Article
Cell & Tissue Engineering
Hua Shen, Ryan A. Lane
Summary: Achilles tendon rupture, a common sports-related injury, often leads to long-term pain and functional deficits. Previous studies have shown that extracellular vesicles from inflammation-primed adipose-derived stem cells (iEVs) can alleviate the early inflammatory response to tendon injury. This study aimed to investigate the mechanistic roles of iEVs in regulating the injury response of tendons and promoting regeneration.
Review
Biochemistry & Molecular Biology
Yixuan Chen, Li Jiang, Kexin Lyu, Jingwei Lu, Longhai Long, Xiaoqiang Wang, Tianzhu Liu, Sen Li
Summary: PDGF-BB has a positive effect on tendon healing by enhancing inflammatory responses, speeding up angiogenesis, stimulating tendon cell proliferation, increasing collagen synthesis and increasing the biomechanics of the repaired tendon. Additional studies are needed to fully understand the dose and application time of PDGF-BB for further applications in the tendon healing process.
Article
Engineering, Biomedical
Fei Han, Tian Li, Mengmeng Li, Bingjun Zhang, Yufeng Wang, Yufang Zhu, Chengtie Wu
Summary: This study utilized natural fish scale modified by calcium silicate nanoparticles as a new biomaterial to overcome the challenge of tendon-bone healing. The fish scale-based scaffold demonstrated excellent tensile strength and bioactivity, making it a promising candidate for clinical tendon repair. The research also showed that the biomaterial played a key role in tendon-bone interface regeneration and biomechanical function.
BIOACTIVE MATERIALS
(2023)
Review
Biotechnology & Applied Microbiology
Varun Arvind, Alice H. Huang
Summary: Inflammation plays a dual role in tendon healing, serving as the root cause of chronic tendinopathy while also aiding tissue repair. Recent research focuses on the cells and cytokines involved in reparative inflammation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Cell Biology
Mingzhao Zhang, Hengchen Liu, Manyu Shi, Tingting Zhang, Wenjun Lu, Shulong Yang, Qingbo Cui, Zhaozhu Li
Summary: The study showed that hepatocyte growth factor (HGF)-expressing tendon stem cells (TSCs + HGF) have a significant promoting effect on tendon healing in rats, mainly by reducing inflammation and fibrosis. This provides a novel therapeutic strategy for tendon injuries.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Bruno Henrique Costa, Alisson Kennedy Rezende, Lais Costa, Gabrielle Fernanda Monteiro Neves, Antonio Carlos Shimano, Alvaro de Oliveira Penoni, Claudia Rocha Carvalho, Raquel Alves Costa, Erika Costa de Alvarenga
Summary: Injection of zein protein can reduce inflammation and promote bone healing. The experiment showed that zein injection improved bone repair and mechanical strength.
SCIENTIFIC REPORTS
(2023)
Review
Critical Care Medicine
Hanyue Li, Shengyu Luo, Hao Wang, Yixuan Chen, Mingzhe Ding, Jingwei Lu, Li Jiang, Kexin Lyu, Shilin Huang, Houyin Shi, Hui Chen, Sen Li
Summary: Tendon injuries are a significant part of musculoskeletal diseases and have limited treatment options due to the lack of understanding of underlying molecular mechanisms. Transforming Growth Factor-beta 1 (TGF-beta 1) is an important profibrogenic factor in the tendon healing process, but blocking it does not effectively enhance tendon healing.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Orthopedics
Charlie M. M. Waugh, Rouhollah Mousavizadeh, Jenny Lee, Hazel R. C. Screen, Alexander Scott
Summary: Hypercholesterolemia is associated with tendon pathology and injury prevalence. Lipids can accumulate in the tendon's extracellular spaces, which may disrupt its hierarchical structure and the tenocytes physicochemical environment. We hypothesized that the tendon's ability to repair after injury would be attenuated with elevated cholesterol levels, leading to inferior mechanical properties.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Review
Multidisciplinary Sciences
Benjamin R. Freedman, Charles Hwang, Simon Talbot, Brian Hibler, Simon Matoori, David J. Mooney
Summary: Skin injuries cause significant disruptions to patients' lives and lead to prolonged hospital stays, infection, and death. Advances in wound healing devices have primarily focused on treating macroscopic healing rather than the underlying microscopic pathophysiology. There is no consensus on the optimal treatment strategies using different wound healing products, prompting the development of new therapies. This article summarizes the progress in the development of novel drug, biologic products, and biomaterial therapies for wound healing, including both approved therapies and those undergoing clinical trials. Perspectives on successful and accelerated translation of these integrated therapies are also discussed.
Article
Orthopedics
Ryan A. Lane, Nicole Migotsky, Necat Havlioglu, Leanne E. Iannucci, Hua Shen, Spencer Lake, Shelly E. Sakiyama-Elbert, Stavros Thomopoulos, Richard H. Gelberman
Summary: By inhibiting IKK-beta, ACHP effectively suppresses NF-kappa B signaling, mitigates the early inflammatory response, and improves tendon healing outcomes.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Review
Engineering, Biomedical
Chiara Rinoldi, Ewa Kijenska-Gawronska, Ali Khademhosseini, Ali Tamayol, Wojciech Swieszkowski
Summary: Injuries to tendons and ligaments are common and have a significant impact on daily life. Current treatment strategies are sometimes inadequate, leading to the development of tissue engineering and regenerative medicine approaches aiming to stimulate regeneration. The design of artificial scaffolds with tailored mechanical properties is crucial for restoring functionality in such cases.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Orthopedics
Surena Namdari, Thema Nicholson, Tyler J. Brolin, Jeffrey Lu, Joseph A. Abboud, Mark D. Lazarus
Summary: The study on complex and revision rotator cuff repairs with dermal allograft augmentation in 35 patients showed that double-row arthroscopic repair led to improved functional outcomes. Approximately half of patients experienced a failure of healing, which was associated with poorer functional results.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Orthopedics
Franciele Dietrich-Zagonel, Per Aspenberg, Pernilla Eliasson
Summary: Dexamethasone treatment for Achilles tendon healing is dose- and time-dependent. The appropriate treatment time and dose can significantly improve the physical properties of the healing tendon while reducing adverse effects. Mechanical loading is also essential for the positive effects of dexamethasone.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Engineering, Environmental
Jin Jing, Yang Qian Qian, Sun Jie, Zhou You Lang
Summary: Inhibiting cyclooxygenases and modulating macrophage polarization can prevent tendon injury and reduce adhesion formation. The roles of Pla1a and Etv1 in this process have been identified.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Orthopedics
Ke Jiang, Yuling Li, Chao Xiang, Yan Xiong, Jiameng Jia
Summary: The study investigated the anti-adhesion and anti-inflammatory effects of TGF-beta 3 on flexor digitorum longus tendon repair in rats. Results demonstrated that TGF-beta 3 effectively protected against flexor tendon injury by regulating adhesion formation.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Statistics & Probability
Ting Tian, Jingwen Zhang, Shiyun Lin, Yukang Jiang, Jianbin Tan, Zhongfei Li, Xueqin Wang
Summary: This study utilized interventions implemented in China and applied them to simulate the potential outcomes in South Korea, Italy, and the United States. The results showed that mild interventions in the early stage were effective in controlling the epidemic, while stricter measures were necessary for severe outbreaks.
JOURNAL OF APPLIED STATISTICS
(2023)
Article
Soil Science
Mengqiu He, Xiuli Xin, Lei Meng, Xiaoyuan Yan, Chang Zhao, Zucong Cai, Anning Zhu, Jinbo Zhang, Christoph Mueller
Summary: This study conducted a (15)N tracing study to examine the impacts of long-term nitrogen fertilization on gross N transformation rates in soil. The results showed that organic or chemical N applications significantly stimulated N mineralization and autotrophic nitrification rates, leading to increased crop yields. However, the immobilization of mineral N decreased after long-term N applications, and N2O emissions also increased. Therefore, a combination of organic and chemical N fertilizers is recommended for climate-smart agricultural practices.
BIOLOGY AND FERTILITY OF SOILS
(2023)
Article
Environmental Sciences
Zheng Li, Zhenghui Fu, Shuhang Wang, Yang Zhang, Jinbo Zhang, Yanxiao Liu, Huaicheng Guo, Pingjian Yang
Summary: This study conducted an ecological and human health risk assessment of metals and heavy metals in Qinghai Lake, the largest inland saltwater lake in China. The concentration, distribution, and source of these metals were investigated. It was found that the metals in the sediments of Qinghai Lake mainly came from five rivers entering the lake, with copper and zinc showing the highest enrichment capacity. The results of the risk assessment indicated low ecological risks and no threat to human health from the heavy metals in the lake's sediments.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qiaowei Li, Huijuan Zhong, Shun Yu, Yanling Cheng, Yalan Dai, Feng Huang, Zhonghua Lin, Pengli Zhu
Summary: This study aims to assess the association between exercise capacity and specific aspects of resting cardiac structure, function, and tissue in older adults.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Biochemical Research Methods
Jing-Jing Zhang, Si-Ying Wang, Hai-Tao Dai, Hai-Chao Li, Yong Wang
Summary: Chiral recognition is an emerging field in modern chemical analysis. This study focuses on the development of a cellulose derivative, cellulose-tris(4-methylphenylcarbamate) (CMPC), for chiral recognition and separation. A CMPC-functionalized extended-gate organic field effect transistor (EG-OFET) was constructed and effectively detected three chiral molecules. The study further explores the enantiomer discrimination mechanism of CMPC using spectroscopy and nuclear magnetic resonance.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Civil
Jing Zhang, Zheng Lu, Chuxuan Tang, Jie Liu, Hailin Yao
Summary: In this paper, a new dynamic forward model of a multilayered highway structure considering the unsaturated characteristics of subgrade soil is established to assess the dynamic response induced by the falling weight deflectometer (FWD) load. The effects of saturation on stress, displacement, and pore water pressure are analyzed. It is found that the effect of saturation on vertical stress is negligible, while vertical displacement and pore water pressure increase significantly with increasing saturation. The vertical displacement response on the pavement surface is sensitive to subgrade deterioration and variations in material properties.
TRANSPORTATION GEOTECHNICS
(2023)
Article
Education & Educational Research
Xue Bai, Daniel W. L. Lai, Jinjin Zhang
Summary: This study proposed and evaluated an infusion active aging education (IAAE) model to help university students develop an age-friendly mind-set and empower older individuals through intergenerational learning. The results showed significant improvements in aging-related knowledge, attitudes, skills, and professional interests among the intervention group students. The older adult participants reported improvements in their understanding of young people, sense of self-worth, and generativity.
GERONTOLOGY & GERIATRICS EDUCATION
(2023)
Article
Computer Science, Interdisciplinary Applications
Chuxuan Tang, Zheng Lu, Siang Huat Goh, Jie Liu, Hailin Yao, Jing Zhang, Xianwen Huang
Summary: This study investigates the dynamic responses of a thermo-poroelastic half-space under circular surface thermal or/and mechanical loads. By considering water seepage and inertia of soil particles and pore water, the governing equations based on Biot's dynamic poroelastic theory are established. Solutions are derived in the transformed domain using Laplace-Hankel transform, and then transformed into the time domain using numerical integration. The resulting dynamic responses of the thermo-poroelastic half-space under rectangular thermal pulse load and/or half-sinusoidal impact mechanical load are graphically presented. The study reveals that both thermal and mechanical loads induce time-dependent responses in the vertical displacements, vertical stresses, and pore water pressures within the saturated poroelastic medium, and the coupled dynamic responses can be obtained by superposing the individual thermal and mechanical responses.
COMPUTERS AND GEOTECHNICS
(2023)
Article
Biochemistry & Molecular Biology
Xiangxiang Sun, Juan Chen, Xinlin Chen, Jianbing Ma, Lin Xiao, Shuxin Yao, Xiaoqian Dang
Summary: Rheumatoid arthritis (RA) is an autoimmune disorder characterized by the immune system attacking joints, and its underlying molecular mechanisms are still being studied. This research found that overexpression of nuclear receptor coactivator 3 (NCOA3) was observed in the joint tissues of mice with type II collagen-induced arthritis (CIA), an important model of RA. Inhibitors of NCOA3 were found to effectively reduce inflammation and improve the condition of the CIA mice. Further experiments revealed that NCOA3 forms a complex with other proteins that regulates the expression of proinflammatory cytokine genes, and targeting this complex could be a potential new approach for treating RA.
Article
Materials Science, Multidisciplinary
Xiaobin Zhang, Wenlong Zhang, Shuwang Bian, Pengfei Zhao
Summary: This paper calculates the relationship between the evolution of microstructure morphology and grain size, and the calculated solidification parameter, by comparing the solidification process percentage of the welding experiment and simulation. The research shows that the method of using the solidification process percentage to calculate the solidification parameter threshold for the microstructure evolution of welding is reliable, and the evolution threshold of microstructure morphology and grain size of AZ31 magnesium alloy is obtained.
Article
Chemistry, Analytical
Shenghua Li, Lingyu Xiao, Longqian Xiao, Hongliang Tan
Summary: This study demonstrated the potential of coordination polymers (CPs) as hosts for integrating multiple guest species into a fluorescence resonance energy transfer (FRET) nanoprobe. The researchers developed CD/PR@ZnCPs by integrating carbon dot (CD) and phenol red (PR) into ZnCPs constructed from zinc(II) and adenine. The confinement effect of ZnCPs brought CD and PR close together, allowing the FRET process from CD to PR, resulting in the quenching of CD fluorescence. The FRET process was disrupted in alkaline medium, switching on the fluorescence of CD/PR@ZnCPs. Based on this finding, a turn-on fluorescent method for detecting urease activity was established.
Article
Virology
Zhenhe Xu, Zihan Ding, Yuanxing Zhang, Xiaohong Liu, Qiyao Wang, Shuai Shao, Qin Liu
Summary: Phage therapy is a potential alternative to antibiotics for bacterial infections. This study found that storing phages at 4 degrees C was optimal and that 10% dimethyl sulfoxide (DMSO) was more effective in protecting the phages at lower temperatures than glycerin. Additionally, the use of hydroxyapatite and a combination of trehalose with tryptic soy broth or skim milk powder alleviated phage inactivation during storage. Furthermore, a model for predicting phage shelf-life was established with high accuracy using the Accelerated Stability Assessment Program (ASAP) based on the Arrhenius equation.
Article
Chemistry, Physical
Jingchao Zhang, Jiawei Luo, Zhaoxin Guo, Zhedong Liu, Cunpeng Duan, Shuming Dou, Qunyao Yuan, Peng Liu, Kemeng Ji, Cuihua Zeng, Jie Xu, Wei-Di Liu, Yanan Chen, Wenbin Hu
Summary: This study reports the use of ultrafine structure-activated porous carbon (UAPC) with N, O functional groups as high-energy density carbon material for supercapacitors (SCs). By utilizing ultrafast joule heating and cooling, general-purposed carbon is converted into electrochemical-activated carbon, resulting in UAPC-based SCs with a high energy density in EMIMBF4 ionic liquid. The outstanding electrochemical performance of UAPC is attributed to its ultrafine structure and N, O functional groups, which increase the surface area, improve the surface wettability of the electrodes, and provide pseudocapacitance.
ADVANCED ENERGY MATERIALS
(2023)
Article
Automation & Control Systems
Zeyi Liu, Jingfei Zhang, Xiao He, Qinghua Zhang, Guoxi Sun, Donghua Zhou
Summary: In this paper, a fault diagnosis methodology of rotating machinery with limited expert interaction is proposed. A novel multicriteria active learning query strategy is designed to select valuable samples for annotation, and the broad learning system is utilized to achieve fast updating or retraining with high diagnostic accuracy. The proposal shows high stability and flexibility in experiments.
IEEE TRANSACTIONS ON CONTROL SYSTEMS TECHNOLOGY
(2023)
Article
Engineering, Multidisciplinary
Jingbo Zhang, Yanjun Zhang, Xingjuan Cai, Liping Xie
Summary: This paper proposes a three-stage hyperspectral image compression sensing algorithm, which improves the reconstruction accuracy by obtaining the intra-band and inter-band characteristics. Simulation results show that this algorithm performs best among all comparison algorithms.
CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES
(2023)
