plasma (CAP) on solid tumors. The effects of CAP on tumor cells, tumor microenvironment, and the immune system are discussed, along with proposed therapeutic schemes and research directions.
FRONTIERS IN MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Jack Turicek, Nicole Ratts, Matey Kaltchev, Nazieh Masoud
Summary: Treatment of UHMWPE with a tubular helium cold atmospheric pressure plasma source resulted in significant improvements in wear resistance, lubrication, and adhesion properties, making the polymer surface more suitable for use in artificial joints.
APPLIED SCIENCES-BASEL
(2021)
Article
Immunology
Sarthak Sahoo, Sonali Priyadarshini Nayak, Kishore Hari, Prithu Purkait, Susmita Mandal, Akash Kishore, Herbert Levine, Mohit Kumar Jolly
Summary: Recent research shows that cells with hybrid epithelial/mesenchymal characteristics can have high levels of PD-L1, important for immune evasion, without needing to fully undergo epithelial-mesenchymal transition. This cellular state in breast cancer is associated with resistance to anti-estrogen therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemical Research Methods
Fang Wang, Chang Li, Ruotong Zhang, Yuan Liu, Haisong Lin, Lang Nan, Muhammad Ajmal Khan, Yang Xiao, Ho Cheung Shum, Hui Deng
Summary: Cold atmospheric plasma chip enables targeted and multi-dosage treatment of multiple cell lines in a single session. This innovative approach provides a new tool for investigating the mechanisms of plasma-induced anticancer effects and guiding clinical applications.
Article
Immunology
Arutha Kulasinghe, Ning Liu, Chin Wee Tan, James Monkman, Jane E. Sinclair, Dharmesh D. Bhuva, David Godbolt, Liuliu Pan, Andy Nam, Habib Sadeghirad, Kei Sato, Gianluigi Li Bassi, Ken O'Byrne, Camila Hartmann, Anna Flavia Ribeiro Dos Santos Miggiolaro, Gustavo Lenci Marques, Lidia Zytynski Moura, Derek Richard, Mark Adams, Lucia de Noronha, Cristina Pellegrino Baena, Jacky Y. Suen, Rakesh Arora, Gabrielle T. Belz, Kirsty R. Short, Melissa J. Davis, Fernando Souza-Fonseca Guimaraes, John F. Fraser
Summary: The study reveals distinct transcriptomic profiles in cardiac tissues of SARS-CoV-2 and pH1N1 influenza infection, with upregulation of genes associated with DNA damage and repair, heat shock, and macrophage infiltration in COVID-19 patients' cardiac tissues. In comparison, pH1N1 infection showed upregulation of interferon and complement pathways. This highlights the need for further understanding of the effects on extra-pulmonary organs, including the cardiovascular system, in COVID-19 patients.
Article
Endocrinology & Metabolism
Mark N. Adams, Laura V. Croft, Aaron Urquhart, Mohamed Ashick Mohamed Saleem, Anja Rockstroh, Pascal H. G. Duijf, Patrick B. Thomas, Genevieve P. Ferguson, Idris Mohd Najib, Esha T. T. Shah, Emma Bolderson, Shivashankar Nagaraj, Elizabeth D. Williams, Colleen C. Nelson, Kenneth J. O'Byrne, Derek J. Richard
Summary: This study evaluated the role of hSSB1/NABP2 in modulating the cellular response to androgens and ionizing radiation in prostate cancer. The expression of hSSB1 in prostate cancer is correlated with genomic instability and it regulates pathways involved in cell cycle progression and transcription. Additionally, hSSB1 is involved in modulating androgen response through transcriptional regulation. Exploiting hSSB1 in prostate cancer treatment might improve patient outcomes in ADT and/or radiotherapy.
Article
Multidisciplinary Sciences
Sharaj Kunjar, Ariana Strandburg-Peshkin, Helge Giese, Pranav Minasandra, Sumantra Sarkar, Mohit Kumar Jolly, Nico Gradwohl
Summary: Consensus decision-making in social groups is influenced by communication links that determine information exchange. This study shows that strategically adjusting communication links can bias group-level outcomes and help achieve consensus, but strong preferences can lead to non-consensus outcomes.
ROYAL SOCIETY OPEN SCIENCE
(2023)
Article
Oncology
Viola Hedrich, Kristina Breitenecker, Gregor Ortmayr, Franziska Pupp, Heidemarie Huber, Doris Chen, Sarthak Sahoo, Mohit Kumar Jolly, Wolfgang Mikulits
Summary: This study identified PRAME as a target gene of the Gas6/Axl signaling pathway in hepatocellular carcinoma. PRAME promotes dedifferentiation, epithelial-to-mesenchymal transition, and invasion in liver cancer cells. The expression of PRAME is associated with an unfavorable prognosis in HCC patients.
Review
Chemistry, Multidisciplinary
Seemadri Subhadarshini, Joel Markus, Sarthak Sahoo, Mohit Kumar Jolly
Summary: Epithelial-mesenchymal plasticity (EMP) is a crucial factor in cancer metastasis and therapeutic resistance, allowing cancer cells to alter their characteristics along the epithelial-mesenchymal spectrum. Single-cell studies have provided valuable insights into the dynamics of EMP, showing the heterogeneity of hybrid epithelial/mesenchymal phenotypes and their impact on patient survival.
Article
Biotechnology & Applied Microbiology
Shengfang Wang, Peiyu Wang, Rik Thompson, Kostya Ostrikov (Ken), Yin Xiao, Yinghong Zhou
Summary: PAM can reduce the inflammatory response of macrophages by activating autophagy and promote the regeneration of periodontal tissues, making it an ideal choice for periodontitis treatment.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Ming Tang, Joshua T. Burgess, Mark Fisher, Didier Boucher, Emma Bolderson, Neha S. Gandhi, Kenneth J. O'Byrne, Derek J. Richard, Amila Suraweera
Summary: This study aimed to explore the binding pose of COMMD4-H2B and develop a H2B peptide that disrupts the COMMD4-H2B interaction, which could serve as a potential therapeutic target for non-small cell lung cancer (NSCLC).
BRITISH JOURNAL OF CANCER
(2023)
Article
Mathematical & Computational Biology
Kishore Hari, William Duncan, Mohammed Adil Ibrahim, Mohit Kumar Jolly, Breschine Cummins, Tomas Gedeon
Summary: Mathematical modeling of gene regulatory networks (GRN) is challenging due to parameter dependence and lack of reliable experimental parameters. This study compares two approaches, RACIPE and DSGRN, for describing GRN dynamics across unknown parameters and finds agreement in simulation and predictions for cellular decision making. The observation is important as DSGRN parameter domains accurately predict ODE model dynamics within a biologically reasonable range of parameters.
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2023)
Article
Materials Science, Multidisciplinary
Liangping Xiao, Rusen Zhou, Tianqi Zhang, Xiaoxiang Wang, Renwu Zhou, Patrick J. Cullen, Kostya (Ken) Ostrikov
Summary: Inspired by biological photosynthesis, developing effective strategies to up-cycle anthropogenic carbon dioxide (CO2) into high-value organics is crucial. In this study, mesoporous indium supported on multi-walled carbon nanotubes (mp-In@MWCNTs) was synthesized via a facile wet chemical method and exhibited high performance in electrochemical CO2 reduction reaction (CO2RR) for formate production. The unique structures of mp-In@MWCNTs with mesoporous surfaces and a conductive network were found to promote both adsorption and desorption of reactants and intermediates, improving electron transfer and leading to outstanding CO2RR performance.
ENERGY & ENVIRONMENTAL MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Jinyong Lin, Dong Li, Changhong Li, Ziqi Zhuang, Chengchao Chu, Kostya (Ken) Ostrikov, Erik W. W. Thompson, Gang Liu, Peiyu Wang
Summary: Cancer cells are more susceptible to oxidative stress and nanomaterials-based therapies that generate reactive oxygen species (ROS) have been effective in eliminating cancer cells. These therapies, including chemodynamic therapy, photodynamic therapy, sonodynamic therapy, as well as multi-modal therapies such as combination therapy, have shown significant inhibition of tumor growth. However, the limitations of multi-modal therapy in material preparation and operation protocols hinder its clinical application. Cold atmospheric plasma (CAP), as a reliable source of ROS, light, and electromagnetic fields, provides a simple alternative for implementing multi-modal treatments. Therefore, the emerging field of tumor precision medicine is expected to benefit from these promising multi-modal therapies based on ROS-generating nanomaterials and reactive media like CAPs.
Article
Oncology
Manas Sehgal, Soundharya Ramu, Joel Markus Vaz, Yogheshwer Raja Ganapathy, Srinath Muralidharan, Sankalpa Venkatraghavan, Mohit Kumar Jolly
Summary: This study investigates the relationship between gene expression patterns and phenotypic plasticity and heterogeneity in colorectal cancer (CRC). The results demonstrate the interconnectedness between different Consensus Molecular Subtypes (CMS) of CRC and specific phenotypes such as epithelial and mesenchymal characteristics. Additionally, the study reveals correlations between metabolic pathways and phenotypic scores, as well as between PD-L1 activity and mesenchymal phenotype. Single-cell RNA sequencing analysis further confirms the heterogeneity of different CMS subtypes. These findings have important implications for understanding CRC heterogeneity and developing targeted therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Chemistry, Physical
Ming Tang, Amila Suraweera, Xuqiang Nie, Zilin Li, Pinglin Lai, James W. Wells, Kenneth J. O'Byrne, Robert J. Woods, Emma Bolderson, Derek J. Richard
Summary: In this study, the atomic-level mechanisms of Banf1-DNA binding and the effects of mono- and di-phosphorylation on Banf1's DNA-binding capability were explored using molecular modelling and dynamics simulations. It was found that mono-phosphorylation induces changes in Banf1's secondary structure, leading to the elimination of its DNA-binding capability. The study also demonstrated that phosphorylated Banf1 binds to DNA with lower affinity and less stable binding poses. These findings have implications for predicting the effects of Banf1 mutations on its DNA-binding capability and potential development of therapeutic drugs targeting cell proliferation.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Multidisciplinary Sciences
Thais Sobanski, Amila Suraweera, Joshua T. Burgess, Iain Richard, Chee Man Cheong, Keyur Dave, Maddison Rose, Mark N. Adams, Kenneth J. O'Byrne, Derek J. Richard, Emma Bolderson
Summary: This study reveals that the glycolytic protein ALDOA plays a direct role in DNA double-strand break (DSB) repair. Upon DNA damage, ALDOA translocates into the nucleus and associates with the DNA DSB marker γ-H2AX. Depletion of ALDOA leads to increased DNA damage before and slower repair after ionising radiation. It is suggested that targeting ALDOA may be a potential strategy for simultaneous disruption of cancer metabolism and DNA repair.
SCIENTIFIC REPORTS
(2023)
Review
Chemistry, Physical
Rusen Zhou, Yadong Zhao, Renwu Zhou, Tianqi Zhang, Patrick Cullen, Yao Zheng, Liming Dai, Kostya (Ken) Ostrikov
Summary: This review explores the use of plasma techniques for up-carbonization, a process that converts low-value, renewable, carbon-rich resources into high-value forms. It discusses the advantages of discharge plasmas in creating intense and reactive environments for efficient conversion, and highlights the potential for integrating plasma-based processes with renewable electricity. The review also identifies the current challenges and research needs in this field.