Vertical sleeve gastrectomy triggers fast β-cell recovery upon overt diabetes

Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity

(2021) Thomas A. Wadden et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

CD81 marks immature and dedifferentiated pancreatic β-cells

(2021) Ciro Salinno et al.   Molecular Metabolism

Wolfram syndrome 1 gene regulates pathways maintaining beta-cell health and survival

(2020) Damien Abreu et al.   LABORATORY INVESTIGATION

Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes

(2020) Joan Camunas-Soler et al.   Cell Metabolism

Sel1L-Hrd1 ER-associated degradation maintains β cell identity via TGF-β signaling

(2020) Neha Shrestha et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic deletion of Urocortin 3 does not prevent functional maturation of beta cells

(2020) Jessica L. Huang et al.   JOURNAL OF ENDOCRINOLOGY

Characterization of Signaling Pathways Associated with Pancreatic β-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes in db/db Mice

(2020) Taewook Kang et al.   MOLECULAR & CELLULAR PROTEOMICS

Factors Associated with Complete and Partial Remission, Improvement or Unchanged Diabetes Status of Obese Adults One Year after Sleeve Gastrectomy

(2020) Isra Elgenaied et al.   Surgery for Obesity and Related Diseases

Once-Weekly Semaglutide Reduces HbA1c and Body Weight in Patients with Type 2 Diabetes Regardless of Background Common OAD: a Subgroup Analysis from SUSTAIN 2–4 and 10

(2020) Matthew Capehorn et al.   Diabetes Therapy

Generalizing RNA velocity to transient cell states through dynamical modeling

(2020) Volker Bergen et al.   NATURE BIOTECHNOLOGY

Glucose-Lipid Metabolism in Obesity with Elevated Prolactin Levels and Alteration of Prolactin Levels After Laparoscopic Sleeve Gastrectomy

(2020) Xingchun Wang et al.   OBESITY SURGERY

Characterizing pancreatic β-cell heterogeneity in the streptozotocin model by single-cell transcriptomic analysis

(2020) Ye Feng et al.   Molecular Metabolism

Caloric restriction recovers impaired β-cell-β-cell gap junction coupling, calcium oscillation coordination, and insulin secretion in prediabetic mice

(2020) Maria Esméria Corezola do Amaral et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

GK-rats respond to gastric bypass surgery with improved glycemia despite unaffected insulin secretion and beta cell mass

(2020) Michael G. Miskelly et al.   PEPTIDES

Pharmacological Targeting of Endoplasmic Reticulum Stress in Pancreatic Beta Cells

(2020) Sara Bilekova et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Endoplasmic Reticulum Associated Degradation (ERAD) Has a Critical Role in Supporting Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells

(2019) Yabing Hu et al.   DIABETES

Single-Cell Heterogeneity Analysis and CRISPR Screen Identify Key β-Cell-Specific Disease Genes

(2019) Zhou Fang et al.   Cell Reports

Insulin resistance and insulin hypersecretion in the metabolic syndrome and type 2 diabetes: Time for a conceptual framework shift

(2019) Christopher J Nolan et al.   Diabetes & Vascular Disease Research

Scrublet: Computational Identification of Cell Doublets in Single-Cell Transcriptomic Data

(2019) Samuel L. Wolock et al.   Cell Systems

Claudin 4 in pancreatic β cells is involved in regulating the functional state of adult islets

(2019) Hongtu Li et al.   FEBS Open Bio

Sleeve Gastrectomy Improves Glycemia Independent of Weight Loss by Restoring Hepatic Insulin Sensitivity

(2018) Samir Abu-Gazala et al.   DIABETES

Pseudotime Ordering of Single Human β-Cells Reveals States of Insulin Production and Unfolded Protein Response

(2018) Yurong Xin et al.   DIABETES

RNA-Seq Analysis of Islets to Characterise the Dedifferentiation in Type 2 Diabetes Model Mice db/db

(2018) Abraham Neelankal John et al.   ENDOCRINE PATHOLOGY

The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones

(2018) Carrie R. Sowers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional Heterogeneity of Beta Cells in the Intact Pancreas

(2018) Lydia Farack et al.   DEVELOPMENTAL CELL

Dimensionality reduction for visualizing single-cell data using UMAP

(2018) Etienne Becht et al.   NATURE BIOTECHNOLOGY

Bariatric Surgery Worldwide: Baseline Demographic Description and One-Year Outcomes from the Fourth IFSO Global Registry Report 2018

(2018) Richard Welbourn et al.   OBESITY SURGERY

Bariatric Surgery versus Intensive Medical Therapy for Diabetes — 5-Year Outcomes

(2017) Philip R. Schauer et al.   NEW ENGLAND JOURNAL OF MEDICINE

db/db Mice Exhibit Features of Human Type 2 Diabetes That Are Not Present in Weight-Matched C57BL/6J Mice Fed a Western Diet

(2017) Susan J. Burke et al.   Journal of Diabetes Research

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes

(2016) Åsa Segerstolpe et al.   Cell Metabolism

Synaptotagmin-7 Functions to Replenish Insulin Granules for Exocytosis in Human Islet β-Cells

(2016) Subhankar Dolai et al.   DIABETES

Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: A Joint Statement by International Diabetes Organizations

(2016) Francesco Rubino et al.   DIABETES CARE

β-Cell Deficit in Obese Type 2 Diabetes, a Minor Role of β-Cell Dedifferentiation and Degranulation

(2016) Alexandra E. Butler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes

(2016) Francesca Cinti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Identification of proliferative and mature β-cells in the islets of Langerhans

(2016) Erik Bader et al.   NATURE

Diffusion pseudotime robustly reconstructs lineage branching

(2016) Laleh Haghverdi et al.   NATURE METHODS

Impact of islet architecture on β-cell heterogeneity, plasticity and function

(2016) Sara S. Roscioni et al.   Nature Reviews Endocrinology

Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus

(2016) Abd A. Tahrani et al.   Nature Reviews Endocrinology

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Preoperative Beta Cell Function Is Predictive of Diabetes Remission After Bariatric Surgery

(2016) Pedro Souteiro et al.   OBESITY SURGERY

Preventative Sleeve Gastrectomy Contributes to Maintaining β Cell Function in db/db Diabetic Mouse

(2016) Feng Li et al.   OBESITY SURGERY

Osteoprotegerin Regulates Pancreatic β-Cell Homeostasis upon Microbial Invasion

(2016) Yukiko Kuroda et al.   PLoS One

Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice

(2016) Ja Young Kim-Muller et al.   Nature Communications

MafA-Controlled Nicotinic Receptor Expression Is Essential for Insulin Secretion and Is Impaired in Patients with Type 2 Diabetes

(2016) Elvira Ganic et al.   Cell Reports

Reversibility ofβ-Cell-Specific Transcript Factors Expression by Long-Term Caloric Restriction in db/db Mouse

(2016) Chunjun Sheng et al.   Journal of Diabetes Research

A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure

(2016) Maayan Baron et al.   Cell Systems

Repurposing an Osteoporosis Drug for β Cell Regeneration in Diabetic Patients

(2015) Felizitas Schmitz et al.   Cell Metabolism

The Role of Gut Adaptation in the Potent Effects of Multiple Bariatric Surgeries on Obesity and Diabetes

(2015) Randy J. Seeley et al.   Cell Metabolism

Osteoprotegerin and Denosumab Stimulate Human Beta Cell Proliferation through Inhibition of the Receptor Activator of NF-κB Ligand Pathway

(2015) Nagesha Guthalu Kondegowda et al.   Cell Metabolism

TGR5 contributes to glucoregulatory improvements after vertical sleeve gastrectomy in mice

(2015) Anne K McGavigan et al.   GUT

Insulin demand regulates β cell number via the unfolded protein response

(2015) Rohit B. Sharma et al.   JOURNAL OF CLINICAL INVESTIGATION

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Sleeve gastrectomy, but not duodenojejunostomy, preserves total beta-cell mass in Goto-Kakizaki rats evaluated by three-dimensional optical projection tomography

(2015) Eivind Grong et al.   SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES

The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells

(2015) Justin R. Hassler et al.   PLOS BIOLOGY

Prolactin Receptors and Placental Lactogen Drive Male Mouse Pancreatic Islets to Pregnancy-Related mRNA Changes

(2015) Lotte Goyvaerts et al.   PLoS One

Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy

(2014) Zhiyu Wang et al.   Cell Metabolism

Gastric Bypass Improves β-Cell Function and Increases β-Cell Mass in a Porcine Model

(2014) Andreas Lindqvist et al.   DIABETES

β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment

(2014) Philippe A. Halban et al.   DIABETES CARE

Bariatric Surgery versus Intensive Medical Therapy for Diabetes — 3-Year Outcomes

(2014) Philip R. Schauer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reduction of pancreatic β-cell dedifferentiation after gastric bypass surgery in diabetic rats

(2014) Bangguo Qian et al.   Journal of Molecular Cell Biology

Characterisation of Age-Dependent Beta Cell Dynamics in the Male db/db Mice

(2013) Louise S. Dalbøge et al.   PLoS One

Acute and long-term effects of Roux-en-Y gastric bypass on glucose metabolism in subjects with Type 2 diabetes and normal glucose tolerance

(2012) N. B. Jørgensen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3

(2012) Barak Blum et al.   NATURE BIOTECHNOLOGY

Urocortin 3 Marks Mature Human Primary and Embryonic Stem Cell-Derived Pancreatic Alpha and Beta Cells

(2012) Talitha van der Meulen et al.   PLoS One

Weight-Independent Changes in Blood Glucose Homeostasis After Gastric Bypass or Vertical Sleeve Gastrectomy in Rats

(2011) Adam P. Chambers et al.   GASTROENTEROLOGY

Defining human ERAD networks through an integrative mapping strategy

(2011) John C. Christianson et al.   NATURE CELL BIOLOGY

C-peptide Predicts the Remission of Type 2 Diabetes After Bariatric Surgery

(2011) Wei-Jei Lee et al.   OBESITY SURGERY

Placental lactogens induce serotonin biosynthesis in a subset of mouse beta cells during pregnancy

(2010) A. Schraenen et al.   DIABETOLOGIA

Sleeve Gastrectomy Induces Loss of Weight and Fat Mass in Obese Rats, but Does Not Affect Leptin Sensitivity

(2010) Margaret A. Stefater et al.   GASTROENTEROLOGY

Regulation of pancreatic islet gene expression in mouse islets by pregnancy

(2010) B T Layden et al.   JOURNAL OF ENDOCRINOLOGY

Identification of Markers for Newly Formed β-Cells in the Perinatal Period: A Time of Recognized β-Cell Immaturity

(2010) Tandy Aye et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

The Roles ofATF3, an Adaptive-Response Gene, in High-Fat-Diet-Induced Diabetes and Pancreatic β-Cell Dysfunction

(2010) Erik J. Zmuda et al.   MOLECULAR ENDOCRINOLOGY

Serotonin regulates pancreatic beta cell mass during pregnancy

(2010) Hail Kim et al.   NATURE MEDICINE

Weight and Type 2 Diabetes after Bariatric Surgery: Systematic Review and Meta-analysis

(2009) Henry Buchwald et al.   AMERICAN JOURNAL OF MEDICINE

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

The Transcriptional Response of the Islet to Pregnancy in Mice

(2009) Sebastian Rieck et al.   MOLECULAR ENDOCRINOLOGY

On the origin of the   cell

(2008) J. M. Oliver-Krasinski et al.   GENES & DEVELOPMENT

Effect of Weight Loss by Gastric Bypass SurgeryVersusHypocaloric Diet on Glucose and Incretin Levels in Patients with Type 2 Diabetes

(2008) Blandine Laferrère et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Fast unfolding of communities in large networks

(2008) Vincent D Blondel et al.   JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT