Article
Biochemistry & Molecular Biology
Martina Capozza, Rachele Stefania, Valentina Dinatale, Valeria Bitonto, Laura Conti, Cristina Grange, Renata Skovronova, Enzo Terreno
Summary: A PSMA-targeted NIRF dye was developed as an intraoperative tool for improving tumour margin delineation and cancer therapy. The dye exhibited high affinity and specificity towards PCa cells and accurately highlighted tumour margins. In addition, the dye had the capability of PDT to kill residual cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Computer Science, Information Systems
Xiaohang Fu, Lei Bi, Ashnil Kumar, Michael Fulham, Jinman Kim
Summary: Multimodal PET-CT combines PET's sensitivity for tumor detection with CT's anatomical information for cancer assessment. Existing automated segmentation methods are often ineffective, leading to manual segmentation by imaging experts which is labor-intensive and error-prone.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2021)
Review
Chemistry, Multidisciplinary
Zhongquan Cheng, Jihuan Shang, Huarong Wang, Leyi Yu, Zhu Yuan, Yinlong Zhang, Yang Du, Jie Tian
Summary: Extracellular vesicles (EVs) have gained attention in cancer treatment due to their high biocompatibility, better stability, and excellent safety as compared to other nano-materials. Engineered EVs have emerged as advanced drug delivery systems for targeted cancer diagnosis and therapy. Recent advancements in molecular imaging and EV labeling strategies have provided new tools for evaluating the pharmacokinetics of engineered EVs, promoting the clinical translation of novel EV-based drug delivery platforms.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Chemistry, Multidisciplinary
Jian-Xuan Sun, Jin-Zhou Xu, Ye An, Si-Yang Ma, Chen-Qian Liu, Si-Han Zhang, Yang Luan, Shao-Gang Wang, Qi-Dong Xia
Summary: Surgery is hindered by concerns such as positive resection margins and damage to vital structures, but fluorescence-guided surgery (FGS) provides a solution. However, existing fluorescence contrast agents have flaws. Extracellular vesicles (EVs) show promise due to their biocompatibility, safety, and targeting ability. This review proposes a novel strategy using EVs in FGS.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Engineering, Environmental
Yu Long, Nannan Wei, Peizhe Yuan, Xiaoying Lv, Xiangming Song, Ziyang Zhu, Qingyao Liu, Dawei Jiang, Xiaoli Lan, Yongkang Gai
Summary: A non-invasive method of tracking γδ T cells through NIRF/PET imaging was developed using metabolic glycoengineering and bioorthogonal click chemistry. The study demonstrated that this method accurately maps the biodistribution, migration, and tumor-homing efficiency of adoptive γδ T cells in vivo, representing a new potential γδ T cell imaging technology.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Clinical Neurology
Gerardo Y. Guinto-Nishimura, Juan L. Gomez-Amador, Nora Kerik-Rotenberg, Rodrigo Uribe-Pacheco, Marcos Sangrador-Deitos, Jose J. Martinez-Manrique
Summary: Primary intraosseous meningiomas are rare tumors with distinct clinical behavior from intracranial meningiomas. Complete resection is the main treatment, and PET/CT may serve as a valuable adjunct in surgical management by providing guidance for achieving complete resection.
NEUROSURGICAL FOCUS
(2021)
Article
Computer Science, Interdisciplinary Applications
Zhenxing Huang, Zhou Liu, Pin He, Ya Ren, Shuluan Li, Yuanyuan Lei, Dehong Luo, Dong Liang, Dan Shao, Zhanli Hu, Na Zhang
Summary: This study proposes a deep learning-based denoising method guided by structural semantic information for low-dose CT imaging. Experimental results demonstrate that the proposed method achieves better performance in quantitative metrics and semantic evaluation.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Review
Nanoscience & Nanotechnology
Chenxuan Bao, Huayuan Xiang, Qiaoqiao Chen, Yuxue Zhao, Qianqian Gao, Feng Huang, Lingxiang Mao
Summary: Small extracellular vesicles (sEVs) are lipid bilayer vesicles released by cells, playing a vital role in intercellular communication and transfer of bioactive molecules. Various labeling techniques, including fluorescent labeling, radioisotope labeling, nanoparticle labeling, chemical contrast agents labeling, and label-free technique, have been developed to study sEVs. This review provides a comprehensive overview of the principles, advantages, disadvantages, and applications of these labeling techniques, aiming to promote future research on sEVs.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Gastroenterology & Hepatology
Takeshi Aoki, Doaa A. Mansour, Tomotake Koizumi, Yusuke Wada, Yuta Enami, Akira Fujimori, Tomokazu Kusano, Kazuhiro Matsuda, Koji Nogaki, Yoshihiko Tashiro, Tomoki Hakozaki, Hideki Shibata, Kodai Tomioka, Takahito Hirai, Tatsuya Yamazaki, Kazuhiko Saito, Satoru Goto, Makoto Watanabe, Koji Otsuka, Masahiko Murakami
Summary: The study evaluated the application of VRCT during laparoscopic hepatectomies, showing that the system provides acceptable anatomical orientation, high success rate, and negative surgical margins.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Respiratory System
Yue Lin, Yanyan Xu, Jie Lin, Liping Fu, Hongliang Sun, Zhenguo Huang, Bee Yen Ooi, Sheng Xie
Summary: This study evaluates the usefulness of intraprocedural CT and prior PET/CT fusion imaging in improving the diagnostic yield of CT-guided transthoracic core-needle biopsy in lung masses. The results show that fusion imaging can increase the diagnostic yield and accuracy rate, especially in heterogeneous lung masses.
BMC PULMONARY MEDICINE
(2022)
Article
Multidisciplinary Sciences
Ehsan Rezayat, Hamed Heidari-Gorji, Pouya Narimani, Farzad Shayanfar, Jalaledin Noroozi, Ebrahim Shahbazi, Abolhassan Ertiaei, Mohammad-Reza A. Dehaqani
Summary: This study proposes an open-source tool for automating brain access using different imaging modalities, with applications in drug administration, neurophysiological recording, and tissue sampling. The software allows for easy calculation of the coordinates of the area of interest relative to a specific point of entry. Experimental results in nonhuman primates and humans demonstrate the efficacy of this tool compared to commercial software.
Article
Chemistry, Multidisciplinary
Zhijin Fan, Yichao Wang, Lanqing Li, Fanchu Zeng, Qiuping Shang, Yuhui Liao, Changhong Liang, Liming Nie
Summary: This study synthesized engineered cellular nanovesicles (ECNVs) with tumor-homing and immune-reprogramming functions for photoacoustic (PA) imaging-guided precision chemo-immunotherapy. The ECNVs effectively targeted tumor tissues and used the photothermal ability to release drugs. The combination of chemotherapy and immune response resulted in enhanced antitumor effects.
Article
Cell Biology
Andrea Ridolfi, Laura Conti, Marco Brucale, Roberto Frigerio, Jacopo Cardellini, Angelo Musico, Miriam Romano, Andrea Zendrini, Laura Polito, Greta Bergamaschi, Alessandro Gori, Costanza Montis, Stefano Panella, Lucio Barile, Debora Berti, Annalisa Radeghieri, Paolo Bergese, Marina Cretich, Francesco Valle
Summary: The overlapping physicochemical properties of lipoproteins and extracellular vesicles pose challenges in isolating and characterizing these biogenic lipid nanoparticles. This study presents a rapid nanomechanical screening method using atomic force microscopy to determine the diameter and stiffness of individual nanometric objects in mixed lipoprotein and extracellular vesicle samples. The method enables discrimination of co-isolated vesicles and lipoproteins based on their specific nanomechanical readouts and provides insights into the relationship between mechanical behavior and structural features. The approach is label-free and can be used to assess the purity of lipoprotein and extracellular vesicle isolates efficiently.
JOURNAL OF EXTRACELLULAR VESICLES
(2023)
Article
Cell Biology
Andrea Ridolfi, Laura Conti, Marco Brucale, Roberto Frigerio, Jacopo Cardellini, Angelo Musico, Miriam Romano, Andrea Zendrini, Laura Polito, Greta Bergamaschi, Alessandro Gori, Costanza Montis, Stefano Panella, Lucio Barile, Debora Berti, Annalisa Radeghieri, Paolo Bergese, Marina Cretich, Francesco Valle
Summary: This study presents a rapid nanomechanical screening method based on atomic force microscopy to determine the diameter and mechanical stiffness of lipoproteins and extracellular vesicles. The method allows for the discrimination and estimation of their relative abundance in mixed samples, providing a useful tool for assessing the purity of isolates.
JOURNAL OF EXTRACELLULAR VESICLES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rene Hosch, Manuel Weber, Miriam Sraieb, Nils Flaschel, Johannes Haubold, Moon-Sung Kim, Lale Umutlu, Jens Kleesiek, Ken Herrmann, Felix Nensa, Christoph Rischpler, Sven Koitka, Robert Seifert, David Kersting
Summary: This study aimed to acquire ultra-low-count FDG PET images on a digital PET/CT scanner at an acquisition time comparable to a CT scan, and generate synthetic full-dose PET images using an artificial neural network. The results showed that synthetic PET images had high visual quality and promising detection and quantification of lesions under extremely fast acquisition times. This has potential importance in applications for assessing total tumor burden.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Review
Chemistry, Multidisciplinary
Zhichao Liu, Ying Zhu, Liming Zhang, Weiping Jiang, Yawei Liu, Qiaowei Tang, Xiaoqing Cai, Jiang Li, Lihua Wang, Changlu Tao, Xianzhen Yin, Xiaowei Li, Shangguo Hou, Dawei Jiang, Kai Liu, Xin Zhou, Hongjie Zhang, Maili Liu, Chunhai Fan, Yang Tian
Summary: Analyzing the complex structures and functions of the brain is crucial for understanding physiological and pathological processes. However, subcellular structures of cells in the live brain and the concentrations, distributions, and interactions of functional molecules are still poorly understood.
SCIENCE CHINA-CHEMISTRY
(2023)
Article
Materials Science, Biomaterials
Boping Jing, Yu Gao, Feng Guo, Dawei Jiang, Rong Guo, Jing Wang, Yuman Li, Yuji Xie, Yihan Chen, He Li, Li Zhang, Mingxing Xie, Rui An
Summary: In this study, a theranostic nanoprobe was designed using goat milk-derived extracellular vesicles (GMVs) as nanocarriers for positron emission tomography/computer tomography/near-infrared fluorescence (PET/CT/NIRF) imaging and image-guided photothermal therapy (PTT) for colon cancer. The nanoprobe triggered anti-tumor immune and inflammation responses to enhance PTT and could attenuate PTT-induced inflammation thanks to the anti-inflammatory efficacy of GMVs. This research conceptually advanced the diagnosis and treatment of colon cancer.
BIOMATERIALS SCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Ke Zhu, Yu Yao, Kun Wang, Fuqiang Shao, Ziyang Zhu, Yangmeihui Song, Zhangyongxue Zhou, Dawei Jiang, Xiaoli Lan, Chunxia Qin
Summary: This study reveals that berberine (BBR) treats myocardial infarction (MI) by regulating inflammatory responses, as determined by network pharmacology. Platelet membrane-coated polylactic-co-glycolic acid (PLGA) nanoparticles (BBR@PLGA@PLT NPs) are used to deliver BBR, which are more enriched in the infarcted myocardium and less uptaken in the liver compared to PLGA nanoparticles. BBR@PLGA@PLT NPs significantly increase the number of repaired macrophages and decrease the number of inflammatory macrophages and apoptotic cells in infarcted rat myocardium on day three after MI. On the 28th day after MI, the BBR@PLGA@PLT group shows a protective effect on cardiac function, reduced cardiac collagen deposition, improved scar tissue stiffness, and excellent angiogenesis effect.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Hao Wei, Dawei Jiang, Bo Yu, Dalong Ni, Mengting Li, Yin Long, Paul A. Ellison, Cerise M. Siamof, Liang Cheng, Todd E. Barnhart, Hyung-Jun Im, Faquan Yu, Xiaoli Lan, Xiaohua Zhu, Qianjun He, Weibo Cai
Summary: A series of controllable PVP-curcumin nanoparticles are designed for efficient treatment of acute kidney injury, enabling precise PET image-guided drug delivery.
BIOACTIVE MATERIALS
(2023)
Article
Materials Science, Biomaterials
Shanshan Niu, Lei-Lei Qian, Pan Du, Nan Si, Dawei Jiang, Yan Feng, Bin Huang, Xiaomin Gu, Qiang Zhao, Jiao Ji, Hua Zhu
Summary: Graphene coupling molybdenum-based nanocomposite structures were synthesized by changing the pyrolytic temperature to optimize the microstructure. The presence of divalent molybdenum on the material surface effectively exposed catalytic sites, enhancing the reduction ability of N-2 and inhibiting hydrogen evolution reaction. Electrochemical investigations showed that the Mo-700/rGO nanocomposite exhibited significantly improved electrochemical ammonia synthesis performance.
Article
Chemistry, Multidisciplinary
Mingming Yin, Yu Chen, Xiaoming Liu, Sidan Tian, Liyuan Zhao, Yaowei Bai, Hao Wang, Jinfeng Lin, Dawei Jiang, Ziqiao Lei, Fanling Meng, De'an Tian, Liang Luo
Summary: In this study, bacterial-flagella-inspired PIDA nanofibers were designed for targeted CT imaging and therapy of IBD. PIDA nanofibers mimicking the morphology of bacterial flagella attached to the mucus layer of the GI tract, allowing CT visualization of the GI lining. PIDA retained in the inflamed lesions longer than in normal GI tissues, enabling targeted CT visualization of IBD. Additionally, PIDA scavenged reactive oxygen species and improved gut dysbiosis, promoting inflammation alleviation and mucosal healing at the targeted IBD lesions while maintaining gut microbiota homeostasis.
Article
Engineering, Biomedical
Ziyang Zhu, Qingyao Liu, Ke Zhu, Kun Wang, Lan Lin, Yaqi Chen, Fuqiang Shao, Ruijie Qian, Yangmeihui Song, Yu Gao, Biao Yang, Dawei Jiang, Xiaoli Lan, Rui An
Summary: In this study, an AIE-PS/bacteria biohybrid (EcN@TTVP) was developed to enhance the effectiveness of Cerenkov radiation-induced photodynamic therapy (CR-PDT) by activating anti-tumor immunity. The combination of targeted bacteria and radiopharmaceuticals resulted in efficient tumor remission and prolonged survival in tumor-bearing mice, providing a promising strategy for deep-seated tumor treatment.
ACTA BIOMATERIALIA
(2023)
Article
Oncology
Jamie M. Sperger, Kyle T. Helzer, Charlotte N. Stahlfeld, Dawei Jiang, Anupama Singh, Katherine R. Kaufmann, David J. Niles, Erika Heninger, Nicholas R. Rydzewski, Liguo Wang, Liewei Wang, Rendong Yang, Yanan Ren, Jonathan W. Engle, Peng Huang, Christos E. Kyriakopoulos, Susan F. Slovin, Howard R. Soule, Shuang G. Zhao, Manish Kohli, Scott T. Tagawa, Weibo Cai, Scott M. Dehm, Joshua M. Lang
Summary: This study analyzed the expression of biomarkers in prostate cancer patients and demonstrated that TROP-2 can serve as a cell surface target for isolating circulating tumor cells, and it may serve as a predictive biomarker for antibody-drug conjugates.
CLINICAL CANCER RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qiaomiao Lu, Yu Long, Yongkang Gai, Qingyao Liu, Dawei Jiang, Xiaoli Lan
Summary: This study aimed to explore the feasibility of using [Lu-177]Lu-PSMA-617 and [Lu-177]Lu-EB-PSMA-617 for in vivo radioligand therapy in PSMA-positive hepatocellular carcinoma. The results showed that these radioligands significantly suppressed tumor growth and prolonged survival time without obvious toxicity, indicating their potential for clinical use in humans.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Editorial Material
Oncology
Yiming Xu, Dawei Jiang, Weiyu Chen
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Ying Ding, Yu Liu, Li Zhang, Yinqian Deng, Huanyu Chen, Xiaoli Lan, Dawei Jiang, Wei Cao
Summary: The study aims to improve the accuracy of glomerular filtration rate (GFR) measurement by preparing a Ga-68-EDTA positron emission tonometry (PET) tracer and comprehensively evaluating its performance in healthy mice and murine models of renal dysfunction. The results demonstrate that Ga-68-EDTA PET provides a reliable and precise means of evaluating renal function and holds promise for widespread clinical application.
FRONTIERS IN MEDICINE
(2023)
Article
Physics, Applied
Xingxing Zhao, Jinqun Cai, Dawei Jiang, Min Cao, Lin Zhao, Yonghao Han
Summary: By combining alternate-current impedance spectrum measurement and first-principle calculations, we investigated the electrical transport behavior of LaAlO3 under high pressure. A pressure-induced ionic-polaronic-ionic transition was discovered through impedance spectroscopy measurements. First-principle calculations revealed that the emergence of polaronic conduction is caused by the distortion of electron density background around Al and O atoms. The discontinuous changes in ion migration starting frequency f(W), relaxation frequency f(b), and ionic resistance R-i at around 13.2 GPa were attributed to the phase transition of LaAlO3 from rhombohedral to cubic phase. Pressure enhances the migration of O2- ions, leading to an increase in the ionic conductivity of LaAlO3. This research deepens our understanding of ion migration in solid electrolytes.
APPLIED PHYSICS LETTERS
(2023)
Article
Engineering, Environmental
Yu Long, Nannan Wei, Peizhe Yuan, Xiaoying Lv, Xiangming Song, Ziyang Zhu, Qingyao Liu, Dawei Jiang, Xiaoli Lan, Yongkang Gai
Summary: A non-invasive method of tracking γδ T cells through NIRF/PET imaging was developed using metabolic glycoengineering and bioorthogonal click chemistry. The study demonstrated that this method accurately maps the biodistribution, migration, and tumor-homing efficiency of adoptive γδ T cells in vivo, representing a new potential γδ T cell imaging technology.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Jiarong Xu, Qi Zeng, Xiuli Chen, Honglian Guo, Yusheng Gong, Rengui Xu, Peng Cao, Chunyu Wei, Fei Xiao, Dawei Jiang, Wei Chen
Summary: In this study, an iron (III) cross-linked alginate microneedle patch (ICAMP) has been developed for long-term treatment of dry skin. The microneedles can be dissolved by exposure to light, allowing controlled release of the drug. This new method provides a regulated way to treat dry skin, especially under intense light radiation.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Oncology
Dawei Jiang, Xiaoli Lan, Weibo Cai
Summary: In a recent study, a new bicyclic peptide radiotracer, 68Ga-N188, was developed for PET imaging of advanced urothelial cancer. Preclinical investigation and first-in-human study showed excellent specificity and sensitivity of 68Ga-N188 in detecting metastases. These promising results support the use of 68Ga-N188 as a companion diagnostic for personalized cancer therapy.
CLINICAL CANCER RESEARCH
(2023)