Optimal Immunosuppression Strategy in the Sensitized Kidney Transplant Recipient

OPTN/SRTR 2019 Annual Data Report: Kidney

(2021) A. Hart et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Functional Characteristics and Phenotypic Plasticity of CD57+PD1− CD4 T Cells and Their Relationship with Transplant Immunosuppression

(2021) Brian I. Shaw et al.   JOURNAL OF IMMUNOLOGY

Outcomes of induction antibody therapies in the nonbroadly sensitized adult deceased donor kidney transplant recipients: a retrospective cohort registry analysis

(2020) Alfonso H. Santos et al.   TRANSPLANT INTERNATIONAL

The Preliminary Results of Bortezomib Used as A Primary Treatment for An Early Acute Antibody-Mediated Rejection after Kidney Transplantation—A Single-Center Case Series

(2020) Aureliusz Kolonko et al.   Journal of Clinical Medicine

Reversing donor‐specific antibody responses and antibody‐mediated rejection with bortezomib and belatacept in mice and kidney transplant recipients

(2020) Dharmendra Jain et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Low-dose alemtuzumab induction in a tailored immunosuppression protocol for sensitized kidney transplant recipients

(2020) Martina Guthoff et al.   BMC Nephrology

Kidney transplantation using alemtuzumab, belatacept, and sirolimus: Five‐year follow‐up

(2020) Robin Schmitz et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Conversion from calcineurin inhibitors to belatacept in HLA- sensitized kidney-transplant recipients with low-level donor specific antibodies.

(2019) Camilo E. Ulloa et al.   TRANSPLANTATION

Increased risk of rejection after basiliximab induction in sensitized kidney transplant recipients without pre‐existing donor‐specific antibodies ‐ a retrospective study

(2019) Annabelle Goumard et al.   TRANSPLANT INTERNATIONAL

Desensitization and treatment with APRIL/BLyS blockade in rodent kidney transplant model

(2019) Natalie M. Bath et al.   PLoS One

Allocation of the Highest Quality Kidneys and Transplant Outcomes Under the New Kidney Allocation System

(2019) Supreet Sethi et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Post‐transplant lymphoproliferative disorders, Epstein‐Barr virus infection, and disease in solid organ transplantation: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice

(2019) Upton D. Allen et al.   CLINICAL TRANSPLANTATION

The past, present, and future of costimulation blockade in organ transplantation

(2019) Paul M. Schroder et al.   Current Opinion in Organ Transplantation

Bortezomib Eliminates Plasma Cells From a Renal Graft in Plasma Cell–Rich Acute Rejection

(2019) Masayuki Tasaki et al.   TRANSPLANTATION PROCEEDINGS

B-Cell Activating Factor Predicts Acute Rejection Risk in Kidney Transplant Recipients: A 6-Month Follow-Up Study

(2019) Xu-Zhen Wang et al.   Frontiers in Immunology

Efficacy and safety of bleselumab in kidney transplant recipients: A phase 2, randomized, open‐label, noninferiority study

(2019) Robert C. Harland et al.   AMERICAN JOURNAL OF TRANSPLANTATION

A Prospective, Iterative, Adaptive Trial of Carfilzomib‐Based Desensitization

(2019) Simon Tremblay et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Outcomes of Conversion from Calcineurin Inhibitor to Belatacept-Based Immunosuppression in HLA Sensitized Kidney Transplant Recipients

(2019) Supreet Sethi et al.   TRANSPLANTATION

Impact of Tocilizumab (Anti-IL-6R) Treatment on Immunoglobulins and Anti-HLA Antibodies in Kidney Transplant Patients with Chronic Antibody-Mediated Rejection

(2019) Bong-Ha Shin et al.   TRANSPLANTATION

Effects of immunotherapy induction on outcome and graft survival of kidney-transplanted patients with different immunological risk of rejection

(2019) Marcus Faria Lasmar et al.   BMC Nephrology

The impact of belatacept on third‐party HLA alloantibodies in highly sensitized kidney transplant recipients

(2019) Ronald F. Parsons et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Managing highly sensitized renal transplant candidates in the era of kidney paired donation and the new kidney allocation system: Is there still a role for desensitization?

(2019) Carrie A. Schinstock et al.   CLINICAL TRANSPLANTATION

T follicular helper and memory cell responses and the mTOR pathway in murine heart transplantation

(2019) Aini Xie et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Pretransplant Desensitization with Costimulation Blockade and Proteasome Inhibitor Reduces DSA and Delays Antibody-Mediated Rejection in Highly Sensitized Nonhuman Primate Kidney Transplant Recipients

(2019) Brian Ezekian et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Autoantibody production significantly decreased with APRIL/BLyS blockade in murine chronic rejection kidney transplant model

(2019) Natalie M. Bath et al.   PLoS One

USE OF DE-NOVO mTOR INHIBITORS IN HYPERSENSITZED KIDNEY TRASPLANT RECIPIENTS

(2019) David Cucchiari et al.   TRANSPLANTATION

First‐in‐human clinical trial to assess pharmacokinetics, pharmacodynamics, safety, and tolerability of iscalimab, an anti‐CD40 monoclonal antibody

(2019) Pascal Espié et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Anti-BAFF Treatment Interferes With Humoral Responses in a Model of Renal Transplantation in Rats

(2019) Louisa Steines et al.   TRANSPLANTATION

Induction Therapy With ATG Compared With Anti-IL2 Basiliximab in Low–Immunologic Risk Kidney Transplant Recipients

(2019) Ivana Dedinská et al.   TRANSPLANTATION PROCEEDINGS

The first 9 years of kidney paired donation through the National Kidney Registry: Characteristics of donors and recipients compared with National Live Donor Transplant Registries

(2018) Stuart M. Flechner et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Characterization of the in vitro and in vivo properties of CFZ533, a blocking and non-depleting anti-CD40 monoclonal antibody

(2018) Jacinda Ristov et al.   AMERICAN JOURNAL OF TRANSPLANTATION

RD-05, a novel anti-CD154 antibody, efficiently inhibits generation of anti-drug antibody without the risk of thrombus formation in non-human primates

(2018) Jae-Il Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Durable renal response after combination of bortezomib, corticosteroids, rituximab, and plasmapheresis for late antibody-mediated renal transplant rejection


(2018) Yanli Ding et al.   CLINICAL NEPHROLOGY

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(2018)   Experimental and Clinical Transplantation

Induction regimen and survival in simultaneous heart-kidney transplant recipients

(2018) Venkatesh K. Ariyamuthu et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Belimumab in kidney transplantation: an experimental medicine, randomised, placebo-controlled phase 2 trial

(2018) Gemma D Banham et al.   LANCET

B-cell activating factor, a predictor of antibody mediated rejection in kidney transplantation recipients

(2018) Wannarat Pongpirul et al.   NEPHROLOGY

Pretransplant serum BAFF levels are associated with pretransplant HLA immunization and renal allograft survival

(2018) Justa Friebus-Kardash et al.   TRANSPLANT IMMUNOLOGY

Graft immunologic events in deceased donor kidney transplant recipients with preformed HLA-donor specific antibodies

(2018) Xicohténcatl Ixtlapale-Carmona et al.   TRANSPLANT IMMUNOLOGY

Intravenous Immunoglobulin and Rituximab in HLA Highly Sensitized Kidney Transplant Recipients

(2018) S. Querido et al.   TRANSPLANTATION PROCEEDINGS

CD4+ T Cell Help Is Mandatory for Naive and Memory Donor-Specific Antibody Responses: Impact of Therapeutic Immunosuppression

(2018) Chien-Chia Chen et al.   Frontiers in Immunology

T Cell Repertoire Maturation Induced by Persistent and Latent Viral Infection Is Insufficient to Induce Costimulation Blockade Resistant Organ Allograft Rejection in Mice

(2018) Jaclyn R. Espinosa et al.   Frontiers in Immunology

Dual targeting: Combining costimulation blockade and bortezomib to permit kidney transplantation in sensitized recipients

(2018) Christopher K. Burghuber et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Belatacept in renal transplant recipient with mild immunologic risk factor: A pilot prospective study (BELACOR)

(2018) Claire Leibler et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Donor IL-6 deficiency evidently reduces memory T cell responses in sensitized transplant recipients

(2018) Juntao Chen et al.   TRANSPLANT IMMUNOLOGY

Inhibition of Membrane-Bound BAFF by the Anti-BAFF Antibody Belimumab

(2018) Christine Kowalczyk-Quintas et al.   Frontiers in Immunology

Safety, pharmacokinetics and pharmacodynamics of single rising doses of BI 655064, an antagonistic anti-CD40 antibody in healthy subjects: a potential novel treatment for autoimmune diseases

(2017) Fredrik N. Albach et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

A Randomized Trial of Bortezomib in Late Antibody-Mediated Kidney Transplant Rejection

(2017) Farsad Eskandary et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Characteristics of donor-specific anti-HLA antibodies and outcome in renal transplant patients treated with a standardized induction regimen

(2017) Daniel Zecher et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

B-cell activating factor BAFF reflects patients' immunological risk profile after kidney transplantation

(2017) A. Schuster et al.   TRANSPLANT IMMUNOLOGY

Center practice drives variation in choice of US kidney transplant induction therapy: a retrospective analysis of contemporary practice

(2017) Vikas R. Dharnidharka et al.   TRANSPLANT INTERNATIONAL

Interleukin-6, A Cytokine Critical to Mediation of Inflammation, Autoimmunity and Allograft Rejection

(2017) Stanley C. Jordan et al.   TRANSPLANTATION

Safety and Efficacy of Alemtuzumab Induction in Highly Sensitized Pediatric Renal Transplant Recipients

(2017) Irene K. Kim et al.   TRANSPLANTATION

Preoperative application of combination of portal venous injection of donor spleen cells and intraperitoneal injection of rapamycin prolongs the survival of cardiac allografts in mice

(2017) Wen-lin Gong et al.   Asian Pacific Journal of Tropical Medicine

Effect of Treatment With Tabalumab, a B Cell-Activating Factor Inhibitor, on Highly Sensitized Patients With End-Stage Renal Disease Awaiting Transplantation

(2016) M. A. Mujtaba et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Antibody-Mediated Rejection in Sensitized Nonhuman Primates: Modeling Human Biology

(2016) C. K. Burghuber et al.   AMERICAN JOURNAL OF TRANSPLANTATION

CD57+CD4 T Cells Underlie Belatacept-Resistant Allograft Rejection

(2016) J. Espinosa et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Induction Therapy for Kidney Transplant Recipients: Do We Still Need Anti-IL2 Receptor Monoclonal Antibodies?

(2016) R. Hellemans et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Clinically-relevant threshold of preformed donor-specific anti-HLA antibodies in kidney transplantation

(2016) Igor Salvadé et al.   HUMAN IMMUNOLOGY

Proliferation Signal Inhibitors Prevent Donor-Specific Antibody Production in Sensitized Patients after Heart Transplantation

(2016) M. Kittleson et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Six-year outcomes in broadly HLA-sensitized living donor transplant recipients desensitized with intravenous immunoglobulin and rituximab

(2016) Joseph Kahwaji et al.   TRANSPLANT INTERNATIONAL

Neutralizing BAFF/APRIL With Atacicept Prevents Early DSA Formation and AMR Development in T Cell Depletion Induced Nonhuman Primate AMR Model

(2015) J. Kwun et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Daclizumab Versus Rabbit Antithymocyte Globulin in High-Risk Renal Transplants: Five-Year Follow-up of a Randomized Study

(2015) R. Hellemans et al.   AMERICAN JOURNAL OF TRANSPLANTATION

A Novel, Blocking, Fc-Silent Anti-CD40 Monoclonal Antibody Prolongs Nonhuman Primate Renal Allograft Survival in the Absence of B Cell Depletion

(2015) F. Cordoba et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Safe Conversion From Tacrolimus to Belatacept in High Immunologic Risk Kidney Transplant Recipients With Allograft Dysfunction

(2015) G. Gupta et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The IL-6/gp130/STAT3 signaling axis: recent advances towards specific inhibition

(2015) Christoph Garbers et al.   CURRENT OPINION IN IMMUNOLOGY

Combined Induction Therapy with Rabbit Antithymocyte Globulin and Rituximab in Highly Sensitized Renal Recipients

(2015) Mark Reza Laftavi et al.   IMMUNOLOGICAL INVESTIGATIONS

Cutting Edge: Circulating Plasmablasts Induce the Differentiation of Human T Follicular Helper Cells via IL-6 Production

(2015) Konstantia-Maria Chavele et al.   JOURNAL OF IMMUNOLOGY

A closer look at rituximab induction on HLA antibody rebound following HLA-incompatible kidney transplantation

(2015) Annette M. Jackson et al.   KIDNEY INTERNATIONAL

Analysis of preformed donor-specific anti-HLA antibodies characteristics for prediction of antibody-mediated rejection in kidney transplantation

(2015) Jorge Malheiro et al.   TRANSPLANT IMMUNOLOGY

Rabbit antithymocyte globulin induction and risk of post-transplant lymphoproliferative disease in adult and pediatric solid organ transplantation: An update

(2015) Alexandre Hertig et al.   TRANSPLANT IMMUNOLOGY

Does belatacept improve outcomes for kidney transplant recipients? A systematic review

(2015) Nishanthi Talawila et al.   TRANSPLANT INTERNATIONAL

Association of Antibody Induction Immunosuppression With Cancer After Kidney Transplantation

(2015) Erin C. Hall et al.   TRANSPLANTATION

Differential Effects of Tacrolimus versus Sirolimus on the Proliferation, Activation and Differentiation of Human B Cells

(2015) Opas Traitanon et al.   PLoS One

New National Allocation Policy for Deceased Donor Kidneys in the United States and Possible Effect on Patient Outcomes

(2014) A. K. Israni et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Antithymocyte Globulin Is Associated With a Lower Incidence of De Novo Donor-Specific Antibodies in Moderately Sensitized Renal Transplant Recipients

(2014) Marissa M. Brokhof et al.   TRANSPLANTATION

A Phase 1, Randomized Ascending Single-Dose Study of Antagonist Anti-Human CD40 ASKP1240 in Healthy Subjects

(2013) R. Goldwater et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Costimulation Blockade Alters Germinal Center Responses and Prevents Antibody-Mediated Rejection

(2013) E. J. Kim et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Impact of alloantibody strength in crossmatch negative DSA positive kidney transplantation

(2013) Pingping Wu et al.   CLINICAL BIOCHEMISTRY

Elevated Pretransplantation Soluble BAFF Is Associated With an Increased Risk of Acute Antibody-Mediated Rejection

(2013) Gemma Banham et al.   TRANSPLANTATION

Proteasome Inhibition Profoundly Affects Activated Human B Cells

(2013) Arend Mulder et al.   TRANSPLANTATION

Peripheral B-Cell Phenotype and BAFF Levels are Associated With HLA Immunization in Patients Awaiting Kidney Transplantation

(2013) Renaud Snanoudj et al.   TRANSPLANTATION

Belimumab reduces autoantibodies, normalizes low complement levels, and reduces select B cell populations in patients with systemic lupus erythematosus

(2012) William Stohl et al.   ARTHRITIS AND RHEUMATISM

IL-2 Requirement for Human Plasma Cell Generation: Coupling Differentiation and Proliferation by Enhancing MAPK-ERK Signaling

(2012) S. Le Gallou et al.   JOURNAL OF IMMUNOLOGY

Living donor kidney transplantation in crossmatch-positive patients enabled by peritransplant immunoadsorption and anti-CD20 therapy

(2012) Christian Morath et al.   TRANSPLANT INTERNATIONAL

Effects of sotrastaurin, mycophenolic acid and everolimus on human B-lymphocyte function and activation

(2012) Mareen Matz et al.   TRANSPLANT INTERNATIONAL

Increased Infection Rate After Preemptive Rituximab Treatment for Epstein-Barr Virus Reactivation After Allogeneic Hematopoietic Stem-Cell Transplantation

(2012) Anna D. Petropoulou et al.   TRANSPLANTATION

The Use of Bortezomib as a Rescue Treatment for Acute Antibody-Mediated Rejection: Report of Three Cases and Review of Literature

(2012) I. Tzvetanov et al.   TRANSPLANTATION PROCEEDINGS

Induction immunosuppressive therapies in renal transplantation

(2011) S. Gabardi et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Three-Year Outcomes from BENEFIT, a Randomized, Active-Controlled, Parallel-Group Study in Adult Kidney Transplant Recipients

(2011) F. Vincenti et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Targeting B Cells and Antibody in Transplantation

(2011) M. R. Clatworthy   AMERICAN JOURNAL OF TRANSPLANTATION

Proteasome inhibition with bortezomib: an effective therapy for severe antibody mediated rejection after renal transplantation

(2011) Kalathil K. Sureshkumar et al.   CLINICAL NEPHROLOGY

Proteasome inhibitor treatment of antibody-mediated allograft rejection

(2011) E. Steve Woodle et al.   Current Opinion in Organ Transplantation

Alemtuzumab Induction in Renal Transplantation

(2011) Michael J. Hanaway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prolonged lymphocyte depletion by single-dose rabbit anti-thymocyte globulin and alemtuzumab in kidney transplantation

(2011) Junichiro Sageshima et al.   TRANSPLANT IMMUNOLOGY

Early and Late Acute Antibody-Mediated Rejection Differ Immunologically and in Response to Proteasome Inhibition

(2011) R. Carlin Walsh et al.   TRANSPLANTATION

Posttransplantation Lymphoproliferative Disorder in Kidney and Heart Transplant Recipients Receiving Thymoglobulin: A Systematic Review

(2011) W.H. Marks et al.   TRANSPLANTATION PROCEEDINGS

Immunosuppression with Belatacept-Based, Corticosteroid-Avoiding Regimens in De Novo Kidney Transplant Recipients

(2010) R. Ferguson et al.   AMERICAN JOURNAL OF TRANSPLANTATION

A Phase III Study of Belatacept Versus Cyclosporine in Kidney Transplants from Extended Criteria Donors (BENEFIT-EXT Study)

(2010) A. Durrbach et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Baseline Donor-Specific Antibody Levels and Outcomes in Positive Crossmatch Kidney Transplantation

(2010) J. M. Gloor et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Peritransplant Immunoadsorption for Positive Crossmatch Deceased Donor Kidney Transplantation

(2010) G. Bartel et al.   AMERICAN JOURNAL OF TRANSPLANTATION

A Phase III Study of Belatacept-based Immunosuppression Regimens versus Cyclosporine in Renal Transplant Recipients (BENEFIT Study)

(2010) F. Vincenti et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Switching from Calcineurin Inhibitor-based Regimens to a Belatacept-based Regimen in Renal Transplant Recipients: A Randomized Phase II Study

(2010) L. Rostaing et al.   Clinical Journal of the American Society of Nephrology

IL-6: Regulator of Treg/Th17 balance

(2010) Akihiro Kimura et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Preexisting Donor-Specific HLA Antibodies Predict Outcome in Kidney Transplantation

(2010) C. Lefaucheur et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Double Filtration Plasmapheresis in Antibody-Incompatible Kidney Transplantation

(2010) Rob Higgins et al.   THERAPEUTIC APHERESIS AND DIALYSIS

Preferential increase in memory and regulatory subsets during T-lymphocyte immune reconstitution after Thymoglobulin induction therapy with maintenance sirolimus vs cyclosporine

(2010) Emmanuel Morelon et al.   TRANSPLANT IMMUNOLOGY

Combined Posttransplant Prophylactic IVIg/Anti-CD 20/Plasmapheresis in Kidney Recipients With Preformed Donor-Specific Antibodies: A Pilot Study

(2010) Alexandre Loupy et al.   TRANSPLANTATION

Proteasome Inhibitor-Based Primary Therapy for Antibody-Mediated Renal Allograft Rejection

(2010) R Carlin Walsh et al.   TRANSPLANTATION

Positive Cross-Match Living Donor Kidney Transplantation: Longer-Term Outcomes

(2009) A. Haririan et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Outcome of Subclinical Antibody-Mediated Rejection in Kidney Transplant Recipients with Preformed Donor-Specific Antibodies

(2009) A. Loupy et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Calcineurin inhibitors affect B cell antibody responses indirectly by interfering with T cell help

(2009) S. Heidt et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Molecular mechanism and function of CD40/CD40L engagement in the immune system

(2009) Raul Elgueta et al.   IMMUNOLOGICAL REVIEWS

Daclizumab versus Antithymocyte Globulin in High-Immunological-Risk Renal Transplant Recipients

(2009) C. Noel et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

KDIGO clinical practice guideline for the care of kidney transplant recipients: a summary

(2009) Bertram L. Kasiske et al.   KIDNEY INTERNATIONAL

Alemtuzumab (CAMPATH-1H) for the Treatment of Acute Rejection in Kidney Transplant Recipients: Long-Term Follow-Up

(2009) Menna R. Clatworthy et al.   TRANSPLANTATION

Long-Term Results of Rabbit Antithymocyte Globulin and Basiliximab Induction

(2008) Daniel C. Brennan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rituximab and Intravenous Immune Globulin for Desensitization during Renal Transplantation

(2008) Ashley A. Vo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bortezomib Provides Effective Therapy for Antibody- and Cell-Mediated Acute Rejection

(2008) Matthew J. Everly et al.   TRANSPLANTATION