EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence

Relative Importance of Soluble and Microsomal Epoxide Hydrolases for the Hydrolysis of Epoxy-Fatty Acids in Human Tissues

(2021) Christophe Morisseau et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ovarian hyperandrogenism and its response to gonadotropin-releasing hormone analogue therapy in primary severe insulin resistance

(2021) Isabel Huang-Doran et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

LIPE-related lipodystrophic syndrome: clinical features and disease modeling using adipose stem cells

(2020) Camille Sollier et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

The Multifaceted Role of Epoxide Hydrolases in Human Health and Disease

(2020) Jérémie Gautheron et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer’s disease

(2020) Anamitra Ghosh et al.   Science Translational Medicine

Diagnostic challenge in PLIN1-associated Familial Partial Lipodystrophy

(2019) Isabelle Jéru et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Lipodystrophic syndromes: From diagnosis to treatment

(2019) Camille Sollier et al.   ANNALES D ENDOCRINOLOGIE

Congenital forms of diabetes: the beta-cell and beyond

(2018) Lisa R Letourneau et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Epoxide hydrolase 1 (EPHX1) hydrolyzes epoxyeicosanoids and impairs cardiac recovery after ischemia

(2018) Matthew L. Edin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Ablation of Soluble Epoxide Hydrolase reprogram white fat to beige-like fat through an increase in mitochondrial integrity, HO-1-adiponectin in vitro and in vivo

(2018) Lu Liu et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

MFN2-associated lipomatosis: Clinical spectrum and impact on adipose tissue

(2018) Emilie Capel et al.   Journal of Clinical Lipidology

Update on Therapeutic Options in Lipodystrophy

(2018) Baris Akinci et al.   Current Diabetes Reports

Phenotypic and Genetic Characteristics of Lipodystrophy: Pathophysiology, Metabolic Abnormalities, and Comorbidities

(2018) Baris Akinci et al.   Current Diabetes Reports

Characterization of MDPL Fibroblasts Carrying the Recurrent p.Ser605del Mutation in POLD1 Gene

(2018) Chiara Fiorillo et al.   DNA AND CELL BIOLOGY

Chiral lipidomics of monoepoxy and monohydroxy metabolites derived from long-chain polyunsaturated fatty acids

(2018) Maximilian Blum et al.   JOURNAL OF LIPID RESEARCH

Modulation of mitochondrial dysfunction and endoplasmic reticulum stress are key mechanisms for the wide-ranging actions of epoxy fatty acids and soluble epoxide hydrolase inhibitors

(2017) Bora Inceoglu et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Reference standards for body fat measures using GE dual energy x-ray absorptiometry in Caucasian adults

(2017) Mary T. Imboden et al.   PLoS One

Genetic enhancement of microsomal epoxide hydrolase improves metabolic detoxification but impairs cerebral blood flow regulation

(2016) Anne Marowsky et al.   ARCHIVES OF TOXICOLOGY

One-year metreleptin improves insulin secretion in patients with diabetes linked to genetic lipodystrophic syndromes

(2016) C. Vatier et al.   DIABETES OBESITY & METABOLISM

The Diagnosis and Management of Lipodystrophy Syndromes: A Multi-Society Practice Guideline

(2016) Rebecca J. Brown et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases

(2016) Pierpaola Davalli et al.   Oxidative Medicine and Cellular Longevity

Microsomal epoxide hydrolase 1 (EPHX1): Gene, structure, function, and role in human disease

(2015) Radka Václavíková et al.   GENE

Clinical application of whole-exome sequencing across clinical indications

(2015) Kyle Retterer et al.   GENETICS IN MEDICINE

Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology

(2015) Sue Richards et al.   GENETICS IN MEDICINE

GeneMatcher: A Matching Tool for Connecting Investigators with an Interest in the Same Gene

(2015) Nara Sobreira et al.   HUMAN MUTATION

The role of epoxide hydrolases in health and disease

(2014) Ahmed A. El-Sherbeni et al.   ARCHIVES OF TOXICOLOGY

A novel activity of microsomal epoxide hydrolase: metabolism of the endocannabinoid 2-arachidonoylglycerol

(2014) Kasem Nithipatikom et al.   JOURNAL OF LIPID RESEARCH

Lipodystrophy-Linked LMNA p.R482W Mutation Induces Clinical Early Atherosclerosis and In Vitro Endothelial Dysfunction

(2013) Guillaume Bidault et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Transcription of the human microsomal epoxide hydrolase gene (EPHX1) is regulated by an HNF-4α/CAR/RXR/PSF complex

(2013) Hui Peng et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Prevalence of Reproductive Abnormalities Among Women with Familial Partial Lipodystrophy

(2013) Tisha Joy et al.   Endocrine Practice

Soluble Epoxide Hydrolase Deficiency or Inhibition Attenuates Diet-induced Endoplasmic Reticulum Stress in Liver and Adipose Tissue

(2013) Ahmed Bettaieb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of Soluble Epoxide Hydrolase and Epoxyeicosanoids on Human Health

(2012) Christophe Morisseau et al.   Annual Review of Pharmacology and Toxicology

Role of epoxide hydrolases in lipid metabolism

(2012) Christophe Morisseau   BIOCHIMIE

EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides

(2012) Martina Decker et al.   JOURNAL OF LIPID RESEARCH

Epoxides and Soluble Epoxide Hydrolase in Cardiovascular Physiology

(2012) John D. Imig   PHYSIOLOGICAL REVIEWS

Lipodystrophies: Genetic and Acquired Body Fat Disorders

(2011) Abhimanyu Garg   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Fat tissue, aging, and cellular senescence

(2010) Tamara Tchkonia et al.   AGING CELL

Microsomal epoxide hydrolase expression in the endometrial uterine corpus is regulated by progesterone during the menstrual cycle

(2010) Simone L. Popp et al.   JOURNAL OF MOLECULAR HISTOLOGY

Epoxyeicosatrienoic Acid Agonist Regulates Human Mesenchymal Stem Cell–Derived Adipocytes Through Activation of HO-1-pAKT Signaling and a Decrease in PPARγ

(2010) Dong Hyun Kim et al.   STEM CELLS AND DEVELOPMENT

Quantitative Profiling Method for Oxylipin Metabolome by Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry

(2009) Jun Yang et al.   ANALYTICAL CHEMISTRY

Mammalian epoxide hydrolases in xenobiotic metabolism and signalling

(2009) Martina Decker et al.   ARCHIVES OF TOXICOLOGY

Oviductal Microsomal Epoxide Hydrolase (EPHX1) Reduces Reactive Oxygen Species (ROS) Level and Enhances Preimplantation Mouse Embryo Development1

(2009) Ana W.Y. Cheong et al.   BIOLOGY OF REPRODUCTION

Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases

(2009) John D. Imig et al.   NATURE REVIEWS DRUG DISCOVERY

Distribution of soluble and microsomal epoxide hydrolase in the mouse brain and its contribution to cerebral epoxyeicosatrienoic acid metabolism

(2009) A. Marowsky et al.   NEUROSCIENCE

Expression and Regulation of Soluble Epoxide Hydrolase in Adipose Tissue

(2009) Bart M. De Taeye et al.   Obesity

Dual Energy X-Ray Absorptiometry Body Composition Reference Values from NHANES

(2009) Thomas L. Kelly et al.   PLoS One