When Leptin Is Not There: A Review of What Nonsyndromic Monogenic Obesity Cases Tell Us and the Benefits of Exogenous Leptin

The pleiotropic roles of leptin in metabolism, immunity, and cancer

(2021) Paola de Candia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Incendiary Leptin

(2020) Patricia Seoane-Collazo et al.   Nutrients

Leptin, Obesity, and Hypertension: A Review of Pathogenetic Mechanisms

(2020) Song Chi Lu et al.   Metabolic Syndrome and Related Disorders

The melanocortin pathway and control of appetite-progress and therapeutic implications

(2019) Giulia Baldini et al.   JOURNAL OF ENDOCRINOLOGY

Congenital Leptin Deficiency and Leptin Gene Missense Mutation Found in Two Colombian Sisters with Severe Obesity

(2019) Hernan Yupanqui-Lozno et al.   Genes

Monogenic leptin deficiency in early childhood obesity

(2019) Gehan ElSaeed et al.   Pediatric Obesity

Roles of JAK2 in Aging, Inflammation, Hematopoiesis and Malignant Transformation

(2019) Perner et al.   Cells

Role of hypothalamic leptin-LepRb signaling in NPY-CART-mediated appetite suppression in amphetamine-treated rats

(2018) Shu-Chen Chu et al.   HORMONES AND BEHAVIOR

The effect of sugar and processed food imports on the prevalence of overweight and obesity in 172 countries

(2018) Tracy Kuo Lin et al.   Globalization and Health

Severe early onset obesity due to a novel missense mutation in exon 3 of leptin gene in an infant from Northwest India

(2018) Devi Dayal et al.   Journal of Clinical Research in Pediatric Endocrinology

Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment

(2018) Jane Wardle et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

POMC: The Physiological Power of Hormone Processing

(2018) Erika Harno et al.   PHYSIOLOGICAL REVIEWS

Arcuate nucleus and lateral hypothalamic CART neurons in the mouse brain exert opposing effects on energy expenditure

(2018) Aitak Farzi et al.   eLife

Cocaine- and amphetamine-regulated transcript (CART): A multifaceted neuropeptide

(2018) Hamid Ahmadian-Moghadam et al.   PEPTIDES

Obesity pandemic: causes, consequences, and solutions—but do we have the will?

(2017) David R. Meldrum et al.   FERTILITY AND STERILITY

Genetics of non-syndromic childhood obesity and the use of high-throughput DNA sequencing technologies

(2017) Ana Carolina Proença da Fonseca et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Early-onset severe obesity due to complete deletion of the leptin gene in a boy

(2017) Elif Ozsu et al.   JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

Health Effects of Overweight and Obesity in 195 Countries over 25 Years

(2017)   NEW ENGLAND JOURNAL OF MEDICINE

Role of Leptin Deficiency, Inefficiency, and Leptin Receptors in Obesity

(2016) Muhammad Wasim et al.   BIOCHEMICAL GENETICS

The long road to leptin

(2016) Jeffrey Friedman   JOURNAL OF CLINICAL INVESTIGATION

Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants

(2016)   LANCET

The Hunger Genes: Pathways to Obesity

(2015) Agatha A. van der Klaauw et al.   CELL

Severe Early-Onset Obesity Due to Bioinactive Leptin Caused by a p.N103K Mutation in the Leptin Gene

(2015) Martin Wabitsch et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Structure, production and signaling of leptin

(2015) Heike Münzberg et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Biologically Inactive Leptin and Early-Onset Extreme Obesity

(2015) Martin Wabitsch et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic variants inLEP,LEPR, andMC4Rexplain 30% of severe obesity in children from a consanguineous population

(2015) Sadia Saeed et al.   Obesity

Obesity genetics in mouse and human: back and forth, and back again

(2015) Fereshteh T. Yazdi et al.   PeerJ

20 YEARS OF LEPTIN: Insights into signaling assemblies of the leptin receptor

(2014) Frank Peelman et al.   JOURNAL OF ENDOCRINOLOGY

20 YEARS OF LEPTIN: Human disorders of leptin action

(2014) I Sadaf Farooqi et al.   JOURNAL OF ENDOCRINOLOGY

A Novel Mutation inLeptinGene Is Associated with Severe Obesity in Chinese Individuals

(2014) Yue Zhao et al.   Biomed Research International

Maternal and Paternal Body Mass Index and Offspring Obesity: A Systematic Review

(2013) Bernadeta Patro et al.   ANNALS OF NUTRITION AND METABOLISM

Imbalance between Neutrophil Elastase and its Inhibitor α1-Antitrypsin in Obesity Alters Insulin Sensitivity, Inflammation, and Energy Expenditure

(2013) Virginie Mansuy-Aubert et al.   Cell Metabolism

A novel mutation of the leptin gene in an Indian patient

(2013) S. Thakur et al.   CLINICAL GENETICS

High prevalence of leptin and melanocortin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families

(2012) Sadia Saeed et al.   MOLECULAR GENETICS AND METABOLISM

Leptin action via LepR-b Tyr1077 contributes to the control of energy balance and female reproduction

(2012) Christa M. Patterson et al.   Molecular Metabolism

Congenital leptin deficiency: diagnosis and effects of leptin replacement therapy

(2011) Gilberto Paz-Filho et al.   Arquivos Brasileiros de Endocrinologia e Metabologia

Leptin deficiency andleptingene mutations in obese children from Pakistan

(2011) Warda Fatima et al.   International Journal of Pediatric Obesity

Ten years of leptin replacement therapy

(2011) G. Paz-Filho et al.   Obesity Reviews

Leptin and mTOR: Partners in metabolism and inflammation

(2010) Clarissa Maya-Monteiro et al.   CELL CYCLE

A New Missense Mutation in the Leptin Gene Causes Mild Obesity and Hypogonadism without Affecting T Cell Responsiveness

(2010) Pamela Fischer-Posovszky et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A historical perspective on leptin

(2010) Douglas L Coleman   NATURE MEDICINE

A novel homozygous missense mutation of the leptin gene (N103K) in an obese Egyptian patient

(2009) I. Mazen et al.   MOLECULAR GENETICS AND METABOLISM

Hypothalamic ERK Mediates the Anorectic and Thermogenic Sympathetic Effects of Leptin

(2008) K. Rahmouni et al.   DIABETES

Global burden of obesity in 2005 and projections to 2030

(2008) T Kelly et al.   INTERNATIONAL JOURNAL OF OBESITY

Molecular and neural mediators of leptin action

(2008) Scott A. Robertson et al.   PHYSIOLOGY & BEHAVIOR

Leptin Replacement Improves Cognitive Development

(2008) Gilberto J. Paz-Filho et al.   PLoS One