期刊
ELIFE
卷 10, 期 -, 页码 -出版社
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.66917
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资金
- Wellcome [098362/Z/12/Z, 104765/Z/14/Z, 219525/Z/19/Z, 212281/Z/18/Z, 203139/Z/16/Z, 091593/Z/10/Z]
- James S. McDonnell Foundaion [JSMF220020372]
- Max Planck Society
- Wellcome Trust [212281/Z/18/Z, 104765/Z/14/Z, 219525/Z/19/Z] Funding Source: Wellcome Trust
Researchers have developed an analysis toolkit called TDLM to study neural activity, finding statistical regularities in neural sequences. TDLM is able to handle confounds and maximize sequence detection ability, contributing to a deeper understanding of neural computation.
Y There are rich structures in off-task neural activity which are hypothesized to reflect fundamental computations across a broad spectrum of cognitive functions. Here, we develop an analysis toolkit - temporal delayed linear modelling (TDLM) - for analysing such activity. TDLM is a domain-general method for finding neural sequences that respect a pre-specified transition graph. It combines nonlinear classification and linear temporal modelling to test for statistical regularities in sequences of task-related reactivations. TDLM is developed on the non-invasive neuroimaging data and is designed to take care of confounds and maximize sequence detection ability. Notably, as a linear framework, TDLM can be easily extended, without loss of generality, to capture rodent replay in electrophysiology, including in continuous spaces, as well as addressing second-order inference questions, for example, its temporal and spatial varying pattern. We hope TDLM will advance a deeper understanding of neural computation and promote a richer convergence between animal and human neuroscience.
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