期刊
ACS SENSORS
卷 6, 期 6, 页码 2108-2124出版社
AMER CHEMICAL SOC
DOI: 10.1021/acssensors.1c00669
关键词
lateral flow assays; low-cost; paper-based sensors; paper-based analytical devices; resource-limited settings; SARS-CoV-2; on-site testing; thread-based sensors; point-of-care medical devices
资金
- Engineering and Physical Sciences Research Council (EPSRC) [EP/T013567/1]
- Fundamental Research Funds for the Central Universities of China [YJ202152]
- Royal Academy NewtonKatip Celebi Transforming Systems Through Partnership award [120N019]
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [404478562]
- Alexander von Humboldt Research Fellowship for Experienced Researchers
- Marie Sklodowska-Curie Individual Fellowship [101003361]
- EPSRC [EP/T013567/1] Funding Source: UKRI
Readily deployable, low-cost point-of-care medical devices are urgently needed in resource-poor settings to screen various chemical and biological analytes for rapid diagnostics, benefiting public health in areas with limited access to healthcare.
Readily deployable, low-cost point-of-care medical devices such as lateral flow assays (LFAs), microfluidic paper-based analytical devices (mu PADs), and microfluidic thread-based analytical devices (mu TADs) are urgently needed in resource-poor settings. Governed by the ASSURED criteria (affordable, sensitive, specific, user-friendly, rapid and robust, equipment-free, and deliverability) set by the World Health Organization, these reliable platforms can screen a myriad of chemical and biological analytes including viruses, bacteria, proteins, electrolytes, and narcotics. The Ebola epidemic in 2014 and the ongoing pandemic of SARS-CoV-2 have exemplified the ever-increasing importance of timely diagnostics to limit the spread of diseases. This review provides a comprehensive survey of LFAs, mu PADs, and mu TADs that can be deployed in resource-limited settings. The subsequent commercialization of these technologies will benefit the public health, especially in areas where access to healthcare is limited.
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