期刊
FRONTIERS IN GENETICS
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2021.686320
关键词
aging; biomarker; health; senescence; survival
资金
- Karls Erdbeerhof, Rovershagen, Germany
- Interdisziplinare Fakultat (Department AGIS) of the Rostock University
- Hermann and Lilly-Schilling Stiftung fur medizinische Forschung im Stifterverband
- BMBF [FKZ 01ZX1903A, 1DS19049]
- European Commission (Aging with elegans) [633589]
The review provides an overview of commonly mentioned and frequently used potential aging-related biomarkers, with a focus on biomarkers related to cellular senescence. Two scoring systems are introduced to reflect biomarker relevance and measurement effort, supporting study designs in both clinical and research settings.
Aging affects most living organisms and includes the processes that reduce health and survival. The chronological and the biological age of individuals can differ remarkably, and there is a lack of reliable biomarkers to monitor the consequences of aging. In this review we give an overview of commonly mentioned and frequently used potential aging-related biomarkers. We were interested in biomarkers of aging in general and in biomarkers related to cellular senescence in particular. To answer the question whether a biological feature is relevant as a potential biomarker of aging or senescence in the scientific community we used the PICO strategy known from evidence-based medicine. We introduced two scoring systems, aimed at reflecting biomarker relevance and measurement effort, which can be used to support study designs in both clinical and research settings.
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