期刊
ADVANCED SCIENCE
卷 8, 期 15, 页码 -出版社
WILEY
DOI: 10.1002/advs.202004769
关键词
aggregation-induced emission; bright bacteria; hypoxia-tolerant photodynamic therapy; interventional photodynamic therapy; orthotopic colon tumors
资金
- State Key Research Development Program of China [2019YFB2203503]
- National Natural Science Foundation of China [61875138, 61435010, 61961136001]
- Research Grants of Council of Hong Kong [N-HKUST609/19, A-HKUST605/16, C6009-17G]
- Innovation of Technology Commission [ITC-CNERC14SC01]
This study developed a novel bacteria-based AIEgen hybrid system that can facilitate hypoxia-tolerant PDT treatment of orthotopic colon tumors through an interventional method, significantly impairing tumor growth and overcoming PDT defects.
While promising, the efficacy of aggregation-induced emission (AIE)-based photodynamic therapy (PDT) is limited by several factors including limited depth of laser penetration and intratumoral hypoxia. In the present study, a novel bacteria-based AIEgen (TBP-2) hybrid system (AE) is developed, that is able to facilitate the hypoxia-tolerant PDT treatment of orthotopic colon tumors via an interventional method. For this approach, an interventional device is initially designed, composed of an optical fiber and an endoscope, allowing for clear visualization of the position of the orthotopic tumor within the abdominal cavity. It is then possible to conduct successful PDT treatment of this hypoxic tumor via laser irradiation, as the TBP-2 is able to generate hydroxyl radicals (center dot OH) via a type I mechanism within this hypoxic microenvironment. Moreover, this interventional approach is proved to significantly impair orthotopic colon cancer growth and overcame PDT defects. This study is the first report involving such an interventional PDT strategy to knowledge, and it has the potential to complement other treatment modalities while also highlighting novel approaches to the design of hybrid AIEgen systems.
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