期刊
GENOMICS
卷 108, 期 5-6, 页码 185-193出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygeno.2016.11.001
关键词
DNA methylation; Homeobox genes; Epigenetic; Solid tumors
资金
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo-FAPESP, Sao Paulo, Brazil [2008/06223-3, 2010/08720-4]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [10/08720-4] Funding Source: FAPESP
Approximately 300 homeobox loci were identified in the euchromatic regions of the human genome, of which 235 are probable functional genes and 65 are likely pseudogenes. Many of these genes play important roles in embryonic development and cell differentiation. Dysregulation of homeobox gene expression is a frequent occurrence in cancer. Accumulating evidence suggests that as genetics disorders, epigenetic modifications alter the expression of oncogenes and tumor suppressor genes driving tumorigenesis and perhaps play a more central role in the evolution and progression of this disease. Here, we described the current knowledge regarding homeobox gene DNA methylation in human cancer and describe its relevance in the diagnosis, therapeutic response and prognosis of different types of human cancers. (C) 2016 Elsevier Inc. All rights reserved.
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