Article
Oncology
Hsiao-Yun Lu, Yi-Jou Tai, Yu-Li Chen, Ying-Cheng Chiang, Heng-Cheng Hsu, Wen-Fang Cheng
Summary: The study developed an ovarian cancer risk score (OVRS) based on the expression of 10 ovarian-cancer-related genes to predict chemoresistance and outcomes in EOC patients. Results showed that patients with OVRS >= 10 had significantly shorter disease-free survival (DFS) and overall survival (OS), and were more likely to be chemoresistant. The high OVRS group also had shorter median OS in patients from the TCGA database.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shikang Liu, Yihang Jiang, Hua Yang, Zhongke Hua, Yu Han, Cai Zhou, Shuling Xu, Shenglan Nie, Gaixia Xu, Xingsheng Shu, Xiaomei Wang
Summary: Colorectal cancer stem cells present challenges in treatment, but the EHMT-2 inhibitor BIX-01294 effectively inhibits their proliferation, with a synergistic therapeutic effect when combined with 5-fluorouracil.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Oncology
Weiwei Xie, Huizhen Sun, Xiaoduan Li, Feikai Lin, Ziliang Wang, Xipeng Wang
Summary: Ovarian cancer is associated with activation of oncogenes and inactivation of tumor suppressor genes, with epigenetic processes playing a key role in tumorigenesis. MicroRNA and long non-coding RNA are promising molecular markers for precision medicine in OC. Clinical application of epigenetic approaches is currently limited by hurdles such as heterogeneity of OC and insufficient sample sizes, but holds promise for future clinical investigation into diagnosis, treatment, and prognosis.
CANCER CELL INTERNATIONAL
(2021)
Review
Endocrinology & Metabolism
Yu Wang, Zhao Huang, Bowen Li, Lin Liu, Canhua Huang
Summary: This article reviews the epigenetic regulation of ovarian cancer drug resistance and highlights the important role of epigenetic modifications, including upregulation of multidrug resistance proteins, remodeling of the tumor microenvironment, and deregulated immune response, in drug resistance of ovarian cancer. A better understanding of these mechanisms may improve outcomes for ovarian cancer patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yajie Shi, Yuanguang Chen, Lu Chen, Jianwen Sun, Guoliang Chen
Summary: A synthetic route to BIX-01294 was designed and successfully achieved through retrosynthetic analysis and convergent synthesis. The final step conditions were optimized to eliminate the need for microwave irradiation, using inexpensive and simple methanesulfonic acid as a catalyst. The overall yield of BIX-01294 over four steps was 26.4%.
RUSSIAN CHEMICAL BULLETIN
(2022)
Review
Oncology
Jayden Sterling, Sharleen V. Menezes, Ramzi H. Abbassi, Lenka Munoz
Summary: Histone lysine demethylases (KDMs) are enzymes that remove methylation marks on lysines in nucleosomes' histone tails, regulating gene transcription and playing important roles in cancer development. KDMs can have activating or repressing effects on gene transcription, regulating the expression of oncogenes and tumor suppressors.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Oncology
Yang Liu, Xiao Li, Tianyu Zhang, Guoyan Liu
Summary: Ovarian cancer has a high fatality rate and poor survival due to nonspecific symptoms in early stages and chemotherapy resistance. Exosomes, nano-sized vesicles secreted by cells, play a significant role in tumor microenvironment remodeling, angiogenesis and metastasis, and immune metastasis and chemotherapy resistance in ovarian cancer. They transfer chemotherapy resistance by delivering proteins and miRNAs, and participate in resistance mechanisms such as multidrug-resistance transporters, apoptosis inhibition, epithelial-to-mesenchymal transition, and signal transduction pathway alteration. Exosomes are also important in early detection, chemotherapy efficacy evaluation, and treatment of ovarian cancer. They can be utilized as chemotherapeutic delivery vehicles and therapeutic targets, as well as for cancer immunotherapy. This article reviews the latest research progress of exosomes in ovarian cancer, elucidating the mechanisms of exosome-mediated chemotherapy resistance and discussing their therapeutic potential in improving chemotherapy sensitivity.
Article
Oncology
Foteinos-Ioannis Dimitrakopoulos, Anastasia Kottorou, Aspasia Tzezou
Summary: Breast cancer, the most common cancer in women, poses a challenge in therapeutic management for hormone receptor-positive patients due to resistance mechanisms. Molecular mechanisms involved in endocrine resistance include changes in hormone receptor signaling, activation of parallel pathways, cell cycle regulator modifications, transcription factor activation, and stem cell activity changes. Epigenetic changes, such as DNA methylation, histone modifications, and ncRNAs alterations, play a pivotal role not only in breast cancer progression but also in resistance to endocrine therapy.
Article
Multidisciplinary Sciences
Yaman Alghamian, Chadi Soukkarieh, Abdul Qader Abbady, Hossam Murad
Summary: Ovarian cancer cells undergo EMT-like changes during the development of chemoresistance, and these changes are regulated by DNA methylation. Specifically, the EMT genes CDH1 and EPCAM show increased DNA methylation and down-regulated gene expression in the cisplatin-resistant A2780cis cells, while the mesenchymal marker TWIST2 exhibits decreased DNA methylation and up-regulated gene expression. These findings contribute to a better understanding of the molecular alterations associated with chemoresistance and may provide potential therapeutic targets for improving chemotherapy sensitivity and efficacy.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Shrabanti Chowdhury, Jacob J. Kennedy, Richard G. Ivey, Oscar D. Murillo, Noshad Hosseini, Xiaoyu Song, Francesca Petralia, Anna Calinawan, Sara R. Savage, Anna B. Berry, Boris Reva, Umut Ozbek, Azra Krek, Weiping Ma, Felipe da Veiga Leprevost, Jiayi Ji, Seungyeul Yoo, Chenwei Lin, Uliana J. Voytovich, Yajue Huang, Sun-Hee Lee, Lindsay Bergan, Travis D. Lorentzen, Mehdi Mesri, Henry Rodriguez, Andrew N. Hoofnagle, Zachary T. Herbert, Alexey I. Nesvizhskii, Bing Zhang, Jeffrey R. Whiteaker, David Fenyo, Wilson McKerrow, Joshua Wang, Stephan C. Schuer, Vasileios Stathias, X. Steven Chen, Mary Helen Barcellos-Hoff, Timothy K. Starr, Boris J. Winterhoff, Andrew C. Nelson, Samuel C. Mok, Scott H. Kaufmann, Charles Drescher, Marcin Cieslik, Pei Wang, Michael J. Birrer, Amanda G. Paulovich
Summary: To enhance our understanding of chemo-refractory high-grade serous ovarian cancers (HGSOCs), we analyzed the proteogenomic landscape of 242 HGSOCs and identified a 64-protein signature that accurately predicts a subgroup of HGSOCs refractory to initial platinum-based therapy. We also found a significant association between the lack of Ch17 loss of heterozygosity (LOH) and chemo-refractoriness, and identified 5 clusters of HGSOC based on pathway protein expression, which may represent different mechanisms of refractoriness and potential therapeutic vulnerabilities.
Review
Biochemistry & Molecular Biology
Futaba Inoue, Kenbun Sone, Yusuke Toyohara, Yu Takahashi, Asako Kukita, Aki Hara, Ayumi Taguchi, Michihiro Tanikawa, Tetsushi Tsuruga, Yutaka Osuga
Summary: Epigenetic changes play a crucial role in endometrial cancer, including DNA methylation and histone modification. There are currently inhibitors targeting epigenetic regulators in preclinical studies and clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Qian Li, Liuqian Wang, Di Ji, Xiaomin Bao, Guojing Tan, Xiaojun Liang, Ping Deng, Huifeng Pi, Yonghui Lu, Chunhai Chen, Mindi He, Lei Zhang, Zhou Zhou, Zhengping Yu, Anchun Deng
Summary: The study suggests that high expression of G9a in nasopharyngeal carcinoma (NPC) may promote tumor growth, while inhibiting G9a with BIX-01294 (BIX) can suppress tumor growth by inducing autophagic dysregulation. This indicates that BIX may serve as a potential novel strategy for NPC therapy.
INVESTIGATIONAL NEW DRUGS
(2021)
Article
Medicine, Research & Experimental
Rebecca L. Porter, Siyu Sun, Micayla N. Flores, Emily Berzolla, Eunae You, Ildiko E. Phillips, K. C. Neelima, Niyati Desai, Eric C. Tai, Annamaria Szabolcs, Evan R. Lang, Amaya Pankaj, Michael J. Raabe, Vishal Thapar, Katherine H. Xu, Linda T. Nieman, Daniel C. Rabe, David L. Kolin, Elizabeth H. Stover, David Pepin, Shannon L. Stott, Vikram Deshpande, Joyce F. Liu, Alexander Solovyov, Ursula A. Matulonis, Benjamin D. Greenbaum, David T. Ting
Summary: The aberrant expression of viral-like repeat elements is a common characteristic of epithelial cancers and their substantial diversity offers a unique perspective on the cancer transcriptome. In-depth analysis of ovarian cancer cell lines reveals that the expression of the satellite repeat element HSATII is highly associated with epithelial-mesenchymal transition (EMT) and negatively correlated with IFN-response genes, indicating a more aggressive cancer phenotype. Moreover, repeat RNAs are enriched in tumor-derived extracellular vesicles that can modulate the tumor microenvironment. Targeting HSATII with antisense locked nucleic acids stimulates IFN response and induces MHC I expression, suggesting a potential strategy for modulating the repeatome to enhance anti-tumor immune surveillance.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Oncology
Tanja Rothhammer-Hampl, Franziska Liesenberg, Natalie Hansen, Sabine Hoja, Sabit Delic, Guido Reifenberger, Markus J. Riemenschneider
Summary: The investigation revealed significant downregulation of DIRAS-1 and DIRAS-2 genes in brain tumors, possibly influenced by epigenetic mechanisms. Treatment strategies to re-express these genes increased sensitivity to chemotherapy, indicating the involvement of these genes in DNA damage response pathways.
Article
Oncology
Linyan Xu, Xiang Gao, Pu Yang, Wei Sang, Jun Jiao, Mingshan Niu, Mengdi Liu, Yuanyuan Qin, Dongmei Yan, Xuguang Song, Cai Sun, Yu Tian, Feng Zhu, Xiaoshen Sun, Lingyu Zeng, Zhenyu Li, Kailin Xu
Summary: This study demonstrates that BIX-01294 can inhibit DLBCL cell proliferation, induce apoptosis and autophagy through various pathways, making it a potential therapeutic drug for DLBCL.
Article
Oncology
Yan Zeng, Jun Zheng, Juan Zhao, Pei-Rong Jia, Yang Yang, Guo-Jun Yang, Jing-Feng Ma, Yong-Qing Gu, Jiang Xu
Article
Oncology
Zheng Li, Matthew S. Block, Robert A. Vierkant, Zachary C. Fogarty, Stacey J. Winham, Daniel W. Visscher, Kimberly R. Kalli, Chen Wang, Ellen L. Goode
Article
Oncology
Ellen L. Goode, Matthew S. Block, Kimberly R. Kalli, Robert A. Vierkant, Wenqian Chen, Zachary C. Fogarty, Aleksandra Gentry-Maharaj, Aleksandra Toloczko, Alexander Hein, Aliecia L. Bouligny, Allan Jensen, Ana Osorio, Andreas D. Hartkopf, Andy Ryan, Anita Chudecka-Glaz, Anthony M. Magliocco, Arndt Hartmann, Audrey Y. Jung, Bo Gao, Brenda Y. Hernandez, Brooke L. Fridley, Bryan M. McCauley, Catherine J. Kennedy, Chen Wang, Chloe Karpinskyj, Christiani B. de Sousa, Daniel G. Tiezzi, David L. Wachter, Esther Herpel, Florin Andrei Taran, Francesmary Modugno, Gregg Nelson, Jan Lubinski, Janusz Menkiszak, Jennifer Alsop, Jenny Lester, Jesus Garcia-Donas, Jill Nation, Jillian Hung, Jose Palacios, Joseph H. Rothstein, Joseph L. Kelley, Jurandyr M. de Andrade, Luis Robles-Diaz, Maria P. Intermaggio, Martin Widschwendter, Matthias W. Beckmann, Matthias Ruebner, Mercedes Jimenez-Linan, Naveena Singh, Oleg Oszurek, Paul R. Harnett, Peter F. Rambau, Peter Sinn, Philipp Wagner, Prafull Ghatage, Raghwa Sharma, Robert P. Edwards, Roberta B. Ness, Sandra Orsulic, Sara Y. Brucker, Sharon E. Johnatty, Teri A. Longacre, Ursula Eilber, Valerie McGuire, Weiva Sieh, Yanina Natanzon, Zheng Li, Alice S. Whittemore, Anna deFazio, Annette Staebler, Beth Y. Karlan, Blake Gilks, David D. Bowtell, Estrid Hogdall, Francisco J. Candido dos Reis, Helen Steed, Ian G. Campbell, Jacek Gronwald, Javier Benitez, Jennifer M. Koziak, Jenny Chang-Claude, Kirsten B. Moysich, Linda E. Kelemen, Linda S. Cook, Marc T. Goodman, Maria Jose Garcia, Peter A. Fasching, Stefan Kommoss, Suha Deen, Susanne K. Kjaer, Usha Menon, James D. Brenton, Paul D. P. Pharoah, Georgia Chenevix-Trench, David G. Huntsman, Stacey J. Winham, Martin Kobel, Susan J. Ramus
Article
Medicine, General & Internal
Matthew S. Block, Robert A. Vierkant, Peter F. Rambau, Stacey J. Winham, Philipp Wagner, Nadia Traficante, Aleksandra Toloczko, Daniel G. Tiezzi, Florin Andrei Taran, Peter Sinn, Weiva Sieh, Raghwa Sharma, Joseph H. Rothstein, Teresa Ramon y Cajal, Luis Paz-Ares, Oleg Oszurek, Sandra Orsulic, Roberta B. Ness, Gregg Nelson, Francesmary Modugno, Janusz Menkiszak, Valerie McGuire, Bryan M. McCauley, Marie Mack, Jan Lubinski, Teri A. Longacre, Zheng Li, Jenny Lester, Catherine J. Kennedy, Kimberly R. Kalli, Audrey Y. Jung, Sharon E. Johnatty, Mercedes Jimenez-Linan, Allan Jensen, Maria P. Intermaggio, Jillian Hung, Esther Herpel, Brenda Y. Hernandez, Andreas D. Hartkopf, Paul R. Harnett, Prafull Ghatage, Jose M. Garcia-Bueno, Bo Gao, Sian Fereday, Ursula Eilber, Robert P. Edwards, Christiani B. de Sousa, Jurandyr M. de Andrade, Anita Chudecka-Glaz, Georgia Chenevix-Trench, Alicia Cazorla, Sara Y. Brucker, Jennifer Alsop, Alice S. Whittemore, Helen Steed, Annette Staebler, Kirsten B. Moysich, Usha Menon, Jennifer M. Koziak, Stefan Kommoss, Susanne K. Kjaer, Linda E. Kelemen, Beth Y. Karlan, David G. Huntsman, Estrid Hogdall, Jacek Gronwald, Marc T. Goodman, Blake Gilks, Maria Jose Garcia, Peter A. Fasching, Anna de Fazio, Suha Deen, Jenny Chang-Claude, Francisco J. Candido dos Reis, Ian G. Campbell, James D. Brenton, David D. Bowtell, Javier Benitez, Paul D. P. Pharoah, Martin Kobel, Susan J. Ramus, Ellen L. Goode
MAYO CLINIC PROCEEDINGS
(2018)
Article
Multidisciplinary Sciences
Madalene Earp, Jonathan P. Tyrer, Stacey J. Winham, Hui-Yi Lin, Ganna Chornokur, Joe Dennis, Katja K. H. Aben, Hoda Anton-Culver, Natalia Antonenkova, Elisa V. Bandera, Yukie T. Bean, Matthias W. Beckmann, Line Bjorge, Natalia Bogdanova, Louise A. Brinton, Angela Brooks-Wilson, Fiona Bruinsma, Clareann H. Bunker, Ralf Butzow, Ian G. Campbell, Karen Carty, Jenny Chang-Claude, Linda S. Cook, Daniel W. Cramer, Julie M. Cunningham, Cezary Cybulski, Agnieszka Dansonka-Mieszkowska, Evelyn Despierre, Jennifer A. Doherty, Thilo Doerk, Andreas du Bois, Matthias Duerst, Douglas F. Easton, Diana M. Eccles, Robert P. Edwards, Arif B. Ekici, Peter A. Fasching, Brooke L. Fridley, Aleksandra Gentry-Maharaj, Graham G. Giles, Rosalind Glasspool, Marc T. Goodman, Jacek Gronwald, Philipp Harter, Alexander Hein, Florian Heitz, Michelle A. T. Hildebrandt, Peter Hillemanns, Claus K. Hogdall, Estrid Hogdall, Satoyo Hosono, Edwin S. Iversen, Anna Jakubowska, Allan Jensen, Bu-Tian Ji, Audrey Y. Jung, Beth Y. Karlan, Melissa Kellar, Lambertus A. Kiemeney, Boon Kiong Lim, Susanne K. Kjaer, Camilla Krakstad, Jolanta Kupryjanczyk, Diether Lambrechts, Sandrina Lambrechts, Nhu D. Le, Shashi Lele, Jenny Lester, Douglas A. Levine, Zheng Li, Dong Liang, Jolanta Lissowska, Karen Lu, Jan Lubinski, Lene Lundvall, Leon F. A. G. Massuger, Keitaro Matsuo, Valerie McGuire, John R. McLaughlin, Iain McNeish, Usha Menon, Roger L. Milne, Francesmary Modugno, Kirsten B. Moysich, Roberta B. Ness, Heli Nevanlinna, Kunle Odunsi, Sara H. Olson, Irene Orlow, Sandra Orsulic, James Paul, Tanja Pejovic, Liisa M. Pelttari, Jenny B. Permuth, Malcolm C. Pike, Elizabeth M. Poole, Barry Rosen, Mary Anne Rossing, Joseph H. Rothstein, Ingo B. Runnebaum, Iwona K. Rzepecka, Eva Schernhammer, Ira Schwaab, Xiao-Ou Shu, Yurii B. Shvetsov, Nadeem Siddiqui, Weiva Sieh, Honglin Song, Melissa C. Southey, Beata Spiewankiewicz, Lara Sucheston-Campbell, Ingvild L. Tangen, Soo-Hwang Teo, Kathryn L. Terry, Pamela J. Thompson, Lotte Thomsen, Shelley S. Tworoger, Anne M. van Altena, Ignace Vergote, Liv Cecilie Vestrheim Thomsen, Robert A. Vierkant, Christine S. Walsh, Shan Wang-Gohrke, Nicolas Wentzensen, Alice S. Whittemore, Kristine G. Wicklund, Lynne R. Wilkens, Yin-Ling Woo, Anna H. Wu, Xifeng Wu, Yong-Bing Xiang, Hannah Yang, Wei Zheng, Argyrios Ziogas, Alice W. Lee, Celeste L. Pearce, Andrew Berchuck, Joellen M. Schildkraut, Susan J. Ramus, Alvaro N. A. Monteiro, Steven A. Narod, Thomas A. Sellers, Simon A. Gayther, Linda E. Kelemen, Georgia Chenevix-Trench, Harvey A. Risch, Paul D. P. Pharoah, Ellen L. Goode, Catherine M. Phelan
Article
Multidisciplinary Sciences
Zheng Li, Na Hong, Melissa Robertson, Chen Wang, Guoqian Jiang
SCIENTIFIC REPORTS
(2017)
Article
Oncology
Min Zhao, Xin Pu, Yi Jun Yan, Shao Zhang, Xue Long, Lei Luo, Zheng Li
Summary: This study found differences in health-related quality of life between Han people and ethnic minorities with cervical cancer and precancerous lesions. It is important to increase awareness and participation in screening programs, especially in minority areas, to ensure accessibility of health resources. Additionally, more equal insurance reimbursement should be suggested to mitigate economic difficulties caused by the diseases.
Article
Oncology
Yuyuan Chen, Caixian Yu, Dedian Chen, Yiyin Tang, Keying Zhu, Rong Guo, Sheng Huang, Zheng Li, Lvjun Cen
Summary: The study aimed to explore a predictive nomogram model for invasive micropapillary carcinoma (IMPC) prognosis. A total of 1855 IMPC patients diagnosed after surgery between 2004 and 2014 were used to build and validate the nomogram. The nomogram accurately predicted overall survival and demonstrated good performance in predicting prognosis.
Article
Oncology
Tian Chu, Yifan Meng, Ping Wu, Zheng Li, Hao Wen, Fang Ren, Dongling Zou, Huaiwu Lu, Lingying Wu, Shengtao Zhou, Ying Chen, Jundong Li, Miaochun Xu, Xiaoliu Wu, Xi Xiong, Zhibin Wang, Misi He, Yuanyuan Zhang, Shitong Lin, Canhui Cao, Wencheng Ding, Yu Chen, Wenhua Zhi, Ting Peng, Ye Wei, Binghan Liu, Yashi Xu, Ding Ma, Jing Wang, Chaoyang Sun, Peng Wu
Summary: This study investigates the factors and treatment methods that affect the prognosis of patients with small cell carcinoma of the cervix. The results show that surgery improves outcomes of patients with this type of cancer, especially for those with locally advanced disease and stage IB3-IIA2 cancer.
Article
Public, Environmental & Occupational Health
Min Zhao, Dan Liu, Ming-Zhu Gao, Meng-jiao Zhang, Guo-yu Ma, Song-rui Ding, Lei Luo, Rong-yan Gu, Xing-Long Zhang, Zheng Li
Summary: The aim of this study was to explore the correlation and difference of influencing factors on the psychological status of patients with cervical precancerous lesions and cancer in Han and Ethnic minorities. The study found that for Han patients, the economic burden of the disease, occupation, and family genetic history of tumor had the greatest impact on their psychological status, while for ethnic minority patients, treatment modalities had the greatest effect.
PREVENTIVE MEDICINE REPORTS
(2023)
Correction
Oncology
Zheng Li, Yang Yang, Yang Gao, Xiaoliu Wu, Xielan Yang, Yingjie Zhu, Hongying Yang, Lin Wu, Chengang Yang, Libing Song
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Yang Gao, Xiaoliu Wu, Yang Yang, Youqin Ruan, Xielan Yang, Yingjie Zhu, Hongying Yang, Zongmei Zhang, Chengang Yang, Zheng Li
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
(2016)
Article
Oncology
Zheng Li, Yang Yang, Yang Gao, Xiaoliu Wu, Xielan Yang, Yingjie Zhu, Hongying Yang, Lin Wu, Chengang Yang, Libing Song
AMERICAN JOURNAL OF CANCER RESEARCH
(2016)
Article
Oncology
Xingrao Wu, Lan Li, Yanqing Li, Meiping Jiang, Kangming Li, Zheng Li, Lan Zhang
Summary: The study investigated the prognostic value of serological markers of HBV infection in squamous cell cervical cancer patients, finding that anti-HBs positivity is a favorable prognostic factor for overall survival in patients younger than 50 years. Other HBV markers showed no significant correlation with overall survival rates.