Article
Biochemistry & Molecular Biology
Yu-Chieh Huang, Mei-Ling Cheng, Hsiang-Yu Tang, Chi-Yao Huang, Kuan-Ming Chen, Jong-Shyan Wang
Summary: This study explores the impact of eccentric cycling training (ECT) on erythrocyte antioxidative capacity and metabolism in sedentary males. The results indicate that ECT enhances antioxidative capacity, promotes oxygen release, and mitigates oxidative stress induced by exercise, suggesting the beneficial effects of ECT on overall health and performance.
Article
Hematology
Samantha Weber-Fishkin, Harrison S. Seidner, Geoffrey Gunter, Mary D. Frame
Summary: This study aims to investigate the kinetics of erythrocyte aggregation under different temperature and oxygen conditions. The results showed that erythrocytes aggregate faster and with a higher magnitude in hyperthermia and hypoxemia, especially in autologous plasma. Furthermore, the C-terminal domain of band 3 plays a pivotal role in erythrocyte aggregation.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Physiology
Chih-Chin Hsu, Yu-Ting Lin, Tieh-Cheng Fu, Shu-Chun Huang, Cheng-Hsien Lin, Jong-Shyan Wang
Summary: Supervised cycling training (SCT) improves aerobic capacity and quality of life by enhancing erythrocyte deformability in patients with peripheral arterial disease (PAD).
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Jun-Hong Ch'ng, Kirsten Moll, Katja Wyss, Ulf Hammar, Mikael Ryden, Olle Kampe, Anna Farnert, Mats Wahlgren
Summary: The study reveals an association between type 2 diabetes and parasite growth and rosetting, potentially explaining the protective effect of good glycemic control against severe malaria in subjects with diabetes.
Article
Obstetrics & Gynecology
A. S. Ducloy-Bouthors, F. J. Mercier, J. M. Grouin, F. Bayoumeu, J. Corouge, A. Le Gouez, T. Rackelboom, F. Broisin, F. Vial, A. Luzi, O. Capronnier, C. Huissoud, A. Mignon
Summary: This study aimed to assess the benefits and safety of early human fibrinogen concentrate in postpartum haemorrhage management, with results showing that 3 g fibrinogen concentrate did not significantly reduce blood loss or transfusion needs in PPH management, but did prevent plasma fibrinogen decrease and was considered safe.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Multidisciplinary Sciences
Katsuhiko Tsunekawa, Kazumi Ushiki, Larasati Martha, Asuka Nakazawa, Rika Hasegawa, Risa Shimizu, Nozomi Shimoda, Akihiro Yoshida, Kiyomi Nakajima, Takao Kimura, Masami Murakami
Summary: This study aimed to verify whether the automated measurement of salivary cortisol concentration via sequential sampling could detect the differences in exercise stress between two altitudes. The results showed that the rate of change in salivary cortisol concentration during morning exercise was significantly higher in the higher-altitude camp than in the lower-altitude camp.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Medicinal
Qianwen Guo, Xue Li, Wenbin Li, Rong Wang, Anpeng Zhao, Zihan Wang
Summary: Purpose of this study was to investigate the preventive effects of roxadustat on hypoxia damage during quick ascent to high altitude. Results showed that roxadustat significantly extended the survival time of mice, increased arterial blood oxygen saturation and oxygen partial pressure, and reduced levels of inflammatory factors. Additionally, roxadustat improved oxidative stress levels in tissues of hypoxic rats and alleviated organ damage. In conclusion, roxadustat can effectively reduce inflammation, oxidative stress, and tissue damage caused by hypoxia at high altitudes.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Materials Science, Multidisciplinary
Qing Yu, Luyao Tian, Wenya Su, Xia Li, Juan Wang, Lanping Guo, Luqi Huang, Wenyuan Gao
Summary: Photodynamic therapy (PDT) is a promising adjuvant therapy for cancer. However, the aggregation of organic photosensitizers in biological systems limits its efficacy. A newly developed self-assembled nanoplatform has addressed this issue and successfully delivered rapamycin. This multifunctional platform combines photodynamic therapy with tumor microenvironment remodeling, making it a forward-looking PDT design strategy.
ACS MATERIALS LETTERS
(2023)
Article
Multidisciplinary Sciences
Ahmet C. Sabuncu, Sinan Muldur, Barbaros Cetin, O. Berk Usta, Nadine Aubry
Summary: This study experimentally examined the aggregation of human red blood cells using Hetastrach as an aggregation agent, measuring parameters such as impedance and sedimentation kinetics to distinguish different aggregation states in blood. Theoretical modeling was used to analyze the complex permittivity of red blood cell aggregates at various concentrations of Hetastrach, providing insights into the dynamics of aggregation and sedimentation processes.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Ivan T. Ivanov, Boyana K. Paarvanova
Summary: Dielectric relaxations were studied on the erythrocyte spectrin network using dielectric spectroscopy. The extraction of membrane lipids preserved γ1(sp) and removed β(sp)-relaxation. The concentration of NaCl and the presence of certain substances influenced the strength of β(sp)-relaxation and γ1(sp)-relaxation differently.
Article
Biochemistry & Molecular Biology
Ian S. LaCroix, Mitchell Cohen, Ernest E. Moore, Monika Dzieciatkowska, Travis Nemkov, Terry R. Jr Jr Schaid, Margaret Debot, Kenneth Jones, Christopher C. Silliman, Kirk C. Hansen, Angelo D'Alessandro
Summary: This study characterized the effectiveness of red blood cell (RBC) transfusion in trauma patients using plasma metabolomics and proteomics. The results showed that transfusion of one or more RBC units can alter the levels of various compounds in circulation, potentially affecting thromboinflammatory modulation after trauma. This effect was most pronounced in patients with higher injury severity scores and was proportional to the number of units transfused. Additionally, transfusion was associated with changes in the circulating levels of coagulation factors, fibrinogen chains, and RBC proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Brett S. Kirby, Matthew A. Sparks, Eduardo R. Lazarowski, Denise A. Lopez Domowicz, Hongmei Zhu, Timothy J. McMahon
Summary: The study found that Panx1 channels participate in hypoxic vasodilation by regulating hypoxia-sensitive extracellular ATP levels in blood. Mice lacking Panx1 showed attenuated decrease in blood pressure and reduced increase in limb blood flow during hypoxia, along with lower plasma ATP levels. This indicates the important role of Panx1 in vascular responses to hypoxia.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Biology
Aneta Teleglow, Mateusz Mardyla, Michal Myszka, Tomasz Palka, Marcin Maciejczyk, Przemyslaw Bujas, Dariusz Mucha, Bartlomiej Ptaszek, Jakub Marchewka
Summary: The study found that 3-week hypoxic training had positive effects on the blood indicators and maximal oxygen uptake of rowers, improving blood rheological properties and erythrocyte deformability.
Article
Obstetrics & Gynecology
Hun-Young Park, Won-Sang Jung, Sung-Woo Kim, Kiwon Lim
Summary: This study verified the effects of interval training under hypoxia on the autonomic nervous system and arterial and hemorheological function in healthy women. The results showed that interval training under hypoxia significantly improved ANS function, arterial stiffness, arterial endothelial function, hemorheological function, and aerobic performance.
INTERNATIONAL JOURNAL OF WOMENS HEALTH
(2022)
Article
Hematology
Rui-Gang Xu, Julia S. Gauer, Stephen R. Baker, Alexandre Slater, Eleyna M. Martin, Helen R. McPherson, Cedric Duval, Iain W. Manfield, Arkadiusz M. Bonna, Steve P. Watson, Robert A. S. Ariens
Summary: The study demonstrates that dimeric GPVI binds to fibrinogen with higher affinity compared to the monomer, primarily through avidity effects. The interaction of GPVI with the α C-region of fibrinogen is crucial for its binding. These findings suggest that clustering of GPVI through the α C-region during fibrin polymerization may lead to downstream signaling, platelet activation, and clot growth.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Sport Sciences
Ming-Lu Lin, Chih-Chin Hsu, Tieh-Cheng Fu, Yu-Ting Lin, Yu-Chieh Huang, Jong-Shyan Wang
Summary: This study investigates the effects of interval and continuous exercise on NK cell phenotypes and mitochondrial bioenergetics. The results show that both high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) can increase the expressions of cytotoxic granule proteins and decrease mitochondrial matrix oxidant burden (MOB) in NK cells. Additionally, HIIT is superior to MICT in improving aerobic capacity.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Biochemistry & Molecular Biology
Chi-Hsiao Yeh, Yi-Ju Chou, Tsung-Hsien Tsai, Paul Wei-Che Hsu, Chun-Hsien Li, Yun-Hsuan Chan, Shih-Feng Tsai, Soh-Ching Ng, Kuei-Mei Chou, Yu-Ching Lin, Yu-Hsiang Juan, Tieh-Cheng Fu, Chi-Chun Lai, Huey-Kang Sytwu, Ting-Fen Tsai
Summary: A study in Taiwan found a high proportion of clopidogrel resistance among diabetic PAD patients, suggesting that platelet function test-guided therapy could reduce adverse events. AI-assisted genome-wide association study identified a SNP signature composed of 20 SNPs in 9 protein-coding genes, revealing a protein interaction network related to the endocytosis and recycling of the drug target of clopidogrel. The findings suggest potential for developing precision medicine for antiplatelet therapy in diabetic PAD patients.
Review
Education, Scientific Disciplines
Ke-Yun Chao, Jong-Shyan Wang, Wei-Lun Liu
Summary: COVID-19 pneumonia patients may require respiratory support, and European experts suggest using helmet continuous positive airway pressure as the first choice to reduce virus spread. In the United States, helmet ventilation was restricted before the COVID-19 pandemic.
Article
Cardiac & Cardiovascular Systems
Li-Hua Wu, Chao-Hung Wang, Min-Hui Liu, Chih-Chin Hsu, Pei-Hsun Yuan, Tieh-Cheng Fu
Summary: This study aimed to investigate the factors associated with participation and completion rates of cardiac rehabilitation (CR) in patients with heart failure (HF) and predict the improvement after CR. Factors associated with CR participation included sex and days between hospital discharge and cardiopulmonary exercise test. CR improved peak oxygen uptake (Vo(2peak)) and quality of life (QOL), and the improvement was related to male sex, younger age, no diabetes mellitus, and higher entry Vo(2peak).
JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
(2023)
Article
Medicine, General & Internal
Ching-Mao Chang, Jr-Rung Lin, Tieh-Cheng Fu
Summary: The study found that in the United States, patients diagnosed with RA are less likely to develop HF or MI compared to those with SLE. There was no significant association between sarcopenia and the presence of HF or MI.
FRONTIERS IN MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Ai Yin Lim, Yi-Ching Chen, Chih-Chin Hsu, Tieh-Cheng Fu, Jong-Shyan Wang
Summary: This systematic review investigated the effect of exercise training on mitochondrial function in cardiovascular disease (CVD) patients. The results showed that exercise can improve mitochondrial morphology, biogenesis, and significantly enhance oxidative capacity in CVD patients. However, the effects on mitochondrial dynamics, antioxidant capacity, and quality were inconclusive or inadequate. Further research, including randomized controlled trials, is needed to explore the pathways through which exercise modifies mitochondrial quantity and quality in CVD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Ming-Yueh Tseng, Jersey Liang, Ching-Tzu Yang, Jong-Shyan Wang, Chi-Chuan Wu, Huey-Shinn Cheng, Ching-Yen Chen, Yueh-E Lin, Yea-Ing L. Shyu
Summary: This study examined the trajectories of social support and their impact on health outcomes for older adults with diabetes mellitus (DM) undergoing hip-fracture surgery. The results showed that a stable and high trajectory of social support was associated with better physical and mental health outcomes, as well as lower levels of depression. These findings suggest the importance of assessing and maintaining social support for individuals with DM after hip-fracture surgery.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Editorial Material
Medicine, General & Internal
Tieh-Cheng Fu, Yen-Ying Kung, Jr-Rung Lin, Ching-Mao Chang
FRONTIERS IN MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Shu-Chun Huang, Chi-Hsiao Yeh, Chih-Chin Hsu, Yu-Ching Lin, Chen-Hung Lee, Ching-Chung Hsiao, Chien-Hung Chiu, Tieh-Cheng Fu
Summary: This study compared the effects of exercise training on cardiopulmonary fitness and quality of life in patients with peripheral arterial disease (PAD), heart failure (HF), and stroke. The results showed that although there was an improvement in cardiorespiratory fitness and quality of life in all three groups, the increase was smaller in PAD patients and they had a higher non-response rate, especially in terms of cardiorespiratory fitness and quality of life. Therefore, a higher dose of exercise may be needed to promote adaptation in PAD patients.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2023)
Article
Medicine, Research & Experimental
Chih-Chin Hsu, Jong-Shyan Wang, Yu-Chiau Shyu, Tieh-Cheng Fu, Yu-Hsiang Juan, Shin-Sheng Yuan, Chao-Hung Wang, Chi-Hsiao Yeh, Po-Cheng Liao, Hsin-Yi Wu, Pang-Hung Hsu
Summary: This translational research examined the implications of DNA methylation associated with high-intensity interval training (HIIT) on cardiac fibrosis in patients with heart failure (HF). The study found that HIIT can reduce cardiac fibrosis and improve cardiorespiratory fitness. This was confirmed through a variety of tests on HF patients, including cardiovascular magnetic resonance imaging and cardiopulmonary exercise tests, as well as cell experiments and proteomics analysis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Letter
Surgery
Chien-Ming Yen, Tieh-Cheng Fu, Ching-Mao Chang
Article
Physiology
Yu-Chieh Huang, Chih-Chin Hsu, Tieh-Cheng Fu, Jong-Shyan Wang
Summary: This study investigated the effects of combined aerobic and resistance exercise training on aerobic/muscular fitness and lymphocyte apoptosis/autophagy in sedentary males. Results showed that interval training (IT) may be more beneficial than continuous training (CT) in improving aerobic/muscular fitness and simultaneously ameliorating apoptosis of blood lymphocytes evoked by intense exercise or adrenergic stimulation in sedentary males.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu-Ching Lin, Tieh-Cheng Fu, Gigin Lin, Shu-Hang Ng, Chi-Hsiao Yeh, Soh-Chin Ng, Tsun-Ching Chang, Yu-Hsiang Juan
Summary: This study aimed to investigate interstitial muscle fibrosis using T1 mapping indices and its relationships with muscle function and conservative treatment outcomes. The results showed that T1 mapping indices were significantly correlated with the 6-min walking test and the 3-min stepping test. The extracellular volume fraction (ECV) was found to be an independent predictor of treatment intolerance.
EUROPEAN RADIOLOGY
(2023)