Article
Agronomy
Jialiang Liu, Wanli Zhang, Meijiao Hu, Yonggui Pan, Yueming Jiang, Zhengke Zhang, Guoxiang Jiang
Summary: This study investigates the interplay between melatonin and nitric oxide (NO) in relation to cold stress tolerance in litchi fruit. The results show that melatonin triggers NO accumulation by activating nitric oxide synthase (NOS) and nitrate reductase (NR) in refrigerated litchi fruit, improving cold tolerance. Melatonin also reduces reactive oxygen species (ROS) accumulation and increases antioxidant activity, protecting membrane integrity. However, the effect of melatonin is partially counteracted by the NO scavenger cPTIO.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2023)
Article
Horticulture
Faisal Hayat, Zixun Sun, Zhaojun Ni, Shahid Iqbal, Wuyi Xu, Zhihong Gao, Yushan Qiao, Muhammad Aammar Tufail, Mohammad Shah Jahan, Ummara Khan, Chunyan Wan, Xianbin Gu
Summary: Melatonin has a defensive role in strawberry plants by reducing the adverse effects of cold stress. Pretreatment with 100 mu M melatonin enhances the antioxidant defense potential and modulates the DREB/CBF-COR pathway, leading to improved cold tolerance in strawberry plants.
Article
Horticulture
Jiapeng Liu, Huan Wu, Bin Wang, Yongyan Zhang, Jiashui Wang, Chunzhen Cheng, Yuji Huang
Summary: Evidence has shown that exogenous melatonin can alleviate cold stress in plants. This study investigated the defensive roles of exogenous melatonin in banana under cold stress. The results demonstrated that exogenous melatonin treatment enhanced the cold resistance of banana by improving antioxidant defense and inducing the expression of cold-responsive genes.
Article
Pharmacology & Pharmacy
Eman Y. AbdelAziz, Mariane G. Tadros, Esther T. Menze
Summary: Gastric ulcer is a common disease that can be induced by non-steroidal anti-inflammatory drugs, especially in diabetic patients. Metformin, a medication for diabetes, has been shown to have healing effects on gastric ulcers induced by inflammation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jingjing Chang, Yanliang Guo, Jiayue Li, Zhuangzhuang Su, Chunxia Wang, Ruimin Zhang, Chunhua Wei, Jianxiang Ma, Xian Zhang, Hao Li
Summary: This study discovered that melatonin induces H2O2 accumulation and upregulates ClRBOHD in the early response to cold stress in watermelon. Furthermore, melatonin and H2O2 induce the accumulation of cytoplasmic free Ca2+ in response to cold, which is associated with the upregulation of ClCNGC2. Blocking of Ca2+ influx channels disrupts melatonin- or H2O2-induced CBF pathway and cold tolerance.
Article
Immunology
Kangkang Chen, Xinyan Wang, Xiangyi Wei, Jiaqian Chen, Youheng Wei, Haobo Jiang, Zhiqiang Lu, Congjing Feng
Summary: This study investigated the impact of nitric oxide (NO) signaling on antimicrobial peptide (AMP) production using the lepidopteran pest Ostrinia furnacalis and Drosophila S2 cells. The findings suggest that NO-induced AMP production is mediated by the enzyme CanA1 via the IMD pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mario de la Fuente Munoz, Marta Roman-Carmena, Sara Amor, Angel Luis Garcia-Villalon, Alberto E. Espinel, Daniel Gonzalez-Hedstrom, Miriam Granado Garcia
Summary: Melatonin is regulated by the hormone melatonin and is mainly synthesized in the pineal gland from tryptophan after its conversion into serotonin. Increased levels of proinflammatory cytokines and cortisol can reduce the availability of tryptophan for the synthesis of melatonin, causing mood and sleep alterations. The supplementation of affron (R) can reduce kynurenine levels and promote melatonin synthesis through its antioxidant and anti-inflammatory effects in rats.
Article
Environmental Sciences
Muhammad Imran, Abdul Latif Khan, Bong-Gyu Mun, Saqib Bilal, Shifa Shaffique, Eun-Hae Kwon, Sang-Mo Kang, Byung-Wook Yun, In -Jung Lee
Summary: The combination of melatonin and nitric oxide enhances plant growth and reduces oxidative stress. It minimizes the toxicity of heavy metals by lowering levels of abscisic acid and jasmonic acid, while increasing levels of endo-melatonin and endo-S-nitrosothiol. Furthermore, the combined application reduces soil mobilization of Cd and Pb and increases plant resistance to heavy metal toxicity.
Article
Plant Sciences
Chengfeng Zhao, Mei Yang, Xi Wu, Yifan Wang, Renhe Zhang
Summary: The application of exogenous melatonin can improve drought tolerance in maize by inhibiting H2O2 accumulation and promoting scavenging of excessive reactive oxygen species. Transcriptomic analysis revealed that melatonin-regulated genes are mainly involved in glutathione metabolism, calcium signaling transduction, and jasmonic acid biosynthesis. Additionally, crosstalk between melatonin and other hormones that mediate drought tolerance was observed.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Review
Plant Sciences
Francisco J. Corpas, Marta Rodriguez-Ruiz, Maria A. Munoz-Vargas, Salvador Gonzalez-Gordo, Russel J. Reiter, Jose M. Palma
Summary: Melatonin plays a crucial role in fruit ripening by interacting with nitric oxide and hydrogen peroxide, expanding the regulatory networks of these molecules.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Environmental Sciences
Tao Wang, Jinxue Song, Ze Liu, Zili Liu, Jin Cui
Summary: The research demonstrates that melatonin can alleviate cadmium toxicity by reducing the accumulation of nitric oxide, leading to increased biomass and photosynthetic parameters in plants. Additionally, melatonin can lower the levels of cadmium-induced nitric oxide and decrease the expression of related genes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
You-Lin Tain, Chien-Ning Hsu
Summary: Oxidative stress occurs when the production of reactive oxygen or nitrogen species exceeds the capacity of antioxidant systems. It has a significant impact on kidney development and can lead to kidney disease in adulthood. Evaluating biomarkers allows us to assess oxidative stress in fetuses and neonates. Animal models have provided valuable insights into the mechanisms of renal programming related to oxidative stress and interventions to prevent kidney disease. This comprehensive review examines the effects of perinatal oxidative stress on renal programming, the role of antioxidant strategies in kidney disease prevention, and the challenges in translating findings from animal models to clinical practice.
Article
Environmental Sciences
Aqeel Ahmad, Waheed Ullah Khan, Anis Ali Shah, Nasim Ahmad Yasin, Shagufta Naz, Aamir Ali, Arifa Tahir, Aima Iram Batool
Summary: The study demonstrates that NO and Si together can alleviate the detrimental effects of As stress on plants, reducing As uptake. It is recommended to co-apply NO and Si in As-contaminated soils for improving plant growth and stress alleviation.
Review
Biochemistry & Molecular Biology
Arbindra Timilsina, Wenxu Dong, Mirza Hasanuzzaman, Binbin Liu, Chunsheng Hu
Summary: Plant survival and adaptation during oxygen deprivation, caused by various biotic and abiotic factors, rely on mechanisms such as fermentation, antioxidant enzymes, and the reduction pathways of nitrate and nitric oxide. Understanding the molecular mechanisms involved in reducing nitric oxide toxicity is important not only for plant physiology, but also for addressing uncertainties in the global nitrous oxide budget.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Benjamin Rioux, Louis M. M. Mouterde, Jimmy Alarcan, Temitope T. Abiola, Matthias J. A. Vink, Jack M. Woolley, Aurelien A. M. Peru, Matthieu M. Mention, Fanny Brunissen, Giel Berden, Jos Oomens, Albert Braeuning, Vasilios G. Stavros, Florent Allais
Summary: Sinapoyl malate, a natural compound in plants, has been found to be an effective UV filter and molecular heater. However, its hydrophilicity limits its application in cosmetic formulations and on plant leaves. In this study, a chemo-enzymatic synthesis method was used to produce sinapoyl malate analogues with varying lipophilicity. The potential toxicity and degradation of these analogues were evaluated, along with their absorption spectroscopy and photostability.