Article
Biochemistry & Molecular Biology
Mansoor Alsahag, Ali Alisaac, Gamil A. A. Al-Hazmi, Rami A. Pashameah, Roba M. S. Attar, Fawaz A. Saad, Nashwa M. El-Metwaly
Summary: A novel aerogel-like wound dressing capable of sensing the progress of wound healing was developed. Anthocyanins extracted from red-cabbage were integrated into a carboxymethyl cellulose/polyvinyl alcohol composite to create a water-soluble direct dye. The resulting composite was freeze-dried to obtain the aerogel-like smart wound dressing, which demonstrated antibacterial and biochromic properties for monitoring wound healing. Colorimetric changes and UV-Vis absorption spectra were used to measure the effects of anthocyanin content on the diagnostic assay. The morphology, stiffness, air-permeability, and mechanical behavior of the wound dressing were analyzed using various methods.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Jinfeng Cao, Ping Wu, Qianqian Cheng, Chen He, Yun Chen, Jinping Zhou
Summary: A new type of injectable CMCh hydrogel wound dressing with self-healing properties is constructed using coordination bonds and alkali/urea aqueous solutions. The hydrogel exhibits self-healing, self-adaption, and thermoresponsive ability, significantly accelerating skin tissue regeneration and wound closure. It has great potential in tissue engineering applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Applied
Vipawan Pitpisutkul, Jutarat Prachayawarakorn
Summary: Incorporating carboxymethyl starch and zinc oxide nanoparticles into hydroxypropyl methylcellulose film can improve its limitations for wound dressing application. The resulting films have increased moisture uptake, water vapor transmission rate, oxygen transmission rate, and antibacterial activity.
CARBOHYDRATE POLYMERS
(2022)
Article
Materials Science, Multidisciplinary
Ang Li, Zhengzhe Han, Zongyue Li, Jingfeng Li, Xiaolin Li, Zhichang Zhang
Summary: The novel PTHrP-2 loaded nanofiber mat CAP promotes cell proliferation, migration, and tube formation, accelerating wound healing in rat models. CAP has a promoting effect on angiogenesis, collagen formation, and re-epithelialization, making it a potential new type of wound dressing.
MATERIALS & DESIGN
(2021)
Article
Chemistry, Applied
Guozhu Chang, Qifeng Dang, Chengsheng Liu, Xiaoyu Wang, Hao Song, Hong Gao, Hantian Sun, Bonian Zhang, Dongsu Cha
Summary: A new dual drug delivery system CMCSH was designed to promote diabetic wound healing effectively. This system improved drug availability, promoted cell proliferation, and reduced inflammation.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Huishuang Yin, Peiqin Song, Xingyu Chen, Qiuyan Huang, Huihua Huang
Summary: In this research, a composite self-healing hydrogel with pH sensitivity for drug delivery was prepared using cellulose and chitosan from hericium erinaceus residues and pineapple peel. The hydrogel showed suitable gel time, good absorbent ability, self-healing characteristic, and controlled release of rutin.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Anshan Huang, Yehong Chen, Chaojun Wu
Summary: This study successfully designed a natural nanocellulose self-healing hydrogel that can quickly self-heal and protect the wound from external damage.
Article
Biochemistry & Molecular Biology
Vipawan Pitpisutkul, Jutarat Prachayawarakorn
Summary: This study successfully prepared a unique antimicrobial crosslinked film, which significantly improved the mechanical properties and swelling degree of the film by adding succinic acid and gallic acid. The film demonstrated potential for inhibiting bacterial growth and wound dressing application.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Materials Science, Paper & Wood
Walid Kamal Abdelbasset, Safaa M. Elkholi, Khadiga Ahmed Ismail, Hasan S. AL-Ghamdi, Sergei Mironov, Hussein S. H. Ridha, Marwah Suliman Maashi, Lakshmi Thangavelu, Trias Mahmudiono, Yasser Fakri Mustafa
Summary: This study developed a drug-delivery wound dressing incorporating mequinol into electrospun scaffolds, showing improved anti-inflammatory and antioxidant activities in vitro with potential for promoting wound healing and tissue repair.
Article
Biochemistry & Molecular Biology
Kimia Sarraf Mamouri, Somayeh Rahaiee, Mahboobeh Zare, Mehrab Nasiri Kenari, Navideh Mirzakhani
Summary: The film-forming potential of bacterial cellulose combined with PVA and BSG loaded with SSEO was investigated for wound dressing. Various analyses were performed to evaluate the structure, morphology, stability, and bioactivity of the biocomposite films. The results showed that the SSEO-loaded composite film exhibited excellent thermal resistance, strong antibacterial activity against gram-negative bacteria, and promising potential for wound healing with improved collagen deposition and reduced inflammatory response.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Gabriela Isopencu, Iuliana Deleanu, Cristina Busuioc, Ovidiu Oprea, Vasile-Adrian Surdu, Mihaela Bacalum, Roberta Stoica, Anicuta Stoica-Guzun
Summary: Bacterial cellulose (BC) is a biopolymer studied intensively for biomedical applications. However, it lacks antimicrobial activity and has limited water retention capacity. To address these limitations, BC composites with carboxymethyl cellulose (CMC) and turmeric extract (TE) were developed using citric acid (CA) as the crosslinking agent. These composites showed high swelling degrees, adsorbing exudate from chronic wounds, and exhibited potential antibacterial properties against Escherichia coli, Staphylococcus aureus, and Candida albicans. The composites were also found to be non-toxic to fibroblast cells, making them promising candidates for wound dressing applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Seiichi Ohta, Kento Mitsuhashi, Arvind K. Singh Chandel, Pan Qi, Noriko Nakamura, Akiko Nakamichi, Hiromi Yoshida, Gento Yamaguchi, Yuichi Hara, Ryo Sasaki, Masaya Fuke, Madoka Takai, Taichi Ito
Summary: Silver-loaded CMC nonwoven sheets with different counterions, CMC-Na/Ag and CMC-H/Ag, showed differences in anti-bacterial and wound-healing properties. CMC-Na/Ag significantly accelerated wound healing in a pressure ulcer mouse model compared to CMC-H/Ag and a commercial product Aquacel Ag.
CARBOHYDRATE POLYMERS
(2022)
Article
Materials Science, Paper & Wood
Nghi Thi-Phuong Nguyen, Huy Hoang Nguyen, Hoan Ngoc Doan, Kien Trung Pham, Khiem Van Nguyen, Binh Thanh Vu, Tin Dai Luong, Bach Thang Phan, Hanh Kieu Thi Ta, Ngoc Quyen Tran, Tuan-Ngan Tang, Nhi Ngoc-Thao Dang, Thi-Hiep Nguyen
Summary: The study found that adding chitosan oligosaccharide to bacterial cellulose membranes can improve their hemostatic properties, although it may decrease the mechanical strength of the membranes. The modified bacterial cellulose membrane with 2 w/v% chitosan oligosaccharide solution (BC-COS2) demonstrated excellent hemostasis promotion in in vitro and in vivo experiments.
Article
Biochemistry & Molecular Biology
Mohamad Khalid Khairunnisa-Atiqah, Kushairi Mohd Salleh, Ainul Hafiza Abd Hair, Nyak Syazwani Nyak Mazlan, Marhaini Mostapha, Sarani Zakaria
Summary: Utilising carboxymethyl cellulose nanoparticles (CMC/NPs) colloidal solution as a coating solution can enhance the therapeutic properties of cotton thread wound dressing. The rheological properties and stability of CMC/NPs in the colloidal solution can influence the appearance of the coating solution and refine the microstructure of the cotton thread.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Pharmacology & Pharmacy
Manuel Horue, Jhonatan Miguel Silva, Ignacio Rivero Berti, Larissa Reis Brandao, Hernane da Silva Barud, Guillermo R. R. Castro
Summary: Bacterial cellulose (BC), produced by microorganisms, can be modified to produce different cellulosic formats. BC has advantages for biomedical applications such as easy moldability, high biocompatibility, and tailoring ability. Its hydroxyl residues and nanoporous morphology make it ideal for wound healing. This article discusses the characteristics of different BC structures, recent advances in BC composites, and the development of antimicrobial BC and drug delivery systems.
Article
Chemistry, Medicinal
Mahnaz Mohammadpour, Hadi Samadian, Nader Moradi, Zhila Izadi, Mahdieh Eftekhari, Masoud Hamidi, Amin Shavandi, Anthony Quero, Emmanuel Petit, Cedric Delattre, Redouan Elboutachfaiti
Summary: In this study, a nanocomposite hydrogel based on Alg and nHA was fabricated and characterized as a bone tissue engineering scaffold. The nanocomposite exhibited a porous architecture with interconnected pores, and showed significant antioxidant activity and biocompatibility, promoting bone regeneration.
Article
Chemistry, Medicinal
Soukaina Bouissil, Claire Guerin, Jane Roche, Pascal Dubessay, Zainab El Alaoui-Talibi, Guillaume Pierre, Philippe Michaud, Said Mouzeyar, Cedric Delattre, Cherkaoui El Modafar
Summary: In this study, the use of alginate, a natural polysaccharide extracted from brown algae, successfully activated the defense response in date palm trees and increased the activity of phenylalanine ammonia-lyase. The results also showed that alginate treatment significantly enhanced the expression of defense genes, and reduced the mortality rate of date palm trees infected with Fusarium oxysporum f. sp. albedinis.
Review
Virology
Hadrien Claus-Desbonnet, Elsa Nikly, Vanya Nalbantova, Diana Karcheva-Bahchevanska, Stanislava Ivanova, Guillaume Pierre, Niko Benbassat, Plamen Katsarov, Philippe Michaud, Paolina Lukova, Cedric Delattre
Summary: In the current COVID-19 pandemic, the scientific resources and medical community appear to be insufficient in combating the rapid global spread of viruses. Several epidemics caused by different viruses, such as dengue, chinkungunya, Ebola, MERS-CoV, and SARS-CoV, have occurred worldwide in recent years, highlighting the difficulty in treating an epidemic before the availability of vaccines. Existing antiviral drugs have limitations, including side effects and decreased effectiveness due to virus mutations. Therefore, it is crucial to develop new antiviral strategies using natural compounds, and polysaccharides have emerged as attractive candidates due to their therapeutic properties, low toxicity, and availability.
Article
Pharmacology & Pharmacy
Mohammad Foad Abazari, Sepehr Torabinejad, Shohreh Zare Karizi, Seyedeh Elnaz Enderami, Hadi Samadian, Nazanin Hajati-Birgani, Sara Norouzi, Fatemeh Nejati, Assil Al Bahash, Vahid Mansouri
Summary: This study aimed to investigate the impact of combining hydrophilic polymers with hydrophobic scaffolds on the osteogenic differentiation of induced pluripotent stem cells. The results showed that iPSCs grown on PCL/PVA/CP had the highest osteoinductive potential compared to other groups.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Vahdat Poortahmasebi, Ahmad Nejati, Mohammad Foad Abazari, Mohsen Nasiri Toosi, Azam Ghaziasadi, Nader Mohammadzadeh, Ahmad Tavakoli, Azam Khamseh, Navid Momenifar, Omid Gholizadeh, Mehdi Norouzi, Seyed Mohammad Jazayeri
Summary: This study used RNA-sequencing to analyze the gene expression differences in PBMCs of HCC patients and identified DEGs related to immune response. Additionally, 7 genes with important diagnostic value for HBV-HCC were screened. These results provide new insights into the pathogenesis and clinical diagnosis of HCC.
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Multidisciplinary Sciences
Masoud Hamidi, Oseweuba Valentine Okoro, Giuseppe Ianiri, Hafez Jafari, Khodabakhsh Rashidi, Saeed Ghasemi, Raffaello Castoria, Davide Palmieri, Cedric Delattre, Guillaume Pierre, Mahta Mirzaei, Lei Nie, Hadi Samadian, Amin Shavandi
Summary: This study characterized and evaluated the biological properties of exopolysaccharides (EPS) produced by the yeast Papiliotrema terrestris PT22AV. The EPS showed potential antibacterial activity and wound healing capacity, making it a promising material for skin wound healing.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Green & Sustainable Science & Technology
Oseweuba Valentine Okoro, Lei Nie, Oguzhan Gunduz, Songul Ulag, Masoud Hamidi, Amin Shavandi
Summary: Marine pollution has been increasing due to seafood processing plants and their improper waste disposal, particularly the shells composed of chitin. This study explored the potential of using crab waste for chitin production. The results showed that the microbial chitin production pathway was the most appropriate technology for future investment. The cost-benefit analysis reinforced the dominant status of the microbial approach as the preferred strategy for valorization of crab waste.
Article
Polymer Science
Anouar Mouhoub, Safae Er Raouan, Amine Guendouz, Zainab El Alaoui-Talibi, Saad Ibnsouda Koraichi, Soumya El Abed, Gedric Delattre, Cherkaoui El Modafar
Summary: This study aimed to develop biodegradable films using chitosan and essential oils to protect against biofilm formation on food-grade surfaces. The results showed that the chitosan film with added essential oils had strong antiadhesion activity, effectively preventing microbial attachment and biofilm development. Therefore, this film has potential for use as an active coating and packaging material in the food industry.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Medicinal
Vesela Kokova, Paolina Lukova, Alexandra Baldzhieva, Plamen Katsarov, Cedric Delattre, Roland Molinie, Emmanuel Petit, Redouan Elboutachfaiti, Marianna Murdjeva, Elisaveta Apostolova
Summary: The study aimed to analyze the chemical composition and structural characteristics of alginate from C. crinita found in the Bulgarian Black Sea. It also investigated the effects of the alginate on histamine-induced paw inflammation in rats. The study measured the levels of inflammatory cytokines in the serum and peritoneal fluid of rats. The results showed that C. crinita alginate had anti-inflammatory activity and could reduce the levels of pro-inflammatory cytokines in rats.
Review
Chemistry, Physical
Zahra Ebrahimvand Dibazar, Lei Nie, Mehdi Azizi, Houra Nekounam, Masoud Hamidi, Amin Shavandi, Zhila Izadi, Cedric Delattre
Summary: Bone tissue engineering combines biomaterials, cells, and bioactive agents to provide advanced treatment options. Scaffolds play a central role, and precise design and fabrication of structures that closely resemble bone tissue have shown promising results. The use of nanotechnology and nanomaterials in scaffolds allows for tailored physicochemical properties and improved interactions with cells and surrounding tissues. Polymeric and carbon nanofibers have attracted attention due to their similarity to bone extracellular matrix and high surface-to-volume ratio. Mineralized nanofibers have shown potential in enhancing bone healing in tissue engineering applications.
Article
Chemistry, Physical
Jihane Zeghlouli, Nicola Schiavone, Haroutioun Askanian, Amine Guendouz, Cherkaoui El Modafar, Philippe Michaud, Cedric Delattre
Summary: Extrusion and hot compressing molding processes were used to fabricate BioPE composites reinforced with argan byproducts as bio-fillers. The mechanical properties of the composites were investigated by dynamical mechanical analysis and rheological testing. The results showed that the addition of argan byproducts improved the mechanical properties of the composites. Furthermore, the thermal analysis revealed that the bio-fillers reduced the decomposition temperatures of the polymer. This study offers an environmentally friendly alternative for utilizing underutilized biomass and has the potential to create new markets for argan byproducts.
Article
Polymer Science
Gwendoline Christophe, Xiaoyang Hou, Emmanuel Petit, Mounir Traikia, Didier Le Cerf, Christophe Rihouey, Christine Gardarin, Cedric Delattre, Philippe Michaud, Guillaume Pierre, Pascal Dubessay
Summary: This study identified Peteryoungia rosettifformans as a wild producer of an exopolysaccharide related to glucuronan. Structural and biochemical analyses revealed that the polysaccharide had a molecular mass of 1.85 x 10(5) Da and was partially O-acetylated at C-2 and/or C-3 positions. The concentration of Mg2+ ions in the cultivation medium was found to impact the structure of the polysaccharide.
Article
Cell Biology
Kayla F. Goliwas, Sarah Libring, Emily Berestesky, Shayan Gholizadeh, Samantha C. Schwager, Andra R. Frost, Thomas R. Gaborski, Jian Zhang, Cynthia A. Reinhart-King
Summary: Cancer-associated fibroblasts (CAFs) communicate with breast cancer cells through contact-dependent tunneling nanotubes (TNTs) to transfer cargo, including mitochondria, and enhance cancer cell migration. This cargo transfer results in an increase in mitochondrial ATP production in cancer cells, while glycolytic ATP production is minimally impacted. Tumor-stromal cell crosstalk via TNTs and the associated metabolic symbiosis is a finely controlled mechanism by which tumor cells promote cancer progression and may be a potential therapeutic target.
JOURNAL OF CELL SCIENCE
(2023)
Article
Cell Biology
Nariman Rezaei Kolarijani, Danial Cheraghali, Hossein Khastar, Arian Ehterami, Morteza Alizade, Ahmad Vaez, Seyed Mohammad Amini, Majid Salehi
Summary: In this study, a potential wound dressing was fabricated by loading gold nanoparticles into poly (epsilon-caprolactone) (PCL)/gelatin nanofibrous matrices. The prepared scaffolds showed appropriate mechanical properties and porosity, and the PCL/gelatin scaffold containing 400 ppm gold nanoparticles demonstrated the greatest cell growth and wound healing effect.
WOUND REPAIR AND REGENERATION
(2023)
