期刊
GENES
卷 12, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/genes12091313
关键词
epigenetics; miRNA; physical activity; exercise; inflammation
Epigenetic modifications in response to environmental changes play a fundamental role in gene expression regulation. In the context of physical activity, the inflammatory response triggered by PA is considered a vital trigger for epigenetic changes that modulate inflammatory actions.
Epigenetic modifications occur in response to environmental changes and play a fundamental role in the regulation of gene expression. PA is found to elicit an inflammatory response, both from the innate and adaptive divisions of the immunological system. The inflammatory reaction is considered a vital trigger of epigenetic changes that in turn modulate inflammatory actions. The tissue responses to PA involve local and general changes. The epigenetic mechanisms involved include: DNA methylation, histone proteins modification and microRNA. All of them affect genetic expression in an inflammatory milieu in physical exercise depending on the magnitude of physiological stress experienced by the exerciser. PA may evoke acute or chronic biochemical and physiological responses and have a positive or negative immunomodulatory effect.
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