Tight nanoscale clustering of Fcγ receptors using DNA origami promotes phagocytosis

Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab

(2020) Lionel Rougé et al.   SCIENCE

Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies

(2020) Hui Yi Chew et al.   CELL

Clustering of the ζ-Chain Can Initiate T Cell Receptor Signaling

(2020) Yuanqing Ma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CD47 Ligation Repositions the Inhibitory Receptor SIRPA to Suppress Integrin Activation and Phagocytosis

(2020) Meghan A. Morrissey et al.   IMMUNITY

Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens

(2020) George Ueda et al.   eLife

Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo

(2020) Yu Kato et al.   IMMUNITY

DNA scaffolds enable efficient and tunable functionalization of biomaterials for immune cell modulation

(2020) Xiao Huang et al.   Nature Nanotechnology

Binding to nanopatterned antigens is dominated by the spatial tolerance of antibodies

(2019) Alan Shaw et al.   Nature Nanotechnology

Size-Dependent Segregation Controls Macrophage Phagocytosis of Antibody-Opsonized Targets

(2018) Matthew H. Bakalar et al.   CELL

Full control of ligand positioning reveals spatial thresholds for T cell receptor triggering

(2018) Haogang Cai et al.   Nature Nanotechnology

Chimeric antigen receptors that trigger phagocytosis

(2018) Meghan A Morrissey et al.   eLife

Membrane nanoclusters of FcγRI segregate from inhibitory SIRPα upon activation of human macrophages

(2017) Filipa B. Lopes et al.   JOURNAL OF CELL BIOLOGY

In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase

(2017) Catherine B. Carbone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein sorting by lipid phase-like domains supports emergent signaling function in B lymphocyte plasma membranes

(2017) Matthew B Stone et al.   eLife

TIRF imaging of Fc gamma receptor microclusters dynamics and signaling on macrophages during frustrated phagocytosis

(2016) Jia Lin et al.   BMC IMMUNOLOGY

Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis

(2016) Spencer A. Freeman et al.   CELL

Computational design of self-assembling cyclic protein homo-oligomers

(2016) Jorge A. Fallas et al.   Nature Chemistry

Size-dependent protein segregation at membrane interfaces

(2016) Eva M. Schmid et al.   Nature Physics

Interactions of fungal pathogens with phagocytes

(2016) Lars P. Erwig et al.   NATURE REVIEWS MICROBIOLOGY

Phagocytosis of immunoglobulin-coated emulsion droplets

(2015) Kalthoum Ben M'Barek et al.   BIOMATERIALS

Mouse and human FcR effector functions

(2015) Pierre Bruhns et al.   IMMUNOLOGICAL REVIEWS

Anti-CD20 Antibody with Multimerized Fc Domains: A Novel Strategy To Deplete B Cells and Augment Treatment of Autoimmune Disease

(2015) Xiaoyu Zhang et al.   JOURNAL OF IMMUNOLOGY

Macrophages are critical effectors of antibody therapies for cancer

(2015) Kipp Weiskopf et al.   mAbs

The T cell receptor resides in ordered plasma membrane nanodomains that aggregate upon patching of the receptor

(2015) Jelena Dinic et al.   Scientific Reports

Actin Cytoskeleton Reorganization by Syk Regulates Fcγ Receptor Responsiveness by Increasing Its Lateral Mobility and Clustering

(2014) Valentin Jaumouillé et al.   DEVELOPMENTAL CELL

Broadly neutralizing hemagglutinin stalk–specific antibodies require FcγR interactions for protection against influenza virus in vivo

(2014) David J DiLillo et al.   NATURE MEDICINE

Tetravalent Antibody-scTRAIL Fusion Proteins with Improved Properties

(2013) O. Seifert et al.   MOLECULAR CANCER THERAPEUTICS

Nanoscale Ligand Spacing Influences Receptor Triggering in T Cells and NK Cells

(2013) Derfogail Delcassian et al.   NANO LETTERS

T Cell Activation is Determined by the Number of Presented Antigens

(2013) Janosch Deeg et al.   NANO LETTERS

Formation of targeted monovalent quantum dots by steric exclusion

(2013) Justin Farlow et al.   NATURE METHODS

Engineered SIRP  Variants as Immunotherapeutic Adjuvants to Anticancer Antibodies

(2013) K. Weiskopf et al.   SCIENCE

Formation and analysis of topographical domains between lipid membranes tethered by DNA hybrids of different lengths

(2012) Minsub Chung et al.   FARADAY DISCUSSIONS

Mechanisms of Fc Receptor and Dectin-1 Activation for Phagocytosis

(2012) Helen S. Goodridge et al.   TRAFFIC

Crystal Structure of Fcγ Receptor I and Its Implication in High Affinity γ-Immunoglobulin Binding

(2011) Jinghua Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Line Tension and Stability of Domains in Cell-Adhesion Zones Mediated by Long and Short Receptor-Ligand Complexes

(2011) Heinrich Krobath et al.   PLoS One

Boltzmann Energy-based Image Analysis Demonstrates that Extracellular Domain Size Differences Explain Protein Segregation at Immune Synapses

(2011) Nigel J. Burroughs et al.   PLoS Computational Biology

Nanomaterials Based on DNA

(2010) Nadrian C. Seeman   Annual Review of Biochemistry

Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin Lymphoma

(2010) Mark P. Chao et al.   CELL

Segregation of receptor–ligand complexes in cell adhesion zones: phase diagrams and the role of thermal membrane roughness

(2010) B Różycki et al.   NEW JOURNAL OF PHYSICS

Coordination of Fc receptor signaling regulates cellular commitment to phagocytosis

(2010) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Binding cooperativity of membrane adhesion receptors

(2009) Heinrich Krobath et al.   Soft Matter

Structurally Distinct Phosphatases CD45 and CD148 Both Regulate B Cell and Macrophage Immunoreceptor Signaling

(2008) Jing W. Zhu et al.   IMMUNITY

FcγRI (CD64) resides constitutively in lipid rafts

(2008) Jeffrey M. Beekman et al.   IMMUNOLOGY LETTERS

Direct observation of the nanoscale dynamics of membrane lipids in a living cell

(2008) Christian Eggeling et al.   NATURE