Article
Biochemistry & Molecular Biology
Yuhao Wang, Yi Shi, Wenhao Li, Shu Wang, Jiyang Zheng, Guanghui Xu, Guixiang Li, Xuefeng Shen, Jianjun Yang
Summary: High-altitude environment disrupts the ecological balance of gut microbiota, leading to damage to the intestinal structure and mucosal barrier. This study found that transplanted gut microbiota from high-altitude environment induced similar intestinal damage, which was inhibited by antibiotic treatment.
Article
Microbiology
Xue Bai, Guiqin Liu, Jianxin Yang, Junbo Zhu, Qian Wang, Yang Zhou, Wenqi Gu, Linli La, Xiangyang Li
Summary: This study investigated the effects of high-altitude hypoxic environments on the gut microbiota. The results showed significant differences in gut microbiota structure and diversity between rats in the high-altitude hypoxic group and rats in other groups. The gut microbiota of rats in the hypoxic groups showed the most significant changes on day 7. Functional analysis revealed significant differences in metabolic pathways between the different groups.
MICROBIOLOGY SPECTRUM
(2022)
Article
Pharmacology & Pharmacy
Xue Bai, Jianxin Yang, Guiqin Liu, Junbo Zhu, Qian Wang, Wenqi Gu, Linli La, Xiangyang Li
Summary: Hypoxia, a key feature of high-altitude environments, has a significant impact on drug metabolism. This study investigated the mechanisms of gut microbial changes in response to hypoxia and found that hypoxia altered gut microbial diversity and composition, which subsequently affected the expressions of CYP3A1 and MDR1.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Microbiology
Feng Wang, Han Zhang, Tong Xu, Youchun Hu, Yugang Jiang
Summary: This study evaluated the microbial changes after acute exposure to simulated high-altitude hypoxia. The results showed that the gut microbiota diversity and composition were significantly altered in the hypoxia group, which may provide a potential target for alleviating acute high-altitude diseases.
ARCHIVES OF MICROBIOLOGY
(2022)
Article
Oncology
Zongmei Zheng, Xinxin Hou, Zhaoxiang Bian, Wei Jia, Ling Zhao
Summary: This review explores the crucial role of gut microbiota in the metastasis of colorectal cancer (CRC) and elucidates the molecular mechanisms through which gut microbiota contribute to the formation of a tumor-permissive microenvironment, as well as facilitate malignant transformation and dissemination of tumor cells, thus mediating CRC metastasis.
Review
Nutrition & Dietetics
Sj Shen, Muxue Gong, Gang Wang, Kamal Dua, Jincheng Xu, Xiaoyue Xu, Gang Liu
Summary: COVID-19-induced gut injury is a common symptom, and the mechanism is mainly due to the binding of SARS-CoV-2 to the ACE2 receptor in host cells. Antiviral drugs and monoclonal antibodies can reduce viral load and shorten the recovery time of the disease. Probiotics, ACE2 inhibitors, and nutrients are promising options for treating COVID-19-induced gut injury.
Review
Gastroenterology & Hepatology
Bingqian Zhou, Xiaoqi Pang, Jingyi Wu, Tianyu Liu, Bangmao Wang, Hailong Cao
Summary: The COVID-19 epidemic is a global health threat with gastrointestinal symptoms being common manifestations. Alterations in the gut microbiota are associated with COVID-19 progression and severity, as well as post-COVID-19 syndrome. Therapeutic strategies such as diet, probiotics/prebiotics, herb, and fecal microbiota transplantation have shown positive effects. Understanding the connections between gut microbiota and COVID-19 could provide new insights for COVID-19 management in the future.
Review
Food Science & Technology
V Rossini, V Tolosa-Enguis, C. Frances-Cuesta, Y. Sanz
Summary: SARS-CoV-2 primarily affects the respiratory system, but it also targets the gastrointestinal tract. Prolonged gut disorders in COVID-19 patients are associated with decreased richness and diversity of the gut microbiota, immune deregulation, and delayed viral clearance. The composition and function of the gut microbiome may play a role in the progression of COVID-19. Strategies to modulate the gut microbiome are being investigated for population stratification and management of COVID-19 infection.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Gastroenterology & Hepatology
Dongqin Zhou, Yongsheng Li
Summary: This review discusses the regulatory role of gut microbiota on tumor-associated macrophages (TAMs) and their potential link with the tumor microenvironment (TME). Recent studies suggest a potential association between gut microbiome and TME, and understanding this association could improve the efficacy of tumor immunotherapy.
Article
Chemistry, Medicinal
Xiao-Chong Li, Bang-Sheng Wu, Yi Jiang, Jie Li, Ze-Fen Wang, Chao Ma, Yi-Rong Li, Jie Yao, Xiao-Qing Jin, Zhi-Qiang Li
Summary: The study demonstrates that the development and progression of glioma alter the composition of gut microbiota. Treatment with temozolomide leads to an enrichment in Akkermansia and Bifidobacterium, as well as prevents the reduction of Anaerotruncus, contributing to its anti-tumor effect. This research helps to reveal the association between specific microbial species in the gut and the anti-tumor effect of temozolomide.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Microbiology
Yichen Hu, Zhiyuan Pan, Zongyu Huang, Yan Li, Ni Han, Xiaomei Zhuang, Hui Peng, Quansheng Gao, Qing Wang, B. J. Yang Lee, Heping Zhang, Ruifu Yang, Yujing Bi, Zhenjiang Zech Xu
Summary: This study investigated the effects of probiotics, prebiotics, and synbiotics on altitude-related cardiac impairment in a rat model. The treatments alleviated cardiac hypertrophy and restored gut microbiota disruptions caused by hypobaric hypoxia. The study suggests that the gut microbiome may play a causal role in high-altitude-related diseases and could be a target for therapeutic interventions.
MICROBIOLOGY SPECTRUM
(2022)
Review
Pharmacology & Pharmacy
Ziqi Chen, Yiwen Lv, Huachong Xu, Li Deng
Summary: COVID-19 is a respiratory disease caused by a virus, with symptoms ranging from mild to life-threatening. Some patients also experience gastrointestinal symptoms. Herbal medicine may play a role in recovering intestinal flora structure and modulating immune function for the treatment and recovery of COVID-19.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Imad Al Kassaa, Sarah El Omari, Nada Abbas, Nicolas Papon, Djamel Drider, Issmat I. Kassem, Marwan Osman
Summary: This study demonstrated a potential association between gut health and COVID-19 severity in Lebanon, a country experiencing a severe economic crisis. The data analysis revealed that low gut health was correlated with more severe COVID-19 cases, and participants with unhealthy food intake were more likely to experience severe symptoms. Multiple logistic regression models showed significant associations between COVID-19 symptoms and variables such as gut health score, working status, and flu-like illness episodes.
Review
Oncology
Yunbo He, Jinliang Huang, Qiaorong Li, Weiping Xia, Chunyu Zhang, Zhi Liu, Jiatong Xiao, Zhenglin Yi, Hao Deng, Zicheng Xiao, Jiao Hu, Huihuang Li, Xiongbing Zu, Chao Quan, Jinbo Chen
Summary: The status and composition of gut microbiota have a profound impact on human antitumor immunity by influencing immune cells and inflammatory factors. Protecting and optimizing gut microbiota can improve the efficacy of immunotherapy, bringing new hope for cancer treatment.
Review
Immunology
Gislane Lelis Vilela de Oliveira, Camilla Narjara Simao Oliveira, Camila Figueiredo Pinzan, Larissa Vedovato Vilela de Salis, Cristina Ribeiro de Barros Cardoso
Summary: COVID-19, caused by SARS-CoV-2, affects respiratory and gastrointestinal systems, with prolonged gastrointestinal manifestations possibly linked to alterations in gut microbiota and immune responses; the bidirectional interactions between respiratory mucosa and gut microbiota may play a crucial role in immune responses to the virus.
FRONTIERS IN IMMUNOLOGY
(2021)