Article
Chemistry, Applied
T. M. Ebaston, Faina Nakonechny, Efrosiniia Talalai, Gary Gellerman, Leonid Patsenker
Summary: The study introduces new NIR photosensitizers based on iodinated xanthene-cyanine dyes, which exhibit high antimicrobial efficacy on Staphylococcus aureus pathogens at low dye concentration and NIR light dose.
Review
Chemistry, Multidisciplinary
Saeid Moghassemi, Arezoo Dadashzadeh, Ricardo Bentes Azevedo, Christiani A. Amorim
Summary: Nanoemulsion, a stable system formed by blending two immiscible liquids and an emulsifying agent, has shown great potential in various fields. In photodynamic therapy, nanoemulsion-loaded photosensitizing agents can overcome limitations of common photosensitizers and provide an effective drug delivery technology.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Shufeng Yan, Luying Dong, Ziyun Hu, Yucheng Zhang, Wei Xu, Jianhong Xing, Juncheng Zhang
Summary: Photodynamic therapy (PDT) and photothermal therapy (PTT) are promising non-invasive approaches to cancer treatment. This study investigated a polydopamine-based nanoparticle loaded with efficient photosensitizer ZnPc(4TAP)(12+) through in vitro and in vivo experiments, achieving synergistic PDT and PTT. The results showed significant efficacy of the nanoparticle, generating reactive oxygen species, inducing photothermal effects, and promoting cancer cell apoptosis. Additionally, the nanoparticle exhibited significant antitumor effects without causing systemic damage, enabling safer treatment.
Review
Biochemistry & Molecular Biology
Saeid Moghassemi, Arezoo Dadashzadeh, Ricardo Bentes de Azevedo, Christiani A. Amorim
Summary: Photodynamic therapy (PDT) has gained attention as a selective and minimally invasive cancer therapy strategy. It selectively activates reactive oxygen species (ROS) through the use of photosensitizers (PS), resulting in direct malignant cell death. This makes it a potential ex vivo tissue purging protocol.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Jinxing Song, Xiaobo Gao, Mei Yang, Weiju Hao, Ding-Kun Ji
Summary: Photodynamic therapy (PDT) utilizes externally produced reactive oxygen species (ROS) to kill cancer cells. Carbon dots (CDs), a rising star in carbon-based nanomaterials, have shown great potential in cancer PDT due to their excellent photoactivity, luminescence properties, low price, and biocompatibility. In particular, photoactive near-infrared CDs (PNCDs) have garnered increasing interest in recent years for their deep tissue penetration, superior imaging performance, excellent photoactivity, and photostability. This review summarizes the recent progress in the design, fabrication, and applications of PNCDs in cancer PDT and provides insights for future directions in accelerating the clinical progress of PNCDs.
Review
Biochemistry & Molecular Biology
Jooho Park, Yong-Kyu Lee, In-Kyu Park, Seung Rim Hwang
Summary: Photodynamic therapy (PDT) using oxygen, light, and photosensitizers is a promising approach for cancer treatment. Current progress involves enhancing accumulation of photosensitizers in tumor sites using nanocarriers and future research directions include improving drug localization and optimizing treatment outcomes.
Article
Engineering, Environmental
Xianjin Hu, Heng Zhang, Yanting Wang, Bing-Chiuan Shiu, Jia-Horng Lin, Shujie Zhang, Ching-Wen Lou, Ting-Ting Li
Summary: The increase in drug resistant bacteria poses challenges to the treatment of infectious diseases. Photodynamic therapy (PDT) is a promising antimicrobial strategy that does not induce bacterial resistance. However, antibacterial PDT (APDT) has limitations, thus synergistic strategies with other treatments can enhance antimicrobial efficacy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Pharmacology & Pharmacy
Anine Crous, Heidi Abrahamse
Summary: Lung cancer remains the leading cause of death globally, with novel treatments like photodynamic therapy showing promising results in selective destruction of malignant cells. Further research and clinical trials are needed to determine the efficacy of these new treatment options.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Orlando Santoro, Miryam Chiara Malacarne, Francesco Sarcone, Luca Scapinello, Stefania Pragliola, Enrico Caruso, Viviana Teresa Orlandi, Lorella Izzo
Summary: In this study, two compounds from the BODIPY family were bound to amino-pendant groups of three random copolymers with varying amounts of MMA and DMAEMA. The copolymers showed inherent bactericidal activity due to the presence of amino groups and quaternized nitrogens bound to BODIPY. Coated filter paper discs with copolymers conjugated to BODIPY inhibited the growth of E. coli and S. aureus under green light irradiation, with the highest efficiency observed in the copolymer containing 43% DMAEMA and approximately 0.70 wt/wt% BODIPY. The copolymers also exhibited residual antimicrobial activity after dark incubation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Brydie A. Thomas-Moore, Carla Arnau del Valle, Robert A. Field, Maria J. Marin
Summary: The rise of antibacterial drug resistance has led to limited treatment options, and alternative strategies such as antibacterial photodynamic therapy (aPDT) are being explored. This technique relies on light, oxygen, and a non-toxic dye to generate cytotoxic reactive oxygen species. Nanotechnology-based techniques have shown potential in addressing the limitations of current aPDT.
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chaoren Yan, Xu Shao, Qi Shu, Yonggang Teng, Youbei Qiao, Ping Guan, Xiaoling Hu, Chaoli Wang
Summary: The designed ultra-thin hollow silica nanoparticles (UHSN) and covalent anchoring of chitosan (UHSN@CS) can enhance the loading and photodynamic property of photosensitizers, thus improving antibacterial performance.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Engineering, Biomedical
Marcella Goetz Moro, Veronica Franco de Carvalho, Bianca A. Godoy-Miranda, Claudio Teruo Kassa, Anna Carolina Ratto Tempestini Horliana, Renato Araujo Prates
Summary: The study evaluated the effect of aPDT as an adjunct to SRP in chronic periodontal patients, showing that the combination of SRP and aPDT promoted significant CAL gain and PPD reduction. Indocyanine green-mediated aPDT and high concentrations of phenothiazine chloride demonstrated favorable clinical improvement.
LASERS IN MEDICAL SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Valina Mylona, Eugenia Anagnostaki, Stylianos Petrakis, Kyriaki Kosma, Steven Parker, Mark Cronshaw, Nektarios Papadogiannis, Martin Grootveld
Summary: This study examined the attenuation properties of different photosensitizers activated by specific laser wavelengths. The results showed that, except for toluidine blue illuminated by an 808 nm laser, the other photosensitizers had an attenuation range of 63% to 99%. Therefore, when used at appropriate concentrations, these photosensitizers can allow sufficient wavelength-dependent light transmission, leading to beneficial photobiomodulation effects.
APPLIED SCIENCES-BASEL
(2023)
Article
Infectious Diseases
Sakari Nikinmaa, Anna Podonyi, Peter Raivio, Jukka Meurman, Timo Sorsa, Juha Rantala, Esko Kankuri, Tuomas Tauriainen, Tommi Paetilae
Summary: Dual-light aPDT shows improved bactericidal effect on Staphylococcus aureus biofilm compared to aPDT or aBL, providing a sustained effect. Increasing the relative ratio of aBL enhances the antibacterial effect, especially with repeated applications.
Article
Chemistry, Physical
Wenbo Wu, Leilei Shi, Yukun Duan, Shidang Xu, Xihui Gao, Xinyuan Zhu, Bin Liu
Summary: A highly efficient metabolizable type-II photosensitizer with aggregation-induced emission characteristics was developed in this study, demonstrating good anti-tumor PDT efficiency in mouse models. Importantly, the photosensitizer can be gradually oxidized by endogenous hypochlorite after PDT and subsequently excreted through urine within 24 hours of administration.
CHEMISTRY OF MATERIALS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Cesar Augusto Abreu-Pereira, Marlise Inez Klein, Carmelia Isabel Vitorino Lobo, Ana Luiza Gorayb Pereira, Claudia Carolina Jordao, Ana Claudia Pavarina
Summary: This study evaluated the effectiveness of DNase I combined with antimicrobial photodynamic therapy against biofilms formed by a fluconazole-resistant Candida albicans strain. The results showed that DNase treatment combined with aPDT could significantly reduce cell viability and the components of the biofilm.
Correction
Biochemical Research Methods
Loraine C. Goenaga-Mafud, Yordania Matos Gamez, Carolina P. Campos, Jose D. Vollet-Filho, Natalia Mayumi Inada, Cristina Kurachi, Vanderlei Salvador Bagnato
Summary: Organ transplantations have a growing medical importance as more individuals are in need of organs. The increase in discarded organs is mainly due to donor infections. This study demonstrates the feasibility of reducing bacterial load in a kidney model using UV-C as a germicidal agent. The results show the effectiveness of this technique.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Chemistry, Physical
Bianca G. Queiroz, Heloisa Ciol, Natalia M. Inada, Elisabete Frollini
Summary: The article focuses on the use of the LiCl/DMAc solvent system with TFA to deconstruct sisal fibers and dissolve their main components in order to generate hydrogels. The crosslinked hydrogels showed improved compressive strength and reduced water absorption capacity. The study suggests potential applications in fields where significant compressive strength is required, such as biomedicine and agriculture.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Editorial Material
Multidisciplinary Sciences
Vanderlei S. S. Bagnato, Rashid G. G. Nazmitdinov, Vyacheslav I. I. Yukalov
Article
Nanoscience & Nanotechnology
Maria Arcentales, Raquel Martin-Sampedro, Ralph Santos-Oliveira, Mohamed F. Attia, Jeffrey N. Anker, Daniel C. Whitehead, Alexis Debut, Liquan Deng, Yuanna Zheng, Bing Hu, Maria P. Romero, Floralba Lopez, Frank Alexis
Summary: Natural and renewable resources from plants or animals are important for biomaterials due to their biocompatibility and availability. Lignin, a biopolymer present in plant biomass, can be used to create lignocellulosic nanoparticles with luminescent properties. These nanoparticles, derived from rose biomass waste, exhibit high photoluminescence in the near-infrared (NIR) region and have potential for bioimaging applications due to their small size, low toxicity, blood circulation, and ability to be excreted.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Nahyun Kwon, Gabriel O. Jasinevicius, Giulia Kassab, Lili Ding, Jiachuan Bu, Leticia P. Martinelli, Vinicius G. Ferreira, Alexander Dhaliwal, Harley H. L. Chan, Yulin Mo, Vanderlei S. Bagnato, Cristina Kurachi, Juan Chen, Gang Zheng, Hilde H. Buzza
Summary: By stabilizing nanoemulsions with ICG, we discovered a nanostructure of dimeric ICG (Nano-dICG) that showed improved photothermal conversion, reduced photodegradation, and undiminished photothermal effect compared to ICG. Nano-dICG also demonstrated excellent colloidal and structural stabilities, allowing real-time tracking of its delivery to mouse tumors for effective photothermal therapy. This finding provides an unprecedented ultra-stable phototheranostic platform.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
David Giancarlo Garcia, Cristina Garzon-Romero, Mateo Alejandro Salazar, Karina J. Lagos, Kleber Orlando Campana, Alexis Debut, Karla Vizuete, Miryan Rosita Rivera, Dario Niebieskikwiat, Maria J. Benitez, Maria Paulina Romero
Summary: This study presents a quick and easy green synthesis method using waste orange peel extract as a reducing, capping, and stabilizing agent to prepare magnetic nanoparticles based on iron oxides (MNPs-Fe). The 50GS-MNPs-Fe sample showed an excellent mass yield and a particle size of about 50 nm with an organic coating.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Nicolas Junhiti de Melo, Johan S. D. Tovar, Livia Nordi Dovigo, Lucas D. Dias, Vanderlei Salvador Bagnato, Natalia Mayumi Inada
Summary: Antimicrobial photodynamic therapy (aPDT) is an alternative method to combat bacterial resistance. The present study compared natural and synthetic curcumin and found that there were no statistical differences in the photoinactivation of S.aureus bacteria. However, synthetic curcumin is preferred due to its controlled availability and less environmental impact.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Review
Nanoscience & Nanotechnology
Karina J. J. Lagos, David Garcia, Coralia Fabiola Cuadrado, Larissa Marila de Souza, Natasha Ferreira Mezzacappo, Ana Paula da Silva, Natalia Inada, Vanderlei Bagnato, Maria Paulina Romero
Summary: Carbon dots (CDs) are carbon-based materials with sizes usually below 10 nm, which exhibit attractive properties such as low toxicity, good stability, and high conductivity. This review summarizes four types of CDs and their preparation methods. Additionally, it focuses on the application of CDs as a novel class of broad-spectrum antibacterial agents, particularly due to their photoactivation capability. The article presents recent advances in utilizing CDs as photosensitizers and photothermal agents in antibacterial strategies.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Article
Health Care Sciences & Services
Vitor Hugo Panhoca, Antonio Eduardo de Aquino Junior, Viviane Brocca de Souza, Simone Aparecida Ferreira, Lais Tatiane Ferreira, Karina Jullienne de Oliveira Souza, Patricia Eriko Tamae, Marcelo Saito Nogueira, Vanderlei Salvador Bagnato
Summary: Our study investigated the outcome of potential alternative and complementary treatment modalities for idiopathic and refractory tinnitus patients. The results showed that positive treatment outcomes were achieved through acupuncture and transmeatal low-level laser therapy. Future research should focus on exploring the long-term effects of laser therapy in tinnitus patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Lucas D. Dias, Fernanda Mansano Carbinatto, Isabelle da Silveira Almeida, Kate C. Blanco, Franciane Marquele-Oliveira, Carla Carolina Munari, Vanderlei Salvador Bagnato
Summary: This study aimed to extract green coffee oil from Arabic coffee using a sustainable cold-pressing method. The obtained green coffee oil was characterized and found to contain linoleic and palmitic acids as major fatty acids. The oil exhibited antioxidant activity and showed no cytotoxic effects on keratinocyte cultures. Additionally, it demonstrated wound healing properties and potential to induce cell proliferation and migration. These findings suggest that green coffee oil is a promising natural product for cosmetic and pharmaceutical applications.
FERMENTATION-BASEL
(2023)
Article
Nanoscience & Nanotechnology
Kelcilene Bruna Ricardo Teodoro, Augusto Duarte Alvarenga, Luis Fernando Rocha Oliveira, Paulo Augusto Marques Chagas, Raphael Guimaraes Lopes, Rafaela da Silveira Andre, Luiza Amim Mercante, Fernanda Alves, Mirian Denise Stringasci, Hilde Harb Buzza, Natalia Mayumi Inada, Daniel Souza Correa
Summary: In this study, a low-cost multifunctional wound dressing was designed by loading curcumin (CC) into poly(epsilon-caprolactone) (PCL) nanofibers using solution blow spinning (SBS) technique. The PCL/CC bandages exhibited various functions, including controlled release of CC, colorimetric indication of wound conditions, microbial barrier, biocompatibility, and a platform for antimicrobial photodynamic therapy (aPDT). The findings indicate the potential of using PCL and CC to produce biocompatible and multifunctional wound dressings.
ACS APPLIED BIO MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Fernanda Alves, Sebastiao Pratavieira, Natalia Mayumi Inada, Claudia Patricia Barrera Patino, Cristina Kurachi
Summary: This study assessed the effects of photodynamic, sonodynamic, and sonophotodynamic inactivation on Staphylococcus aureus biofilms. The results showed that sonophotodynamic inactivation had the greatest antimicrobial effects, reducing adhesion capability, biofilm formation ability, and causing structural changes in the biofilm. In addition, all treatments produced reactive oxygen species and led to the degradation of the sensitizer curcumin.
Article
Spectroscopy
Rodrigo C. Silva, Hilde H. Buzza, Eli S. A. Ducas, Kleber T. Oliveira, Vanderlei S. Bagnato, Guilherme R. L. Souza, Luciane M. Almeida, Pablo J. Goncalves
Summary: A supramolecular assembly of methylene blue and curcumin was synthesized and evaluated for its potential in photodynamic antiangiogenic therapy. The results demonstrated that the MB-Curc assembly exhibited a synergistic vascular effect, causing significant damage to the vascular network after irradiation.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)