Article
Immunology
Ella A. Zuiderwijk-Sick, Celine van der Putten, Raissa Timmerman, Jennifer Veth, Erica M. Pasini, Linda van Straalen, Paul van der Valk, Sandra Amor, Jeffrey J. Bajramovic
Summary: Exposure to IL-4 induces changes in the cell surface protein expression profile of primary rhesus macaque microglia and enhances their potential to induce proliferation of T cells with a regulatory signature. Additionally, IL-4 exposure broadly impairs TLR-induced cytokine production and inhibits microglial innate immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Laura Couloume, Juliette Ferrant, Simon Le Gallou, Marion Mandon, Rachel Jean, Nadege Bescher, Helene Zephir, Gilles Edan, Eric Thouvenot, Aurelie Ruet, Marc Debouverie, Karin Tarte, Patricia Ame, Mikael Roussel, Laure Michel
Summary: This study explored immune response profiles in blood of early MS patients using CyTOF panels, identifying increased abundance of a T-bet-expressing B cell subset and a CD206(+) classical monocyte subset. T-bet-expressing B cells were found to be enriched in aggressive MS patients. Further research is needed to validate these findings and determine the exact role of the identified clusters in neuroinflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jonas Lanfer, Johanna Kaindl, Laura Krumm, Miguel Gonzalez Acera, Markus Neurath, Martin Regensburger, Florian Krach, Beate Winner
Summary: In this study, we developed an easy-to-use method to convert human induced pluripotent stem cells into functional microglia-like cells. The protocol involved efficient differentiation and maturation steps, sequential harvesting and freezing techniques, as well as culturing on uncoated glass surfaces to increase yield while maintaining differentiation efficiency and functional characteristics. This method is highly valuable for research on microglia-like cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Kousuke Yonemoto, Fumihiko Fujii, Ryoji Taira, Masahiro Ohgidani, Katsuhide Eguchi, Sayaka Okuzono, Yuko Ichimiya, Yuri Sonoda, Pin Fee Chong, Hironori Goto, Hikaru Kanemasa, Yoshitomo Motomura, Masataka Ishimura, Yuhki Koga, Keita Tsujimura, Takao Hashiguchi, Hiroyuki Torisu, Ryutaro Kira, Takahiro A. Kato, Yasunari Sakai, Shouichi Ohga
Summary: This study investigated the response of human induced microglia-like (iMG) cells to innate immune ligands and found that cell heterogeneity and mitochondrial stability underlie the immunoreactivity of iMG.
CLINICAL IMMUNOLOGY
(2023)
Article
Cell Biology
Inka Berglar, Stephanie Hehlgans, Andrej Wehle, Caterina Roth, Christel Herold-Mende, Franz Roedel, Donat Koegel, Benedikt Linder
Summary: In this study, we investigated the role of CHRDL1 in glioma stem-like cells and found that depletion of CHRDL1 reduces stemness and enhances radiation sensitivity. Additionally, high expression of CHRDL1 may also serve as a marker protein for determining BMP4 susceptibility.
Review
Neurosciences
Miguel A. Cuadros, M. Rosario Sepulveda, David Martin-Oliva, Jose L. Marin-Teva, Veronika E. Neubrand
Summary: Microglia are tissue-resident macrophages in the central nervous parenchyma, originating from yolk sac precursors. In addition to true microglia, there are also microglia-like cells from bone marrow that mainly appear under pathological conditions. These two types of cells share similarities but have differences, which are important for understanding their development and potential therapeutic strategies for diseases they are involved in.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biology
Xiaoting Wu, Takashi Saito, Takaomi C. Saido, Anna M. Barron, Christiane Ruedl
Summary: The study conducted a comprehensive fate-mapping analysis of murine microglia and border-associated macrophages (BAMs). Results showed that microglia remain a stable embryonic-derived population, while BAMs are minimally replaced by bone marrow-derived cells. These findings are crucial for identifying potential therapeutic targets in neurodegenerative diseases.
Article
Medicine, Research & Experimental
Fang Cao, Xiangping Xia, Yinchun Fan, Qian Liu, Jiancheng Song, Qiang Zhang, Yu Guo, Shengtao Yao
Summary: The study revealed a correlation between the expression level of PLK2 and the malignancy of gliomas, with high expression associated with poor prognosis. RNF180 may influence glioma cell apoptosis by regulating the ubiquitination of PLK2. Knocking down of PLK2 may suppress glioma development through inhibition of cell proliferation and promotion of cell apoptosis.
Review
Biochemistry & Molecular Biology
Johannes Wurm, Henna Konttinen, Christian Andressen, Tarja Malm, Bjoern Spittau
Summary: Microglia are resident immune cells in the central nervous system and play critical roles in brain development, homeostasis, and pathologies. Human-induced pluripotent stem cells have been successfully differentiated into microglia-like cells, but the differentiation protocols vary and may impact the similarity to primary human microglia and study outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Zesheng Peng, Jiajing Wang, Shiao Tong, Yuxi Wu, Dongye Yi, Wei Xiang
Summary: PDCL3 is an oncogene that is upregulated in multiple cancers and serves as a potential prognostic biomarker in glioma. Its expression is associated with epigenetic modifications and genetic mutations, and it may regulate cellular malignancy, cell communication, and extracellular matrix by interacting with the TCP1 complex. PDCL3 is also involved in the modulation of the glioma immune landscape, and its interference can inhibit the proliferation, invasion, and migration of glioma cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Apeng Chen, Yinan Jiang, Zhengwei Li, Lingxiang Wu, Ulises Santiago, Han Zou, Chunhui Cai, Vaibhav Sharma, Yongchang Guan, Lauren H. McCarl, Jie Ma, Yijen L. Wu, Joshua Michel, Yi Shi, Liza Konnikova, Nduka M. Amankulor, Pascal O. Zinn, Gary Kohanbash, Sameer Agnihotri, Songjian Lu, Xinghua Lu, Dandan Sun, George K. Gittes, Qianghu Wang, Xiangwei Xiao, Dean Yimlamai, Ian F. Pollack, Carlos J. Camacho, Baoli Hu
Summary: The CHI3L1 signaling pathway plays a crucial role in modulating the immune suppression microenvironment in glioblastoma by affecting tumor-associated macrophages. Gal3BP competes with Gal3 to bind CHI3L1, thus negatively regulating the immune evasion process. Administering a Gal3BP mimetic peptide in mouse models can reverse immune suppression and slow tumor progression.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Oncology
Huikai Zhang, Fanen Yuan, Yangzhi Qi, Baohui Liu, Qianxue Chen
Summary: Liquid biopsy has been applied in various cancers but little progress has been made in validating circulating biomarkers for brain malignancies. Data on circulating tumor cells in glioma are limited, and their application as a biomarker has just begun.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Valeria Chichagova, Maria Georgiou, Madeleine Carter, Birthe Dorgau, Gerrit Hilgen, Joseph Collin, Rachel Queen, Git Chung, Jila Ajeian, Marina Moya-Molina, Stefan Kustermann, Francois Pognan, Philip Hewitt, Michael Schmitt, Evelyne Sernagor, Lyle Armstrong, Majlinda Lako
Summary: Microglia are important immune cells in the retina, regulating neuronal survival and synaptic pruning. Researchers co-cultured retinal organoids with microglia-like cells and found that the organoids developed normally and retained their function. This immunocompetent in vitro retinal model provides a more relevant platform for studying the human retina.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Neurosciences
Atoshi Banerjee, Yimei Lu, Kenny Do, Travis Mize, Xiaogang Wu, Xiangning Chen, Jingchun Chen
Summary: This study utilized a microglia-like cellular model derived from peripheral blood monocytes and characterized it through various analyses, showing its similarity to human microglia and unique gene expression. The model is valuable for studying microglial function in various brain diseases, such as schizophrenia and Alzheimer's disease (AD).
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Tao Wang, Yunxia Zhou, Yunping Fan, Hao Duan, Xiaoyu Guo, Jinlong Chang, Youheng Jiang, Changxue Li, Zhang Fu, Yunfei Gao, Xiaoran Guo, Kastytis Sidlauskas, Zhenqiang He, Clive Da Costa, Xia Sheng, Dinglan Wu, Jinqiu Yuan, Huiliang Li, Yulong He, Yonggao Mou, Ningning Li
Summary: This study demonstrates that IDH mutation induces metabolic reprogramming in gliomas and influences the phenotypes of glioma-associated microglia/macrophages (GAMs). Gliomas expressing mutant IDH promote M1-like polarization of GAMs, while typical IDH induces M2-like polarization. Furthermore, the study reveals the involvement of the PERK/miR-19a/LDLR signaling pathway in regulating gliomal cholesterol transport and GAM phenotypes, suggesting it as a potential target pathway for glioma therapy.
Article
Clinical Neurology
Shinichiro Mori, Satoshi O. Suzuki, Hiroyuki Honda, Hideomi Hamasaki, Nobutaka Sakae, Naokazu Sasagasako, Hirokazu Furuya, Toru Iwaki
Summary: Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disease characterized by progressive ossification of skeletal muscles. The causative gene for FOP has been identified as the ACVR1 gene, with mutations like R206H being common. Additionally, rare mutations like G356D have been found in some FOP patients.
Article
Clinical Neurology
Hideomi Hamasaki, Masahiro Shijo, Ayaka Nakamura, Hiroyuki Honda, Yuichi Yamada, Masanao Oda, Tomoyuki Ohara, Toshiharu Ninomiya, Toru Iwaki
Summary: This study investigated the relationship between degenerative changes of the brain and heart, with reference to AD pathologies, ATTR deposition, and cardiac fibrosis in a Japanese population. It found that cardiac ATTR deposition correlated with AD brain pathology among older adults aged 90 or below.
Article
Oncology
Pavlina Chuntova, Yafei Hou, Ryosuke Naka, Akane Yamamichi, Tiffany Chen, Yitzhar Goretsky, Ryusuke Hatae, Takahide Nejo, Gary Kohanbash, Abigail L. Mende, Megan Montoya, Kira M. Downey, David Diebold, Jayne Skinner, Hong-Erh Liang, Bjoern Schwer, Hideho Okada
Summary: This study developed a new transgenic mouse model, which can be used to address clinically relevant questions and develop future immunotherapeutic strategies.
Article
Clinical Neurology
Kosuke Takigawa, Nobuhiro Hata, Yuhei Sangatsuda, Satoshi O. Suzuki, Noritoshi Sirozu, Ryusuke Hatae, Yojiro Akagi, Toru Iwaki, Shinji Nagata, Masahiro Mizoguchi
Summary: This report describes a rare case of intraventricular mucin-producing GBM in a 73-year-old woman, who remained clinically well for five years following surgery and postoperative treatment. The specific spatial and pathological findings in this case, as well as treatment strategies, are discussed.
Letter
Oncology
Shunsuke Yamamoto, Yuhki Koga, Hiroaki Ono, Hironori Goto, Nobuhiro Hata, Hidetaka Yamamoto, Satoshi O. Suzuki, Yasunari Sakai, Toru Iwaki, Shouichi Ohga
PEDIATRIC BLOOD & CANCER
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hanae Takase, Osamu Togao, Kazufumi Kikuchi, Nobuhiro Hata, Ryusuke Hatae, Toru Chikui, Kenji Tokumori, Yukiko Kami, Daisuke Kuga, Yuhei Sangatsuda, Masahiro Mizoguchi, Akio Hiwatashi, Kousei Ishigami
Summary: This study found that diffusion MRI based on the gamma distribution (GD) model is useful in evaluating the IDH mutation status of glioblastomas. The GD model-derived parameters could differentiate between IDH-mutant and IDH-wildtype glioblastomas.
BRITISH JOURNAL OF RADIOLOGY
(2022)
Article
Clinical Neurology
Kaoru Yagita, Hiroyuki Honda, Tomoyuki Ohara, Hideomi Hamasaki, Sachiko Koyama, Hideko Noguchi, Akane Mihara, Taro Nakazawa, Jun Hata, Toshiharu Ninomiya, Toru Iwaki
Summary: This study evaluated the aging-related tau astrogliopathy (ARTAG) in 110 autopsies and found differences in the distribution and affected variables of ARTAG across Alzheimer disease (AD) and cognitive healthy cases (HC). The findings suggest that age at death, neurofibrillary tangle Braak stage, gender, and Thal phase significantly affect the presence of ARTAG in both AD and HC individuals.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2022)
Article
Clinical Neurology
Yutaro Fujii, Ryusuke Hatae, Nobuhiro Hata, Satoshi O. Suzuki, Yuhei Sangatsuda, Kosuke Takigawa, Yusuke Funakoshi, Yutaka Fujioka, Daisuke Kuga, Masahiro Mizoguchi, Toru Iwaki, Koji Yoshimoto
Summary: This article presents a rare case of ganglioglioma grade 3 with H3 K27M mutation in an elderly man. The patient underwent tumor resection and received chemotherapy and radiotherapy.
Article
Clinical Neurology
Yusuke Funakoshi, Kosuke Takigawa, Nobuhiro Hata, Daisuke Kuga, Ryusuke Hatae, Yuhei Sangatsuda, Yutaka Fujioka, Ryosuke Otsuji, Aki Sako, Tadamasa Yoshitake, Osamu Togao, Akio Hiwatashi, Toru Iwaki, Masahiro Mizoguchi, Koji Yoshimoto
Summary: Bevacizumab treatment can prolong progression-free survival and deterioration-free survival in glioblastoma patients without worsening the clinical course after relapse. The emergence of nonenhancing tumor pattern and a significant decrease in early focal recurrence were observed after bevacizumab approval.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Kaoru Yagita, Hideko Noguchi, Sachiko Koyama, Hideomi Hamasaki, Takashi Komori, Shinichi Aishima, Takayuki Kosaka, Mitsuharu Ueda, Yoshihiro Komohara, Akihiro Watanabe, Naokazu Sasagasako, Toshiharu Ninomiya, Yoshinao Oda, Hiroyuki Honda
Summary: The study aimed to understand the differential effects of sporadic Creutzfeldt-Jakob disease (sCJD) on the hippocampus and other neocortical areas. By examining the histological patterns of cellular prion protein (PrP (c)) and abnormal prion protein (PrPSc) in the hippocampi of sCJD patients and normal controls (NCs), the chronology of histopathological alterations in the CA4 region in sCJD patients was highlighted.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Sachiko Koyama, Hideko Noguchi, Kaoru Yagita, Hideomi Hamasaki, Masahiro Shijo, Motoi Yoshimura, Kohei Inoshita, Naokazu Sasagasako, Hiroyuki Honda
Summary: This study investigates the presence of prion proteins in endocrine and exocrine tissues and their molecular properties in comparison to normal brain tissue. The findings are important for understanding and controlling prion disease.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Hideomi Hamasaki, Norihisa Maeda, Naokazu Sasagasako, Hiroyuki Honda, Masahiro Shijo, Shin-Ichiro Mori, Kaoru Yagita, Hajime Arahata, Toru Iwaki
Summary: Myotonic dystrophy type 1 (DM1) is a genetic disorder that causes abnormal accumulation of tau protein in the central nervous system. A study on the brains of four DM1 patients revealed the presence of neurofibrillary tangles in the limbic area and a distinctive pattern of tau deposits in the brainstem. This suggests that DM1 is associated with an early onset of PART-like pathology and abnormal splicing in the brainstem.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2022)
Article
Clinical Neurology
Hideko Noguchi, Sachiko Koyama, Kaoru Yagita, Masahiro Shijo, Kosuke Matsuzono, Hideomi Hamasaki, Takaaki Kanemaru, Tsuyoshi Okamoto, Keita Kai, Shinichi Aishima, Koji Abe, Naokazu Sasagasako, Hiroyuki Honda
Summary: Compared to Gerstmann-Straussler-Scheinker disease and sporadic Creutzfeldt-Jakob disease, GPI anchorless prion diseases exhibit more stable resident microglial phenotypes with less PrP deposition, leading to milder tissue damage and a lower incidence of dementia.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2022)
Article
Cell Biology
Kentaro Tanaka, Kenji Chamoto, Sho Saeki, Ryusuke Hatae, Yuki Ikematsu, Kazuko Sakai, Nobuhisa Ando, Kazuhiro Sonomura, Shinsuke Kojima, Masanori Taketsuna, Young Hak Kim, Hironori Yoshida, Hiroaki Ozasa, Yuichi Sakamori, Tomoko Hirano, Fumihiko Matsuda, Toyohiro Hirai, Kazuto Nishio, Takuro Sakagami, Masanori Fukushima, Yoichi Nakanishi, Tasuku Honjo, Isamu Okamoto
Summary: Researchers conducted a clinical trial of bezafibrate in combination with nivolumab for advanced non-small cell lung cancer patients. The combination therapy was well tolerated and showed potential in promoting T cell function and extending the duration of response. This T cell metabolism-targeting combination strategy may have implications for maintaining the antitumor activity of immune checkpoint inhibitors and requires further validation.
SCIENCE TRANSLATIONAL MEDICINE
(2022)