Review
Gastroenterology & Hepatology
Leilei Yu, Yaru Liu, Shunhe Wang, Qingsong Zhang, Jianxin Zhao, Hao Zhang, Arjan Narbad, Fengwei Tian, Qixiao Zhai, Wei Chen
Summary: Cholestasis is a condition characterized by abnormal bile production or excretion, which can have various causes with complex factors. A better understanding and distinction of cholestasis from different etiologies is essential and will provide theoretical support for the development of corresponding therapeutic drugs.
Article
Microbiology
Chihyeok An, Hyeyeon Chon, Wanrim Ku, Sunho Eom, Mingyu Seok, Sangha Kim, Jaesun Lee, Daesung Kim, Sanghyuk Lee, Hoonsup Koo, Hyunjung Cho, Seungyun Han, Juik Moon, Miil Kang, Kihyun Ryu
Summary: Bile acids have antimicrobial properties and show different inhibitory effects on various microorganisms. They have low inhibitory activity on microbiota in the intestine and bile duct, but significantly inhibit flora in other organs.
Article
Biochemistry & Molecular Biology
Yuting Zhang, Huimin Chen, Wei Cong, Ke Zhang, Yimin Jia, Lei Wu
Summary: Heat stress can hinder the growth performance of broilers, leading to economic losses. The study found that chronic heat stress resulted in a decrease in total bile acids and an increase in cholic acid, chenodeoxycholic acid, and taurolithocholic acid in broilers. The expression of CYP8B1 and BSEP increased in the liver, while the expression of FGF19 decreased in the ileum of heat-stressed broilers. Significant changes in gut microbial composition were also observed, with the enrichment of Peptoniphilus being positively correlated with the increased serum level of taurolithocholic acid.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Junwei Xiang, Zhengyan Zhang, Hongyi Xie, Chengcheng Zhang, Yan Bai, Hua Cao, Qishi Che, Jiao Guo, Zhengquan Su
Summary: FXR, a nuclear receptor for bile acids, plays a key role in regulating metabolic pathways and improving various diseases. Bile acids link the intestine with the liver through the enterohepatic circulation, with different types of bile acids having diverse effects on the intestines, providing a foundation for new treatment methods.
Article
Biochemistry & Molecular Biology
Ling Huang, Junping Zheng, Guangjun Sun, Huabing Yang, Xiongjie Sun, Xiaowei Yao, Aizhen Lin, Hongtao Liu
Summary: It has been found that 5-aminosalicylic acid (5-ASA) can improve colitis symptoms by modulating gut microbiota and bile acid metabolism. In a mouse model, treatment with 5-ASA alleviated colitis symptoms, increased body weight and colon length, and reduced disease activity index and spleen index. Moreover, 5-ASA protected colonic tissues by suppressing inflammation and decreasing levels of tight junction, mucin, and water-sodium transport proteins, and it reshaped the gut microbiota community structure by promoting beneficial bacteria and reducing harmful bacteria. Additionally, 5-ASA improved abnormal bile acid metabolism through specific signaling pathways. However, the protective effect of 5-ASA was only observed in mice with normal gut microbiota, emphasizing the importance of gut microbiota in colitis treatment.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Niklas Gruener, Jochen Mattner
Summary: Bile acids synthesized in hepatic tissues are secreted into the intestinal lumen, where they interact with gut microbiota to regulate various physiological processes of the host. Disruptions in the interactions between gut bacteria and bile acids are associated with a range of disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Tao Jiang, Chuyun Xu, Huifang Liu, Muyi Liu, Minmin Wang, Jiarui Jiang, Guangji Zhang, Chuqi Yang, Jianbo Huang, Zhaohuan Lou
Summary: The study found that the ethanol extract of Linderae radix effectively reduced TC, TG, and LDL levels, alleviated liver injury, improved gut microbiota disturbance caused by a high-fat diet, and restored abnormal bile acid metabolism caused by hyperlipidemia.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Qianbo Song, Sau Wan Cheng, Dan Li, Huiyuan Cheng, Yuen Sze Lai, Quanbin Han, Hoi Yan Wu, Pang Chui Shaw, Zhong Zuo
Summary: This study investigated the role of gut microbiota in the hypoglycemic effect of Astragalus membranaceus polysaccharides (AMP) in db/db mice. Treatment with AMP significantly alleviated diabetic symptoms and restored gut microbiota community, leading to increased production of short chain fatty acids (SCFA) in feces. The relative abundance of two intestinal bacteria, Akkermansia and Faecalibaculum, were found to be positively correlated with the hypoglycemic effect of AMP and fecal SCFA production. Furthermore, AMP treatment stimulated the secretion of glucagon-like peptide-1 (GLP-1) and improved intestinal integrity. Mechanistic study revealed that the increased SCFA after AMP treatment could enhance the expression of G protein-coupled receptors 41/43 and tight junction proteins, resulting in the alleviation of diabetic symptoms in db/db mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Jung Wan Choe, Jae Min Lee, Jong Jin Hyun, Hong Sik Lee
Summary: The study identifies microbial dysbiosis and changes in bile components as important factors leading to recurrent bile duct stone formation, especially infection with bacteria exhibiting beta-glucuronidase activity. Compared to the non-recurrence group, the recurrence group showed lower microbial richness and evenness, with distinct overall microbial communities.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Ruolin Gao, Xiangjing Meng, Yili Xue, Min Mao, Yaru Liu, Xuewen Tian, Bo Sui, Xun Li, Pengyi Zhang
Summary: This review article focuses on the interaction between bile acids and gut microbiota in improving type 2 diabetes mellitus (T2DM). The findings highlight the critical role of bile acids in glucose metabolism and suggest their potential as therapeutic targets for T2DM.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yanan Li, Junping Zheng, Yao Wang, Huabing Yang, Lu Cao, Shuiyong Gan, Jun Ma, Hongtao Liu
Summary: This study investigates the role of gut microbiota in the immune-enhancing activity of Astragalus polysaccharides (APS) in mice. The results show that APS can ameliorate immunosuppression in mice and activate Toll-like receptor 4 (TLR4) and mitogen-activated protein kinase (MAPK) pathways. APS treatment also reverses gut microbiota dysbiosis in immunocompromised mice.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Bing Yang, Zhiwei Xiong, Meng Lin, Yanjun Yang, Yaping Chen, Jingqi Zeng, Xiaobin Jia, Liang Feng
Summary: This study found that polysaccharides, the main components of Astragalus, a traditional Chinese medicine, can regulate the gut microbiota associated with type 1 diabetes (T1D). It improves gut barrier function, gut microbiota composition, lowers blood glucose, and increases insulin levels. This effect may be related to the production of short-chain fatty acids and the modulation of inflammatory response.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nutrition & Dietetics
Ting Hong, Jun Zou, Xin Jiang, Jie Yang, Zhuo Cao, Youming He, Dan Feng
Summary: This study found that curcumin reduces cholesterol levels and bile cholesterol supersaturation by modulating gut microbiota and inhibiting intestinal cholesterol absorption.
Article
Pharmacology & Pharmacy
Melissa Metry, Nathaniel D. A. Dirda, Jean-Pierre Raufman, James E. Polli, Joseph P. Y. Kao
Summary: Transport of bile acids within the enterohepatic circulation is critical for bile acid regulation. Deficiency of FGF19 leads to bile acid diarrhea. We attempted to use nitroxide-conjugated bile acids as MRI contrast agents, but found that they were not effective in vivo.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Soumia Majait, Max Nieuwdorp, Marleen Kemper, Maarten Soeters
Summary: In recent decades, the potential role of the gut microbiome and bile acids in type 2 diabetes mellitus (T2DM) has been explored. Bile acids can impact gut bacteria and vice versa, and the gut microbiome regulates the bile acid pool. Various interventions, including probiotics, antibiotics, fecal microbiome transplantation, and nutritional interventions, can influence bile acid levels. The heterogeneity of studies, diseases, bacterial species, and (epi)genetic influences may hinder the establishment of specific interventions targeting the gut microbiome and bile acids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Jinnian Cheng, Xianjun Xu, Qian Zhuang, Shengzheng Luo, Xiaoyuan Gong, Xiaowan Wu, Xinjian Wan, Hui Zhou
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Article
Oncology
Zhixia Dong, Qian Zhuang, Min Ning, Shan Wu, Lungen Lu, Xinjian Wan
ANNALS OF TRANSLATIONAL MEDICINE
(2020)
Article
Gastroenterology & Hepatology
Jinnian Cheng, Jie Xia, Qian Zhuang, Xianjun Xu, Xiaowan Wu, Xinjian Wan, Jing Wang, Hui Zhou
ZEITSCHRIFT FUR GASTROENTEROLOGIE
(2020)
Article
Gastroenterology & Hepatology
Zhenyang Shen, Jingbo Xiao, Junjun Wang, Lungen Lu, Xinjian Wan, Xiaobo Cai
BMC GASTROENTEROLOGY
(2020)
Article
Engineering, Biomedical
Lili Guo, Lanting Yu, Qiuyan Zhao, Xiaoyuan Gong, Haoran Xie, Guangyin Yuan, Baiwen Li, Xinjian Wan
Summary: Through studying the JDBM alloy and its coating products for biliary stent application, we found that the JDBM alloy shows promise as a potential clinical material with uniform degradation and good compatibility for treating benign biliary strictures.
BIOMEDICAL MATERIALS
(2021)
Editorial Material
Gastroenterology & Hepatology
Zhixia Dong, Jie Xia, Xinjian Wan
Article
Pharmacology & Pharmacy
Xin Ye, Shuang Shen, Zhengjie Xu, Qian Zhuang, Jingxian Xu, Jingjing Wang, Zhixia Dong, Xinjian Wan
Summary: NaB attenuates cholesterol gallstone by modulating the gut microbiota to regulate the FXR-FGF-15/SHP signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Immunology
Huixiang Yao, Yan Shi, Junqing Yuan, Ri Sa, Wei Chen, Xinjian Wan
Summary: This study demonstrated that matrine attenuated DSS-induced colitis by improving gut barrier integrity, inhibiting the PPAR-alpha signaling pathway, and modulating gut microbiota. These findings suggest that matrine may serve as a therapeutic agent for treating ulcerative colitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Junjun Wang, Mingxing Xia, Yubiao Jin, Haiming Zheng, Zhenyang Shen, Weiming Dai, Xiaoman Li, Mei Kang, Rong Wan, Lungen Lu, Bing Hu, Xinjian Wan, Xiaobo Cai
Summary: Endoscopic biliary brushing is commonly used for sampling in patients with malignant biliary strictures, but its sensitivity is relatively low. This study found that brushing 30 times in 1 specimen can increase diagnostic sensitivity without increasing complications, making it preferred for endoscopic sampling and diagnosis of MBSs.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Haiming Zheng, Meiying Zhu, Wenhua Li, Zunqiang Zhou, Xinjian Wan
Summary: This study found that NKILA is significantly upregulated in CCA and its overexpression is associated with poor prognosis in CCA patients. NKILA can promote CCA growth and metastasis, interact with NSUN2 and miR-582-3p, and function via YAP1 in CCA.
LIVER INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Zhixia Dong, Qian Zhuang, Xin Ye, Min Ning, Shan Wu, Lungen Lu, Xinjian Wan
FRONTIERS IN MEDICINE
(2020)
Article
Pharmacology & Pharmacy
Xianjun Xu, Jinnian Cheng, Shengzheng Luo, Dan Huang, Jingxian Xu, Yueqin Qian, Hui Zhou, Xinjian Wan
EUROPEAN JOURNAL OF PHARMACOLOGY
(2020)
Article
Oncology
Chongxin He, Jie Xia, Yinghua Gao, Zhilong Chen, Xinjian Wan
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2020)
Article
Gastroenterology & Hepatology
Weixing Zhang, Fariha Kanwal, Muhammad Fayyaz ur Rehman, Xinjian Wan
Summary: The study investigated the safety and efficacy of biodegradable PDO and PLA braided biliary stents for the treatment of BBS, with the PLA group showing significantly longer potency time compared to the PDO group. The results suggest that these biodegradable stents could be a better choice for treating benign biliary strictures, with different rates of degradation.
TURKISH JOURNAL OF GASTROENTEROLOGY
(2021)