Article
Chemistry, Analytical
Xijian Lin, Yan He
Summary: This study investigates the effect of active urease system on the environment using high-speed dark-field imaging. The results show that the catalytic reaction has minimal impact on the physicochemical properties of the environment but can lead to the inhomogeneous distribution of enzymes in free solution.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Sanne Mol, Esther W. M. Taanman-Kueter, Baltus A. van der Steen, Tom Groot Kormelink, Marleen G. H. van de Sande, Sander W. Tas, Marca H. M. Wauben, Esther C. de Jong
Summary: Spondyloarthritis (SpA) patients have inactive neutrophils in their synovial fluid (SF), despite the presence of activating stimuli. Inhibitors in the SF, such as hyaluronic acid, play a role in preventing neutrophil activation. This new finding provides insights into regulating neutrophil function and may lead to the development of therapeutics targeting neutrophil activation via hyaluronic acid.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Devera Venkata Krishna, Mamilla Ravi Sankar
Summary: Researchers have developed an artificial synovial fluid (ASF) using bovine colostrum-derived IgG and glycerol, which exhibits good rheological properties and lubrication performance. Bovine colostrum is inexpensive and easily available, making it an ideal choice for preparing the ASF.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Mathematics
Mo Sadique, Sapna Ratan Shah, Sunil Kumar Sharma, Sardar M. N. Islam
Summary: Synovial joints, with the help of synovial fluid, enable efficient mobility in the human body. Synovial fluid acts as a biological lubricant that reduces wear and friction on the articular cartilage. Understanding the lubricating properties and behavior of synovial fluid is crucial for maintaining joint health and preventing joint diseases.
Article
Biochemistry & Molecular Biology
Mengying Zhang, Huimin Yu, Jinglu Hu, Zhengyu Zhao, Lei Liu, Gaomin Yang, Tingli Wang, Guang Han, Shiyong Song
Summary: This study prepared a nanocarrier based on hyaluronic acid and solanesol, which showed great potential in cancer therapy. Loading doxorubicin into the nanocarrier enabled pH-sensitive drug release, with lower cardiotoxicity and hepatotoxicity compared to free doxorubicin.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Arne Werner
Summary: Diffusion is an inevitable prerequisite for ribonucleic acids to regulate gene expression and perform gene editing. The empirical models derived in this study accurately predict the three-dimensional translational and rotational diffusion velocities of RNA.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Nutrition & Dietetics
Jianlin Shen, Xiaoning Lin, Yujin Lin, Jiecheng Xiao, Changfu Wu, Feng Zheng, Xianwei Wu, Haibin Lin, Guoli Chen, Huan Liu
Summary: This study investigated the effects of vitamin D supplementation with HA injection on OA. The results showed that vitamin D supplementation improved the oxidative stress status in synovial fluid, reduced knee pain, and improved knee function in OA patients.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Danuta Kruk, Elzbieta Masiewicz, Sylwia Lotarska, Roksana Markiewicz, Stefan Jurga
Summary: H-1 spin-lattice relaxation experiments were conducted on a series of ionic liquids containing different alkyl chain lengths of bis(trifluoromethanesulfonyl)imide anion and cations. The results provided insights into the rotational and translational dynamics of the cations in comparison to molecular liquids, indicating a temperature-dependent ratio between the correlation times of these motions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Oumeng Zhang, Weiyan Zhou, Jin Lu, Tingting Wu, Matthew D. Lew
Summary: We present a radially and azimuthally polarized microscope that achieves high detection and estimation performance in single-molecule orientation-localization microscopy (SMOLM). This microscope allows us to measure the localization, orientation, and rotational wobble of Nile red (NR) within supported lipid bilayers (SLBs). The imaging results reveal the presence of randomly oriented binding pockets and cholesterol-rich nanodomains within the SLBs.
Article
Chemistry, Applied
Genyang Ye, Tianlong Wu, Zhaohua Li, Manlin Teng, Lixue Ma, Mengdi Qin, Peixu Zhao, Qiang Fu
Summary: In this study, hyaluronic acid (HA) was used to improve the delivery efficiency of naringenin (NAR) by loading it into zein nanoparticles. The optimized Nar/zein-HA nanoparticles had uniform spherical shape with desirable particle size, polydispersity index, and zeta-potential. The microstructure of the nanoparticles was maintained by hydrophobic, electrostatic, and hydrogen-bonding interactions. Furthermore, the nanoparticles showed favorable physical stability, enhanced encapsulation efficiency, improved antioxidant capacity, and release in simulated gastrointestinal digestion of Nar.
Article
Nanoscience & Nanotechnology
Zhongshan Wang, Guangsheng Wu, Zhujun Yang, Xuejian Li, Zhihong Feng, Yimin Zhao
Summary: In this study, miR-21-loaded chitosan/tripolyphosphate/hyaluronic acid nanoparticles were prepared and formed a stable biological seal on titanium surfaces. The miR-21-functionalized titanium surface enhanced fibroblast adhesion, proliferation, and expression of extracellular matrix-related genes.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Polymer Science
Lisa Efriani Puluhulawa, I. Made Joni, Khaled M. Elamin, Ahmed Fouad Abdelwahab Mohammed, Muchtaridi Muchtaridi, Nasrul Wathoni
Summary: Chitosan-hyaluronic acid nanoparticles have the potential to be an effective and targeted treatment for various types of cancer, with good characteristics and active targeting capabilities.
Article
Biochemistry & Molecular Biology
Chien-Hsing Lee, Chi-Fu Chiang, Feng-Chih Kuo, Sheng-Chiang Su, Chia-Luen Huang, Jhih-Syuan Liu, Chieh-Hua Lu, Chang-Hsun Hsieh, Chih-Chien Wang, Chian-Her Lee, Pei-Hung Shen
Summary: The study indicated HMW-HA can protect synovium from inflammation and macrophage polarization by reducing IL-6 and PGE2 levels. The involvement of the GRP78-NF-kappa B signaling pathway was highlighted in this protective mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Afsana Sheikh, Sahim Aziz Hazari, Nagashekhara Molugulu, Saad Ali Alshehri, Shadma Wahab, Amirhossein Sahebkar, Prashant Kesharwani
Summary: This article investigates the potential of chitosan nanoparticles loaded with gallic acid (GA) for the treatment of psoriasis. The study found that coating the nanoparticles with hyaluronic acid (HA) slightly increased the particle size but enhanced their inhibitory effect on cells. In vivo experiments demonstrated the potential of HA-modified nanoparticles in restricting psoriasis. Further research should explore the application of HA-modified nanoparticles in the treatment of other skin-related conditions.
ENVIRONMENTAL RESEARCH
(2023)
Article
Orthopedics
Bo Shao, Yingjie Xu, Mengying Jia, Chen-xi Li, Zhong-cheng Gong
Summary: In this retrospective study, the levels of HMGB1 in the synovial fluid of patients with TMJOA were investigated, and its correlation with disease severity and the therapeutic effect of hyaluronic acid (HA) were explored. The results showed that HMGB1 levels were associated with the severity of TMJOA, and HA treatment improved symptoms of TMJOA.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Instruments & Instrumentation
W. Zubrzycka, P. Grybos
Summary: Semiconductor strip sensors are widely used in radiation detection and measurement for particle physics experiments, X-ray imaging, and material science. This paper focuses on the analysis and noise optimization of the read-out electronics for short silicon strip detectors used in X-ray spectroscopy. The goal is to achieve high spatial resolution and low noise levels, considering the constraints of power consumption and channel area.
JOURNAL OF INSTRUMENTATION
(2023)
Article
Instruments & Instrumentation
P. Grybos, R. Kleczek, P. Kmon, P. Otfinowski, P. Fajardo
Summary: This paper presents the design and simulation of a prototype chip in the CMOS 40 nm process for high spatial resolution operation at the ESRF-EBS synchrotron. The chip utilizes a pixel matrix with 50 μm pitch and operates in a single photon counting mode. It includes a Charge Sensitive Amplifier (CSA) with a fast discharge block and leakage current compensation circuit, as well as algorithms for interpixel communication to increase spatial resolution.
JOURNAL OF INSTRUMENTATION
(2023)
Article
Chemistry, Physical
Yuyin Xi, Ryan P. Murphy, Qingteng Zhang, Aurora Zemborain, Suresh Narayanan, Junsu Chae, Siyoung Q. Choi, Andrei Fluerasu, Lutz Wiegart, Yun Liu
Summary: Bicontinuous structures have broad applications in various research fields. A new gel called SeedGel has been developed to create reversible bicontinuous channels with tunable particle sizes. The mechanical properties of SeedGel were characterized using temperature-dependent rheology, showing excellent reproducibility and an interesting temperature dependence. The gelation transition and solvent exchange between domains were studied using SANS measurements, while the long-time dynamics of the gel were studied with X-ray Photon Correlation Spectroscopy (XPCS).
Article
Chemistry, Physical
Sohaib Mohammed, Meishen Liu, Qingteng Zhang, Suresh Narayanan, Fan Zhang, Greeshma Gadikota
Summary: The presence of CaCl2, MgCl2, and CsCl salts in 3 wt.% laponite suspensions accelerates the formation of arrested gel states, with CaCl2 having the most significant impact. The size and charge of the ions have a competing effect on relaxation behavior, with the dominant factor depending on the specific scenario. These studies provide insights into the physics of the relaxation behavior of viscoelastic fluids and their connection to the underlying chemical changes.
Article
Engineering, Electrical & Electronic
Rafal Kleczek, Piotr Kmon, Piotr Maj, Robert Szczygiel, Miroslaw Zoladz, Pawel Grybos
Summary: The paper presents a low noise integrated circuit designed in a CMOS 130 nm for a hybrid pixel detector operating in single photon counting mode. The circuit includes a matrix of 128 x 256 square shaped pixels with a pitch of 75 μm. Each readout pixel consists of a charge sensitive amplifier (CSA), a shaper, two discriminators, and two 14-bit counters. The paper introduces a novel CSA feedback circuitry with low noise operation and fast return to the CSA output baseline, allowing for operation with a higher flux of input pulses. The measured results show that the IC has a low equivalent noise charge, small offset spread, and high energy resolution, making it currently the best result in single photon counting pixel detectors. The hybrid pixel detector can register a high number of photons per unit area per second while maintaining low power consumption per pixel.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS I-REGULAR PAPERS
(2023)
Article
Instruments & Instrumentation
A. Krzyzanowska, R. Szczygiel, P. Grybos, J. Koczwara, K. Cislo, A. Stasiak
Summary: Hybrid pixel detectors are segmented devices used for X-ray detection, and the subpixel algorithm can improve their spatial resolution by analyzing charge sharing. This study simulated and tested the influence of different factors, such as bias voltage and sensor materials, on the resolution of detectors. The results showed that the simulator accurately described the spatial resolution and can be used for further studies on detectors with the subpixel algorithm.
JOURNAL OF INSTRUMENTATION
(2023)
Article
Instruments & Instrumentation
A. Koziol, R. Szczygiel, D. Kuznar, K. Strzalka, M. Wielgosz, P. Otfinowski, P. Maj
Summary: This article presents the design of an in-pixel artificial intelligence (AI) for extracting the amplitude of a pulse in a semiconductor detector. The AI is designed using a traditional multi-level perceptron scheme with 6 layers and a total of 420 parameters. The implementation achieves a measurement accuracy of 0.34%. The AI block is input by a 6-bit ADC at a 5 MHz sampling rate. The standard front-end is optimized for low-noise pulses carrying 1000-3000 electrons. The methodology is tested using FPGA and shows promising results. The design is intended to be fabricated and verified in a prototype solution.
JOURNAL OF INSTRUMENTATION
(2023)
Article
Chemistry, Multidisciplinary
Sitong Liu, Matthew Po, Anahita Heshmat, Evan Anguish, Jennifer Andrew, Carlos M. Rinaldi-Ramos
Summary: Hafnium oxide nanoparticles (HNCs) formulated using flash nanoprecipitation (FNP) exhibit high X-ray attenuation and low cost, making them attractive as computed tomography (CT) contrast agents. A simple 3D-printed FNP mixer was used to produce HNCs with controlled hydrodynamic size ranging from 100-300 nm. Evaluation in both pre-clinical small animal scanner and clinical scanner showed that the HNCs provide approximately 1.5 times greater contrast enhancement compared to the commercially used iodinated molecular contrast agent Omnipaque.
JOURNAL OF NANOPARTICLE RESEARCH
(2023)
Article
Chemistry, Physical
Victor G. Rivera-Llabres, Kara N. Gentry, Matthew Po, Carlos M. Rinaldi-Ramos
Summary: The study reports the formulation of size tunable magnetic alginate microparticles (MAMs) using a 3D flow-focusing microfluidic device. The stability of iron oxide nanoparticles (IONPs) coated with polyethylene glycol (PEG) in alginate and calcium ethylenediamine tetraacetic acid solutions is investigated. The average size and coefficient of variance of MAMs are found to vary with droplet and continuous phase flow rates and viscosities. Crosslinking and drying of droplets result in smaller MAMs with a low coefficient of variance. The findings can guide future research on the role of MAM size in different applications.
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
(2023)
Article
Chemistry, Multidisciplinary
Jill K. Wenderott, Eric M. Dufresne, Yan Li, Hui Cao, Qingteng Zhang, K. V. L. V. Narayanachari, D. Bruce Buchholz, Supratik Guha, Dillon D. Fong
Summary: This study investigates the structural and electronic phase transitions driven by changes in the concentration of oxygen ions in a complex oxide system. The diffusion of oxygen ions across the bilayer of SrCoO2.5 and SrCoO3-δ is studied, and it is found that the behavior is strongly asymmetric, with slower dynamics in reducing environments. The results suggest that the interface is stable and reversible, making SrCoOx a model system for the study of iontronic behavior.
ADVANCED MATERIALS INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Huaxin Gong, Diego Uruchurtu Patino, Jan Ilavsky, Ivan Kuzmenko, Amnahir Estefania Pena-Alcantara, Chenhui Zhu, Aidan H. Coffey, Lukas Michalek, Ahmed Elabd, Xin Gao, Shucheng Chen, Chengyi Xu, Hongping Yan, Yuanwen Jiang, Weichen Wang, Yucan Peng, Yitian Zeng, Hao Lyu, Hanul Moon, Zhenan Bao
Summary: A versatile method for synthesizing nanostructured carbon materials based on flower-like PAN chemistry is reported. The resulting PAN superstructures can be easily converted to carbon superstructures. Surface modification of the nanostructured films resulted in high surface roughness and a contact angle of approximately 180 degrees. This study offers a strategy for the synthesis of nanostructured carbon materials for various applications.
Correction
Chemistry, Physical
D. Sheyfer, Michael J. Servis, Qingteng Zhang, J. Lal, T. Loeffler, E. M. Dufresne, A. R. Sandy, S. Narayanan, Subramanian K. R. S. Sankaranarayanan, R. Szczygiel, P. Maj, L. Soderholm, Mark R. Antonio, G. B. Stephenson
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Chenzhao Li, Kang Yu, Ashley Bird, Fei Guo, Jan Ilavsky, Yadong Liu, David A. Cullen, Ahmet Kusoglu, Adam Z. Weber, Paulo J. Ferreira, Jian Xie
Summary: The high cost of polymer electrolyte membrane fuel cells (PEMFCs) is mainly due to the use of platinum catalysts. The researchers have proposed a design of an ideal ionomer/catalyst interface to enhance catalyst utilization and fuel cell performance.
ENERGY & ENVIRONMENTAL SCIENCE
(2023)
Article
Chemistry, Physical
Jason K. Phong, Christopher B. Cooper, Lukas Michalek, Yangju Lin, Yuya Nishio, Yuran Shi, Huaxin Gong, Julian A. Vigil, Jan Ilavsky, Ivan Kuzmenko, Zhenan Bao
Summary: Dynamic block copolymers (DBCPs) combine the phase separation of traditional block copolymers with the supramolecular self-assembly of periodic dynamic polymers, resulting in the spontaneous self-assembly of high aspect ratio nanofibers with well-ordered PEG and PDMS domains. DBCPs with a periodic block sequence exhibit superior properties compared to those with a random sequence, including delayed onset of terminal flow and higher ionic conductivity values.
JOURNAL OF MATERIALS CHEMISTRY A
(2024)