Article
Biochemistry & Molecular Biology
Bin Zhang, Ruenn Chai Lai, Wei Kian Sim, Sai Kiang Lim
Summary: The study suggests that mesenchymal stem/stromal cell small extracellular vesicles (MSC-sEVs) could be potential biologic disease-modifying antirheumatic drugs (DMARDs) for rheumatoid arthritis (RA). MSC-sEVs can reduce disease progression, disease severity, inflammation, and joint damage by increasing anti-inflammatory M2 macrophages and decreasing pro-inflammatory M1 macrophages.
Article
Oncology
Zhenbo Tu, Antoine E. Karnoub
Summary: Mesenchymal stem/stromal cells (MSCs) are a heterogeneous population of fibroblastic progenitor cells that reside in multiple tissues around the body and have the ability to differentiate into various connective tissue cells. They play critical regulatory roles in breast tumor development and progression, participating in multiple aspects of the process.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Immunology
Eliana Lara-Barba, Maria Jesus Araya, Charlotte Nicole Hill, Felipe A. Bustamante-Barrientos, Alexander Ortloff, Cynthia Garcia, Felipe Galvez-Jiron, Carolina Pradenas, Noymar Luque-Campos, Gabriela Maita, Roberto Elizondo-Vega, Farida Djouad, Ana Maria Vega-Letter, Patricia Luz-Crawford
Summary: The study discusses osteoarticular diseases and their treatment options, with a focus on cell therapy using MSCs and acellular therapy based on MSC secreted factors. It highlights the potential therapeutic impact of sEVs derived from MSCs and their miRNA cargo on target cells associated with the pathology of RA and OA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Elia Bari, Fulvio Tartara, Fabio Cofano, Giuseppe di Perna, Diego Garbossa, Sara Perteghella, Marzio Sorlini, Delia Mandracchia, Lorella Giovannelli, Paolo Gaetani, Maria Luisa Torre, Lorena Segale
Summary: The study found that the mesenchymal stem cell-secretome Lyosecretome has a significant improvement effect on the osteoinductive and osteoconductive properties of titanium cages, leading to increased mineralized matrix when used during culturing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Elia Bari, Ilaria Roato, Giuseppe Perale, Filippo Rossi, Tullio Genova, Federico Mussano, Riccardo Ferracini, Marzio Sorlini, Maria Luisa Torre, Sara Perteghella
Summary: A new strategy was developed to improve the osteoinductivity of SmartBone (SB) by loading the SB scaffolds with freeze-dried formulation of mesenchymal stem cell (MSC)-secretome. The study showed that SBlyo significantly enhanced cell proliferation and tissue formation compared to SB, suggesting a more effective bone formation induction by SBlyo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell & Tissue Engineering
Ahmed Lotfy, Noha M. AboQuella, Hongjun Wang
Summary: Mesenchymal stromal/stem cells (MSCs) are widely used in cell therapy due to their immunomodulatory and regenerative properties. The production of various factors via extracellular vesicles, especially exosomes, governs the efficacy of MSCs. MSC-derived exosomes (MSC-Exos) show advantages over MSCs themselves by reducing adverse effects. Clinical studies are assessing the therapeutic effect of MSC-Exos in different diseases, and production methods, dosage, and administration routes are being explored.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Oncology
Bushu Harna, Pulkit Kalra, Shivali Arya, Naveen Jeyaraman, Arulkumar Nallakumarasamy, Madhan Jeyaraman, Ramya Lakshmi Rajendran, Eun Jung Oh, Manish Khanna, Uma Maheswari Rajendran, Ho Yun Chung, Byeong-Cheol Ahn, Prakash Gangadaran
Summary: The management of relapses and refractory rheumatoid arthritis (RA) patients is complex and difficult. There are serious side effects and drug interactions with disease-modifying anti-rheumatic drugs (DMARDs), and some subsets of RA patients do not respond to DMARDs. Mesenchymal stem cells (MSCs) provide a promising alternative for RA treatment, with the potential to manage refractory cases not responding to conventional treatment.
EXPERIMENTAL CELL RESEARCH
(2023)
Review
Cell Biology
Yusuke Shimizu, Edward Hosea Ntege, Chinatsu Azuma, Fuminari Uehara, Takashi Toma, Kotaro Higa, Hiroki Yabiku, Naoki Matsuura, Yoshikazu Inoue, Hiroshi Sunami
Summary: Rheumatoid arthritis is a chronic autoimmune disorder that primarily affects joints and muscles. Conventional treatments only address symptoms, and some patients experience adverse effects or poor responses. Transplanting multipotent adult stem cells, such as mesenchymal stromal/stem cells, has shown promise in controlling inflammation and promoting tissue regeneration in patients with refractory diseases, including rheumatoid arthritis. This review discusses the current status and challenges of MSC-based therapies for rheumatoid arthritis, offering opportunities for broader clinical application.
Article
Pharmacology & Pharmacy
Paula Laranjeira, Monia Pedrosa, Catia Duarte, Susana Pedreiro, Brigida Antunes, Tania Ribeiro, Francisco dos Santos, Antonio Martinho, Margarida Fardilha, M. Rosario Domingues, Manuel Abecasis, Jose Antonio Pereira da Silva, Artur Paiva
Summary: This study found that BM-MSC effectively reduced TNF-alpha, CD83, CCR7, and MIP-1 beta protein levels in mDCs and all monocyte subsets in RA patients. BM-MSC exhibited a suppressive action over antigen-presenting cells from RA patients, potentially affecting their ability to stimulate the immune adaptive response at different levels.
Review
Cell & Tissue Engineering
Mahnaz Babaahmadi, Behnoosh Tayebi, Nima Makvand Gholipour, Mehrnaz Tayebi Kamardi, Sahel Heidari, Hossein Baharvand, Mohamadreza Baghaban Eslaminejad, Ensiyeh Hajizadeh-Saffar, Seyedeh-Nafiseh Hassani
Summary: Rheumatoid arthritis is a chronic and systemic autoimmune disease for which there is currently no cure. MSCs have shown promise in modulating the immune system and could be used as a potential tool for treating autoimmune diseases.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Andrew Owen, Daniel Patten, Vasanthy Vigneswara, Jon Frampton, Philip N. Newsome
Summary: Research shows that the use of mesenchymal stromal cells (MSC) can reduce inflammation and complications following liver transplantation, decrease liver injury, and increase the number of restorative cells. Systemic administration of MSC has a positive therapeutic effect on liver injury and cell death, while subcutaneous injection of MSC does not have a significant effect. MSC represent a potential novel therapy in marginal organ transplantation that warrants further study.
Review
Cell & Tissue Engineering
Maria Jose Alcaraz, Maria Isabel Guillen
Summary: This review provides an extensive overview of the immunomodulatory properties of mesenchymal stem/stromal cells (MSCs) extracellular vesicles (EVs) and their effects on rheumatoid arthritis (RA), as well as their potential mechanisms and improvements in efficacy.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Melissa Payet, Franck Ah-Pine, Xavier Guillot, Philippe Gasque
Summary: CD248 belongs to a glycoprotein family and its expression can be regulated in response to IL1- beta and PMA treatment, resulting in the formation of soluble CD248 (sCD248). Furthermore, inflammatory MSCs express CD248 abundantly and shed it in response to cytokines and pro-angiogenic growth factors, suggesting its potential involvement in the pathogenesis of RA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Kilian Kelly, John E. J. Rasko
Summary: GvHD is a life-threatening complication of hematopoietic stem cell transplantation, often requiring high-dose corticosteroid treatment. MSCs show promise as a potential therapy due to their immunosuppressive and immunoregulatory effects, but their efficacy may be influenced by donor variability and manufacturing processes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell & Tissue Engineering
Dimitrios Tsiapalis, Achilleas Floudas, Tobias Tertel, Verena Boerger, Bernd Giebel, Douglas J. Veale, Ursula Fearon, Lorraine O'Driscoll
Summary: This study investigated the effect of human mesenchymal/stromal stem cells and their extracellular vesicles (EVs) on CD4+ T cells from rheumatoid arthritis (RA) patients. The researchers found that EVs from IFN-beta-primed MSCs had a stronger immune-regulatory effect on RA CD4+ T cells compared to MSCs or EVs from naive MSCs. In addition, EVs from IFN-beta-primed MSCs effectively inhibited RA FLS migration and downregulated RA FLS surface markers. These findings suggest that EVs from IFN-beta-primed MSCs could be a potential therapy for RA.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Mercedes Lopez-Santalla, Rosario Hervas-Salcedo, Maria Fernandez-Garcia, Juan Antonio Bueren, Marina Inmaculada Garin
JOURNAL OF CROHNS & COLITIS
(2020)
Review
Cell Biology
Mercedes Lopez-Santalla, Raquel Fernandez-Perez, Marina I. Garin
Article
Immunology
Raquel Fernandez-Perez, Mercedes Lopez-Santalla, Rebeca Sanchez-Dominguez, Omaira Alberquilla, Irene Gutierrez-Canas, Yasmina Juarranz, Juan A. Bueren, Marina Garin
Summary: Galectin-1 is a beta-galactoside-binding lectin that plays a crucial role in regulating intestinal inflammation by modulating T cell reactivity, affecting the development and severity of colitis. Studies have shown that deficiency of endogenous galectin-1 leads to enhanced inflammatory responses, characterized by altered Th17/Th1 profiles and increased regulatory T cells in the colon lamina propria. Additionally, adoptive transfer of wild type regulatory T cells can alleviate exacerbated intestinal inflammation in galectin-1 deficient mice.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Javier Leceta, Marina Garin, Carmen Conde
Summary: The K/BxN mouse model of rheumatoid arthritis closely resembles the human disease, with arthritis being caused by activation of autoreactive T cells and production of pathogenic antibodies, while the neuropeptide VIP has anti-inflammatory and immunoregulatory properties that can reduce antibody titers by modulating Th1/Th2 balance and Treg activity in the treatment of rheumatoid arthritis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mercedes Lopez-Santalla, Marina Inmaculada Garin
Summary: Inflammatory bowel diseases (IBD) are characterized by persistent and relapsing inflammatory processes, with genetic, environmental, and commensal microbiota factors playing a role. Current biological treatments have some drawbacks, leading to the need for novel effective therapies. Mesenchymal stem/stromal cell (MSCs) therapy has shown promise preclinically, but successful results have not always been replicated in clinical trials. New approaches are being explored to enhance the beneficial effects of MSC-based therapy for IBD.
Article
Immunology
Mercedes Lopez-Santalla, Carmen Conde, Angela Rodriguez-Trillo, Marina Garin
Summary: Rheumatoid arthritis is an autoimmune disease with unresolved treatment issues. Mesenchymal stem cell therapy has emerged as a potential alternative, but its effectiveness may vary in different arthritis models.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Marta Garcia, Jose Bonafont, Jesus Martinez-Palacios, Rudan Xu, Giandomenico Turchiano, Stina Svensson, Adrian J. Thrasher, Fernando Larcher, Marcela Del Rio, Ruben Hernandez-Alcoceba, Marina Garin, Angeles Mencia, Rodolfo Murillas
Summary: In this study, adenoviral vectors were developed for CRISPR-Cas9 delivery to remove exon 80 of COL7A1, leading to successful treatment of skin lesions in patients with recessive dystrophic epidermolysis bullosa (RDEB).
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2022)
Meeting Abstract
Immunology
Raquel Fernandez Perez, Mercedes Lopez Santalla, Rebeca Sanchez Dominguez, Omaira Alberquilla, Irene Gutierrez Canas, Yasmina Juarranz, Juan A. Bueren, Marina I. Garin
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Meeting Abstract
Immunology
Mercedes Lopez Santalla, Rosario Hervas Salcedo, Maria Fernandez Garcia, Juan Antonio Bueren, Marina Inmaculada Garin
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Meeting Abstract
Immunology
Mercedes Lopez Santalla, Miriam Hernando Rodriguez, Miguel Angel Martin, Rosa Maria Yanez, Juan Antonio Bueren, Marina Inmaculada Garin
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
